Abstract: A cell-based screening method is provided. The screening method aims to identify drugs for the treatment of cancers characterized by cells with an over-activated signalling pathway in a combination medicament with an inhibitor of the respective over-activated signalling pathway. In particular, the expression level of SOX2 is determined to identify compounds that prevent the development of resistance to inhibitors of the MAPK and EGFR pathway.
Type:
Application
Filed:
December 20, 2017
Publication date:
March 19, 2020
Applicant:
ETH ZURICH
Inventors:
Wilhelm KREK, Stefanie FLUCKIGER-MANGUAL
Abstract: A 3D printed core-shell filament comprises an elongated core radially surrounded by an outer shell with a barrier layer in between, where the elongated core comprises a ductile polymer and the outer shell comprises a stiff polymer having a Young's modulus higher than that of the ductile polymer. A lightweight lattice structure may comprise a plurality of the 3D printed core-shell filaments deposited in layers.
Type:
Application
Filed:
December 5, 2017
Publication date:
March 5, 2020
Applicant:
ETH Zurich (Swiss Federal Institute of Technology)
Inventors:
Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea
Abstract: Systems, methods and articles of manufacture for rendering three-dimensional virtual environments using reversible jumps are disclosed herein. In one embodiment, mappings from random numbers to light paths are modeled as an explicit iterative random walk. Inverses of path construction techniques are employed to turn light transport paths back into the random numbers that produced them. In particular, such inverses may be used to extend the Multiplexed Metropolis Light Transport (MMLT) technique to perform path-invariant perturbations that produce a new path sample using a different path construction technique but preserve the path's geometry.
Type:
Grant
Filed:
November 9, 2017
Date of Patent:
March 3, 2020
Assignees:
Disney Enterprises, Inc., ETH Zurich (Eidgenoessische Technische Hochschule Zurich)
Inventors:
Jan Novák, Wenzel A. Jakob, Wojciech Jarosz, Benedikt Martin Bitterli
Abstract: The present disclosure relates to an apparatus, system and method for processing transmedia content data. More specifically, the disclosure provides for identifying and inserting one item of media content within another item of media content, e.g. inserting a video within a video, such that the first item of media content appears as part of the second item. The invention involves analysing a first visual media item to identify one or more spatial locations to insert the second visual media item within the image data of the first visual media item, detecting characteristics of the one or more identified spatial locations, transforming the second visual media item according to the detected characteristics and combining the first visual media item and second visual media item by inserting the transformed second visual media item into the first visual media item at the one or more identified spatial locations.
Type:
Grant
Filed:
September 26, 2017
Date of Patent:
March 3, 2020
Assignees:
DISNEY ENTERPRISES, INC., ETH ZÜRICH (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
Inventors:
Alex Sorkine-Hornung, Simone Meier, Jean-Charles Bazin, Sasha Schriber, Markus Gross, Oliver Wang
Abstract: The present invention relates to core-shell particles comprising encapsulated nucleic acids—a sensing sequence and a control sequence; the invention further relates to the use of such particles as a sensing element; to methods for measuring a property of interest in a setting employing such particles; to measuring systems and analytical kits comprising such particles.
Type:
Grant
Filed:
April 19, 2016
Date of Patent:
March 3, 2020
Assignee:
ETH Zurich
Inventors:
Robert N. Grass, Wendelin Jan Stark, Gediminas Mikutis, Michela Puddu
Abstract: In one aspect, the present disclosure provides a nozzle for 3-D printing. The nozzle may include a first nozzle tip defining a first outlet, where the first nozzle tip includes a first channel extending therethrough. The nozzle may further include a second nozzle tip defining a second outlet, where the second nozzle tip includes a second channel extending therethrough, and where the first channel surrounds the second outlet. The second nozzle tip may be retracted longitudinally with respect to the first nozzle tip such that the second outlet of the second nozzle tip is located in the first channel.
Type:
Application
Filed:
December 5, 2017
Publication date:
February 27, 2020
Applicants:
President and Fellows of Harvard College, ETH Zurich (Swiss Federal Institute of Technology)
Inventors:
Jennifer A. Lewis, Jochen Mueller, Jordan R. Raney, Kristina Shea
Abstract: An electro-optic element includes a first waveguide, which is a plasmonic waveguide, including a first core having a ferroelectric material and a cladding having a first cladding portion. The first cladding portion includes, at a first interface with the ferroelectric material, a first cladding material. The electro-optic element includes a first and a second electrode for producing an electric field in the ferroelectric material when a voltage is applied between the first and second electrodes, for modulating a real part of a refractive index of the ferroelectric material. The element includes, in addition, a crystalline substrate on which the ferroelectric material is epitaxially grown with zero or one or more intermediate layers present between the substrate and the ferroelectric material. The element may have a second waveguide, which is a photonic waveguide, including for enabling evanescent coupling between the first and second waveguides.
Abstract: The invention relates to a method for preparing a polymer scaffold that comprises the steps of providing a piece of a fabric of filaments of a first biodegradable or biocompatible polymer, applying a coating of a second polymer to said arrangement of filaments, and stretching the piece along its axis of longitudinal extension, thereby obtaining an aligned microfibrillar scaffold. The invention further relates to a method for providing an artificial tissue, and to a microfibrillar scaffold of aligned filaments obtained by the method of the invention.
Type:
Application
Filed:
October 27, 2017
Publication date:
February 20, 2020
Applicants:
ETH ZÜRICH, UNIVERSITÄT ZÜRICH
Inventors:
Simon Philipp HOERSTRUP, Seyedvahid HOSSEINI, Viola VOGEL
Abstract: According to a first aspect of the invention, there is provided a method for operating a multicopter experiencing a failure during flight, the multicopter comprising a body, and at least four effectors attached to the body, each operable to produce both a torque and a thrust force which can cause the multicopter to fly when not experiencing said failure.
Type:
Grant
Filed:
April 22, 2019
Date of Patent:
February 18, 2020
Assignee:
ETH Zurich
Inventors:
Mark W. Mueller, Sergei Lupashin, Raffaello D'Andrea, Markus Waibel
Abstract: A pump having at least a fluid pump chamber (11) and a first driver chamber (12) separated from the fluid pump chamber (11) by an elastic wall (13, 13-1, 13-2) is described with the first driver chamber (12) expanding after a chemical reaction between fuel and oxidant and driving through deformation of the elastic wall fluid out of the fluid pump chamber (11), with the main parts of the pump being made of an elastic material to be used for example as a body implant.
Type:
Grant
Filed:
October 1, 2014
Date of Patent:
February 4, 2020
Assignee:
ETH Zurich
Inventors:
Wendelin Jan Stark, Christoph Schumacher, Roland Fuhrer, Michael Loepfe
Abstract: The invention relates to a top-cover for a controlled environmental system (CES) for use with a measurement technique that requires introducing a probe to a sample placed on a sample holder, a CES and a procedure to control the environment for a sample in a system in particular a CES during a measurement with a probe based technique.
Type:
Grant
Filed:
July 15, 2016
Date of Patent:
January 28, 2020
Assignees:
ETH ZURICH, UNIVERSITÄT BASEL
Inventors:
David Martinez-Martin, Daniel J. Mueller, Sascha Martin, David Alsteens, Gotthold Flaschner
Abstract: The disclosure provides an approach for edge-aware spatio-temporal filtering. In one embodiment, a filtering application receives as input a guiding video sequence and video sequence(s) from additional channel(s). The filtering application estimates a sparse optical flow from the guiding video sequence using a novel binary feature descriptor integrated into the Coarse-to-fine PatchMatch method to compute a quasi-dense nearest neighbor field. The filtering application then performs spatial edge-aware filtering of the sparse optical flow (to obtain a dense flow) and the additional channel(s), using an efficient evaluation of the permeability filter with only two scan-line passes per iteration. Further, the filtering application performs temporal filtering of the optical flow using an infinite impulse response filter that only requires one filter state updated based on new guiding video sequence video frames.
Type:
Grant
Filed:
May 5, 2017
Date of Patent:
January 28, 2020
Assignees:
Disney Enterprises, Inc., ETH Zurich (Eidgenoessische Technische Hochschule Zurich)
Inventors:
Tunc Ozan Aydin, Florian Michael Scheidegger, Michael Stefano Fritz Schaffner, Lukas Cavigelli, Luca Benini, Aljosa Aleksej Andrej Smolic
Abstract: Method of fabricating a 3-dimensional structure, mesh formwork element for fabricating a 3-dimensional structure, and method of fabricating the same. The method of fabricating a 3-dimensional structure comprises providing a mesh formwork element such that a cavity bound by at least two opposing portions of the mesh formwork is formed; accumulating a material in the cavity; and allowing the material to harden; wherein apertures in the at least two opposing portions of the mesh formwork element are adapted to the hydro-static pressure of the accumulated material or vice versa such that at least two surfaces of the hardened material substantially take on the respective shapes defined by the two opposing portions of the mesh formwork element.
Type:
Grant
Filed:
September 4, 2014
Date of Patent:
January 28, 2020
Assignees:
ETH SINGAPORE SEC LTD., ETH ZURICH (SWISS FEDERAL INSTITUTE OF TECHNOLOGY ZURICH), SIKA TECHNOLOGY AG
Inventors:
Norman Peter Hack, Willi Viktor Lauer, Fabio Matteo Gramazio, Matthias Kohler, Norman Blank
Abstract: Supervised machine learning using convolutional neural network (CNN) is applied to denoising images rendered by MC path tracing. The input image data may include pixel color and its variance, as well as a set of auxiliary buffers that encode scene information (e.g., surface normal, albedo, depth, and their corresponding variances). In some embodiments, a CNN directly predicts the final denoised pixel value as a highly non-linear combination of the input features. In some other embodiments, a kernel-prediction neural network uses a CNN to estimate the local weighting kernels, which are used to compute each denoised pixel from its neighbors. In some embodiments, the input image can be decomposed into diffuse and specular components. The diffuse and specular components are then independently preprocessed, filtered, and postprocessed, before recombining them to obtain a final denoised image.
Type:
Application
Filed:
September 26, 2019
Publication date:
January 23, 2020
Applicants:
Disney Enterprises, Inc., ETH ZÜRICH (EIDGENÖSSISCHE TECHNISCHE HOCHSCHULE ZÜRICH)
Inventors:
Thijs Vogels, Jan Novák, Fabrice Rousselle, Brian McWilliams
Abstract: The invention relates to a device (1) for generating droplets (30) comprising a plurality of channels (20), wherein each channel (20) extends from an inlet (201) along a respective longitudinal axis (L) to an outlet (202), wherein said device (1) comprises a plurality of layers (10) of a substrate material arranged in a stack (100), wherein each layer (10) comprises a first side (101) and a second side (102) facing away from each other, and wherein said first side (101) of each layer (10) comprises a plurality of grooves (103), wherein said channels (20) are formed by said grooves (103) of said first side (101) of a respective layer (10) of said stack (100) and said second side (102) of a respective adjacent layer (10) of said stack (100). The invention further relates to a method for generating droplets (30) and a fabrication method of the device (1).
Type:
Application
Filed:
March 22, 2018
Publication date:
January 23, 2020
Applicant:
ETH ZURICH
Inventors:
André R. STUDART, Alessandro OFNER, Pascal SCHWENDIMANN
Abstract: The present invention relates to a method of providing a graft scaffold for cartilage repair, particularly in a human patient. The method of the invention comprising the steps of providing particles and/or fibres; providing an aqueous solution of a gelling polysaccharide; providing mammalian cells; mixing said particles and/or fibres, said aqueous solution of a gelling polysaccharide and said mammalian cells to obtain a printing mix; and depositing said printing mix in a three-dimensional form. The invention further relates to graft scaffolds and grafts obtained by the method of the invention.
Type:
Grant
Filed:
December 11, 2015
Date of Patent:
January 14, 2020
Assignee:
ETH ZURICH
Inventors:
Matti Kesti, Marcy Zenobi-Wong, Michael Muller
Abstract: A medical ultrasound system comprises an ultrasound transducer (1) for emitting and receiving ultrasound, and a processor (51). The ultrasound transducer (1) is electrically connected to the processor (51), and the processor (51) is configured to determine an ultrasound based tomographic image subject to ultrasound waves (usr) received by the ultrasound transducer (1) in response to ultrasound waves emitted by the ultrasound transducer (1) and scattered and/or reflected by tissue to be investigated.
Abstract: An apparatus for emitting pulsed electromagnetic laser radiation includes a laser gain element; an optical arrangement defining a laser resonator and arranged to re-direct radiation emitted by the gain element along a beam path back onto the gain element, the optical arrangement comprising an output coupler configured to couple a portion of the radiation in the laser resonator out of the laser resonator; and, a pump arrangement configured to pump the laser gain element. The optical arrangement includes a mode locker placed in the laser resonator in the beam path, and a birefringent element placed in the laser resonator in the beam path.
Type:
Grant
Filed:
September 30, 2015
Date of Patent:
January 7, 2020
Assignee:
ETH ZÜRICH
Inventors:
Sandro Michael Link, Bonifatius Wilhelmus Tilma, Mario Mangold, Christian Anton Zaugg, Alexander Klenner, Ursula Keller
Abstract: Virtual oscillator control systems, devices, and techniques are provided. One example device includes a processor configured to implement a virtual oscillator circuit and output an oscillating waveform based on the virtual oscillator circuit and power electronics operatively coupled to the processor and configured to convert, based on the oscillating waveform, direct current (DC) electricity to alternating current (AC) electricity. The processor may be further configured to extract, from the virtual oscillator circuit, a virtual current based on an output current of the AC electricity, and output the oscillating waveform further based on an input voltage of the DC electricity.
Type:
Grant
Filed:
April 28, 2017
Date of Patent:
January 7, 2020
Assignees:
Alliance for Sustainable Energy, LLC, ETH Zürich
Inventors:
Brian Benjamin Johnson, Nathan Ainsworth, Sairaj Vijaykumar Dhople, Mohit Sinha, Florian Anton Dörfler