Abstract: The present invention relates to novel compositions comprising specific consortia of living bacteria strains; to the manufacturing of such compositions, particularly by co-cultivation; and to the use of such compositions in pharmaceutical applications, such as the treatment of diseases associated with intestinal microbiota dysbiosis, particularly intestinal infections such as CDI (Clostridium difficile infection) and IBD (Inflammatory bowel diseases). When compared to the traditional FMT therapy () the inventive compositions () are more efficient and safer as demonstrated on an acute colitis model and therefore more appropriate for therapeutic use.

Abstract: A method for generating an image data set of an image area located in a measurement volume of a magnetic resonance system comprising a gradient system and an RF transmission/reception system, comprises the following method steps: —reading out k-space corresponding to the imaging area, by: (a) activating a frequency encoding gradient in a predetermined spatial direction and with a predetermined strength G0 by means of said gradient system, (b) after the activated frequency encoding gradient achieves its strength G0, radiating a non-slice-selective RF excitation pulse by means of said RF transmission/reception system, (c) after a transmit-receive switch time ?tTR following the radiated excitation pulse, acquiring FID signals with said RF transmission/reception system and storing said FID signals as raw data points in k-space along a radial k-space trajectory that is predetermined by the direction and strength G0 of the frequency encoding gradient, (d) repeating (a) through (c) with respectively different freque

Abstract: According to one implementation, a pixel error detection system includes a hardware processor and a system memory storing a software code. The hardware processor is configured to execute the software code to receive an input image, to mask, using an inpainting neural network (NN), one or more patch(es) of the input image, and to inpaint, using the inpainting NN, the masked patch(es) based an input image pixels neighboring each of the masked patch(es). The hardware processor is configured to further execute the software code to generate, using the inpainting NN, a residual image based on differences between the inpainted masked patch(es) and the patch(es) in the input image and to identify one or more anomalous pixel(s) in the input image using the residual image.

Abstract: A 3D printed core-shell filament comprises an elongated core radially surrounded by an outer shell with a barrier layer in between, where the elongated core comprises a ductile polymer and the outer shell comprises a stiff polymer having a Young's modulus higher than that of the ductile polymer. A lightweight lattice structure may comprise a plurality of the 3D printed core-shell filaments deposited in layers.

Abstract: The invention relates to double stranded ribonucleic acid (dsRNA) agents and compositions targeting a High Density Lipoprotein Binding Protein (Hdlbp/Vigilin) gene, as well as methods of inhibiting expression of Hdlbp/Vigilin and methods of treating subjects having a disorder of lipid metabolism, such as mixed hyperlipidemia, hypertriglyceridemia or hypercholesterolemia, using such dsRNA agents and compositions.

Abstract: According to the present invention there is provided a receiver device comprising, a first electrode (3) which can capacitive couple to an electrode of a transmitter device; a second electrode (5) which can capacitive couple to said electrode of said transmitter device; an energy harvesting circuit (7), which comprises a first capacitor (9), wherein said first electrode (3) is electrically connected to the energy harvesting circuit (7) so that energy from a signal which was transmitted from the electrode of the transmitter device and received at the first electrode (3), can be used to increase voltage across the first capacitor (9); and a comparator (15), wherein the first capacitor (9) is electrically connected to a positive supply input terminal (15c) of the comparator (15) so that voltage across the first capacitor (9) can be used to power the comparator (15); a demodulator circuit (11) wherein said second electrode (5) is electrically connected to the demodulator circuit (11); a first filter circuit (17),

Abstract: The present invention relates to compositions, particularly baby food compositions, including living propionic acid-producing bacteria, preferably lactate-utilizing propionic acid-producing bacteria, their manufacture and use in the treatment of digestive diseases, particularly for treatment of infantile colic.

Abstract: The present invention is directed to all aspects of novel methyl transferase enzymes that methylate backbone amides of (poly)peptides. The present invention also relates to nucleic acids encoding these enzymes as well as corresponding vectors and host cells comprising these. Moreover, the present invention encompasses the use of said enzymes for modifying (poly)peptides as well as corresponding methods. Also, the present invention pertains to further novel enzymes for modifying (poly)peptides derived from the omphalotin gene cluster of O. olearius and the homologous gene clusters from D. bispora, L. edodes and F. mediterranea as well as related aspects.

Abstract: The present invention refers to Biodegradable, biocompatible, water-suspensable nanoparticle (1), for generating a second- or third-harmonic light signal upon illumination, as well as a method for preparing an aqueous suspension comprising said nanoparticle, a method for second-harmonic generation imaging of the nanoparticle (1) as and a use of the nanoparticle (1) for second-harmonic generation imaging. The nanoparticle (1) according to the invention comprises —a shell layer (2) comprising a biodegradable polymer (3), wherein the shell layer (2) encloses —a plurality (40) of oligopeptides (4), wherein the plurality (40) of oligopeptides (4) is structured such that a second-harmonic light signal is generated upon illumination of the nanoparticle (1) with light.

Abstract: The present invention relates to a cell comprising a first nucleic acid sequence encoding a first polypeptide fused to the N-terminus of a first variant of a histidine kinase comprising a DHp domain and a CA domain, wherein said first variant does not comprise a transmembrane domain, a second nucleic acid sequence encoding a second polypeptide fused to the N-terminus of a second variant of said histidine kinase comprising a DHp domain and a CA domain, wherein said second variant does not comprise a transmembrane domain, and a third nucleic acid sequence encoding a response regulatory protein specifically phosphorylatable by said DHp domain of said first or said second variant. The present invention further relates to uses of the cell of the invention.

Abstract: A method of investigating a sample using a wide-field multiphoton microscope with tunable excitation wavelength (?) is disclosed. The sample is illuminated at some excitation wavelength. Images of the sample are acquired at wavelengths different from the excitation wavelength, e.g., at half the excitation wavelength for SHG microscopy, using an image sensor. Based on the obtained images, an autoalignment procedure is carried out for optimizing the position of the sample relative to the illumination and/or collection beam paths. An image or spectrum that has been obtained for the optimal relative position is stored. The procedure is repeated for multiple excitation wavelengths.

Abstract: Thin films of lithium-containing materials and methods for fabricating them are generally described. In some embodiments, the formation of a first vapor is induced from a first target and the formation of a second vapor is induced from a second target, resulting in the formation of a thin film. In some embodiments, at least a portion of the formation of the first vapor and the formation of the second vapor occurs under vacuum conditions. In some embodiments, the thin film has a relatively high ionic conductivity, mixed ionic/electronic conductivity, or other properties beneficial for applications such as active electrode materials or solid-state electrolytes.

Abstract: An additive manufacturing process for the manufacture of an object in an additive manufacturing apparatus, wherein the object is formed by one or several individual solid filamentous units, said additive manufacturing process comprises the steps of, discharging a polymer composition in a molten state from a nozzle of a print head, thereby imparting an orienting flow on the polymer composition in a molten state being discharged from the nozzle of the print head and depositing said discharged polymer composition in a molten state along at least one predefined, preferably horizontal, path and allowing the thus formed one or several filamentous units to solidify such as to form one or several solid filamentous units of the object to be manufactured; optionally repeating the previous step until the object is formed; wherein said polymer composition comprises a thermotropic liquid crystal polymer as a polymer component of the polymer composition and the solid filamentous units are characterized in that the smal

Abstract: The present invention to provide a method of operating a thermal energy storage device comprising a body of heat transfer fluid, said body of heat transfer fluid comprising an upper temperature region comprising heat transfer fluid having a temperature above a upper threshold temperature, a lower temperature region comprising heat transfer fluid having a temperature below a lower threshold temperature and a thermocline region separating the upper and lower temperature regions and comprising heat transfer fluid having a temperature above a lower threshold temperature and below an upper threshold temperature, wherein during charging of the thermal energy storage device, heat transfer fluid is removed from the thermocline region of the body of heat transfer fluid and when the temperature of the heat transfer fluid being removed from the thermocline region of the body of heat transfer fluid rises above a maximum temperature, said heat transfer fluid being removed is brought to a temperature equal to or below said

Abstract: This disclosure presents systems and methods to provide an interactive environment in response to touch-based inputs. A first body channel communication device coupled to a user may transmit and/or receive signals configured to be propagated along skin of the user such that the skin of the user comprises a signal transmission path. A second body channel communication device coupled to an interaction entity may be configured to transmit and/or receive signals configured to be propagated along the skin of the user along the signal transmission path. A presentation device may present images of virtual content to the user. Information may be communicated between the first body channel communication device, the second body channel communication device, and the presentation device so that virtual content specific to the interaction entity may be presented to augment an appearance of the interaction entity.

Abstract: The invention is related to an inositol polyphosphate oligo alkyl ether compound, or its pharmaceutically acceptable salt, for use in treatment or prevention of a disease associated with formation of calcium salt crystals.

Abstract: A method for analysing an analyte (3) using surface enhanced Raman spectroscopy (SERS), comprising the following steps: (a) providing an essentially flat or topologically structured metal surface (1) of a SERS-active metal; (b) depositing the analyte (3) or an open pore matrix material (5) on the surface (1); (c) depositing a multitude of nano-droplets (2) of a SERS-active metal on top of the analyte (3) or the open pore matrix material (5), respectively; and (d) spectroscopically analysing, by scanning laser irradiation and using SERS, the analyte sandwiched between the surface (1) and the multitude of nano-droplets (2). The diameter of the nano-droplets (2) is in the range of 5-70 nm, and the distance between adjacent nano-droplets (2) is smaller than their diameter, and wherein step c) is carried out by PVD or by sputtering SERS-active metal.

Abstract: The present invention provides a pressure transducer (1) and a method for fabricating a pressure transducer. The pressure transducer is for use in a gas pressure gauge and uses a squeeze-film. The pressure transducer comprises a first wafer (2) and a second wafer (3), wherein—at least the first wafer comprises a device layer (2.1) and a handle layer (2.3); —the second wafer (3) has a top and bottom surface; and wherein—at least the device layer (2.1) of the first wafer (2) is structured. The pressure transducer further comprises a membrane (4.1), a cavity (5) between the membrane (4.1) and the second wafer (3), wherein the cavity (5) has a cavity bottom, an inlet (12) connecting the cavity (5) to a surrounding, a suspension (6) of the membrane (4.1), wherein the suspension (6) allows oscillation of the membrane (4.1), and an oscillation generator to set the membrane (4.1) in oscillation. The pressure transducer is characterized in that the structured device layer (2.

Abstract: The present invention relates to the field of water treatment/metal recovery and to materials/devices useful in such processes. Specifically the invention provides for composite materials comprising amyloid fibrils; activated carbon; optionally a support material; whereby said amyloid fibrils and said activated carbon are in intimate contact. The invention further provides for the treatment of water using such composite materials.

Abstract: In particular embodiments, a 2D representation of an object may be provided. A first method may comprise: receiving sketch input identifying a target position for a specified portion of the object; computing a deformation for the object within the context of a character rig specification for the object; and displaying an updated version of the object. A second method may comprise detecting sketch input; classifying the sketch input, based on the 2D representation, as an instantiation of the object; instantiating the object using a 3D model of the object; and displaying a 3D visual representation of the object.