Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.
Type:
Grant
Filed:
October 23, 2018
Date of Patent:
May 18, 2021
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
Abstract: The present invention is directed to a device for delivering a sealant to a tissue, comprising a sealant compartment, a cooling gas compartment, and a heater, all disposed inside a unified housing; with heater configured for rendering the sealant liquid or semi-liquid or molten and flowable; with sealant compartment configured for expressing the sealant in a flowable form from device via an exit nozzle; with gas compartment configured for expressing a cooling gas via a gas expression port; with exit nozzle and gas expression port co-directed into the same direction.
Type:
Grant
Filed:
January 30, 2019
Date of Patent:
May 18, 2021
Assignee:
Ethicon, Inc.
Inventors:
Nir I. Nativ, Thomas C. Weindl, Leo B. Kriksunov
Abstract: The present invention is directed to a hemostatic semi-solid paste material comprising a bioabsorbable carrier hemostatic material; and a supplemental hemostatic agent; wherein the paste material has an elongated form extending along a lengthwise axis with an aspect ratio of at least 3; wherein the paste is self-supporting and syringe extrudable; and wherein the supplemental hemostatic agent has a non-homogenous distribution profile across a cross-section taken across the lengthwise axis. In another aspect, the present invention relates to devices for forming and expressing the hemostatic material.
Abstract: A drug-eluting self-retaining suture comprises a filament, a plurality of retainers, and a drug impregnated in or coated on the filament. The shape and distribution of retainers modifies the in vivo release kinetics of the drug. The drug release kinetics may be modified uniformly or region by region. The self-retaining suture may for example be used for reattaching severed nerves and release nerve growth factor or other regeneration accelerating agents into the region of the nerve injury.
Type:
Grant
Filed:
November 3, 2011
Date of Patent:
May 18, 2021
Assignees:
Ethicon, Inc., Ethicon, LLC, Tissuegen, Inc.
Inventors:
Jeffrey M. Gross, Lev Drubetsky, Alexander Naimagon, Rui Avelar, William L. D'Agostino, Kevin Don Nelson, Brent B. Crow, Nickolas B. Griffin
Abstract: The invention relates to a hemostatic composition comprising a mixture of cellulose-based short and long fibers, preparation and use thereof.
Type:
Grant
Filed:
October 24, 2018
Date of Patent:
May 18, 2021
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
Abstract: A method of attaching a surgical suture to a needle and testing the attachment includes dispensing a length of suture from a spool by using a first suture gripper, and using a surgical needle gripper for holding a surgical needle stationary. A leading end of the suture is inserted into and attached to a receiving end of the surgical needle. A second suture gripper is located between the first suture gripper and the spool. After the second suture gripper is closed for gripping the suture, the second suture gripper is advanced downstream toward the surgical needle to reduce the tension on the suture. The tension on the suture is reduced by moving the second suture gripper a pre-determined distance. The first suture gripper is opened for releasing the suture and the first suture gripper is moved toward the suture spool for re-grasping the suture at a location between the second gripper and the suture spool.
Abstract: Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
May 11, 2021
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach
Abstract: Novel recessed surgical fastening devices are disclosed. The fastening devices have a compressible member and a fastening element disposed at least partially within the compressible member. The fastening element has at least one tissue engagement member that is extensible through the compressible member to engage tissue when a force is applied to the fastening device.
Type:
Grant
Filed:
July 23, 2018
Date of Patent:
May 11, 2021
Assignee:
Ethicon, Inc.
Inventors:
Robert J. Tannhauser, Emil Richard Skula
Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site, especially when sealing an anastomosis between adjacent intestinal sections so as to improve tissue viability, prevent tissue infection, and to prevent leakage. The present invention further relates to an expandable compression device for application to anastomotically joined tubular tissues, comprising: an upper ring-shaped or disk-shaped flange at a distal end of said device connected to a lower ring-shaped inflatable flange at a proximal end of said device via a hollow cylindrical tubular body, with an opening forming an axial passage through said upper flange, lower flange, and tubular body.
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
May 4, 2021
Assignee:
Ethicon, Inc.
Inventors:
John Matonick, Robert J. Tannhauser, Leo B. Kriksunov
Abstract: The present invention relates to surgical instruments and methods for enhancing properties of tissue repaired or joined by surgical staples and, more particularly to surgical instruments and methods designed to enhance the properties of repaired or adjoined tissue at a target surgical site. The present invention further relates to hypothermic linear stapling instruments configured to pre-cool the tissues being joined by staples.
Type:
Grant
Filed:
October 20, 2017
Date of Patent:
May 4, 2021
Assignee:
Ethicon, Inc.
Inventors:
Nir I. Nativ, Leo B. Kriksunov, Robert J. Tannhauser, Silvia Chen
Abstract: Novel mesh implant positioning systems for use in laparoscopic body wall defect repairs, such as hernia defects, are disclosed. The systems utilize one or more bar members combined with surgical sutures and needles to position a mesh implant adjacent to a body wall defect without the need for stay sutures. Also disclosed are assemblies of the positioning systems with surgical mesh repair implants, and methods of repairing body wall defects such as hernias with the assemblies.
Type:
Grant
Filed:
September 27, 2018
Date of Patent:
May 4, 2021
Assignee:
Ethicon, Inc.
Inventors:
Jianxin Guo, Simon Cohn, Michael Cardinale, Doug Souls
Abstract: A device for application onto incisions or wounds with a liquid rapidly polymerizable adhesive for forming skin closure systems, having a flat porous mesh elongated along a longitudinal axis and having an upper side and an opposing lower or wound facing side and a central portion in immediate vicinity of the axis; further having a plurality of pores and windows in said mesh, said windows substantially larger than said pores and arranged along said longitudinal axis in said central portion; a crosslinking or polymerization accelerator or initiator disposed in or on the mesh; and a pressure sensitive adhesive disposed on at least a portion of the lower surface of the mesh.
Type:
Grant
Filed:
July 31, 2018
Date of Patent:
May 4, 2021
Assignee:
Ethicon, Inc.
Inventors:
Julian Quintero, Leo B. Kriksunov, Elena Wolfe
Abstract: The present invention relates to improved hemostatic compositions comprising cellulose-based fibers supplemented with compounds, preparation and use thereof.
Type:
Grant
Filed:
February 6, 2020
Date of Patent:
March 30, 2021
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
Erez Ilan, Omri Faingold, Nataly Freizus, Ronen Eavri, Dwayne Looney, Sridevi Dhanaraj, James Galloway, Walter Danker
Abstract: A swaging system for attaching surgical needles to sutures and testing the attachment strength includes a frame, a bottom swaging die mounted on the frame, and a top swaging die mounted on the frame and being moveable up and down along a swaging axis that is aligned with the bottom swaging die. The bottom swaging die includes a hinge mechanism with a bottom plate mounted to the frame and a top plate overlying the bottom plate. The top and bottom plates are pivotally connected for enabling the top plate to pivot relative to the bottom plate. The bottom swaging die includes a swaging tool that extends toward the top swaging die along the swaging axis, and a load cell disposed between the top and bottom plates for monitoring load. The system includes a control system having one or more pull test programs stored therein for conducting pull tests on armed surgical needles to determine if the armed surgical needles are acceptable or unacceptable.
Type:
Grant
Filed:
March 22, 2017
Date of Patent:
March 30, 2021
Assignee:
Ethicon, Inc.
Inventors:
Alexander M. Cannara, Frank Richard Cichocki, Jr.
Abstract: A dispensing device and cartridge for simultaneous delivery and mixing of multiple co-reactive materials, the cartridge having proximal and distal ends, and having an elongated holder body with substantially parallel longitudinal voids. Multiple syringe bodies are disposed parallel within the voids and multiple co-reactive materials are separately disposed in the syringe bodies. The dispensing device also includes a longitudinal housing which is structured and arranged to receive the cartridge.
Type:
Grant
Filed:
April 19, 2018
Date of Patent:
March 30, 2021
Assignee:
Ethicon, Inc.
Inventors:
Jianxin Guo, Jared Schneider, Simon Cohn, Christopher Anthony Kokinelis
Abstract: Provided is a method of enhancing toxicity of a glycolytic dependent compound towards a cell, tissue and/or organ e.g. a diseased cell, tissue and/or organ, the method comprises contacting Oxidized Regenerated Cellulose (ORC) and/or Oxidized Cellulose (OC); and a glycolytic dependent compound with the cell, tissue and/or organ. The ORC and/or OC; and the glycolytic dependent compound are contacted with the cell, tissue and/or organ in a non-blended form.
Type:
Grant
Filed:
August 11, 2016
Date of Patent:
March 30, 2021
Assignees:
Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
Inventors:
James Galloway, Tamara Byk-Tennenbaum, Erez Ilan, Lior Weissman, Sivan Doron, Eve Montia
Abstract: A laser-machining system and method is disclosed for forming retainers on a suture thread. The laser system is preferably a femtosecond laser system which is capable of creating submicron features on the suture thread while preserving strength of the suture thread. The laser-machining system enables creation of retainers and self-retaining suture systems in configurations which are difficult and/or impossible to achieve using mechanical cutting technology. The laser-machining system includes a stabilization device configured to provide contactless stabilization of the suture thread during a machining operation on the suture thread.
Type:
Grant
Filed:
December 14, 2016
Date of Patent:
March 23, 2021
Assignees:
Ethicon, Inc., Ethicon LLC
Inventors:
Jeffrey M. Gross, William L. D'Agostino, Lev Drubetsky, Alexander Naimagon, Jacob D. Conner, Kevin R. Whitworth, Ryan T. Woolsey, Fred M. Dickey
Abstract: The present is directed to systems for ex vivo testing performance of a hemostatic or sealing product attached to an animal organ and fully covering a cored channel in said organ, comprising: a pressure sensor positioned proximate to said hemostatic or sealing product in said cored channel; a monitoring or recording device configured to receive pressure readings from said pressure sensor; and a pressurized fluid source connected to said cored channel and configured to supply said pressurized fluid into said cored channel under constant or variable pressure. The present invention is also directed to methods of use for such systems.
Type:
Application
Filed:
September 13, 2019
Publication date:
March 18, 2021
Applicant:
Ethicon, Inc.
Inventors:
John Matonick, Kevin Hengst, Matthew Pfefferkorn, Robert J. Tannhauser, Leo B. Kriksunov
Abstract: A method of reinforcing subcutaneous fragile tissue includes obtaining an absorbable surgical mesh having top and bottom major surfaces, the absorbable surgical mesh including a stitching zone and first and second reinforcing zones that bound opposite sides of the stitching zone. The method includes making an incision in a patient's skin for exposing subcutaneous fragile tissue, using one or more absorbable adhesives for adhering the bottom major surface of the absorbable surgical mesh to the subcutaneous fragile tissue, creating an incision through the stitching zone of the absorbable surgical mesh and into the subcutaneous fragile tissue, performing a surgical procedure through the incision, and passing an absorbable suture through the stitching zone of the absorbable surgical mesh and the fragile tissue for closing the incision.
Type:
Grant
Filed:
September 13, 2017
Date of Patent:
March 16, 2021
Assignee:
Ethicon, Inc.
Inventors:
Julian Quintero, Leo B. Kriksunov, Shane A. Lacy, Ibraheem T. Badejo