Patents Assigned to Ethicon, Incorporated
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Publication number: 20190105351Abstract: Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: December 19, 2009Publication date: April 11, 2019Applicant: Ethicon, IncorporatedInventors: Brian C. Kramer, Uri Herzberg
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Patent number: 7875273Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.Type: GrantFiled: December 22, 2005Date of Patent: January 25, 2011Assignee: Ethicon, IncorporatedInventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko
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Patent number: 7875272Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.Type: GrantFiled: December 22, 2005Date of Patent: January 25, 2011Assignee: Ethicon, IncorporatedInventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska
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Publication number: 20100260843Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.Type: ApplicationFiled: April 24, 2009Publication date: October 14, 2010Applicant: Ethicon, IncorporatedInventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20100215714Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.Type: ApplicationFiled: January 29, 2010Publication date: August 26, 2010Applicant: Ethicon, IncorporatedInventors: Darin J. MESSINA, Sanjay K. Mistry, L.S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko, Anna Gosiewska
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Publication number: 20100210013Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.Type: ApplicationFiled: February 19, 2009Publication date: August 19, 2010Applicant: Ethicon, IncorporatedInventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20100159588Abstract: A stable and scalable process is provided to manufacture reduced serum umbilical cord tissue-derived (UTC)-conditioned media. The method includes the culture of a UTC under reduced serum conditions. Subsequently, the UTC is washed and grown in serum-free basal media. After approximately 24 hours, the conditioned media is collected, filtered and concentrated by use of an approximately 5 kDa or similar cut-off membrane.Type: ApplicationFiled: December 19, 2008Publication date: June 24, 2010Applicant: Ethicon, IncorporatedInventors: Alexander M. Harmon, Abel Ang
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Publication number: 20100159025Abstract: Methods for treating chronic pain, neuropathic pain or spasticity are provided. Some embodiments are to methods for treatment comprising administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of nerves in the patient to decrease chronic pain, neuropathic pain or spasticity. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: December 19, 2009Publication date: June 24, 2010Applicant: Ethicon, IncorporatedInventors: Brian C. Kramer, Uri Herzberg
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Publication number: 20100158877Abstract: Compositions and methods of using cells derived from umbilical cord tissue to stimulate and support lung tissue angiogenesis, to improve blood flow to lung tissue, to regenerate, repair, and improve lung tissue damaged by lung disease, disorder and/or injury, and to protect lung tissue from damage caused by lung disease, disorder and/or injury in a patient.Type: ApplicationFiled: December 19, 2009Publication date: June 24, 2010Applicant: Ethicon, IncorporatedInventors: David C. Colter, Anthony J. Kihm, Christine K. Ward, Anna Gosiewska
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Publication number: 20100158880Abstract: Methods, pharmaceutical compositions and kits for regenerating or repairing neural tissue, decreasing apoptosis and improving neurological function following injury are disclosed.Type: ApplicationFiled: December 19, 2009Publication date: June 24, 2010Applicant: Ethicon, IncorporatedInventors: Agnieszka Seyda, Anna Gosiewska
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Patent number: 7618622Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, pharmaceutical compositions comprising such cells, and methods for using such cells and pharmaceutical compositions to treat patients having a neurodegenerative condition of the substantia nigra or striatum, such as Parkinson's disease, are provided.Type: GrantFiled: December 22, 2005Date of Patent: November 17, 2009Assignee: Ethicon, IncorporatedInventors: Darin J. Messina, Sanjay Mistry, L. S. Klaudyne Hong, Brian C. Kramer, Michael J. Romanko
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Patent number: 7560276Abstract: Cells derived from postpartum tissue having the potential to support cells of and/or differentiate to cells of a soft tissue lineage, and methods of preparation and use of those postpartum tissue-derived cells, are provided by the invention. The invention also provides methods for the use of such postpartum-derived cells and products related thereto in therapies for conditions of soft tissue.Type: GrantFiled: June 25, 2004Date of Patent: July 14, 2009Assignee: Ethicon, IncorporatedInventors: Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Sanjay Mistry, Darin J. Messina, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20090166178Abstract: Provided are methods for sterilizing a material comprising a biologically-active agent comprising irradiating said material with ionizing radiation at a dose of about 5 kGy to about 25 kGy while maintaining said material in an atmosphere comprising at least 95% by volume inert gas and at a temperature of about 4° C. or lower. Also provided are sterilized materials comprising a biologically-active agent, wherein said materials exhibit substantially the same amount of biological activity as a non-sterilized control.Type: ApplicationFiled: December 17, 2008Publication date: July 2, 2009Applicant: Ethicon, IncorporatedInventors: Alexander M. Harmon, Laura J. Brown, Charles J. Buckle, Frederick Halperin, Stanko Bodnar
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Publication number: 20090169597Abstract: Methods for treating a patient having a disease or condition related to IVD degeneration are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. In some embodiments, administering the cells promotes repair and regeneration of degenerated IVD tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: December 17, 2008Publication date: July 2, 2009Applicant: Ethicon, IncorporatedInventors: Laura J. Brown, Anna Gosiewska, Anthony J. Kihm, Brian C. Kramer
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Publication number: 20090162411Abstract: Provided are therapeutic implants comprising renal tissue encapsulated within a polymer bead. Also disclosed are methods for treating a disease state in a subject comprising implanting within said subject a therapeutic implant comprising renal tissue encapsulated within a polymer bead. Also provided are methods for making a therapeutic implant comprising: providing renal tissue; mixing the renal tissue with a solution comprising a polymer, thereby forming a tissue-polymer suspension; extruding the tissue-polymer suspension into an bead-forming solution, thereby forming a therapeutic implant comprising beads of said polymer within which the renal tissue is encapsulated.Type: ApplicationFiled: December 17, 2008Publication date: June 25, 2009Applicant: Ethicon, IncorporatedInventors: Charito S. Buensuceso, David C. Colter, Brian C. Kramer, Agnieszka Seyda
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Patent number: 7524489Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of neural tissue using the postpartum-derived cells are also disclosed.Type: GrantFiled: June 25, 2004Date of Patent: April 28, 2009Assignee: Ethicon IncorporatedInventors: Darin J. Messina, Sanjay Mistry, Alexander M. Harmon, Ian Ross Harris, Anthony J. Kihm, Agnieszka Seyda, Chin-Feng Yi
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Publication number: 20090092653Abstract: Methods for treating a patient having a disease or damage to at least one kidney are provided. The methods comprise administering cells obtained from human umbilical cord tissue, or administering pharmaceutical compositions comprising such cells or prepared from such cells. When administered, the cells promote and support the repair and regeneration of the diseased or damaged kidney tissue in the patient. Pharmaceutical compositions for use in the inventive methods, as well as kits for practicing the methods are also provided.Type: ApplicationFiled: October 3, 2008Publication date: April 9, 2009Applicant: Ethicon, IncorporatedInventors: David C. COLTER, Anna Gosiewska
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Patent number: 7510873Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.Type: GrantFiled: June 25, 2004Date of Patent: March 31, 2009Assignee: Ethicon, IncorporatedInventors: Sanjay Mistry, Anthony J. Kihm, Ian Ross Harris, Alexander M. Harmon, Darin J. Messina, Chin-Feng Yi, Anna Gosiewska
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Patent number: 7413734Abstract: Cells derived from postpartum umbilicus and placenta are disclosed. Pharmaceutical compositions, devices and methods for the regeneration or repair of ocular tissue using the postpartum-derived cells are also disclosed.Type: GrantFiled: June 25, 2004Date of Patent: August 19, 2008Assignee: Ethicon, IncorporatedInventors: Sanjay Mistry, Darin J. Messina, Ian Ross Harris, Alexander M. Harmon, Agnieszka Seyda, Chin-Feng Yi, Anna Gosiewska
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Publication number: 20070264269Abstract: Cell-based compositions and methods of their use to inhibit an adverse immune response such as graft versus host disease or rejection of transplanted tissue in a transplant recipient that is histocompatibility mismatched to the transplant donor are disclosed. The compositions and methods utilize postpartum-derived cells, such as cells derived from the placenta or umbilicus.Type: ApplicationFiled: December 15, 2006Publication date: November 15, 2007Applicant: Ethicon, IncorporatedInventors: Alexander Harmon, Janet Davis