Abstract: Compositions and methods of using cells derived from postpartum tissue such as the umbilical cord and placenta, to stimulate and support angiogenesis, to improve blood flow, to regenerate, repair, and improve skeletal muscle damaged by a peripheral ischemic event, and to protect skeletal muscle from ischemic damage in peripheral vascular disease patients are disclosed.

Abstract: Methods for the maximizing parameter of the in vitro growth and expansion of mammalian cells, specifically postpartum-derived cells in containers such as roller bottles is described. Methods of optimizing growth rate and cell yield in such culture systems are provided. The methods are particularly adapted for human postpartum-derived cells, such as umbilicus-derived cells.

Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Abstract: Cells derived from human umbilical cords are disclosed along with methods for their therapeutic use. Isolation techniques, culture methods and detailed characterization of the cells with respect to their cell surface markers, gene expression, and their secretion of trophic factors are described.

Abstract: Cells derived from postpartum tissue such as the umbilical cord and placenta, and methods for their use to regenerate, repair, and improve neural tissue, and to improve behavior and neurological function in stroke patients are disclosed.

Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Abstract: Cells derived from postpartum tissue and methods for their isolation and induction to differentiate to cells of a chondrogenic or osteogenic phenotype are provided by the invention. The invention further provides cultures and compositions of the postpartum-derived cells and products related thereto. The postpartum-derived cells of the invention and products related thereto have a plethora of uses, including but not limited to research, diagnostic, and therapeutic applications, for example, in the treatment of bone and cartilage conditions.

Abstract: A system and method for capturing and placing a cardiac assist device on a heart. A cardiac assist device is delivered to a chest cavity of a being through an opening provided in a chest wall. A magnetically charged tether is provided at each corner or extremity of the cardiac assist device. Capture instruments magnetically couple with a corresponding tether. The magnetically coupled instruments and tethers then maneuver the cardiac assist device to a desired position about the heart. The cardiac assist device is then secured directly to the heart or to anchoring devices separately provided and secured to the heart.

Abstract: Systems and methods for sizing a cardiac assist device to a heart. A bio-compatible material placed as a cardiac assist device over portions of the heart as desired, is sized to fit the exterior contours of the heart by gathering excess material using a reduction ring, draw strings, or a roller. The remaining material of the cardiac assist device may be sutured, clipped, or otherwise anchored to achieve the desired fit of the cardiac assist device to the heart. Subsequent adjustments to increase or decrease the size of the cardiac assist device may be made to accommodate subsequent changes to the size of the heart by re-performing the reduction ring, draw strings, or roller procedure and re-orienting the sutures, clips, or other anchoring techniques to fit the cardiac assist device to the subsequent heart size.

Abstract: A compact, low-profile surgical retractor (100) avoids the need for a bulky frame. The retractor includes retractor blade components (110, 120, 130, 140, 150, 160) joined pivotally. A cable (170) is guided by each retractor blade component. A winding mechanism (180), such as a spool, is carried by one of the retractor blade components (120) for winding up the cable to cause the retractor blade components to transition from a closed position to an open position. The winding mechanism may be actuated by a detachable handle (200). The retractor blade components may be unitary, injection-molded pieces. The retractor blade components may be fixed pivotally, such as by pins, or pivotally joined by living hinges. A less-invasive surgical method is also provided in which the retractor is inserted into the body through an incision.

Abstract: Systems and methods for reducing distention in designated portions of a heart muscle while assisting cardiac valve alignment and coaptation. Anchoring devices are secured to the heart muscle and a bio-compatible cardiac assist device placed over portions of the heart muscle is separately secured to the anchoring devices. The cardiac assist device may be a material that wraps portions of the heart muscle, or may be straps that wrap portions of the heart muscle. Tightening and securing the cardiac assist device in place helps to reduce distention in chambers of the heart muscle and aids alignment and coaptation of cardiac valves.

Abstract: A stabilizing device having a flexible shaft with a terminal connector and surgical tools used therewith. The flexible shaft is responsive to a tension element connected to a distal end of the shaft and in communication with a proximal end of the shaft. An elastic means interfacing between the proximal end of the tension element and an actuating cam cause the shaft to adapt for differences in activating tension between straight and curved positions. Accordingly, stretching and deformation of the tensioning element is reduced and shaft stiffness upon activation of the tensioning element is repeatable. The terminal connector includes a ball-and-socket arrangement adapted to resiliently absorb movement of an organ during surgery. A bendable suction stabilizer foot adaptable to contours of an organ is also provided as an attachment to the stabilizer device.