Patents Assigned to ETHRIS GMBH
  • RNA with a combination of unmodified and modified nucleotides for protein expression
    Patent number: 10745698
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
    Type: Grant
    Filed: August 28, 2015
    Date of Patent: August 18, 2020
    Assignee: ETHRIS GMBH
    Inventors: Carsten Rudolph, Michael Kormann
  • Conjugate with target-finding ligand and use thereof
    Patent number: 10583195
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: March 10, 2020
    Assignee: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • RNA for use in the treatment of ligament or tendon lesions
    Patent number: 10272161
    Abstract: Described is a liquid composition containing naked RNA, such as mRNA encoding a polypeptide, for use in the treatment or prevention of ligament or tendon lesions as well as a method for treating ligament or tendon lesions comprising the administration of a liquid composition containing naked RNA, such as mRNA encoding a polypeptide, which is beneficial in the process of healing the ligament or tendon lesions.
    Type: Grant
    Filed: July 16, 2015
    Date of Patent: April 30, 2019
    Assignee: ETHRIS GMBH
    Inventors: Günther Hasenpusch, Carsten Rudolph
  • Conjugate with target-finding ligand and use thereof
    Patent number: 10080804
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: September 25, 2018
    Assignee: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20150291678
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidine nucleotides are modified uridine nucleotides or modified cytidine nucleotides.
    Type: Application
    Filed: April 27, 2015
    Publication date: October 15, 2015
    Applicant: ETHRIS GMBH
    Inventors: Carsten RUDOLPH, Michael Kormann
  • Conjugate With Target-Finding Ligand and Use Thereof
    Publication number: 20140341995
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Application
    Filed: March 24, 2014
    Publication date: November 20, 2014
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • SPRAY SYSTEM FOR PRODUCTION OF A MATRIX FORMED IN SITU
    Publication number: 20140243395
    Abstract: A spray system for production of a matrix formed in situ is described, which comprises at least one lipophilic component comprising at least one polymer based on glycolic acid and lactic acid and at least one biocompatible solvent having an X log P3 value of less than 0.2, and at least one hydrophilic component, wherein the at least two components are present separately from each other prior to use and are not mixed until or in the course of spraying, with components forming a film when sprayed onto human tissue.
    Type: Application
    Filed: September 25, 2012
    Publication date: August 28, 2014
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Senta Üzgün
  • CONJUGATE WITH TARGET-FINDING LIGAND AND USE THEREOF
    Publication number: 20120328520
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 27, 2012
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20120195936
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
    Type: Application
    Filed: July 30, 2010
    Publication date: August 2, 2012
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Michael Kormann