Patents Assigned to ETHRIS GMBH
  • CFTR mRNA compositions and related methods and uses
    Patent number: 9713626
    Abstract: Pharmaceutical compositions comprising an mRNA-loaded nanoparticle, wherein the mRNA is an in vitro transcribed mRNA and has a coding sequence at least 80% identical to SEQ ID NO: 3, and wherein the mRNA encodes a human cystic fibrosis transmembrane conductance regulator (CFTR) protein comprising the amino acid sequence of SEQ ID NO:1 are provided. The present invention is particularly useful for treating cystic fibrosis.
    Type: Grant
    Filed: October 6, 2015
    Date of Patent: July 25, 2017
    Assignees: RaNA Therapeutics, Inc., Ethris GmbH
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • Conjugate with target-finding ligand and use thereof
    Patent number: 9555122
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Grant
    Filed: March 24, 2014
    Date of Patent: January 31, 2017
    Assignee: ethris GmbH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • CFTR mRNA compositions and related methods and uses
    Patent number: 9181321
    Abstract: Materials, formulations, production methods, and methods for delivery of CFTR mRNA for induction of CFTR expression, including in the mammalian lung are provided. The present invention is particularly useful for treating cystic fibrosis.
    Type: Grant
    Filed: June 17, 2014
    Date of Patent: November 10, 2015
    Assignees: Shire Human Genetic Therapies, Inc., Ethris GMBH
    Inventors: Michael Heartlein, Braydon Charles Guild, Frank DeRosa, Carsten Rudolph, Christian Plank, Lianne Smith
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20150291678
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidine nucleotides are modified uridine nucleotides or modified cytidine nucleotides.
    Type: Application
    Filed: April 27, 2015
    Publication date: October 15, 2015
    Applicant: ETHRIS GMBH
    Inventors: Carsten RUDOLPH, Michael Kormann
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20150290288
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
    Type: Application
    Filed: February 20, 2015
    Publication date: October 15, 2015
    Applicant: ethris Gmbh
    Inventors: Carsten RUDOLPH, Michael Kormann
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20150258174
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
    Type: Application
    Filed: February 20, 2015
    Publication date: September 17, 2015
    Applicant: ethris Gmbh
    Inventors: Carsten RUDOLPH, Michael Kormann
  • Conjugate With Target-Finding Ligand and Use Thereof
    Publication number: 20140341995
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Application
    Filed: March 24, 2014
    Publication date: November 20, 2014
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • Conjugate with target-finding ligand and use thereof
    Patent number: 8871230
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Grant
    Filed: December 21, 2010
    Date of Patent: October 28, 2014
    Assignee: ethris GmbH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • SPRAY SYSTEM FOR PRODUCTION OF A MATRIX FORMED IN SITU
    Publication number: 20140243395
    Abstract: A spray system for production of a matrix formed in situ is described, which comprises at least one lipophilic component comprising at least one polymer based on glycolic acid and lactic acid and at least one biocompatible solvent having an X log P3 value of less than 0.2, and at least one hydrophilic component, wherein the at least two components are present separately from each other prior to use and are not mixed until or in the course of spraying, with components forming a film when sprayed onto human tissue.
    Type: Application
    Filed: September 25, 2012
    Publication date: August 28, 2014
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Senta Üzgün
  • Magnet-field controlled active substance transfer for aerosol therapy
    Patent number: 8567410
    Abstract: The present invention relates to aerosols containing magnetic particles, wherein the aerosols comprise magnetic particles and a pharmaceutical active agent. The invention furthermore relates to the use of such aerosols containing magnetic particles for directed magnetic field-guided transfer of the active agents contained therein in aerosol therapy.
    Type: Grant
    Filed: August 25, 2006
    Date of Patent: October 29, 2013
    Assignee: Ethris GmbH
    Inventors: Carsten Rudolph, Joseph Rosenecker
  • CONJUGATE WITH TARGET-FINDING LIGAND AND USE THEREOF
    Publication number: 20120328520
    Abstract: Described is a conjugate of agent complex and at least one target-finding ligand, where the agent complex comprises an agent encapsulated by an encapsulation material and where the target-finding ligand is a prostacyclin analog, and the use of the conjugate.
    Type: Application
    Filed: December 21, 2010
    Publication date: December 27, 2012
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Johannes-Peter Geiger
  • RNA WITH A COMBINATION OF UNMODIFIED AND MODIFIED NUCLEOTIDES FOR PROTEIN EXPRESSION
    Publication number: 20120195936
    Abstract: The invention relates to a polyribonucleotide with a sequence that codes a protein or protein fragment, wherein the polyribonucleotide comprises a combination of unmodified and modified nucleotides, wherein 5 to 50% of the uridine nucleotides and 5 to 50% of the cytidin nucleotides are modified uridine nucleotides or modified cytidin nucleotides.
    Type: Application
    Filed: July 30, 2010
    Publication date: August 2, 2012
    Applicant: ETHRIS GMBH
    Inventors: Carsten Rudolph, Michael Kormann