Abstract: The present invention relates to an opioid controlled release oral dosage form comprising at least one opioid for the manufacture of a medicament to treat patients with Chronic Obstructive Pulmonary Disease (COPD).
Type:
Application
Filed:
June 8, 2005
Publication date:
August 9, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Wolfgang Fleischer, Karen Reimer, Petra Leyendecker
Abstract: The present invention relates to an opioid controlled release oral dosage form comprising at least one opioid for the manufacture of a medicament to treat patients with restless leg syndrome (RLS).
Type:
Application
Filed:
June 1, 2005
Publication date:
August 9, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Wolfgang Fleischer, Karen Reimer, Karin Gawora
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Application
Filed:
March 29, 2007
Publication date:
August 2, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Robert Chapman, Lonn Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: This invention relates to a method of treating disorders responsive to the blockade of sodium ion channels using novel aryl-substituted pyrimidine compounds of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein A, R1, R2, R3 and R4 are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Type:
Grant
Filed:
March 13, 2003
Date of Patent:
June 12, 2007
Assignee:
Euro-Celtique S.A.
Inventors:
R. Richard Goehring, Sam F. Victory, Donald J. Kyle
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Application
Filed:
January 16, 2007
Publication date:
May 24, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Robert Chapman, Lonn Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Application
Filed:
January 16, 2007
Publication date:
May 24, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Robert Chapman, Lonn Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: In certain embodiments the invention is directed to a process for preparing an oxycodone hydrochloride composition having less than 25 ppm of 14-hydroxycodeinone.
Type:
Application
Filed:
January 16, 2007
Publication date:
May 24, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Robert Chapman, Lonn Rider, Qi Hong, Donald Kyle, Robert Kupper
Abstract: A solid, oral controlled release pharmaceutical dosage form has a water-soluble active ingredient dispersed in a matrix and releases the active ingredient at such a rate upon administration that the median tmax is 2.5 to 6 hours and the ratio of mean Cmax to mean plasma level of the active ingredient at 24 hours is in the range of 1.5 to 3.5.
Type:
Application
Filed:
December 18, 2006
Publication date:
May 3, 2007
Applicant:
Euro-Celtique S.A.
Inventors:
Ronald Brown Miller, Stewart Thomas Leslie, Santa Therese Antoinette Malkowska, Derek Allan Prater, Trevor John Knott, Hassan Mohammad
Abstract: 4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.
Abstract: The present invention provides a dosage form that prevents misuse of the medicament contained within. The dosage form contains an inactivating substance in combination with the medicament, wherein the two substances are separated by a permeable or semi-permeable partition. The partition becomes impermeable upon activation by a medical professional, thereby effectively sequestering the inactivating substance from the medicament and allowing for the intended administration of the medicament to the patient. Unless activated, however, the inactivating substance and medicament remain commingled in the dosage form, and any attempt to dispense the medicament before activation will result in the release of inactivated medicament.
Abstract: This invention relates aryl substituted thiazolidinones of Formula I: or a pharmaceutically acceptable salt, or solvate thereof, wherein R1 and R2, are defined in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Type:
Grant
Filed:
July 16, 2002
Date of Patent:
January 30, 2007
Assignee:
Euro-Celtique S.A.
Inventors:
Qun Sun, Donald J. Kyle, Parviz Gharagozloo, Ji Yang
Abstract: This invention relates aryl substituted pyridines of Formula I: or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein Ar and R1—R4 are set in the specification. The invention is also directed to the use of compounds of Formula I for the treatment of neuronal damage following global and focal ischemia, for the treatment or prevention of neurodegenerative conditions such as amyotrophic lateral sclerosis (ALS), and for the treatment, prevention or amelioration of both acute or chronic pain, as antitinnitus agents, as anticonvulsants, and as antimanic depressants, as local anesthetics, as antiarrhythmics and for the treatment or prevention of diabetic neuropathy.
Abstract: A compound of formula: wherein Ar, Ar1, Ar2, R3–R6, R13, m, and t are disclosed herein, or a pharmaceutically acceptable salt thereof (a “Hydroxyiminopiperazine Compound”); compositions comprising an effective amount of a Hydroxyiminopiperazine Compound; and methods for treating or preventing pain and other conditions in an animal comprising administering to an animal in need thereof an effective amount of a Hydroxyiminopiperazine Compound are disclosed.
Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of an irritant to impart an irritating sensation to an abuser upon administration of said dosage form after tampering.
Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of an opioid analgesic; an opioid antagonist; and a bittering agent in an effective amount to impart a bitter taste to an abuser upon administration of the dosage form after tampering.
Type:
Grant
Filed:
August 6, 2002
Date of Patent:
December 5, 2006
Assignee:
Euro-Celtique S.A.
Inventors:
Benjamin Oshlack, Robert Colucci, Curtis Wright, Christopher Breder
Abstract: A controlled release preparation for oral administration contains tramadol, or a pharmaceutically acceptable salt thereof, as active ingredient.
Type:
Application
Filed:
May 16, 2006
Publication date:
November 30, 2006
Applicant:
Euro-Celtique S.A.
Inventors:
Ronald Brown Miller, Stewart Leslie, Sandra Malkowska, Kevin Smith, Walter Wimmer, Horst Winkler, Udo Hahn, Derek Prater
Abstract: Disclosed in certain embodiments is an oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse; and an effective amount of a bittering agent to impart a bitter taste to an abuser upon administration of said dosage form after tampering.
Type:
Grant
Filed:
August 6, 2002
Date of Patent:
November 28, 2006
Assignee:
Euro-Celtique S.A.
Inventors:
Benjamin Oshlack, Robert Colucci, Curtis Wright, Christopher Breder
Abstract: Disclosed are compounds of the formula (I) wherein A, R1, R2, R3, R4 and X1 are as disclosed herein. The compounds have affinity for the ORL1 receptor and are useful in the treatment of chronic and acute pain.
Type:
Application
Filed:
July 28, 2006
Publication date:
November 23, 2006
Applicant:
Euro-Celtique S.A.
Inventors:
Donald Kyle, Richard Goehring, Bin Shao