Abstract: The invention relates to an oral multiparticle pharmaceutical dosage form in the form of a receptacle reducing the pH values of stomach, containing a plurality of pellets, particles, granules or agglomerates whose mean diameter ranges from 50 to 2500 ?n substentially consisting of a) an internal matrix layer containing an active agent which is neither peptide or protein, nor the derivatives or conjugates thereof, a lipophilic matrix whose melting point is greater than 37° C. and a polymer with mucoadhesive effect, b) an external film coating substentially consisting of a polymer or an anionic copolymer which is optionally formulated with conventional pharmaceutical additives, wherein the active agent has a water solubility according to DAB 10, of at least 30 volume parts of water for one part by weight of the active agent and is coated with the lipophilic matrix and said active agent-containing lipophilic matrix is coated with a matrix made of a polymer with mucoadhesive effect.
Type:
Grant
Filed:
July 8, 2005
Date of Patent:
September 25, 2012
Assignee:
Evonik Roehm GmbH
Inventors:
Rosario Lizio, Hans-Ulrich Petereit, Peter Langguth, Marcus Knöll
Abstract: The invention relates to a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid, comprising the steps of A) reacting a carbonyl compound with hydrocyanic acid to produce a hydroxycarboxylic acid nitrile, B) hydrolysis of the hydroxycarboxylic acid nitrile obtained in step A) in the presence of a catalyst comprising manganese dioxide, wherein a molar excess of carbonyl compound is used in relation to the hydrocyanic acid to react the carbonyl compound with hydrocyanic acid according to step A), and the reaction mixture obtained in step A) is not purified by distillation before the hydrolysis according to step B) is carried out. The invention furthermore relates to a method for producing alkyl(meth)acrylates from polymers, moulding compounds and moulded bodies, wherein a method for producing a carboxylic acid amide from a carbonyl compound and hydrocyanic acid is carried out in accordance with the method described above.
Type:
Application
Filed:
October 29, 2009
Publication date:
September 13, 2012
Applicant:
EVONIK ROEHM GmbH
Inventors:
Alexander MAY, Martin KOESTNER, Joerg BECKER, Joerg SCHALLENBERG, Hermann SIEGERT, Bernd VOGEL
Abstract: The invention provides a process for preparing 1-alkoxy-2-methyl-1-oxopropan-2-yl(meth)acrylate, e.g. 1-methoxy-2-methyl-1-oxopropan-2-yl(meth)acrylate, by transesterifying alkyl ?-hydroxyisobutyrates. Copolymerization of such monomers in the preparation of poly(meth)acrylate-based moulding materials improves the heat distortion resistance thereof.
Type:
Application
Filed:
September 7, 2010
Publication date:
September 13, 2012
Applicant:
Evonik Roehm GmbH
Inventors:
Thorben Schütz, Joachim Knebel, Guenther Graeff, Ruediger Carloff, Roger Recktenwald, Volker Herzog
Abstract: The invention relates to a novel polymerization method for (meth)acrylates, wherein the polymerization is initiated by isocyanates and special bases having an imine structure. By means of said novel method that can be deliberately employed, even high-molecular-weight poly(meth)acrylates having in part a narrow molecular weight distribution can be produced. Furthermore, a wide variety of polymer architectures, such as block, star or comb polymers, are available using said novel polymerization method.
Type:
Application
Filed:
November 29, 2010
Publication date:
September 6, 2012
Applicants:
Evonik Roehm GmbH, Evonik Degusa GmbH
Inventors:
Friedrich Georg Schmidt, Emmanouil Spyrou, Simon Krause, Stefan Spange, Ingmar Polenz, Katja Hase
Abstract: The present invention relates to a rear-end element (1) for a motor vehicle encompassing an illumination unit (2) for the illumination of a number plate, where the illumination unit (2) illuminates the rear side of the number plate and the illumination unit (2) has a translucent body (3) and an illuminant (4), where the translucent body of the illumination unit (2) has been introduced by way of the side area (5) into the rear-end element (1). The present invention moreover describes a motor vehicle which encompasses a rear-end element described above.
Type:
Grant
Filed:
May 9, 2008
Date of Patent:
August 28, 2012
Assignee:
Evonik Roehm GmbH
Inventors:
Sven Schroebel, Rudolf Blass, Anton Halblaender
Abstract: The present invention provides a process for converting a solid (meth)acrylate copolymer into a dispersed form by preparing an aqueous dispersion comprising the components (a) a (meth)acrylate copolymer which is composed of free-radical polymerized methyl methacrylate, ethylacrylate and a salt of 2-trimethylammoniumethyl methacrylate, present in solid form as a powder or as a granulate, (b) up to 50% by weight calculated on the (meth)acrylate copolymer (a) of a dispersing agent selected from the groups of (b) i) plasticizers in combination with emulsifiers and/or (b) ii) pharmaceutically acceptable carbohydrates having 6 to 18 carbon atoms with a functional group and (c) water by mixing the components (a), (b) and (c) to give a suspension which becomes an aqueous dispersion during the conversion of the solid (meth)acrylate copolymer into the dispersed form, characterized in that, the (meth)acrylate copolymer is converted into the dispersed form by means of the presence of the dispersing agent at a temperature
Abstract: The invention relates to a one-component, storage-stable formulation for marking road surfaces. The invention in particular relates to a formulation for roadway marking comprising encapsulated radical initiators which do not influence the storage stability of the roadway marking and are simple to break open upon application in order to release the initiator.
Type:
Application
Filed:
September 7, 2010
Publication date:
July 26, 2012
Applicant:
EVONIK ROEHM GMBH
Inventors:
Mandy Muehlbach, Patrick Stenner, Silke Suhr, Peter Neugebauer, Heike Heeb, Guenter Schmitt, Peter Reinhard
Abstract: Composition containing, based in each case on its total weight, A) 50.0% by weight to 99.5% by weight of at least one (meth)acrylate (co)polymer and B) 0.5% by weight to 50.0% by weight of at least one copolymer obtainable by polymerization of a monomer mixture comprising i. 70% by weight to 92% by weight of a vinylaromatic monomer and ii. 8% by weight to 30% by weight of acrylonitrile or methacrylonitrile or mixtures thereof and iii. 0% by weight to 22% by weight of at least one further monomer, the composition having a haze according to ASTM D1003 of less than 2.0% at 23° C. and a haze according to ASTM D1003 of less than 4.0% at 40° C. and the composition containing at least one (meth)acrylate (co)polymer a) having a solution viscosity in chloroform at 25° C. (ISO 1628—part 6) of greater than 55 ml/g. The moldings obtainable from the composition are distinguished in particular by improved stress cracking resistance and are suitable in particular for coverings, finishes or films.
Type:
Grant
Filed:
April 9, 2008
Date of Patent:
July 24, 2012
Assignee:
Evonik Röhm GmbH
Inventors:
Klaus Schultes, Werner Hoess, Nils Mehler
Abstract: The present invention relates to an aqueous dispersion comprising at least one alkyd resin and at least one addition polymer having at least one (meth)acrylate segment which comprises 1% to 30% by weight of units derived from (meth)acrylates which in the alkyl radical have at least one double bond and 8 to 40 carbon atoms, 0.1% to 10% by weight of units derived from monomers containing acid groups, and 50% to 98.9% by weight of units derived from (meth)acrylates having 1 to 6 carbon atoms in the alkyl radical, based on the weight of the (meth)acrylate segment.
Type:
Grant
Filed:
October 6, 2008
Date of Patent:
July 17, 2012
Assignee:
Evonik Röhm GmbH
Inventors:
Christine Breiner, Joachim Knebel, Gerold Schmitt
Abstract: A pellet or pellets having an average particle size in the range from 300 to 1,100 ?m, comprising a pharmaceutically active substance embedded in a polymer matrix of one or more water-insoluble polymers, wherein the polymer matrix additionally contains 10 to 90% by weight of an anionic polymer and with the proviso that the pellets release no more than 10% of the active compound contained in the release test according to USP in artificial gastric juice at pH 1.2 after 120 min and release at least 50% of the active compound contained after altogether a further 300 min at pH 6.8 and/or pH 7.5.
Abstract: The invention relates to novel poly(meth)acrylates for producing moulding compositions. In particular, the invention relates to novel methacrylates having ester groups which, in the cleavage process, liberate at most only a very small amount of components which are not re-copolymerizable. Copolymerization of monomers of this type in the production of the novel poly(meth)acrylates for moulding compositions brings about only minimal alteration of the heat resistance of these materials or may indeed improve the same.
Abstract: The invention relates to the production of core-shell particles for encapsulating reactive components for single-component resin systems. In particular, the invention relates to the encapsulation of radical initiators such as peroxides. The invention further relates to a method for the 100% encapsulation of reactive components, whereby novel, storage-stable resin systems can be provided. At the same time, the core-shell particles are designed such that they can be opened nearly completely, easily and quickly during application, but have sufficient storage and shear stability before application.
Type:
Application
Filed:
September 7, 2010
Publication date:
July 5, 2012
Applicant:
EVONIK ROEHM GmbH
Inventors:
Mandy Muehlbach, Patrick Stenner, Silke Suhr, Peter Neugebauer, Heike Heeb, Guenter Schmitt, Peter Reinhard
Abstract: The invention relates to a device and method for producing thick-walled plastic molded parts by injection molding or embossing. The device comprises a mold for injection molding or embossing, having a cavity, and is characterized in that the mold comprises a wall region adjacent to the cavity, and a body removed from the cavity and adjacent to the wall region near the cavity, wherein the body of the mold is designed for a temperature T1 and the wall region is designed for a temperature T2 different from the temperature T1.
Type:
Application
Filed:
May 25, 2010
Publication date:
July 5, 2012
Applicant:
Evonik Roehm GmbH
Inventors:
Arne Schmidt, Marc Poth, Christian Eberle, Werner Hoess
Abstract: An intumescent coating composition and a process for curing the coating to obtain an intumescent coating is provided. The intumescent coating composition contains a thermoplastic polymer which comprises as a copolymerized component, an acid (meth)acrylate or a copolymerizable polyfunctional carboxylic acid; at least one ethylenically unsaturated monomer; an azo or organic peroxide initiator; an acid source; a carbon source; and a gas source.
Type:
Application
Filed:
March 7, 2012
Publication date:
June 28, 2012
Applicant:
Evonik Roehm GmbH
Inventors:
Günter SCHMITT, Peter NEUGEBAUER, Sybille SCHOLL, Heike HEEB, Peter REINHARD, Gilbert KÜHL
Abstract: The present invention relates to a process for preparing (meth)acrylic acid, characterized in that a cyclic ester is converted to (meth)acrylic acid in the presence of a catalyst. The (meth)acrylic acid prepared can in particular be converted to (meth)acrylates.
Type:
Grant
Filed:
August 30, 2007
Date of Patent:
June 26, 2012
Assignee:
Evonik Röhm GmbH
Inventors:
Bernd Vogel, Alexander May, Hermann Siegert
Abstract: The present invention describes a process for the surface finishing of materials via application of specific polymethacrylate layers. The polymethacrylate layers are composed of blends of at least two (co)polymers of polymethacrylates, and specific “reactive monomers” are present here in a polymerized mixture which forms the polymethacrylate layer. At the application temperature established, these form a chemical and, where appropriate, also a physical bond to the substrate, and therefore have adhesion-promoting action.
Type:
Grant
Filed:
July 3, 2004
Date of Patent:
June 26, 2012
Assignee:
Evonik Roehm GmbH
Inventors:
Uwe Numrich, Michael Wicker, Achim Neuhaeuser, Christoph Krohmer, Guenther Dickhaut-Bayer
Abstract: The invention relates to the synthesis of (meth)acrylate-based mass polymers which are soluble in aqueous alkaline. The invention in particular relates to the synthesis of polymers by means of a mass polymerization. Said mass polymers have a significantly improved solubility in aqueous alkaline media over corresponding polymers produced by means of a heterogeneous aqueous polymerization method, such as emulsion or suspension polymerization. Improved solubility in said context refers to the dissolution rate being faster among particles of equal size, to no significant turbidity remaining after dissolution and to the viscosity of the obtained solutions being lower at the identical ratio of solids content. Furthermore, the compatibility of the compounds according to the invention with water-based varnishes is at least comparable or even improved.
Type:
Application
Filed:
October 7, 2010
Publication date:
June 21, 2012
Applicant:
EVONIK ROEHM GmbH
Inventors:
Dirk Poppe, Wolfgang Janas, Frank Kleinsteinberg, Anja Christofzik
Abstract: The invention relates to hydrogels containing water and polyethylene glycol-dimethacrylates in a polymerized form. The polymethacrylate blocks are so short that they form no proper phase. The invention further relates to methods for producing said hydrogels. The inventive hydrogels are provided with reduced haze and are used as materials for contact lenses, electrophoresis gels, membrane materials, and sound-absorbing materials.
Abstract: The invention relates to an oral dosage form, comprising at least one biologically active agent, formulation auxiliary substances and magnetizable particles, wherein the dosage form has an at least two phase composition, wherein the phases can dissolve in the body after oral administration due to their formulation and the magnetizable particles are bound in formulation auxiliary substances and are present in a magnetized state, wherein the magnetized particles are present in at least two phases of the dosage form and generate magnetic fields, wherein these phases dissolve at different times in the body after oral administration, and wherein the magnetic field strength with respect to time, position and movement in the body is acquired using a detection system and can be evaluated using a computer-based evaluation system.
Type:
Application
Filed:
August 30, 2010
Publication date:
June 7, 2012
Applicant:
Evonik Roehm GmbH
Inventors:
Benedikt Hartwig, Norbert Windhab, Melanie Liefke, Juan Tome Alcalde, Michael Damm, Rosario Lizio, Michael Gottschalk, Angela Olf, Christian Meier, Andreas Gryczke
Abstract: The present invention describes a process for the surface finishing of materials via application of specific polymethacrylate layers. The polymethacrylate layers are composed of blends of at least two (co)polymers of polymethacrylates, and specific “reactive monomers” are present here in a polymerized mixture which forms the polymethacrylate layer. At the application temperature established, these form a chemical and, where appropriate, also a physical bond to the substrate, and therefore have adhesion-promoting action.
Type:
Grant
Filed:
December 23, 2009
Date of Patent:
June 5, 2012
Assignee:
Evonik Röhm GmbH
Inventors:
Uwe Numrich, Michael Wicker, Achim Neuhaeuser, Christoph Krohmer, Guenther Dickhaut-Bayer