Abstract: A method for determining a total volume of anticoagulant required for performing a plasmapheresis procedure prior to connecting the donor to the fluid flow circuit, by determining: a total blood volume for a donor, volume of plasma to be collected, a volume of anticoagulant that will be collected together with the plasma and estimating a separation efficiency for the blood separator. Then calculating volume of anticoagulant to be returned to the donor based on the separation efficiency, total volume of anticoagulant to be used and suggesting and attaching either a single container or multiple containers of anticoagulant based on said calculations. The system comprises a touch screen for receiving input and providing said calculation of a total volume of anticoagulant needed for the procedure, and recommendation the number of containers of anticoagulant needed.

Abstract: Systems and methods are provided for determining and controlling the location of an interface between separated fluid components within a channel of a centrifugal separation chamber being rotated about a rotational axis. Light from a light source is received by a collimator, which directs collimated light through the channel in a direction substantially parallel to the rotational axis. At least a portion of the collimated light exiting the channel is received by a light detector configured as a photodetector array. A signal emitted by the light detector is received by a controller, which determines the location of an interface between separated fluid components within the channel based at least in part on the signal. When the controller determines that the interface is not at a target location within the channel, the controller controls a centrifugal separator and/or a pump system to move the interface to the target location.

Abstract: A configurable automated blood component manufacturing system includes a durable hardware component and a single use fluid flow circuit. The hardware component includes a pump station, a centrifuge, and a controller including a touchscreen. The hardware component further includes hangers for suspending containers, a weight scale associated with each hanger, a plurality of tubing clamps, and a cassette nesting module including a plurality of valves and pressure sensors. The fluid flow circuit includes a separation chamber received in the centrifuge, a fluid flow control cassette mounted in the cassette nesting module, and a plurality of containers in fluid communication with the fluid flow cassette. The controller is pre-programmed to automatically operate the system to perform one or more standard blood processing procedures selected by an operator by input to the touchscreen, and is configured to be further programmed by the operator to perform additional blood processing procedures.

Abstract: A method of processing blood includes receiving from a touch screen user input data for a protocol for a wash procedure. The user input data includes a numeric value. The method includes storing the protocol in a memory, receiving an identifier from a user, determining if the identifier permits the user to modify the protocol and receiving a modification of the protocol from the user. The method includes providing a plurality of authorizations, a second authorization being a default and an administrator authorization permitting the user to change a setting. The method includes comparing a password to a password stored in memory and, if there is a match, determining that the password is associated with an administrator. If a command to change the setting is received, the command is applied to change the setting. The blood is processed employing a wash procedure using the modified protocol and the changed setting.

Abstract: A blood separation device for collecting plasma from whole blood has a disposable fluid flow circuit, a collection container to receive plasma from the blood separator, and a reusable blood separation device. The reusable device has a blood separator comprising a centrifuge and/or a spinning membrane. A control circuit receives a height, weight and hematocrit of a human donor of the whole blood and provides a total blood volume of the human donor. The control circuit determines an initial target amount of blood to be processed, measures an actual yield of plasma in the container, subtracts the actual yield of plasma from a target yield of plasma, determines an adjusted target amount of blood to be processed and separates the adjusted target amount of blood into the container.

Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib associated with the membrane that decreases the gap between the membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously collected whole blood into components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Abstract: The pressure of fluid being conveyed through a fluid flow path during a biological fluid procedure is detected during the procedure. The fluid is conveyed through the fluid flow path 1) at a first pre-determined rate if pressure is zero to a first pressure threshold; 2) at the first pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to a second pressure threshold and if an immediately preceding rate is equal to the first pre-determined rate; 3) at a second pre-determined rate if pressure is greater than the first pressure threshold but less than or equal to the second pressure threshold and if an immediately preceding rate is equal to the second pre-determined rate; and 4) at the second pre-determined rate if pressure value is greater than the second pressure threshold but less than or equal to a third pressure threshold.

Abstract: A processing system includes a processor including a separator, a set configured to cooperate with the separator to separate whole blood into plasma and other components, the set including an inlet line attachable to a patient to receive whole blood and an return line attachable to a patient to return processed fluid, and a source of replacement fluid connected to the disposable set, the processor configured to combine the other components with replacement fluid to define the processed fluid. The processor includes a controller and an input device coupled to the controller, the controller configured to receive an input via the input device, the input representing a volume of replacement fluid, and to control the processor to separate whole blood passing through the set and to combine the other components with the replacement fluid according to the input until the source of replacement fluid is empty.

Abstract: Biological fluid processing cassettes with integrated filter structures are disclosed. A cassette body is formed of a generally rigid material, defining a plurality of internal fluid flow paths. The cassette body may be secured to a cassette cap to define a cavity, with a filter sealed within the cavity. Each of the cassette body and the cassette cap defines a port opening into the cavity, which allows fluid to flow from one of the internal fluid flow paths, into the cavity and through the filter, and then out of the cavity via the port of the cassette cap. Alternatively, the cassette body may define an external slot which receives at least a portion of a filter. Such a filter includes two ports, with one of the ports in fluid communication with a cassette port of the cassette body to allow fluid flow between the cassette body and the filter.

Abstract: Systems and methods are provided for separating blood components from whole blood. A blood processing device, as part of a blood processing system, has a controller configured to operate the blood processing device based on a plurality of collection protocols. The blood processing device is wirelessly connected to a remote computing device configured to maintain a plurality of collection protocols. At least one additional computing device is configured to update one or more of the plurality of collection protocols on said remote computing device by communicating changes to a protocol maintained on the remote computing device which updates the plurality of collection protocols at the controller of the blood processing device.

Abstract: Systems and methods are provided for improving efficiency and quality of plasma being removed from a blood separation chamber. The system includes a separation chamber in which plasma is separated from cellular blood components, a pump for moving the plasma and an outlet line for removing the separated plasma from the blood separation chamber. An optical sensor assembly is configured to monitor the blood separation chamber and measure an interface position between the separated component and the plasma, and to generate an output indicative of the measured interface position. A controller is programmed to utilize a lipid concentration input of the blood and to set an original lipemia offset, a lipemia threshold and lipemia final setpoint from a predetermined database, and to use a proportional-integral-derivative control loop to assess the actual interface position plus the lipemia threshold to adjust and achieve a final lipemia setpoint for use during separation procedures.

Abstract: A fluid separation device includes a centrifugal separator configured to receive a centrifugal separation chamber of a disposable fluid flow circuit, a pump system configured to convey a fluid into the centrifugal separation chamber and to remove a separated fluid component from the centrifugal separation chamber via an outlet, a color-based interface monitoring system configured to determine an interface position between separated fluid components continuously flowing through the centrifugal separation chamber based on dominant wavelength measurements of layers of separated fluid components during a centrifugal separation procedure, and a controller configured to measure the dominant wavelengths of the layers, calculate a duration as a color time for each measured dominant wavelength, set target color times, calculate error signals and calculate control signals to adjust the pump system to control the flow rate and interface position.

Abstract: A blood donation collection system includes a blood collection device configured to perform an apheresis function to collect blood components. A database stores records for a plurality of blood donors. A processing circuit is configured to display data from a plurality of the records on a display screen, run a collection optimization algorithm based on blood center inventory level and past donation history data to make a recommendation for a blood collection procedure, and display the recommendation. The processing circuit is configured to receive a user selection of the recommendation for the blood collection procedure and send an instruction to collect a blood component to the blood collection device. The processing circuit is configured to monitor the collection by the blood collection device.

Abstract: Systems and methods for performing apheresis procedures, including photopheresis. The systems and methods utilize a disposable fluid circuit that can be converted from a double needle configuration to a single needle configuration and from a single needle configuration to a double needle configuration. A controller directs the action of system pumps to clear potentially stagnant blood residing in the fluid circuit, tracks system parameters and status before and after conversion, and verifies that the procedure may proceed in its new configuration.

Abstract: A processing device includes a pump system, a valve system, a centrifuge, and a controller. A fluid flow circuit is mounted to the device to execute a procedure in which whole blood is processed into a red blood cell product, a plasma product, and a platelet concentrate product. The blood is first separated into red blood cells, buffy coat, and plasma using the centrifuge, with the red blood cells and plasma being removed from the centrifuge, while the buffy coat remains in the centrifuge. The fluid remaining in the centrifuge is circulated through the centrifuge to form a homogenous mixture. Once the mixture is formed, it is separated in the centrifuge into platelet concentrate and red blood cells. A platelet product is then collected by using whole blood or previously collected red blood cells to push the platelet concentrate from the centrifuge to a collection container.

Abstract: A method is provided for controlling fluid flow through a tubing segment is provided in which a pump draws fluid through the tubing segment using negative pressure P.

Abstract: A blood donation collection method includes transmitting a request for data from a donor record to a remote server computer over a network interface circuit and receiving the data from the donor record from the remote server computer. The data comprises an indication of a blood component collected at a previous donor collection. The method includes providing display data indicating an amount of the blood component the donor may donate at a current donor collection based on the indication of the blood component collected at a previous donor collection. The method includes receiving a user request to schedule a current donor collection, and transmitting instructions for the requested current donor collection to a blood component collection device, wherein the blood component collection device collects a blood component from a donor using the instructions.

Abstract: A magnetic selector includes a housing configured to receive a container and having a floor upon which the container is disposed. The selector also includes a magnet carrier disposed on an opposite side of the floor from the container. The magnet carrier has at least one magnet disposed thereon and being moveable relative to the floor between a first state wherein the magnet carrier is adjacent the floor and a second state wherein the magnet carrier is spaced from the floor. The selector may include a door. The magnetic selector is usable in a fluid processing system that includes a fluid processor connectable to a source container filled with a biological fluid. A container is disposed in the magnetic selector and connected to the processor along a fluid pathway. The processor is configured to separate the biological fluid from the source container into at least two streams of material.

Abstract: A fluid separation system and method includes a durable hardware component including a pump station with plurality of pumps, a centrifuge mounting station and drive unit, a plurality of valves and clamps, and a controller. The system includes a single use fluid flow circuit having a separation chamber configured to be received by the centrifuge and the fluid flow circuit is engageable with the durable hardware component to control fluid flow within the fluid flow circuit. The fluid flow circuit having an air access component configured to selectively receive air and to provide the air into a conduit to induce plug flow between the separated fluid component and another separated fluid component, wherein the controller is configured to operate the system to perform one or more blood processing procedures to convey a fluid into the separation chamber and to remove a separated fluid component from the separation chamber.

Abstract: Systems and methods are provided for separating blood into two or more components for collection of red blood cells, plasma, or both red blood cells and plasma. A blood separation system includes a blood separation device and a fluid flow circuit configured to be mounted to the blood separation device. The blood separation device includes a centrifugal separator and a spinning membrane separator drive unit, with the blood being separated into its constituents by the centrifugal separator. Separated plasma may be collected following separation by the centrifugal separator or may first be conveyed from the centrifugal separator into the spinning membrane separator drive unit to separate cellular blood components from the plasma prior to collection of the filtered plasma. The cellular blood components filtered from the plasma may be retained in the circuit as a waste product or may be flushed out of the circuit to a recipient.