Abstract: A fluid processing device includes a detection assembly having a source and a detector. The source emits a signal to fluid or a fluid component in the fluid processing device, with at least a portion of the signal reaching the detector. The detection assembly further includes one or more adjustment systems configured to adjust the position and/or orientation of one or more components of the detection assembly. The position and/or orientation of the entire source and/or the entire detector, the position and/or orientation of a component of the source with respect to another component of the source, and/or the position and/or orientation of a component of the detector with respect to another component of the detector may be adjusted to increase the signal received by the detector.

Abstract: Systems and methods for performing low volume (e.g., 500 mL or less) extracorporeal photopheresis (ECP) procedures are disclosed. Each of the different systems and methods eliminates the need for multiple kits and solutions and reduce some of the potential risks inherent in the use of such multiple kits and solutions.

Abstract: Systems and methods for managing inventories of blood components are disclosed. Such systems and methods are configured to improve the predictability, efficiency, and/or automation of blood component supply chains. Tools are provided for tracking blood component inventories, forecasting blood component demand, and coordinating donations to meet current and anticipated demand. Some embodiments of the systems and methods identify when blood component units at a health care facility are beginning to run low or are approaching expiration, before the need for additional units becomes critical. Some embodiments of the systems and methods coordinate new donations and modify existing scheduled donations to meet real-time and forecasted demand for blood components.

Abstract: A system and method for collecting whole blood from blood donors includes first and second whole blood collection devices disposed at different blood donation centers. A remote server computer is in communication with the blood collection devices. The whole blood collection devices transfer donation procedure information to the remote server. The remote server computer facilitates retrieval of the donation procedure information at a handheld computing device. The donation procedure information includes data based on product volume collected and data indicating performance of operators of the whole blood collection devices. The handheld computing device displays a number of whole blood units collected. Blood collection can be improved using the donation procedure information.

Abstract: A fluid processing cassette includes first and second covers, with an interior wall positioned between the covers. The interior wall includes a first surface facing the first cover and defining a portion of a plurality of macrofluidic channels. A second surface of the interior wall faces the second cover and defines a portion of a plurality of microfluidic channels. At least one opening defined in the interior wall provides fluid communication between at least one of the macrofluidic channels and at least one of the microfluidic channels. An additional interior wall may also be positioned between the covers, with each interior wall secured to a different one of the covers and to the other interior wall. The additional interior wall may be positioned between the first cover and the interior wall, with macrofluidic channels defined on each side of the additional interior wall.

Abstract: A sterile connection device includes first and second carriages. The first carriage defines a first portion of a proximal slot and a first portion of a distal slot, while the second carriage defines second portions of the proximal and distal slots. A controller executes a sterile connection procedure in which a solid cutting blade is heated, followed by the heated blade being moved to a cutting position to cut sealed proximal and distal tubes received by the slots. The second carriage moves proximally or distally with respect to the first carriage so as to align the cut ends of the tubes. The heated blade then moves out of the cutting position, followed by the first carriage moving toward the second carriage so as to press the cut ends of the tubes into contact with each other so as to sterilely connect the cut ends and define a joined tube.

Abstract: A disposable syringe for use with a pneumatic driver. The syringe has an elongated barrel with a cap secured to the proximal end that has a through bore. A filter is secured to the cap interior of the barrel that covers an opening in the through bore interior of the barrel. The pneumatic driver includes a source of pressurized air; a support for receiving and locating the syringe; and a supply block configured to receive pressurized air from the source and having an outlet for delivery of pressurized air. The supply block is movable between a first position spaced apart from the cap of the syringe and a second position in contact with the cap with fluid communication being established between the outlet of the supply block and the through-bore in the cap.

Abstract: Methods and systems for sampling blood components in a photopheresis procedure are disclosed. The methods include collecting samples at selected times during a photopheresis procedure.

Abstract: A processing system includes a processor including a separator, a set configured to cooperate with the separator to separate whole blood into plasma and other components, the set including an inlet line attachable to a patient to receive whole blood and an return line attachable to a patient to return processed fluid, and a source of replacement fluid connected to the disposable set, the processor configured to combine the other components with replacement fluid to define the processed fluid. The processor includes a controller and an input device coupled to the controller, the controller configured to receive an input via the input device, the input representing a volume of replacement fluid, and to control the processor to separate whole blood passing through the set and to combine the other components with the replacement fluid according to the input until the source of replacement fluid is empty.

Abstract: A method for prophylaxis or treatment of a graft's rejection of a recipient, driven and adjusted by a microprocessor-based controller. Provided is a fluid circuit comprising a first container configured to receive a transplant component and a second container configured to receive an apoptotic component. Provided is a separator configured to associate with the fluid circuit and separate whole blood into a red blood cell component, a plasma component, and a white blood cell component. Whole blood is directed into the fluid circuit and the separator. The whole blood is separated into the red blood cell component, the plasma component, and the white blood cell component. A first portion comprising the transplant component of the white blood cell component is directed to the first container. A second portion of the white blood cell component is directed to the second container and the second portion is rendered apoptotic.

Abstract: A method of collecting plasma includes receiving donor parameters at a controller of a plasma collection device electronically from a donor management system. The method includes storing a target volume for raw plasma which is based at least in part on donor height and weight used to calculate total donor blood volume, the target volume for raw plasma based on the total donor blood volume. The method includes setting the target volume for raw plasma and controlling the plasma collection device to operate draw and return phases to withdraw whole blood from a donor and separate the whole blood into the plasma product and a second blood component comprising red blood cells and to return the second blood component to the donor. The controller operates the draw and return phases until a volume of raw plasma in the collection container equals the target volume of raw plasma.

Abstract: A cell processing system includes a processor connectable to a source container filled with a biological fluid, the processor including a separator configured to separate the biological fluid from the source container into at least two streams according to a process including at least one process parameter, and a controller coupled to the processor and an input. The controller is configured to receive the at least one process parameter, to evaluate the process using the at least one process parameter before performing the process, and to carry out one or more actions based on the evaluation, such as providing an output estimate to the operator, preventing the process from being performed according to a comparison between a calculated condition and a control, or providing an error indication to the operator according to the calculated condition and a measured in-process condition.

Abstract: A system and method for collecting whole blood from blood donors includes first and second whole blood collection devices disposed at different blood donation centers. A remote server computer is in communication with the blood collection devices. The whole blood collection devices transfer donation procedure information to the remote server. The remote server computer facilitates retrieval of the donation procedure information at a handheld computing device. The donation procedure information includes data based on product volume collected and data indicating performance of operators of the whole blood collection devices. The handheld computing device displays a number of whole blood units collected. Blood collection can be improved using the donation procedure information.

Abstract: A system and method are provided for separating previously-collected whole blood into a red blood cell fraction and a plasma fraction by which the container of previously-collected whole blood is determined to be empty based on using the combination of the measured gross weight of the container and a calculated fluid flow rate from the container, based on weigh scale feedback. Upon detection of the empty container, flow from the container is stopped.

Abstract: Mid-procedure termination of a mononuclear cell collection procedure may prevent collection of an amount of red blood cells that is required to harvest a complete mononuclear cell product. Blood separation systems and methods are provided for minimizing the impact of or recovering from mid-procedure termination of such a mononuclear cell collection procedure. According to one approach, blood or separated red blood cells are conveyed into a red blood cell collection container relatively early in the procedure to minimize the impact of a later termination of the procedure. According to another approach, blood and/or separated red blood cells within a fluid processing assembly are redirected through the fluid processing assembly following mid-procedure termination to allow for at least partial mononuclear cell collection.

Abstract: A computer-implemented method comprises providing a fluid circuit comprising fluid pathways configured to mount and associate with a durable processing device comprising a pressure sensor in communication with a controller and a fluid pathway. A container is connected to the pressure sensor and may receive a volume of fluid. A change in pressure values between a first and second time is measured from when the volume of fluid is not in communication with the pressure sensor to when the volume of fluid is in communication with the pressure sensor, the volume of fluid within the container or a presence or absence of a fluid connection to the fluid pathway based on the change in pressure values is determined, and a response action is executed if the volume of fluid within the container is not within an authorized volume range for the time period, or if a fluid connection is unauthorized.

Abstract: A method is provided for removing red blood cells from a suspension comprising red blood cells, white blood cells, platelets and plasma using a spinning membrane separator.

Abstract: A characteristic of a blood product in a blood product container is determined. Using a smartphone, an image is acquired of a blood bag or tubing of the blood product container disposed in front of the smartphone. The image is processed using a processing circuit of the smartphone or a remote computer in wireless communication with the smartphone. The processing identifies a characteristic of the blood product from the image. A visual notification is generated on a display of the smartphone of the identified characteristic of the blood product.

Abstract: An extracorporeal photopheresis system includes a separator with a disposable fluid circuit including a treatment container, an irradiation device configured to treat the contents of the treatment container, and a controller configured to control the system to perform a procedure including drawing anticoagulated whole blood into the fluid circuit from a blood source and returning to the blood source a treated target cell component, a portion of a red blood cell component remaining in the fluid circuit, and/or a portion of a plasma component remaining in the fluid circuit. The controller is further configured to estimate an end-of-procedure fluid balance estimated based on manual or automatic inputs including a patient body weight associated with the blood source and a total blood volume of the blood source, indicate the fluid balance to an operator, and receive one or more changes that affect the fluid balance after indicating the fluid balance.

Abstract: An aqueous storage solution for the storage of red blood cells, comprising an aqueous solution and at least one lipid, wherein the at least one lipid is effective in suppressing hemolysis in red blood cells and wherein the at least one lipid is emulsified within the aqueous solution.