Abstract: Systems and methods are provided for separating a red blood cell-containing fluid into separated red blood cells and another fluid constituent. A suitable system includes a disposable fluid flow circuit and a durable, reusable separation system, with the circuit being mounted onto or otherwise associated with the separation system. The circuit includes a membrane separator for separating the fluid into its constituent parts, as well as a leukoreduction filter. The leukoreduction filter may be used before or after the red blood cell-containing fluid has been passed into the membrane separator. The red blood cell-containing fluid (if the leukoreduction filter is positioned upstream of the membrane separator) or the separated red blood cells (if the leukoreduction filter is positioned downstream of the membrane separator) may also be passed through a microaggregate filter prior to passing through the leukoreduction filter.

Abstract: A system for providing remote updates on medical devices includes a wireless communication network, a wearable update output device comprising a wireless receiver in wireless communication with the wireless communication network, and a medical system comprising a medical device, an update generator, and a wireless transmitter. The update generator is configured to monitor a process carried out using the medical device, to generate one or more updates according to device states that occur during the process, and to route the updates to the wireless transmitter. The network is in wireless communication with the wireless transmitter, and is configured to route updates received from the wireless transmitter to the wireless receiver of the wearable update output device.

Abstract: A sterile tube connector for a fluid circuit system comprising a housing. A first opening is configured to receive a first length of tubing in communication with a first chamber. A second opening is configured for communicating with the first chamber when the tube connector is in an open configuration but not in a closed configuration. The second opening is configured to reversibly engage a third opening to form a second chamber. The third opening is configured for communicating with a second length of tubing. A first portion of the housing forming the first opening comprises a material at least partially permeable to a sterilization energy source for sterilizing contents of the second chamber.

Abstract: A fluid processing system including an integrated blood component collection and pathogen inactivation fluid circuit is disclosed.

Abstract: Needle protector assemblies including needle assemblies and needle protectors for housing used blood collection needles are disclosed. The needle protectors are single-piece protectors that include an open distal end for receiving a needle hub (with a needle mounted thereon). A retaining member locks the needle hub when the needle hub is substantially retracted. A stop engages the needle hub in a fully retracted position such that a needle post is completely contained within an interior chamber of the needle protectors. A viewing slot in the needle protectors is provided.

Abstract: A distributed computing system for managing blood processing procedures in a blood processing facility includes a system server, a plurality of computerized blood collection instruments, a network, a reception staff computer and an administrative level computer, with operations distributed among the various computing devices. The system server stores data identifiers for a plurality of different human operators. The computerized blood collection instruments collect blood components from donors to generate collected products and transmit real-time data regarding the blood collection instrument to the system server. The reception staff computer intakes donor data and uploads the donor data to the system server. The administrative level computer presents the donor data and the real-time data regarding the blood collection instruments on a display and receives assignments of different donors to different blood collection instruments from a human administrator.

Abstract: A cell washing system includes a fluid circuit, a source container, a source of wash solution, a pump, and a separator device. The system also includes a touch screen configured to receive user input and to display data to a user, and a controller coupled to the touch screen and configured to control the separator device and pump to operate a wash procedure, wherein the controller is configured to receive from the touch screen user input data for at least one protocol, the at least one protocol including values for a set of process parameters for a wash procedure, to store the at least one protocol in a memory, to receive an identifier associated with a user, to apply the at least one protocol based at least in part on the identifier, and to operate the wash procedure using the applied protocol.

Abstract: Fluid separation chambers are provided for rotation about an axis in a fluid processing system. The fluid separation chamber may be provided with first and second stages, with the first and second stages being positioned at different axial locations. In another embodiment, at least one of the stages may be provided with a non-uniform outer diameter about the rotational axis, which may define a generally spiral-shaped profile or a different profile for fractionating a fluid or fluid component. One or more of the stages may also have a varying outer diameter along the axis. The profile of the chamber may be provided by the chamber itself (in the case of rigid chambers) or by an associated fixture or centrifuge apparatus (in the case of flexible chambers).

Abstract: A membrane separation device is disclosed along with systems and methods employing the device in blood processing procedures. In one embodiment, a spinning membrane separator is provided in which at least two zones or regions are created in the gap between the spinning membrane and the shell, such that mixing of the fluid between the two regions is inhibited by a radial rib or ridge associated with the spinning membrane that decreases the gap between the spinning membrane and the shell to define two fluid regions, the ridge isolating the fluid in the two regions to minimize mixing between the two. Automated systems and methods are disclosed for separating a unit of previously-collected whole blood into selected blood components, such as concentrated red cells and plasma, for collecting red cells and plasma directly from a donor in a single pass, and for cell washing. Data management systems and methods and priming methods are also disclosed.

Abstract: A head-mounted display device interfaces with a medical device configured to perform an invasive procedure on a patient. The display device includes a frame for mounting on a person's head, a display, a wireless transceiver configured to communicate with a network, and a processing circuit. The processing circuit is coupled to the frame, the display and the wireless transceiver and receives input data relating to the medical device. The processing circuit retrieves from a memory an instruction relating to the medical device based on the input data and displays the instruction relating to the medical device on the display.

Abstract: Red blood cell products and compositions are disclosed. The product includes a container made from PVC or a non-PVC material that is substantially free of a phthalate plasticizer but otherwise includes one or more non-phthalate plasticizers or extractable agents. The product includes a RBC concentrate which has been combined with an additive solution for storing the RBCs.

Abstract: A method of collecting mononuclear cells, comprising separating whole blood into cellular components and platelets suspended in plasma, separating the platelets suspended in plasma into platelet concentrate and platelet-poor plasma, combining the cellular components with the platelet-poor plasma to form a first mixture, and separating the first mixture into mononuclear cells and at least one component.

Abstract: Systems and methods for managing inventories of blood components are disclosed. Such systems and methods are configured to improve the predictability, efficiency, and/or automation of blood component supply chains. Tools are provided for tracking blood component inventories, forecasting blood component demand, and coordinating donations to meet current and anticipated demand. Some embodiments of the systems and methods identify when blood component units at a health care facility are beginning to run low or are approaching expiration, before the need for additional units becomes critical. Some embodiments of the systems and methods coordinate new donations and modify existing scheduled donations to meet real-time and forecasted demand for blood components.

Abstract: A centrifuge rotor assembly includes a chamber assembly, a bearing support, and a counterweight that is substantially diametrically opposed to the bearing support with respect to the chamber assembly. The chamber assembly receives a processing chamber of a fluid circuit, while the bearing support receives a portion of an umbilicus that is fluidly connected to the processing chamber. The bearing support and counterweight are rotated about a central axis of the chamber assembly by an electric drive of the centrifuge rotor assembly, with the bearing support and counterweight remaining substantially diametrically opposed to each other with respect to the chamber assembly while being rotated about the central axis. The electric drive may rotate the bearing support and counterweight at a plurality of different speeds, with the counterweight automatically moving with respect to the bearing support between radially innermost and radially outermost positions to balance the centrifuge rotor assembly.

Abstract: A server computer processes infusion pump data for presentation on an operator interface. The computer includes a network circuit configured to provide communications over a network and a processing circuit. The processing circuit receives infusion pump history data from a plurality of infusion pumps, including an indication that a user inputted to an infusion pump a parameter which was outside of a prestored limit, an indication that a user was notified that the parameter was outside the prestored limit, an indication that the infusion pump parameter was returned to within the prestored limit, and an indication that the user started infusion on the pump at the parameter within the prestored limit. Display data indicating reprogram and override events is generated for display on an operator interface.

Abstract: A plasmapheresis system and a method for operating a plasmapheresis system are provided by which the volume/weight of anticoagulated plasma that is collected is optimized. In one example, a nomogram is provided that utilizes the donor's hematocrit to calculate the volume/weight of raw plasma within a plasma product having the maximum volume permitted by the FDA nomogram. In a plasmapheresis procedure having multiple collection phases followed by a reinfusion cycle in which concentrated red blood cells are returned to the donor, the volume of plasma product to be collected is calculated prior to the start of each collection cycle to account for the donor's increasing hematocrit, thus resulting in a greater total volume of plasma product to be collected during the plasmapheresis procedure.

Abstract: A method of recovering white blood cells from a leukoreduction filter, the method comprising providing a solution comprising a sugar, flowing a volume of the solution through a leukoreduction filter containing captured white blood cells, and collecting elute from the leukoreduction filter, wherein the elute comprises the solution and recovered white blood cells.

Abstract: Filter media, filter devices and methods of making filter media are disclosed. The filter media includes a coating on at least a portion of said outer surface. The coating may be polymeric composition having a molecular chain that includes segments of non-polar groups and segments of at least one of polar groups or segments of ionic groups.

Abstract: Methods and systems for reducing bacterial contamination of platelets are disclosed. The methods and systems disclosed herein provide for the processing of a pre-determined volume of whole blood so as to reduce the risk that platelets separated and collected from the whole blood have a reduced risk of bacterial contamination.

Abstract: A method for controlling the flow rate of a pneumatic syringe in a system that includes a disposable fluid circuit and reusable hardware configured to accept the disposable fluid circuit. The disposable fluid circuit includes one or more syringes, while the reusable hardware includes a syringe pump for each syringe of the disposable fluid circuit and a controller. The syringe pump includes a vacuum/pressure source for moving the piston within the syringe and a position detector for indicating the position of the piston within the syringe. The method controls several distinct phases of the process: break pressure targeting, glide control and vent control, and the method is the same regardless of whether a positive pressure or a vacuum is applied to the piston of the syringe. Preferably, a proportional-integral-derivative (“PID”) feedback loop is used for controlling the movement of the piston in the syringe.