Abstract: There is provided an aerosol inhalation device, suitable for use in association with a pressurized medicament container (10), comprising an elongate member (1) provided at one end with a mouthpiece (5), and adjacent the other end being pivotably connected (3,4) to an aerosol dispenser (2), the aerosol dispenser (2) comprising a body (6) and a spray orifice (9), the elongate member (1) being pivotable to an open inhalation position, in which the spray orifice (9) is directed towards the mouthpiece (5), and to a closed position, in which the elongate member (1) fits around the body (6) of the aerosol dispenser (2), and is of such a length that the mouthpiece (5) is able to fit over the end of the aerosol dispenser (1).

Abstract: There are described compounds of formula I, ##STR1## in which X is O, S or N--R.sub.7,each Y, which may be the same or different, is H, OH, alkyl C1-C8, alkoxy C1-C8 or halogen,n is an integer from 1 to 4 inclusive,R and R.sub.1, which may be the same or different, are each H; alkanoyl C2-C8 or a group R.sub.4 in which R.sub.4 is alkyl C1-C8 optionally substituted by phenyl; or is cycloalkyl C5 or C6; or is a group of formula XVI, ##STR2## in which W and Z, which may be the same or different, are each H, OH, alkoxy C1-C8, phenyl-alkoxy C7 to C10, alkyl C1-C8, halogen, --NR.sub.2 R.sub.3, --COOR.sub.2, NO.sub.2, alkanoyloxy C2-C8, or --OCH.sub.2 CH.sub.2 NR.sub.2 R.sub.3, andR.sub.2, R.sub.3 and R.sub.7, which may be the same or different, are each H or alkyl C1-C8,provided that when X is N--R.sub.7 and R is H, then R.sub.1 is not (a) H when any Y groups are H, alkyl C1-C8, alkoxy C1-C8 or halogen, or (b) unsubstituted phenyl when all Y groups are H,and pharmaceutically acceptable salts thereof.

Abstract: There are described compounds of formula I, ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and R.sub.7, which may be the same or different, each represent hydrogen, hydroxy, alkyl Cl to 6, alkoxy C1 to 6, amino, acyl C2 to 6, acylamino C2 to 6, alkenyl C2 to 6, halogen, or alkoxy C1 to 6 substituted by phenyl,X is a hydrocarbon chain of 1 to 10 carbon atoms optionally substituted by a hydroxy group,A is --Q--COOH,Q is absent or represents a straight or branched alkylene, alkenylene or alkynylene group of up to and including 6 carbon atoms,R.sub.8 and R.sub.9, which may be the same or different, each represent hydrogen or alkyl C1 to 6 or together form a single bond,D, Y and Z, which may be th same or different, each represent sulphur, oxygen or --NR.sub.10 --, andR.sub.10 is hydrogen or alkyl C1-C6,provided that(i) when D, Z and Y are all oxygen, R.sub.8 and R.sub.9 do not together form a single bond,(ii) when D is oxygen, R.sub.8 and R.sub.9 together form a single bond, X is (CH.sub.2).sub.

Abstract: There is described a process for the production of a compound of formula I, ##STR1## in which R is hydrogen or alkyl Cl to 6, and R.sub.5 and R.sub.10, which may be the same or different, are each hydrogen or alkyl Cl to 6,or a pharmaceutically acceptable derivative thereof,which comprises removal of an activating group from a compound of formula II, ##STR2## or a suitable derivative thereof, in which R, R.sub.5 and R.sub.10 are as defined above, andX represents an activating group,and if desired or necessary converting the resulting compound of formula I to a pharmaceutically acceptable derivative thereof, or vice versa.There is also described a process for the production of a compound of formula II in which R is hydrogen, or a suitable derivative thereof, which comprises reaction of a compound of formula III, ##STR3## or a suitable derivative thereof, in which R.sub.5 and R.sub.10 are as defined above, with a compound of formula IV,X--N.dbd.C.dbd.O IVin which X is as defined above.

Abstract: There are described compounds of formula I ##STR1## in which X is --CN, --CONH.sub.2, --CSNH.sub.2, ##STR2## or --CO.sub.2 R.sub.3, R is H or alkyl C 1 to 8,R.sub.1 and R.sub.3, which may be the same or different, are each alkyl C 1 to 8, andR.sub.2 is H or alkanoyl C 2 to 8,and the pharmaceutically acceptable acid addition salts thereof.There are also described processes for producing the compounds, and pharmaceutical, e.g. immunoregulant, compositions containing them.