Patents Assigned to Flint Hills Scientific, L.L.C.
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Publication number: 20230058287Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by: increasing the parasympathetic input to said patient's heart, such as by electrically stimulating a parasympathetic nervous structure, applying cooling energy to a sympathetic nervous structure, or administering a cholinergic or a sympatho-blocking agent to said patient. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.Type: ApplicationFiled: November 7, 2022Publication date: February 23, 2023Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20220304616Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: June 3, 2022Publication date: September 29, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN Osorio
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Publication number: 20220296155Abstract: A method of determining a responsiveness of a patient having brain state changes, comprising receiving an indication of a triggering event; administering to the patient, in response to the indication, a test of responsiveness; determining, based upon a result of the test, at least one responsiveness parameter selected from the group consisting of (i) a time of occurrence of a change in the patient's responsiveness, (ii) a duration of a change in the patient's responsiveness; (iii) a magnitude of a change in the patient's responsiveness, (iv) a time interval from the indication of event occurrence to a change in the patient's responsiveness, (v) a type of change in the patient's responsiveness, (vi) an estimation of a seizure severity; (vii) a classification of a seizure into clinical or subclinical; (viii) a classification of a clinical seizure into simple partial, complex partial, or generalized; (ix) an assessment of efficacy of a therapy for the patient's medical condition; (x) an assessment of the state oType: ApplicationFiled: June 4, 2022Publication date: September 22, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Patent number: 11412995Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively.Type: GrantFiled: July 14, 2020Date of Patent: August 16, 2022Assignee: Flint Hills Scientific, L.L.C.Inventor: Ivan Osorio
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Publication number: 20220176124Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: February 27, 2022Publication date: June 9, 2022Applicant: Flint Hills Scientific, L.L.C.Inventor: Ivan OSORIO
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Patent number: 11350871Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: GrantFiled: January 31, 2020Date of Patent: June 7, 2022Assignee: Flint Hills Scientific, L.L.C.Inventor: Ivan Osorio
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Publication number: 20220142558Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: January 24, 2022Publication date: May 12, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20220134112Abstract: We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.Type: ApplicationFiled: January 11, 2022Publication date: May 5, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20220111207Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: December 21, 2021Publication date: April 14, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20220095994Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.Type: ApplicationFiled: December 11, 2021Publication date: March 31, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: Ivan Osorio
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Publication number: 20220096835Abstract: A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or brain state change.Type: ApplicationFiled: October 12, 2021Publication date: March 31, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.CInventors: IVAN OSORIO, Mark Frei
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Publication number: 20220061744Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.Type: ApplicationFiled: November 10, 2021Publication date: March 3, 2022Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventors: Ivan Osorio, Mark Frei
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Patent number: 11219374Abstract: A method, comprising receiving a time series of patient body signal, determining first and second sliding time windows for the time series; applying an autoregression algorithm, comprising: applying an autoregression analysis to each of the first and second windows, yielding autoregression coefficients and a residual variance for each window; estimating a parameter vector for each window based on the autoregression coefficients and residual variances; and determining a difference between the parameter vectors; and determining seizure onset and seizure termination based on the difference between the parameter vectors. A non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.Type: GrantFiled: October 10, 2017Date of Patent: January 11, 2022Assignee: Flint Hills Scientific, L.L.C.Inventors: Ivan Osorio, Alexey Lyubushin, Didier Sornette
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Publication number: 20210401355Abstract: A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.Type: ApplicationFiled: July 10, 2021Publication date: December 30, 2021Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20210386361Abstract: We report method of detecting a pathological body state of a patient, comprising receiving a body signal of the patient; determining a body index from said body signal; determining an activity level of said patient; determining a value range for said body index for said patient, based at least in part on said activity level; comparing said body index to said value range; and detecting a pathological state when said body index is outside said value range. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.Type: ApplicationFiled: July 12, 2021Publication date: December 16, 2021Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Patent number: 11185695Abstract: A system and method for analyzing and logging changes in brain state of a subject for administering therapy to the subject based on the at least one cardiac signal wherein the system and method comprises the steps of receiving at least one cardiac signal of the subject into a processor, analyzing the cardiac signal to detect at least one cardiac signal change indicative of a brain state change, and logging at least one characteristic of the detected signal change or the brain state change.Type: GrantFiled: December 3, 2008Date of Patent: November 30, 2021Assignee: Flint Hills Scientific, L.L.C.Inventors: Ivan Osorio, Mark G. Frei
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Patent number: 11179094Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.Type: GrantFiled: November 13, 2018Date of Patent: November 23, 2021Assignee: FLINT HILLS SCIENTIFIC, L.L.C.Inventors: Ivan Osorio, Mark G. Frei
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Publication number: 20210321935Abstract: A method, comprising receiving at least one of a signal relating to a first cardiac activity and a signal relating to a first body movement from a patient; triggering at least one of a test of the patient's responsiveness, awareness, a second cardiac activity, a second body movement, a spectral analysis test of the second cardiac activity, and a spectral analysis test of the second body movement, based on at least one of the signal relating to the first cardiac activity and the signal relating to the first body movement; determining an occurrence of an epileptic event based at least in part on said one or more triggered tests; and performing a further action in response to said determination of said occurrence of said epileptic event. Further methods allow classification of epileptic events. Apparatus and systems capable of implementing the method.Type: ApplicationFiled: May 4, 2021Publication date: October 21, 2021Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20210268284Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.Type: ApplicationFiled: May 3, 2021Publication date: September 2, 2021Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO
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Publication number: 20210236819Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.Type: ApplicationFiled: February 23, 2021Publication date: August 5, 2021Applicant: FLINT HILLS SCIENTIFIC, L.L.C.Inventor: IVAN OSORIO