Patents Assigned to Flint Hills Scientific, L.L.C.
  • Patent number: 10933241
    Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: March 2, 2021
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 10682515
    Abstract: Disclosed are methods and systems for treating epilepsy by stimulating a main trunk of a vagus nerve, or a left vagus nerve, when the patient has had no seizure or a seizure that is not characterized by cardiac changes such as an increase in heart rate, and stimulating a cardiac branch of a vagus nerve, or a right vagus nerve, when the patient has had a seizure characterized by cardiac changes such as a heart rate increase.
    Type: Grant
    Filed: February 20, 2017
    Date of Patent: June 16, 2020
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 10172550
    Abstract: Methods, systems, and apparatus for assessing a state of an epilepsy disease or a comorbidity thereof are provided. The methods comprise receiving at least one autonomic index, neurologic index, stress marker index, psychiatric index, endocrine index, adverse effect of therapy index, physical fitness index, or quality of life index of a patient; comparing the at least one index to at least one reference value; and assessing a state of an epilepsy disease or a body system of the patient based on the comparison. A computer readable program storage device encoded with instructions that, when executed by a computer, perform the method described above is also provided. A medical device system capable of implementing the method described above is also provided.
    Type: Grant
    Filed: December 23, 2014
    Date of Patent: January 8, 2019
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 9895101
    Abstract: A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.
    Type: Grant
    Filed: December 5, 2016
    Date of Patent: February 20, 2018
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 9889302
    Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.
    Type: Grant
    Filed: March 4, 2015
    Date of Patent: February 13, 2018
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 9808207
    Abstract: A method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy is provided. The method includes receiving cardiac data and determining a cardiac index based upon the cardiac data. The method includes determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. Also presented is a second method for determining and responding in real-time to an increased risk of death relating to a patient with epilepsy comprising receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: November 7, 2017
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20170296820
    Abstract: A method for assessment, optimization and logging of the effects of a therapy for a medical condition, including (a) receiving into a signal processor input signals indicative of the subject's brain activity; (b) characterizing the spatio-temporal behavior of the brain activity using the signals; (c) delivering a therapy to a target tissue of the subject; (d) characterizing the spatio-temporal effect of the therapy on the brain activity; (e) in response to the characterizing, optimizing at least one parameter of the therapy if the brain activity has not been satisfactorily modified and/or has been adversely modified by the therapy; (f) characterizing the spatio-temporal effect of the at least one optimized parameter; and (g) logging to memory the at least one optimized parameter. A computer readable program storage unit encoded with instructions that, when executed by a computer, performs the method.
    Type: Application
    Filed: May 4, 2017
    Publication date: October 19, 2017
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan OSORIO
  • Patent number: 9788779
    Abstract: We report a method of determining an occurrence of an epileptic convulsive seizure in a patient, comprising: receiving body data from a patient during a first time period, determining a work level relating to said first time period at least based partially upon said body data; determining whether said work level exceeds an extreme work level threshold; performing a responsive action, in response to a determination that said work level exceeds said extreme work level threshold. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: October 17, 2017
    Assignee: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Patent number: 9659216
    Abstract: A method, computer program, and system for real-time signal analysis providing characterization of temporally-evolving densities and distributions of signal features of arbitrary-type signals in a moving time window by tracking output of order statistic filters (also known as percentile, quantile, or rank-order filters). Given a raw input signal of arbitrary type, origin, or scale, the present invention enables automated quantification and detection of changes in the distribution of any set of quantifiable features of that signal as they occur in time. Furthermore, the present invention's ability to rapidly and accurately detect changes in certain features of an input signal can also enable prediction in cases where the detected changes associated with an increased likelihood of future signal changes.
    Type: Grant
    Filed: September 10, 2012
    Date of Patent: May 23, 2017
    Assignee: Flint Hills Scientific, L.L.C.
    Inventors: Alexei V. Nikitin, Mark G. Frei, Naresh C. Bhavaraju, Ivan Osorio, Ruslan L. Davidchack
  • Publication number: 20160213271
    Abstract: Methods, systems, and apparatus for detecting and/or validating a detection of a state change by matching the shape of one or more of an cardiac data series, a heart rate variability data series, or at least a portion of a heart beat complex, derived from cardiac data, to an appropriate template.
    Type: Application
    Filed: January 28, 2016
    Publication date: July 28, 2016
    Applicant: Flint Hills Scientific, L.L.C.
    Inventors: Ivan Osorio, Mark G. Frei
  • Publication number: 20160128580
    Abstract: A method includes receiving cardiac data and determining a cardiac index based upon the cardiac data; determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A second method comprises receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively; determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A non-transitory computer readable program storage device encoded with instructions that, when executed by a computer, perform a method is also provided.
    Type: Application
    Filed: September 13, 2013
    Publication date: May 12, 2016
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20160058359
    Abstract: A method for identifying changes in an epilepsy patient's disease state, comprising: receiving at least one body data stream; determining at least one body index from the at least one body data stream; detecting a plurality of seizure events from the at least one body index; determining at least one seizure metric value for each seizure event; performing a first classification analysis of the plurality of seizure events from the at least one seizure metric value; detecting at least one additional seizure event from the at least one determined index; determining at least one seizure metric value for each additional seizure event, performing a second classification analysis of the plurality of seizure events and the at least one additional seizure event based upon the at least one seizure metric value; comparing the results of the first classification analysis and the second classification analysis; and performing a further action.
    Type: Application
    Filed: November 9, 2015
    Publication date: March 3, 2016
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: IVAN OSORIO
  • Publication number: 20150174407
    Abstract: A method, comprising detecting, in at least a first brain region of a patient, an electrical activity relating to an epileptic activity; determining a first regularity index of said electrical activity; and applying at least one first electrical stimulation to at least one neural target of said patient for treating said epileptic event, in response to said first regularity index being within a first range. A non-transitive, computer-readable storage device for storing instructions that, when executed by a processor, perform the method. A medical device system suitable for use in the method.
    Type: Application
    Filed: March 4, 2015
    Publication date: June 25, 2015
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20150080670
    Abstract: A method includes receiving cardiac data and determining a cardiac index based upon the cardiac data; determining an increased risk of death associated with epilepsy if the indices are extreme, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A second method comprises receiving at least one of arousal data, responsiveness data or awareness data and determining an arousal index, a responsiveness index or an awareness index, where the indices are based on arousal data, responsiveness data or awareness data respectively; determining an increased risk of death related to epilepsy if indices are extreme values, issuing a warning of the increased risk of death and logging information related to the increased risk of death. A non-transitory computer readable program storage device encoded with instructions that, when executed by a computer, perform a method is also provided.
    Type: Application
    Filed: September 13, 2013
    Publication date: March 19, 2015
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140275828
    Abstract: We report method of detecting a pathological body state of a patient, comprising receiving a body signal of the patient; determining a body index from said body signal; determining an activity level of said patient; determining a value range for said body index for said patient, based at least in part on said activity level; comparing said body index to said value range; and detecting a pathological state when said body index is outside said value range. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: November 19, 2013
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140276551
    Abstract: We report a method of treating an epileptic seizure in a patient, comprising: detecting said epileptic seizure, based on body data from said patient; and reducing a flow of blood to a brain of said patient in response to said detected seizure; wherein said reducing is effected by at least one of: applying a pressure, applying a cooling, or administering a vasoconstrictive agent to a vessel supplying blood to at least a portion of the brain. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: January 31, 2014
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140276128
    Abstract: We report a method for detecting epileptic or non-epileptic seizures, comprising: receiving a heart rate of a patient; calculating a percentage change of the heart rate in reference to at least one of the patient's maximal heart rate, reserve heart rate, or a resting heart rate; detecting an epileptic seizure if the percentage increase in the heart rate reaches a threshold value; and taking at least one responsive action selected from issuing a warning, delivering a therapy, determining a seizure severity, or logging at least one of a date and time of occurrence of the seizure, its severity, the type of therapy, or its effect, in response to the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: January 31, 2014
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140276129
    Abstract: We report a method comprising receiving a first indication to gather a first biological signal or feature thereof from a patient; gathering the first biological signal or feature thereof; receiving a second indication to stop gathering the first biological signal or feature thereof, wherein the second indication relates to a detection of an end of a brain state change; and stopping gathering the first biological signal or feature thereof. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140277256
    Abstract: We report a method of automatically titrating an electrical therapy administered to a patient by an implanted medical device to a target dosage, comprising programming the medical device with a programmed electrical therapy comprising a first target value for a first therapy parameter; programming at least one titration parameter for automatically adjusting the first therapy parameter from a first value to the first target value over a titration time period initiating the electrical therapy, wherein the first therapy parameter comprises said first value; and automatically titrating the electrical therapy by making a plurality of adjustments to the value of the first therapy parameter, whereby the first electrical therapy parameter is changed from the first value to the first target value according to a titration function. We also report a medical device system configured to implement the method.
    Type: Application
    Filed: March 10, 2014
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio
  • Publication number: 20140275838
    Abstract: We report a method of a method for detecting an epileptic seizure, comprising providing a first body signal reference value; determining a current body signal value from a time series of body signals; comparing the current body signal value and the first reference value; determining a work level of the patient; determining whether the current body signal value comprises an ictal component, based on the work level and the comparing; issuing a detection of an epileptic seizure in response to the determination that the current body signal value comprises the ictal component; and taking at least one further action (e.g. warning, delivering a therapy, etc.), based on the detection. We also report a medical device system configured to implement the method. We also report a non-transitory computer readable program storage unit encoded with instructions that, when executed by a computer, perform the method.
    Type: Application
    Filed: March 13, 2014
    Publication date: September 18, 2014
    Applicant: Flint Hills Scientific, L.L.C.
    Inventor: Ivan Osorio