Abstract: A method of producing soluble polyphosphides from red phosphorous using alkali metal compounds and organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: A method of generating soluble polyphosphides using solution chemistry is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: A method of synthesizing soluble polyphosphides by activating red phosphorous using organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: A method of generating soluble polyphosphides using solution chemistry is presented. A reaction between potassium ethoxide and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: A method of synthesizing soluble polyphosphides using shelf-stable reagents and common organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: An ultrafast electromechanical switch having a drive mechanism comprising three non-movable contacts, an actuator and two movable contacts. The switch further including a switching chamber to provide a self-contained environment that may consist of a high-pressure gas or a vacuum and one or more precision adjustment screws coupled to the non-movable contacts for adjusting the contact pressure. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.

Abstract: An ultrafast electromechanical switch having a drive mechanism comprising two non-movable contacts connected to electrical feedthroughs, one actuator and one movable contact. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.

Abstract: A method of synthesizing soluble polyphosphides using shelf-stable reagents and common organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: The present invention concerns the use of castanospermine or other alpha-glucosidase inhibitors for the treatment or prevention of Zika virus infections. Aspects of the invention include methods for treating or preventing Zika virus infection by administering an alpha-glucosidase inhibitor (e.g., an alpha-glucosidase I inhibitor) to a subject in need thereof; methods for inhibiting a Zika virus infection in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Zika virus infection.

Abstract: An ultrafast electromechanical switch having a drive mechanism comprising three non-movable contacts, an actuator, two movable contacts and a first and second mounting plate forming an elliptical shell configuration about said actuator. The switch further including a switching chamber to provide a self-contained environment that may consist of a high-pressure gas or a vacuum and one or more precision adjustment screws coupled to the non-movable contacts for adjusting the contact pressure. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.

Abstract: An ultrafast electromechanical switch having a drive mechanism comprising three non-movable contacts, an actuator and two movable contacts. The switch further including one or more precision adjustment screws coupled to the non-movable contacts for adjusting the contact pressure. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.

Abstract: The present invention provides a new therapeutic method for modeling neuronal responses. Human induced pluripotent stem cells (hiPSCs) emerge recently as alternative sources of primary brain cells to establish Alzheimer's disease (AD) models in vitro. While previous investigations demonstrate the potential of hiPSCs in modeling AD, the 2-D cultures used in these studies cannot fully recapitulate AD-associated neuropathology. 3-D cortical spheroids (forebrain-like structure) were derived from human induced pluripotent stem cells in a bioreactor culture, which can be used to recapitulate AD-associated neuropathology, to screen the therapeutic drugs and to predict neurotoxicity.

Abstract: A method for preparing a crude oil solution for analysis, including adding water to a porous adsorbent to obtain a supported water substrate, having a plurality of water monolayers disposed on the porous adsorbent. The method further includes exposing the crude oil solution to the supported water substrate for a period of time; separating the supported water substrate from the crude oil solution; washing the supported water substrate with a water immiscible solvent to remove at least one hydrocarbon; displacing water from the plurality of water monolayers and the at least one interfacially active compound from the porous adsorbent with an alcohol and a co-solvent to obtain a displaced phase. The displaced phase can include the water, the at least one interfacially active compound, the alcohol, and the co-solvent. Finally, the method can include drying the displaced phase to isolate the at least one interfacially active compound.

Abstract: A method of synthesizing soluble polyphosphides by conversion of red phosphorous using alkali metal compounds and organic solvents is presented. A reaction between an alkali metal alkoxy compound or alkali metal alkyl thiolate compound, such as potassium ethoxide, and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.

Abstract: Click reactions may be used to bond polymers to lignin by taking advantage of lignin's terminal hydroxyl and thiol groups via an alkyne-azide click reaction or a thiol-alkene or thiol-alkyne click reaction. By selecting functional polymers, these methods may be used to synthesize lignin-containing polymer materials with an array of different properties, such as self-healing polymers.

Abstract: D-serine is used to treat a neurological disorder, such as epilepsy, that cases seizures. A composition comprising D-serine is artificially administered to a patient in an effective amount by selectively contacting a region of the patient's brain with the composition. The region of the brain selectively contacted with the composition has cells expressing GluN3 subunit-containing triheteromeric NMDARs.

Abstract: This describes homogeneous catalysts that are recoverable from solution by being phase selective and through host-guest interactions. An example of a method includes separating a water soluble N-heterocyclic carbene homogeneous catalyst from a solution by: (a) forming a host-guest compound between the catalyst and an inclusion compound in the solution; and (b) isolating the host-guest compound from the solution.

Abstract: A series of multicoordinating and multifunctional ligands optimized for the surface-functionalization of luminescent quantum dots (QDs) and gold nanoparticles (AuNPs) alike is disclosed. An L-aspartic acid precursor is modified with functionality, through simple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG) moieties in the same ligand. These ligands were combined with a new photoligation strategy to yield hydrophilic and reactive QDs that are colloidally stable over a broad range of conditions, including storage at nanomolar concentration and under ambient conditions.

Abstract: A device and methodology for concomitant ejection and suction of a perfusate (CESOP) within a region of interest without spillover of the perfusate to a juxtaposed anatomical region. An inflow line, connected to a perfusate cistern, is coupled to an outflow line, connected to outflow control mechanisms, via an elongate rigid support. Perfusate can flow through the inflow line to the region of interest, and nearly simultaneously, the outflow line can suction the perfusate out of the region of interest. The amount of time that the perfusate remains in the region of interest is sufficient to take effect in the region of interest. The rigid support helps control the inflow and outflow lines. A micromanipulator can also be used to control the lines and application tip thereof. Either or both lines may also have adjustable flow rates therethrough and may include stoppers/regulators.

Abstract: Working memory deficits are treated and working memory is improved with a composition that comprises a therapeutically effective amount of one or more respective selective dopamine D4 receptor agonists and/or pharmaceutically acceptable analogs, salts or hydrates of the respective one or more selective dopamine D4 receptor agonists. This composition can be administered to a subject to improve the subject's working memory.