Abstract: Certain embodiments herein relate to, among other things, designing data cache systems to enhance energy efficiency and performance of computing systems. A data filter cache herein may be designed to store a portion of data stored in a level one (L1) data cache. The data filter cache may reside between the L1 data cache and a register file in the primary compute unit. The data filter cache may therefore be accessed before the L1 data cache when a request for data is received and processed. Upon a data filter cache hit, access to the L1 data cache may be avoided. The smaller data filter cache may therefore be accessed earlier in the pipeline than the larger L1 data cache to promote improved energy utilization and performance. The data filter cache may also be accessed speculatively based on various conditions to increase the chances of having a data filter cache hit.

Abstract: A system for analyzing and modifying passwords in a manner that provides a user with a strong and usable/memorable password. The user would propose a password that has relevance and can be remembered. The invention would evaluate the password to ascertain its strength. The evaluation is based on a probabilistic password cracking system that is trained on sets of revealed passwords and that can generate password guesses in highest probability order. If the user's proposed password is strong enough, the proposed password is accepted. If the user's proposed password is not strong enough, the system will reject it. If the proposed password is rejected, the system modifies the password and suggests one or more stronger passwords. The modified passwords would have limited modifications to the proposed password. Thus, the user has a tested strong and memorable password.

Abstract: This disclosure provides for new methods for quantification of metabolite concentrations in metabolomics studies, which addresses the difficulties in quantification through 1D peak integrals due to significant peak overlaps in metabolomics samples. For samples from uniformly 13C-labeled organisms the 2D NMR 13C-13C constant-time (CT) TOCSY experiment provides high-resolution information about individual metabolites that allows their identification via database searching or, in the case of novel compounds, through the reconstruction of their backbone-carbon topology. This disclosure further demonstrates using CT-TOCSY spectra for quantification purposes.

Abstract: Automated, standardized and accurate extraction of relationships within text. Automatic extraction of such relationships/information allows the information to be stored in structured form so that it can be easily and accurately retrieved when needed. Such information can be used to build online search engines for highly specific and accurate information retrieval. The current invention discloses a novel approach to extract such information from raw text based on natural language processing (NLP) and graph theoretic algorithm. The novel method can be applied, for example, to extract protein-protein relationships in biomedical literature. The method can be easily extended to extract other biological relationships between biological terms such as proteins, genes, pathways, diseases and drugs. The method can also be applied to other information domains to extract other relationships.

Abstract: The present invention enables a safe and noninvasive assessment of tumor resistance using one diffusion or sodium MRI scan over the entire tumor. The evaluation can be done before therapy and can help select a strategy of treatment. The invention can be used in different types of tumors in most parts of the human body. The level of tumor resistance can be determined reproducibly and quickly. The results can be used immediately to create individualized therapy. The invention allows clinicians to avoid ineffective therapies, which may be more harmful than useful, or come up with the other more appropriate alternatives.

Abstract: Unsymmetrical bisazides containing chelating and non-chelating azido groups undergo chemoselective three-component copper(I)-catalyzed azide-alkyne conjugation reactions with two different alkyne molecules. In conjunction with the reactivity gap between aromatic and aliphatic alkynes, a bistriazole molecule can be generated with an excellent regioselectivity by mixing two alkynes and a bisazide in a single reaction container. This method is applicable in aqueous solutions at neutral pH, which may lend utilities in bioconjugation applications.

Abstract: An efficient method and associated systems for segmentation of high throughput sequential data, such as genomic datasets. The technique first utilizes dynamic programming to compute the significance for a large number of candidate segments. It then uses tree-based data structures to detect overlapping significant regions and update them simultaneously. Refinement and merging of significant segments are performed at the end to generate the final segmentation.

Abstract: An isolated antibody that has a specific binding affinity to a polypeptide comprising the amino acid sequence HTEGKP (SEQ ID NO: 2) phosphorylated at threonine is provided. The antibody may be used as biomarker for mitotic cells. A method for using the antibody in accordance with the invention comprises contacting a cell with the antibody and detecting antibody bound to the cell as an indicator of the cell being in the mitotic state. A reagent kit comprising the antibody is also provided.

Abstract: A heat sink and method for gaseous cooling of superconducting power devices. Heat sink is formed of a solid material of high thermal conductivity and attached to the area needed to be cooled. Two channels are connected to the heat sink to allow an inlet and an outlet for cryogenic gaseous coolant. Inside the hollow heat sink are fins to increase metal surface in contact with the coolant. The coolant enters through the inlet tube, passes through the finned area inside the heat sink and exits through the outlet tube.

Abstract: L2Relay is a novel packet relay protocol for Wi-Fi networks that can improve the performance and extend the range of the network. A device running L2Relay is referred to as a relayer, which overhears the packet transmissions and retransmits a packet on behalf of the Access Point (AP) or the node if no acknowledgement is overheard. L2Relay is ubiquitously compatible with all Wi-Fi devices. L2Relay is designed to be a layer 2 solution that has direct control over many layer 2 functionalities such as carrier sense. Unique problems are solved in the design of L2Relay including link measurement, rate adaptation, and relayer selection. L2Relay was implemented in the OpenFWWF platform and compared against the baseline without a relayer as well as a commercial Wi-Fi range extender. The results show that L2Relay outperforms both compared schemes.

Abstract: A heat sink and method for gaseous cooling of superconducting power devices. Heat sink is formed of a solid material of high thermal conductivity and attached to the area needed to be cooled. Two channels are connected to the heat sink to allow an inlet and an outlet for cryogenic gaseous coolant. Inside the hollow heat sink are fins to increase metal surface in contact with the coolant. The coolant enters through the inlet tube, passes through the finned area inside the heat sink and exits through the outlet tube.

Abstract: The orthogonal space random walk (OSRW) algorithm is generalized to be the orthogonal space tempering (OST) method via the introduction of the orthogonal space sampling temperature. A double-integration recursion method enables practically efficient and robust OST free energy calculations, augmented by a ?-dynamics approach. The double-integration OST method performs alchemical free energy simulations, to calculate the free energy difference between benzyl phosphonate and difluorobenzyl phosphonate in aqueous solution, to estimate the solvation free energy of the octanol molecule, and to predict the nontrivial Barnase-Barstar binding affinity change induced by the Barnase N58A mutation. The DI-OST method robustly enables practically efficient free energy predictions, particularly when strongly coupled slow environmental transitions are involved. A classical set of p38? MAP Kinase inhibitors are also employed as a test bed for evaluating relative binding affinity calculation methods.

Abstract: A method for making an actuator capable of dry actuation is provided. The method includes providing a first nanoscale fiber film, providing a second nanoscale fiber film, positioning a solid polymer electrolyte at least partially between and adjacent to the first nanoscale fiber film and the second nanoscale fiber film, and then affixing the solid polymer electrolyte to the first nanoscale fiber film and the second nanoscale fiber film. The nanoscale fiber films may be buckypapers, made of carbon nanotubes. The actuator is capable of dry actuation.

Abstract: NMR probe coils designed to operate at two different frequencies, producing a strong and homogenous magnetic field at both the frequencies. This single coil, placed close to the sample, provides a method to optimize the NMR detection sensitivity of two different channels. In addition, the present invention describes a coil that generates a magnetic field that is parallel to the substrate of the coil as opposed to perpendicular as seen in the prior art. The present invention isolates coils from each other even when placed in close proximity to each other. A method to reduce the presence of electric field within the sample region is also considered. Further, the invention describes a method to adjust the radio-frequency tuning and coupling of the MAR probe coils.

Abstract: A cable termination utilizing liquid and gaseous cryogen. The liquid cryogen maintains cryogen temperatures of all dielectric surfaces exposed to gaseous cryogen and to high voltage potential. The invention further includes capacitive grading, minimizing the electric field on the surface of the bushing in the vapor phase of the cryogen used in the liquid cryogen compartment. The cross-section of the conductor within the cable termination is adjusted along its axis enabling thermal optimization for reduction in the loss of liquid cryogen. Heat sink, for helium gas cooling of superconducting power devices, is surrounded by a metal of high thermal conductivity and placed near the area needed to be cooled. Cryogenic gaseous coolant flows through two tubes connected to the heat sink. Fins inside heat sink increase metal surface in contact with the coolant. The coolant flows from first tube, passes through the finned are and exits through the second tube.

Abstract: L2Relay is a novel packet relay protocol for Wi-Fi networks that can improve the performance and extend the range of the network. A device running L2Relay is referred to as a relayer, which overhears the packet transmissions and retransmits a packet on behalf of the Access Point (AP) or the node if no acknowledgement is overheard. L2Relay is ubiquitously compatible with all Wi-Fi devices. L2Relay is designed to be a layer 2 solution that has direct control over many layer 2 functionalities such as carrier sense. Unique problems are solved in the design of L2Relay including link measurement, rate adaptation, and relayer selection. L2Relay was implemented in the OpenFWWF platform and compared against the baseline without a relayer as well as a commercial Wi-Fi range extender. The results show that L2Relay outperforms both compared schemes.

Abstract: Certain embodiments herein relate to using tagless access buffers (TABs) to optimize energy efficiency in various computing systems. Candidate memory references in an L1 data cache may be identified and stored in the TAB. Various techniques may be implemented for identifying the candidate references and allocating the references into the TAB. Groups of memory references may also be allocate to a single TAB entry or may be allocated to an extra TAB entry (such that two lines in the TAB may be used to store L1 data cache lines), for example, when a strided access pattern spans two consecutive L1 data cache lines. Certain other embodiments are related to data filter cache and multi-issue tagless hit instruction cache (TH-IC) techniques.

Abstract: Fire retardant materials are provided that contain carbon nanotubes and particles capable of endothermically reacting when exposed to elevated temperatures. The carbon nanotubes may be a buckypaper. Methods also are provided for making a fire retardant material and for improving the fire retardation capabilities of a material.

Abstract: Embodiments of the invention include compositions effective for inhibiting collagen production and related methods. A preferred method comprises contacting at least one cell capable of producing collagen with a composition effective for inhibiting collagen production thereby. The composition comprises one or more of the compounds effective for inhibiting collagen production disclosed herein.

Abstract: A direct double-frequency ripple current control in a two-stage high-frequency-link (HFL) based fuel cell converter that can achieve low-frequency ripple free input current without using large electrolytic capacitors is provided. To eliminate the double-frequency ripple current disturbance introduced by the single-phase inverter load, a proportional-resonant (PR) controller is developed to achieve an extra high control gain at designed resonant frequency. This high gain can be viewed as the virtual high impedance for blocking the double-frequency ripple energy propagation from inverter load to fuel cell stack. More particularly, the proposed control system can realize the utilization of all capacitive ripple energy sources in the system by regulating all the capacitors to have large voltage swing and the voltage swing is synchronized to keep real-time balancing of the transformer primary-side and secondary-side voltages.