Abstract: A device and method is provided for stimulation of neurons. The device includes a stimulation unit that can be implanted into a body of a patient and has stimulation elements that apply a stimulation signal to tissue of the patient to stimulate neurons in the brain and/or the spinal cord of the patient. Moreover, a measuring unit receive a measurement signal that reflects a neuronal activity of the stimulated neurons. Further, a control unit generate a modulation signal from the measurement signal, and modulates an amplitude of a pulse train with the modulation signal. Individual pulses of the pulse train include a first and second pulse portions that introduce and remove charge from the tissue. Moreover, the control unit varies a pause between the pulse portions until the synchronization of the stimulated neurons is minimized or falls below a predetermined threshold.

Abstract: Amyloid beta-binding peptides and the use thereof for the treatment and the diagnosis of Alzheimer's disease.

Abstract: A method for monolithically depositing a monocrystalline IV-IV layer that glows when excited and that is composed of a plurality of elements of the IV main group, in particular a GeSn or Si—GeSn layer, the IV-IV layer having a dislocation density less than 6 cm?2, on an IV substrate, in particular a silicon or germanium substrate, including the following steps: providing a hydride of a first IV element (A), such as Ge2H6 or Si2H6; providing a halide of a second IV element (B), such as SnCl4; heating the substrate to a substrate temperature that is less than the decomposition temperature of the pure hydride or of a radical formed therefrom and is sufficiently high that atoms of the first element (A) and of the second element (B) are integrated into the surface in crystalline order, wherein the substrate temperature lies, in particular, in a range between 300° C. and 475° C.

Abstract: A device and method for desynchronizing a patient's neuronal brain activity in which the neuron population is firing in a pathologically synchronized manner. The device includes a stimulation unit that generates an acoustic stimulation signal that includes both a first tone and a second tone. The first tone is provided to shift the phase of the neuronal brain activity of a first subpopulation of the neuron population relative to the phase of the neuronal brain activity of a second subpopulation of the neuron population when the first tone is acoustically received by the patient. Further, the second tone is provided to shift the phase of the neuronal brain activity of the second subpopulation relative to the phase of the neuronal brain activity of the first subpopulation when the second tone is acoustically received by the patient. As a result, the acoustic stimulation signal desynchronizes the stimulated neuron population.

Abstract: Hydrogenated amorphous silicon-containing colloids or composite colloids have a silicon-containing shell which surrounds the hollow colloids or composite colloids. The colloids have a spherical geometry. The silicon-containing composite colloids have a spherical geometry and a diameter of between 2 nm and 7 nm in scanning electron micrographs, and the silicon-containing colloids have a spherical geometry with a cavity and a diameter of between 50 and 200 nm in scanning transmission electron micrographs. The cavity is surrounded by a shell with a thickness of between 3 and 10 nm.

Abstract: A device for stimulation of a patient with acoustic stimulation signals includes a stimulation unit for generating acoustic stimulation signals and a control unit for controlling the stimulation unit. The control unit is configured so that it determines a bandwidth of an auditory filter with a frequency of a predetermined tone as a center frequency, wherein this bandwidth is a reference bandwidth. The control unit determines a frequency of a first acoustic therapy signal such that a measure of coverage between the reference bandwidth around the frequency of the predetermined tone and a first bandwidth of an auditory filter with the frequency of the first acoustic therapy signal as a center frequency assumes a predetermined first value, and controls the stimulation unit such that the stimulation unit generates the first acoustic therapy signal.

Abstract: A method for calibration of electromagnetic induction measurement systems. The method includes transmitting, by at least one transmitter of an electric induction measurement system, a magnetic field as a primary signal, wherein the transmitting the magnetic field as the primary signal triggers a current in the soil which current generates a secondary signal, and recording, by a receiver of the electric induction measurement system, the secondary signal at each of at least two heights of the receiver relative to a soil to be measured in order to create an input vector that is a combination of soil properties and environmental properties that contain the properties of the electric induction measurement system, that contains a dataset of n conductivity values of n layers, and that creates, as a starting value, an initial value vector. The initial value vector includes assumptions and apparent electrical conductivities for m measurement heights.

Abstract: A method for determining movement of an object to be imaged in a medical imaging method which includes at least one Magnetic Resonance Imaging, wherein the method comprises the following steps determining first coefficients of a mathematical transformation based on first navigator data of the object, wherein the first navigator data are recorded by a magnetic resonance tomograph (100) using a first spherical Lissajous navigator in the k-space with kr<0.2/cm, preferably kr<0.15/cm, and particularly preferably kr<0.1/cm, wherein kr represents the absolute value of the wave vector k.

Abstract: The present invention relates to novel D-enantiomeric A-beta-oligomer-binding peptides, homologs, fragments, parts and polymers thereof and use thereof.

Abstract: A method for generating a structured surface on a substrate includes analyzing a substrate surface of the substrate and selecting, as a function of a condition of the substrate surface, method parameters including focus diameter, pulse peak power, pulse energy, point spacing, pulse length, pulse spacing and/or pulse sequence. The method further includes generating, by partial ablation and partial deposition via treatment with an intensive pulsed laser beam, surface structures having dimensions in the sub-micrometer range such that a multi-scale surface structure in the sub-micrometer and micrometer range adapted to intrinsically inhomogeneous properties of the substrate surface in the sub-micrometer range is generated. The substrate is an inhomogeneous substrate.

Abstract: A device and a method for measuring small voltages and potentials on biological, chemical and other samples. The device comprises at least one field effect transistor including a source, a drain, a gate that is in contact with the sample and insulated by a gate dielectric from the conducting channel of the field effect transistor, means for applying a voltage between the source and the drain, and means for applying a bias voltage to the gate. The gate dielectric includes at least one attachment site in the interior thereof, which is able to trap charge carriers from the channel and, conversely, to release these to the channel.

Abstract: A device is provide for stimulating neurons. The device includes a stimulation unit that is implantable into a patient's body and that includes multiple stimulation elements for stimulating neurons in a target area of the brain and/or spinal cord of the patient with stimuli. Moreover, the device includes a control unit that actuates the stimulation unit such that multiple groups of stimulation elements generate respective stimuli. In this aspect, each group includes multiple stimulation elements of the stimulation unit with two or more of the groups generating sequences of stimuli in a repetitive manner in a respective time pattern which includes successive cycles. Furthermore, the sequences of stimuli generated by the two or more groups differ in terms of the number of cycles in which the sequence in which the stimulation elements generate the stimuli within one sequence is constant and/or in terms of the duration of respective cycles.

Abstract: A method for producing a memory cell includes providing a non-conductive substrate, mounting a first conductor track made of conductive material on the non-conductive substrate, mounting a porous dielectric with or without redox-active molecules in a form of points on the first conductor track, and mounting a second conductor track orthogonally to the first conductor track, wherein the first and second conductor tracks have an electrode function at their intersection point, and wherein the porous dielectric is arranged between the electrodes. The method further includes mounting a passivation layer on the substrate, the first conductor track, the dielectric, and the second conductor track, so that the conductor track remains contactable. The first and the second conductor track form a memory at their intersection point with the dielectric arranged between them, in which the redox reaction of the redox-active molecules is configured to be driven by a voltage.

Abstract: A device for stimulating neurons that includes a stimulation unit implantable in the body of a patient and having stimulation elements that stimulate neurons in the brain and/or spinal cord. A control unit controls the stimulation unit during first and second time intervals in different stimulation modes. The control unit controls the stimulation unit during 75% or more of the first time interval in the first stimulation mode to repeatedly generate sequences of stimuli and the order in which the stimulation elements generate stimuli is constant for not more than 5 successively generated sequences and then varied. The control unit controls the stimulation unit during 75% or more of the second time interval in a second stimulation mode such that the stimulation elements repeatedly generate sequences of stimuli and the order in which the stimulation elements generate stimuli is constant for at least 25 successively generated sequences and then varied.

Abstract: The invention relates to the treatment of blood, blood products and organs for the removal and/or detoxification of amyloid-beta oligomers.

Abstract: The invention relates to a method of producing D-xylonate from D-xylose, which includes converting D-xylose to D-xylonate from a coryneform bacterium in which the activity of the iolR gene is reduced or completely switched off compared with the wild type or a mutation of the wild type, or the iolR gene is completed or partially deleted, as well as to a bacterium for carrying out the method.

Abstract: A method for producing a transparent polycrystalline ceramic includes forming at least one planar transparent region near a surface within the ceramic, wherein the at least one planar transparent region has a lower thermal expansion coefficient than other regions of the ceramic. The method further includes generating compressive stresses in the at least one planar transparent region near the surface after a thermal treatment and cooling.

Abstract: A method for the quantitative characterization of substances with regard to their properties of binding to amyloid-? (A?) conformers, comprising the steps of: —fractionating a sample including various A? conformers; —immobilizing a biotinylated A? conformer of the desired fraction on the surface of a substrate having high affinity for biotin; and —deriving the binding behavior of an aggregate quality control probe to the desired A? conformer from the measurement signal by determining the kinetic and/or thermodynamic parameters. A device for carrying out the method.

Abstract: The invention relates to a method for producing a device for the electrochemical detection of molecules by way of redox cycling, to a device therefor, and to the use thereof. A porous dielectric layer is present between two electrode layers, which is able to receive redox-active molecules and may be biofunctionalized. The individual layers are preferably applied by way of an ink jet printing method.

Abstract: A device for stimulating neurons that includes a non-invasive stimulation unit for generating stimuli in stimulation channels. A control unit controls the stimulation unit during first and second time intervals in different stimulation modes. The control unit controls the stimulation unit during 75% or more of the first time interval in the first stimulation mode to repeatedly generate sequences of stimuli and the order in which the stimulation channels generate stimuli is constant for not more than 5 successively generated sequences and then varied. The control unit controls the stimulation unit during 75% or more of the second time interval in a second stimulation mode such that the stimulation channels repeatedly generate sequences of stimuli and the order in which the stimulation channels generate stimuli is constant for at least 25 successively generated sequences and then varied.