Abstract: The present invention provides a method of inhibiting the growth of or promoting differentiation and destruction of cancer stem cells (CSCs) comprising contacting the cancer stem cells with a compound having the structure: or a pharmaceutically acceptable salt thereof.

Abstract: Systems, methods and devices are provided for fitting kinetic models to measurements of dynamic curves where the kinetic models give rise to nonlinear fitting equations in two or more unknowns that can be formulated so that they are linear in one or more of the unknown parameters and nonlinear in one or more of the unknown parameters. Such systems, methods and devices may be utilized to monitor and characterize the attributes of a given tracer such as a radioactive substance within a body, a drug within the body, a concentration of a substance within a particular medium, and the like.

Abstract: The present disclosure relates to salts of the compound (I), polymorphic forms thereof, methods for preparation and use thereof, and pharmaceutical compositions thereof.

Abstract: Systems and methods for detecting protein-protein interactions and/or detecting a targeted cell using a split supercharged protein reporter system are described.

Abstract: Provided herein is a robot for inspecting pipelines as it moves along an outer surface of a pipeline, the robot comprising: a plurality of body parts detachably provided along a longitudinal direction of the pipeline; a connector configured to connect adjacent body parts, and to distance one of the connected body parts away from the pipeline so that the plurality of body parts may cross an obstacle; and a controller configured to control the connector to lift one of the body parts to cross an obstacle, with another body part secured to the pipeline.

Abstract: Provided are a material for forming a channel layer for a stretchable TFT, a method of preparing a channel layer for a stretchable TFT, a channel layer for a stretchable TFT, and a stretchable TFT. The material for forming the channel layer for the stretchable TFT includes an elastomer, an organic semiconductor material and a solvent. By mixing an elastomer and an organic semiconductor material and forming a thin film, a channel layer having an excellent conductivity and stretchability may be obtained.

Abstract: The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.

Abstract: Systems and methods for segmenting a medical image are provided. In some embodiments, the method includes receiving an image acquired from at least a portion of a subject's anatomy, selecting a first point within a target structure identified on the image, and determining a second and a third point associated with extents of a target biological tissue, the first, second and third points defining a sector described by the first point, a central angle and a subtended arc. The method also includes determining a plurality of arc points along the subtended arc, and extending a plurality of linear segments along directions determined by the first point and the plurality of arc points. The method further includes determining an intensity profile along each linear segment to identify boundaries of the target biological tissue, and generating a contour of the target biological tissue using the identified boundaries.

Abstract: Provided is a method for obtaining a conformal mapping of first image data corresponding to a source mesh to a target mesh, by generating a template of the source mesh and a template of the target mesh, processing the generated source mesh template and the generated target mesh template to obtain a conformal mapping from the source mesh to the target mesh, mapping the first image data corresponding to the source mesh to second image data corresponding to the target mesh according to the obtained conformal mapping, and outputting a mapped texture corresponding to the mapped second image data to the display corresponding to the target mesh.

Abstract: A battery charging apparatus for an electric vehicle includes a first converter part configured to convert a first voltage, which is inputted with rectification, into a second voltage; and a second converter part configured to output a third voltage for charging a battery for the electric vehicle by converting the second voltage into a direct current. The output end of the first converter part comprises a first and a second output terminal. The second converter part comprises a first switching element connected with the first output terminal; a second switching element connected with the second output terminal; a first output capacitor serially connected with the first switching element; and a second output capacitor serially connected with the second switching element. The time during which the first switching element is turned on does not overlap the time during which the second switching element is turned on.

Abstract: Metallic thermal emitters consisting of two layers of differently structured nickel gratings on a homogeneous nickel layer are fabricated by soft lithography and studied for polarized thermal radiation. A thermal emitter in combination with a sub-wavelength grating shows a high extinction ratio, with a maximum value close to 5, in a wide mid-infrared range from 3.2 to 7.8 ?m, as well as high emissivity up to 0.65 at a wavelength of 3.7 ?m. All measurements show good agreement with theoretical predictions. Numerical simulations reveal that a high electric field exists within the localized air space surrounded by the gratings and the intensified electric-field is only observed for the polarizations perpendicular to the top sub-wavelength grating. This result suggests how the emissivity of a metal can be selectively enhanced at a certain range of wavelengths for a given polarization.

Abstract: This document relates to methods and materials for detecting premalignant and malignant neoplasms. For example, methods and materials for determining whether or not a stool sample from a mammal contains nucleic acid markers or polypeptide markers of a neoplasm are provided.

Abstract: This disclosure relates to a skating rink that includes a skating area, a wall at least partially surrounding the skating area, and a visible mark extending along a perimeter region of the skating area to indicate to a skater traveling head first toward the wall that the skater should look up and to related methods.

Abstract: Devices and methods for immobilizing micrometer sized liquid domains onto a chemically functionalized substrate surface are disclosed. A multifunctional polymer is adsorbed at the surface interface of the liquid microdomains, and the liquid microdomains are immobilized by covalent bonding or non-covalent forces such as electrostatic attraction between the adsorbed multifunctional polymer and the functionalized substrate surface.

Abstract: Method and System for providing a signal from an insulin pump, artificial pancreas, or another insulin delivery device as a source of information for improving the accuracy of a continuous glucose sensor (CGS). The effect of using insulin information to enhance sensor accuracy is most prominent at low blood glucose levels, i.e. in the hypoglycemic range, which is critical for any treatment. A system for providing a filtering/state estimation methodology that may be used to determine a glucose state estimate at time t-?. The estimation may be extrapolated to some future time t and then the extrapolated value is used to extract the blood glucose component. The blood glucose component of the extrapolation and the output of the CGS are weighted and used to estimate the blood glucose level of a subject.

Abstract: A three-dimensional, microscale-textured, grating-shaped organic solar cell geometry. The solar cells are fabricated on gratings to give them a three-dimensional texture that provides enhanced light absorption. Introduction of microscale texturing has a positive effect on the overall power conversion efficiency of the devices. This grating-based solar cell having a grating of pre-determined pitch and height has shown improved power-conversion efficiency over a conventional flat solar cell. The improvement in efficiency is accomplished by homogeneous coverage of the grating with uniform thickness of the active layer, which is attributed to a sufficiently high pitch and low height of the underlying gratings. Also the microscale texturing leads to suppressed reflection of incident light due to the efficient coupling of the incident light into modes that are guided in the active layer.

Abstract: A method of attaching reduced graphene oxide and/or graphene oxide to a polymer layer that includes: forming a polymer layer having a hydrophobic, exterior surface; subjecting the hydrophobic, exterior surface of the polymer layer to ultraviolet/ozone (UV/O3) exposure to change the hydrophobic, exterior surface to a hydrophilic, exterior surface; and applying reduced graphene oxide and/or graphene oxide to the hydrophilic surface of the polymer layer. The UV/O3 exposure reduces the contact angle of droplets on the exterior surface of the polymer layer so that greater amounts of reduced graphene oxide and/or graphene oxide can be applied to the surface.

Abstract: N-Substituted indenoisoquinoline compounds, and pharmaceutical formulations of N-substituted indenoisoquinoline compounds are described. Also described are processes for preparing N-substituted indenoisoquinoline compounds. Also described are methods for treating cancer in mammals using the described N-substituted indenoisoquinoline compounds or pharmaceutical formulations thereof.

Abstract: A compound represented by the following Structural Formula (A) or a salt thereof. The compound or the salt thereof is suitably produced from a microorganism belonging to the genus Saccharothrix and can be suitably used as a prostaglandin production inhibitor.

Abstract: A photodetector has a photoactive layer of semiconducting inorganic nanoparticles positioned between a hole transport electron blocking layer of a first metal oxide and an electron transport hole blocking layer of a second metal oxide. The nanoparticles are responsive to electromagnetic radiation in at least the infrared region of the spectrum. The first metal oxide can be NiO, and the second metal oxide can be ZnO or TiO2. The metal oxide layers render the photodetector stable in air, even in the absence of an encapsulating coating around the photodetector. The photodetector has a P-I-N structure.