Patents Assigned to Foundation
  • Method for detecting fire-flame using fuzzy finite automata
    Patent number: 8611664
    Abstract: A method for detecting a fire flame using fuzzy finite automata is provided. The fire-flame detection method comprises (1) acquiring an image required for the detection of fire-flame, (2) dividing the image into a number of blocks, (3) extracting a fire-flame candidate block using a brightness distortion of a pixel in the block, (4) detecting a fire-flame candidate region from the fire-flame block using a color probability model, and (5) determining whether the fire-flame candidate region corresponds to a fire-flame via fuzzy finite automata. The fire-flame detection method can detect fire-flames in a variety of fire images with relatively high precision, by establishing a probability model using the brightness distortion and wavelet energy in fire-flame regions with continuous and irregular fluctuation patterns and using the upward motion, and applying the model to fuzzy finite automata.
    Type: Grant
    Filed: November 15, 2011
    Date of Patent: December 17, 2013
    Assignee: Industry Academic Cooperation Foundation Keimyung University
    Inventors: ByoungChul Ko, JaeYeal Nam, SunJae Ham
  • Stat3 inhibitor having anti-cancer activity and methods
    Patent number: 8609639
    Abstract: A small-molecule Stat3 dimerization inhibitor, S3I-M2001, is described and the dynamics of intracellular processing of activated Stat3 within the context of the biochemical and biological effects of the Stat3 chemical probe inhibitor are elucidated. S3I-M2001 is a newly-identified oxazole-based peptidomimetic of the Stat3 Src Homology (SH) 2 domain-binding phosphotyrosine peptide that selectively disrupts active Stat3:Stat3 dimers. Stat3-dependent malignant transformation, survival, and migration and invasion of mouse and human cancer cells harboring persistently-activated Stat3 were inhibited by S3I-M2001. S3I-M2001 inhibited Stat3-dependent transcriptional regulation of tumor survival genes, such as Bcl-xL. The disclosed compound is useful as a new potential treatment for certain cancers.
    Type: Grant
    Filed: December 5, 2007
    Date of Patent: December 17, 2013
    Assignees: University of South Florida, Yale University, University of Central Florida Research Foundation, Inc.
    Inventors: James Turkson, Said Sebti, Richard Jove, Andrew D. Hamilton
  • Flexible microcavities through spin coating
    Patent number: 8610103
    Abstract: A mechanically flexible array of optically pumped vertical cavity surface emitting lasers, fabricated using spin coating. The array uses InGaP colloidal quantum dots as an active medium and alternating polymer layers of different refractive indices as Bragg mirrors. Enhanced spontaneous emission is produced. The flexible array can be peeled off a substrate, producing a flexible structure that can conform to a wide variety of shapes, and having an emission spectrum that can be mechanically tuned. The flexible array can be used to create a flexible infrared light bandage.
    Type: Grant
    Filed: January 13, 2010
    Date of Patent: December 17, 2013
    Assignee: Research Foundation of the City University of New York
    Inventors: Vinod M. Menon, Nikesh V. Valappil
  • Fire retardant materials and methods
    Patent number: 8608989
    Abstract: Fire retardant materials arc provided that contain carbon nanotubes and particles capable of endothermically reacting when exposed to elevated temperatures. The carbon nanotubes may be a buckypaper. Methods also are provided for making a fire retardant material and for improving the fire retardation capabilities of a material.
    Type: Grant
    Filed: March 2, 2012
    Date of Patent: December 17, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Changchun Zeng, Chuck Zhang, Ben Wang, Richard Liang, Chase Knight
  • 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs
    Patent number: 8609643
    Abstract: This invention discloses 2-methylene-(20S,25R)-19,26-dinor-vitamin D analogs, and specifically 2-methylene-(20S,25R)-19,26-dinor-1?,25-dihydroxyvitamin D3, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: December 17, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Margaret Clagett-Dame, Lori A. Plum, Grazia Chiellini, Pawel Grzywacz
  • Systems and methods for improving motor function with assisted exercise
    Patent number: 8608622
    Abstract: One embodiment of the present invention includes a system and method for alleviating symptoms of a medical disorder of a patient by forced exercise. The system includes an exercise machine having movable portions that move in response to a first contribution by a patient and in response a second contribution by a motor. The system further includes at least one mechanical sensor and a control system programmed to alter the second contribution by the motor in response to the sensed data.
    Type: Grant
    Filed: July 23, 2013
    Date of Patent: December 17, 2013
    Assignee: The Cleveland Clinic Foundation
    Inventor: Jay L. Alberts
  • Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
    Patent number: 8609338
    Abstract: The invention provides tandem single nucleotide polymorphisms and methods for their use, for example, in diagnosing Down Syndrome.
    Type: Grant
    Filed: January 19, 2010
    Date of Patent: December 17, 2013
    Assignee: University of Louisville Research Foundation, Inc.
    Inventors: Aoy Tomita Mitchell, Michael Mitchell
  • Leg rehabilitation system having game function
    Patent number: 8608623
    Abstract: The present invention relates to a leg rehabilitation system having a game function. The rehabilitation system comprises: a back plate for supporting a back of a patient; a stepper part having two foothold parts, the back plate being extended from a bottom portion of the back plate in such a manner that a patient can move the two foothold parts downwardly in turn with legs of the patient, a load sensor positioned on the stepper part for sensing a load transferred to each foothold part and the movement speed of the foothold part when the patient moves the legs; a controller configured for generating game data based on load data according to the load sensed by the load sensor and speed data according to the movement speed; and a display unit for displaying graphical game elements corresponding to the game data generated by the controller.
    Type: Grant
    Filed: April 6, 2011
    Date of Patent: December 17, 2013
    Assignee: Industry-Academic Corporation Foundation, Kyungpook National University
    Inventor: Yang-Soo Lee
  • Pharmaceutical composition used in treatment of hyperproliferative skin conditions and malignant melanomas comprising pachastrissamine as active ingredient
    Patent number: 8609718
    Abstract: Disclosed is a novel use of phytosphingosine. More particularly, disclosed are a composition for preventing or treating hyper-proliferative skin diseases comprising pachastrissamine as an active ingredient, a use of pachastrissamine or a pharmaceutically acceptable salt thereof for preparing a preventing/therapeutic agent of hyper-proliferative skin diseases, and a method for treating hyper-proliferative skin diseases administering an effective amount of pachastrissamine or a pharmaceutically acceptable salt thereof to a subject in need thereof. The pachastrissamine inhibits the degradation of FoxO3a protein and increases the expression of FoxO3a protein. Thus, the inventive pharmaceutical composition has a preventing of treating effect on hyper-proliferative diseases by inducing apoptosis of hyper-proliferative cells and inhibiting the cell cycle.
    Type: Grant
    Filed: September 19, 2011
    Date of Patent: December 17, 2013
    Assignee: Catholic University Industry Academy Cooperation Foundation
    Inventors: Dong Heon Shin, Tae Yoon Kim
  • Neurons, astrocytes and oligodendrocytes differentiated from a mammalian pluripotent or neural stem cells exposed to a pyridine deriviative
    Patent number: 8609413
    Abstract: A method of preparing neural precursor cells by exposing pluripotent stem cells or neural stem cells to a differentiation agent. The agent is a pyridine analog, which in preferred embodiments is a phenylethynyl-substituted or phenylazo-substituted pyridine. In other embodiments, a method of enhancing neural precursor cell survival is provided in which the survival is enhanced by exposure to the pyridine analog. In further embodiments, a method of preparing neuronal cells is provided in which pluripotent or neural stem cells exposed to the pyridine analog are then incubated without the pyridine analog, resulting in differentiation into neurons, astrocytes and oligodendrocytes. These methods may be used in toxicological screens, e.g., to evaluate the neurotoxicity of a test compound.
    Type: Grant
    Filed: December 11, 2008
    Date of Patent: December 17, 2013
    Assignee: Research Development Foundation
    Inventors: David M. Suter, Olivier Preynat-Seauve, Karl-Heinz Krause
  • Method for adipose tissue quantification with magnetic resonance imaging
    Patent number: 8611624
    Abstract: A system and method for calculating a quantitative metric of adipose tissue using a magnetic resonance imaging (MRI) system are provided. The MRI system is used to acquire k-space data by sampling echo signals that are formed at a plurality of different echo times. From the acquired k-space data, a fat-concentration map, such as a fat-fraction map is produced. A maximum fat-concentration value is estimated from the fat-concentration map, and is used to threshold the fat-concentration map to produce an adipose mask. From the adipose mask, a quantitative metric of adipose tissue can be calculated.
    Type: Grant
    Filed: March 19, 2012
    Date of Patent: December 17, 2013
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Aziz Hatim Poonawalla, Scott Reeder
  • Robust signal detection using correntropy
    Patent number: 8611839
    Abstract: A method (200) for detecting a periodic signal (141) in a noisy signal (101) is provided. The method can include applying (210) correntropy to the noisy signal to generate a non-linear mapping, and applying (220) a sub-space projection to the non-linear mapping to produce principal components. A correntropy kernel can be applied to the noisy signal to generate a Gram matrix that is used in a Temporal Principal Component Analysis (TPCA). The correntropy kernel projects nonlinearly the input data to a reproducing kernel Hilbert Space (RKHS) preserving the input time structure and attenuating impulsive noise. The correntropy kernel is data dependent, and the RKHS correlation matrix has the same dimension as the input data correlation matrix. A principal component having a majority of signal energy can be chosen (230) to detect the periodic signal.
    Type: Grant
    Filed: April 26, 2007
    Date of Patent: December 17, 2013
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Jose C. Principe, Weifeng Liu
  • Apparatus and method for diagnosing permanent magnet demagnetization of permanent magnet synchronous motor, and apparatus for driving permanent magnet synchronous motor
    Patent number: 8610452
    Abstract: Provided are an apparatus and a method for diagnosing permanent magnet demagnetization of a permanent magnet synchronous motor. The apparatus includes a magnetic field generating unit, a stator current measuring unit, and a demagnetization diagnosing unit. The magnetic field generating unit generates magnetic fields of which directions are respectively parallel to a predetermined direction among a plurality of directions passing through a rotation axis of a rotor, on a plane vertical to the rotation axis of the rotor which is in a standstill. The stator current measuring unit measures currents which flow in a stator winding in correspondence with the respective generated magnetic fields.
    Type: Grant
    Filed: April 23, 2010
    Date of Patent: December 17, 2013
    Assignee: Korea University Research and Business Foundation
    Inventors: Sang-Bin Lee, Jong-Man Hong
  • Self-body biasing sensing circuit for resistance-based memories
    Patent number: 8611132
    Abstract: A resistance based memory sensing circuit has reference current transistors feeding a reference node and a read current transistor feeding a sense node, each transistor has a substrate body at a regular substrate voltage during a stand-by mode and biased during a sensing mode at a body bias voltage lower than the regular substrate voltage. In one option the body bias voltage is determined by a reference voltage on the reference node. The substrate body at the regular substrate voltage causes the transistors to have a regular threshold voltage, and the substrate body at the body bias voltage causes the transistors to have a sense mode threshold voltage, lower than the regular threshold voltage.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: December 17, 2013
    Assignees: QUALCOMM Incorporated, Industry-Academic Cooperation Foundation, Yonsei University
    Inventors: Seong-Ook Jung, Jisu Kim, Youngdon Jung, Jung Pill Kim, Seung H. Kang
  • Algorithm for motion estimation from the tomographic data
    Patent number: 8611630
    Abstract: The methods and systems of the present invention is an algorithm which estimates motion inside objects that change during the scan. The algorithm is flexible and can be used for solving the misalignment correction problem and, more generally, for finding scan parameters that are not accurately known. The algorithm is based on Local Tomography so it is faster and is not limited to a source trajectory for which accurate and efficient inversion formulas exist.
    Type: Grant
    Filed: June 3, 2011
    Date of Patent: December 17, 2013
    Assignees: University of Central Florida Research Foundation, Inc., Toshiba Medical Research Institute USA
    Inventors: Alexander Katsevich, Michael D. Silver, Alexander Zamyatin
  • Variable filter length local tomography
    Patent number: 8611631
    Abstract: Methods, processes and systems of image reconstruction using variable filter length local tomography, for reconstructing internal body images in medical applications, and the like. Algorithm uses less radiation, less computer power than prior art, and without using iteration algorithms so that all target sizes from large to small can be reconstructed.
    Type: Grant
    Filed: December 20, 2012
    Date of Patent: December 17, 2013
    Assignees: University of Central Florida Research Foundation, Inc., iTomography Corporation
    Inventors: Alexander Katsevich, Michael Frenkel
  • High efficiency photovoltaic cell for solar energy harvesting
    Patent number: 8609984
    Abstract: A photovoltaic cell comprising having improved absorption of electromagnetic radiation is disclosed. The photovoltaic cell can include a rear contact, a first cell having a first band-gap energy, and a rear contact in electrical communication with an electromechanical device. The first cell can include InxGaySbz, where x+y+z=1 and z ranges from 0.00001 to 0.025. the photovoltaic cell can also include a second cell having a second band-gap energy, and a first tunnel disposed between the first and second cells. The photovoltaic cell can include at least a third cell and a second tunnel disposed between the second and third cells. The uppermost cell can include GaP or InP.
    Type: Grant
    Filed: June 24, 2010
    Date of Patent: December 17, 2013
    Assignee: Florida State University Research Foundation, Inc.
    Inventors: Indranil Bhattacharya, Simon Y. Foo
  • Multivalent vaccines comprising recombinant viral vectors
    Patent number: 8609402
    Abstract: The invention relates to vaccines comprising recombinant vectors, such as recombinant adenoviruses. The vectors comprise heterologous nucleic acids encoding for at least two antigens from one or more tuberculosis-causing bacilli. Also described is the use of specific protease recognition sites linking antigens through which the encoded antigens are separated upon cleavage. After cleavage, the antigens contribute to the immune response in a separate manner. The recombinant vectors may comprise a nucleic acid encoding the protease cleaving the linkers and separating the antigens. Further described is the use of genetic adjuvants encoded by the recombinant vectors, wherein such genetic adjuvants may also be cleaved through the presence of the cleavable linkers and the specific protease.
    Type: Grant
    Filed: May 31, 2011
    Date of Patent: December 17, 2013
    Assignees: Aeras Global TB Vaccine Foundation, Crucell Holland B.V
    Inventors: Menzo Jans Emco Havenga, Ronald Vogels, Jerald C. Sadoff, David Hone, Yasir Abdul Wahid Skeiky, Katarina Rado{hacek over (s)}evic
  • Neurostimulation for affecting sleep disorders
    Patent number: 8612005
    Abstract: A method of affecting a sleep disorder in a subject having the sleep disorder and a method of affecting a normal awakeness-sleep cycle in a subject having an abnormal awakeness-sleep cycle, said methods comprising: a) identifying at least one nucleus in a brain of the subject, said nucleus being a nucleus of the sleep circuitry of the brain; and b) stimulating the at least one identified nucleus so as to modulate the nucleus, thereby affecting the sleep disorder.
    Type: Grant
    Filed: January 31, 2003
    Date of Patent: December 17, 2013
    Assignee: The Cleveland Clinic Foundation
    Inventors: Ali Rezai, Jorge Alvaro Gonzalez-Martinez, Ashwini Sharan
  • Wide area stamp for antireflective surface
    Patent number: 8608468
    Abstract: Nanoimprint molds for molding a surface of a material are provided. A nanoimprint mold includes a body with a molding surface that is formed by shaped nanopillars. The nanopillars may be formed on a substrate and shaped by performing at least a first partial oxidation of the nanopillars and then removing at least a portion of the oxidized material. Once shaped, a hard substance is deposited on the nanopillars to begin forming the molding surface of the nanoimprint mold. The deposition of a hard substance is followed by the deposition of carbon nanotube on the hard substance and then the removal of the substrate and nanopillars from the molding surface.
    Type: Grant
    Filed: February 28, 2012
    Date of Patent: December 17, 2013
    Assignee: Korea University Research and Business Foundation
    Inventor: Kwangyeol Lee