Abstract: The invention relates to protein binding inhibitor compounds and methods of identifying and using them. The invention further relates to pharmaceutical compositions and methods for treating a variety of diseases and disorders, including cell proliferative disorders, especially cancer.

Abstract: The present invention relates to proteins and polypeptides as well as methods of using these proteins and polypeptides to: identify the location of an RXP-binding domain of Cx43CT, modulate a Cx43 gap junction channel, screen for compounds that modulate Cx43CT, and measure Cx43CT-binding affinity of a compound that binds to Cx43CT.

Abstract: A compression splint is provided for reduction, compression and stabilization of spinal, pelvic, and long bone fractures. The compression splint includes a plurality of plates selectively disposed at a plurality of positions of a fracture site; a plurality of inflatable cushions, each cushion positioned between respective plates of the plurality of plates and the fracture site; and a support means for supporting the plurality of plates and plurality of cushions compressively against the fracture site in three dimensions, Additionally, the plates of the compression splint can be adjusted, removed or additional plates added to further customize the compressive force applied to the fracture site.

Abstract: Provided are an LMA, a proxy router, and a management method for supporting NEMO in a PMIPv6 network. To support mobility in the PMIPv6 network for mobile nodes forming one node group within a mobile network, the proxy router for delivering signal and data between the mobile nodes and the PMIPv6 network delivers mobile home network prefixes allocated by the LMA of the PMIPv6 network to the mobile nodes. The LMA generates a group ID corresponding to the node group. Packet delivery costs due to an unnecessary tunnel may be reduced by grouping a plurality of mobile nodes constituting a mobile network, and using and managing flags and the same group ID.

Abstract: The present invention relates to a pharmaceutical composition comprising compound for induction of apoptosis, a method for inducing cancer cell apoptosis, a method to suppress lymphocyte activation, a method to improve intracellular trafficking of misfolded mutants and a screening method to identify additional compounds useful for inducing apoptosis, and more specifically, it relates to pharmaceutical compositions comprising imidazole derivatives as active gradients for induction of apoptosis to treat various diseases including cancers and immune-related diseases, the method of inducing apoptosis by treating cancer cells with the pharmaceutical composition, the method of inactivating human lymphocytes by treating lymphocytes with the pharmaceutical composition, the method of improving intracellular trafficking of misfolded mutants by treating cells containing the mutants with the pharmaceutical composition, and the screening method for identifying additional compound useful for inducing apoptosis, wherein cel

Abstract: A method for encoding a channel in a communication system using a Low-Density Parity-Check (LDPC) code. The method includes generating a plurality of column groups by grouping (categorizing) columns corresponding to an information word in a parity-check matrix of the LDPC code, and ordering the column groups; determining a range of an information word desired to be obtained by performing shortening; based on the determined range of the information word, performing column group-by-column group shortening on the column groups in order according to a predetermined shortening pattern; and LDPC encoding the shortened information word.

Abstract: The present invention provides a family of peptides based upon the M2GlyR sequence. These peptides are derivatives of the M2GlyR sequence and can be modified at their ends to include a plurality of polar amino acid residues to enhance their solubility. Particularly preferred derivatives include portions of the M2GlyR sequence which are palindromic to another portion of the peptide or to the M2GlyR sequence itself. Preferably these portions are at least 7 amino acid residues in length. Peptides embraced by the present invention are characterized by having greater effects on the transepithelial electrical resistance of cells at lower concentrations. Peptides of the present invention have been shown to increase Isc in MDCK epithelial cell monolayers with half maximal effects observed at or below 30 ?M, a nearly 10-fold improvement over any peptide previously characterized in the M2GlyR family.

Abstract: The invention provides various photoacid generator compounds and ionic components thereof. Photoresist compositions that include the ions and non-ionic photoacid generator compounds are also provided. The invention further provides methods of making and using the photoacid generator compounds and photoresist compositions disclosed herein. The compounds and compositions are useful as photoactive components in chemically amplified resist compositions for use in, for example, various microfabrication applications.

Abstract: A reversible vasectomy device includes a first and a second connector piece for attachment to the severed ends of the vas deferens. Each connector piece has an outer vas deferens attaching end, an opposite inner end, and a passage from the outer to the inner end. A midpiece has end portions that are connectable to the inner ends of the connector pieces, a passage in one end portion and a vent from the passage to an exterior surface. When the connector pieces are connected to the end portions, the passage in one of the connector pieces is in fluid communication with the vent, but is not in fluid communication with the passage in the other connector piece.

Abstract: The present invention features a qualitative method to detect independent motion revealed in successive frames of a compressed surveillance MPEG video stream using linear system consistency analysis without decompression of the stream, identifying the segments containing independent motion in a real-time or faster manner, for the retrieval of these segments. The linear system is constructed using the macroblocks of MPEG compressed video frames. The normal flow value of the macroblock is obtained by taking the dot product between the macroblock gradient vector, computed by averaging the four block gradient vectors, and the motion vector of this macroblock. The normal flow value is filtered for inclusion in the linear system, and the statistic of the matrices of the resulting linear system is determined, filtered to screen out false negatives and outliers, and used to determine the presence or absence of independent motion.

Abstract: A signal processing system adapted for sparse representation of signals is provided, comprising: (i) one or more training signals; (ii) a dictionary containing signal-atoms; (iii) a representation of each training signal using a linear combination of said dictionary's signal-atoms; (iv) means for updating the representation of the training signal; (v) means for updating the dictionary one group of atoms at a time, wherein each atom update may include all representations referring to said updated atom; and (vi) means for iterating (iv) and (v) until a stopping rule is fulfilled. The system uses the K-SVD algorithm for designing dictionaries for sparse representation of signals.

Abstract: Decubitus ulcer prevention garments for a dog are provided that include a fluid-filled bladder. The garments can include an inner layer that contacts and interacts with the body of the dog; an intermediate layer that interfaces with the inner layer and includes the fluid-filled bladder; and an outer layer joined to the inner layer and interfacing with the intermediate layer. The garments have a shape that is adapted to fit over and envelop the pelvic region of the dog such that the garments alleviate or reduce pressure on the soft tissues overlying the bony prominences of the pelvic region of a dog when the dog is lying in a recumbent position on a surface.

Abstract: A spin bus quantum computing architecture includes a spin bus formed of multiple strongly coupled and always on qubits that define a string of spin qubits. A plurality of information bearing qubits are disposed adjacent a qubit of the spin bus. Electrodes are formed to the information bearing qubits and the spin bus qubits to allow control of the establishment and breaking of coupling between qubits to allow control of the establishment and breaking of coupling between each information bearing qubit and the spin bus qubit adjacent to it. The spin bus architecture allows rapid and reliable long-range coupling of qubits.

Abstract: Described herein are methods for separating one or more analytes present in a fluid sample. The methods involve passing the fluid through or into a microporous material, wherein the analytes are localized near the surface of the microporous material. Additional processing steps such as hybridization and amplification can be performed once the analyte is localized. In one method, once the analyte is localized, the analyte can be detected, counted, and correlated in order to determine the concentration of the analyte in the sample. In another method, the localized analyte is destabilized to make the localized analyte more accessible for chemical manipulation. Modified microporous materials and composite materials are also disclosed that can be used in any of the methods and articles described herein. The composite is composed of a microporous material and a pigment, wherein the pigment is incorporated in the microporous material.

Abstract: The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.

Abstract: The present invention relates generally to products, compositions and methods useful for promoting neural repair and regeneration. The products and compositions of this invention include myelin-associated glycoprotein (MAG) derivatives that are inhibitors of endogenous MAG (e.g., mutant MAG proteins) and Nogo Receptor (NgR) binding inhibitors that are peptides derived from MAG, Nogo and OMgp that can bind to NgR and block NgR signaling. Peptides that can bind and activate NgR signaling are also provided. Inhibitory MAG derivatives and NgR binding inhibitors are useful for blocking the inhibition of neural regeneration mediated by proteins such as MAG, Nogo and/or OMgp in the nervous system. These inhibitors are also useful for treating neural degeneration associated with injuries, disorders or diseases.

Abstract: Embodiments of the present invention provide a Gaussian adaptive filter for ground clutter filtering and signal parameter estimation for weather radars in the time domain. In some embodiments, the filtering can be applied to dual polarization radar systems. In some embodiments, the clutter component of the signal can be transformed to noise. An interpolation procedure can then be used to recover the transformed part of the weather. A unique filter can be designed to use for both H and V channels for dual-polarization parameter estimation. In addition, the filter can be directly extended for staggered PRT 2/3 sampling scheme.

Abstract: Disclosed is a domain DRM system, a license sharing method for the domain DRM system, and a license server. The domain DRM system includes at least one domain including at least one user module adapted for encryption or decryption using a provided encryption key and a domain manager adapted for decryption using a provided encryption key, and a license server for creating encryption keys corresponding to the domain manager and the one user module, respectively, and providing them with the created contents, respectively, so that, when at least one user module requests contents, a contents encryption key used to encrypt the contents is encrypted by using an encryption key of the user module and an encryption key of the domain manager according to a commutative encryption scheme, and one of the domain manager and the user module is provided with a shared license obtained as a result of encryption.

Abstract: A cast iron brake caliper with improved fatigue life, and a process and process equipment for pre-stressing a cast iron brake caliper to provide improved fatigue life, is provided. In the process, a load is applied to a cast iron caliper, where the load is high enough to locally yield and plastically deform the cast iron material, but not high enough to cause material failure, such as cracking. Upon load removal, residual compressive stresses in the cast iron caliper lower the mid-point of the stress range the plastically-deformed region of the caliper sees during in-service use, and thereby lowers the peak stress seen in this region, increasing fatigue life. The process permits a cast iron brake caliper to be designed to use less material and thus fit within constrained wheel rim envelopes, without the need to resort to high cost materials or other alternative design strategies.

Abstract: A method for manufacturing functionally graded cemented tungsten carbide with hard and wear-resistant surface and tough core is described. The said functionally graded cemented tungsten carbide (WC—Co) has a surface layer having a reduced amount of cobalt. Such a hard surface and tough core structure is an example of functionally graded materials in which mechanical properties are optimized by the unique combination of wear-resistance and toughness. WC—Co with reduced-cobalt surface layer may be fabricated through a carburization heat treatment process following conventional liquid phase sintering. The graded WC—Co thus obtained contains no brittle ? phase.