Abstract: Methods of fabricating complex three-dimensional structures on patterned substrates and related compositions are provided. The methods involve depositing on the substrate a block copolymer material that is “mismatched” to the substrate pattern, and then ordering the material to form a complex three-dimensional structure. According to various embodiments, the copolymer material mismatches the substrate pattern in that the symmetry and/or length scale of its bulk morphology differs from that of the pattern. When ordered, a balance between the physics that determines the bulk block copolymer morphology and the physics that determines the substrate surface interfacial interactions results in a thermodynamically stable complex three-dimensional film that varies in a direction perpendicular to the substrate and has a morphology that differs from its bulk morphology.
Type:
Grant
Filed:
October 5, 2006
Date of Patent:
May 1, 2012
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Paul Franklin Nealey, Mark Petar Stoykovich, Konstantinos C. Daoulas, Marcus Muller, Juan J. de Pablo, SangMin Park
Abstract: A method of stimulating neurite outgrowth in a subject may include administering to the subject a formulation that includes a tctex-1-related polypeptide that stimulates neurite outgrowth in vitro.
Abstract: Visual inspection of an interior surface of a borehole. A housing adapted to be lowered in the borehole supports a portable camera for generating images of a portion of the interior surface of the borehole and a light source for illuminating an area adjacent the camera. A monitor receives signals from the camera and, in response thereto, displays the images generated by the camera. A viewing envelope positioned adjacent the camera defines a viewing area adjacent the camera, particularly for use in visually inspecting slurry-filled boreholes.
Type:
Grant
Filed:
February 7, 2007
Date of Patent:
May 1, 2012
Assignee:
Florida State University Research Foundation, Inc.
Inventors:
Kamal Tawfiq, Edward J. Mallory, Sastry Putcha, Dan Turner
Abstract: The invention relates to a method for enhancing an endogenous immune response-mediated elimination of a population of cancer cells in a host. The method comprises the steps of administering to the host a composition comprising an immunogen conjugated to a vitamin receptor-binding ligand selected from the group consisting of a vitamin, or an analog or a derivative thereof, and administering to the host a therapeutically effective amount of radiation wherein the amount of radiation can range from about 0.5 to about 10 Gy per dose.
Type:
Grant
Filed:
February 2, 2007
Date of Patent:
May 1, 2012
Assignee:
Purdue Research Foundation
Inventors:
Philip Stewart Low, Emanuela Ionela Sega
Abstract: A core-shell catalyst material can include a core and a shell material. Each of the core material and the shell material can have crystal structures and lattice parameters which allow for a substantially coherent core-shell interface. The shell material can include a catalytically active metal. The circumferential stress of the shell material, ???, at the core-shell interface and at the shell surface, is greater than 0 (tensile) or can be compressive of a lower magnitude than a catalyst made of the shell material alone. The crystal structures of the core material can often be the same as the shell material, although this is not always required.
Abstract: Infusion devices with blockage detection capability and methods of monitoring infusion devices. High resolution pressure sensing and/or the sensing of a reflected pressure event may be used to detect a blockage.
Type:
Grant
Filed:
December 9, 2006
Date of Patent:
May 1, 2012
Assignee:
The Alfred E. Mann Foundation For Scientific Research
Inventors:
Sam W. Bowman, Scott R. Gibson, Richard E. Purvis, Brian Michael Shelton, Lawrence Eric Ong, John Paul D'Brot
Abstract: Methods, systems, apparatus and devices for a variable fiber optic delay line that includes an electro-optic modulator for receiving and modulating an input signal, a switchless discrete long time delay module for injecting a long time delay into the modulated signal to produce a long delayed signal, and a switchless analog variable short delay module injecting a variable short time delay into the long delayed signal for a delayed output signal having a delay approximately equal to the long plus the short time delay. The module may also include non-dispersive single mode fibers for transmission between components and a circulator coupled for routing the input signal to the discrete long time delay module and routing the first delayed output signal to the analog variable short delay module. The VFODL can be used for Radio Frequency, digital electrical signals requiring time delay and amplitude processing or optical signal processing.
Type:
Grant
Filed:
March 5, 2009
Date of Patent:
May 1, 2012
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: Methods and systems for coding SAW OFC devices to mitigate code collisions in a wireless multi-tag system. Each device producing plural stepped frequencies as an OFC signal with a chip offset delay to increase code diversity. A method for assigning a different OFC to each device includes using a matrix based on the number of OFCs needed and the number chips per code, populating each matrix cell with OFC chip, and assigning the codes from the matrix to the devices. The asynchronous passive multi-tag system includes plural surface acoustic wave devices each producing a different OFC signal having the same number of chips and including a chip offset time delay, an algorithm for assigning OFCs to each device, and a transceiver to transmit an interrogation signal and receive OFC signals in response with minimal code collisions during transmission.
Type:
Grant
Filed:
February 18, 2011
Date of Patent:
May 1, 2012
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: The present invention provides methods and compositions relating to the labeling of target cells with nanometer scale fluorescent semiconductors referred to as quantum dots (QDs). Specifically, a delivery system is disclosed based on the use of negatively charged QDs for delivery of a tracking fluorescent signal into the cytosol of target cells via a passive endocytosis-mediated delivery process. In a specific embodiment of the invention the target cell is a stem cell, preferably a mesenchymal stem cell (MSC). Such labeled MSCs provide a means for tracking the distribution and fate of MSCs that have been genetically engineered to express, for example, a hyperpolarization-activated cyclic nucleotide-gated (“HCN”) channel and administered to a subject to create a biological pacemaker. The invention is based on the discovery that MSCs can be tracked in vitro for up to at least 6 weeks.
Type:
Grant
Filed:
March 21, 2008
Date of Patent:
May 1, 2012
Assignees:
The Trustees of Columbia University in the City of New York, The Research Foundation of State University of New York
Inventors:
Ira S. Cohen, Amy B. Rosen, Peter R. Brink, Glenn Gaudette, Michael R. Rosen, Richard B. Robinson
Abstract: A system for tracking location of person having signal transmitter includes at least one receiver for receiving unique ID signal transmitted by signal transmitter that transmits ID signal uniquely determined for respective mobile signal transmitter at at least one predetermined period. The receiver receives unique ID signal near circumference of the person having signal transmitter spaced apart from the receiver by given distance, and stores the received unique ID signal in ID store unit. The receiver, when search request for specific ID is received from external server, searches for the requested ID in ID store unit and transmits transmission information including ID corresponding to requested ID to external server. The person, such as abducted person, has only small signal transmitter, and thus the current location of the abducted person and path along which the abducted person moved can be tracked using the signal continually transmitted by the signal transmitter.
Type:
Grant
Filed:
April 8, 2009
Date of Patent:
May 1, 2012
Assignee:
Sungkyunkwan University Foundation for Corporate Collaboration
Inventors:
Hyunseung Choo, Jaewan Seo, Jaehyung Lee, Jinwook Park, Soko Jang
Abstract: A method and a system for generating a magnetic resonance image of a subject. The method and system include generating a first pulse having first random data having a first amplitude and a first linear phase; applying the first pulse to the subject as an radio frequency pulse; collecting a first signal from the subject; generating a second pulse having second random data having a second amplitude and a second linear phase, wherein the second amplitude is substantially equal to the first amplitude, and wherein the second phase has a different slope from the first phase; applying the second pulse to the subject as an radio frequency pulse; collecting a second signal from the subject; and reconstructing an image of the subject.
Abstract: The present invention discloses a physical/biochemical sensor using a multisized piezoelectric microcantilever resonator array which enables to quantitatively and simultaneously analyze a mass loading effect and a surface stress change effect and a manufacturing method thereof. In the physical/biochemical sensor using the multisized piezoelectric microcantilever resonator array, a plurality of piezoelectric micro-cantilever resonators having different sizes is arrayed so as to quantitatively and discriminately analyze a surface stress change as well as a sensor surface mass change induced by an adsorbed sensing-target material occurring in a sensing process. Thus, the mass loading effect and the surface stress change effect can be quantitatively and simultaneously analyzed.
Type:
Grant
Filed:
October 15, 2009
Date of Patent:
May 1, 2012
Assignee:
Sungkyunkwan University Foundation for Corporate Collaboration
Abstract: The presently-disclosed subject matter provides sensors and methods for detecting hydrogen by determining the conductivity of a chemiresistant film upon exposure to hydrogen, including for example chemiresistant films comprised of alkylamine-, alkylthiolate-, and/or surfactant-coated metal alloy nanoparticles.
Type:
Grant
Filed:
July 26, 2008
Date of Patent:
May 1, 2012
Assignee:
University of Louisville Research Foundation, Inc.
Inventors:
Francis P. Zamborini, Francisco J. Ibanez
Abstract: A system and method for performing a handover of a mobile station (MS) by considering Quality of Service (QoS) in a broadband mobile communication system. The method can include the steps of: receiving information about one or more neighbor base stations and reception strengths for the neighbor base stations from a Serving Radio Access System (RAS) currently communicating with the MS; extracting a value of a specific field from the received information about the neighbor base stations; combining the extracted value of the specific field with the reception strengths to thereby obtain combined values, and selecting a maximum value among the combined values; and transmitting a handover (handoff) request message to a base station corresponding to the selected maximum value. The system includes an MS that analyzes information about neighbor stations received in a Mobile Neighbor Base-station Advertisement (MOB_NBR_ADV) message to select a target RAS.
Type:
Grant
Filed:
March 18, 2008
Date of Patent:
May 1, 2012
Assignees:
Samsung Electronics Co., Ltd, Korea University Industrial & Academic Collaboration Foundation
Inventors:
Chang-Hyun Lee, Sung-Jea Ko, Yun-Je Oh, Tae-Sung Park, Jeong-Rok Park, Jeong-Seok Choi, Young-Hun Joo, Hye-Soo Kim, Kyung-Ho Chae
Abstract: The present invention relates to method of regulating mammalian target-of-rapamycin (mTOR) based on a novel finding of a regulating mechanism of mTOR by a phospholipase D (PLD), and Ras homolog enriched in brain (Rheb). Further, the present invention also relates to a method of screening inhibitors of mTOR, and a method and a composition for treating mTOR-related metabolic diseases by inhibiting mTOR.
Type:
Grant
Filed:
August 3, 2007
Date of Patent:
May 1, 2012
Assignee:
Postech Academy-Industry Foundation
Inventors:
Sung-Ho Ryu, Pann-Ghill Suh, Sang-Hoon Ha, Mi-Nam Lee, Hyun-Ju Lee, Il-Shin Kim, Do-Hyung Kim, Tae-Hoon Lee
Abstract: A semiconductor device includes at least one semiconductor layer, a metal layer in electrical contact with the semiconductor layer, and a carbon nanotube contact layer interposed between the metal layer and the semiconductor layer. The contact layer electrically couples the metal layer to the semiconductor layer and provides a semiconductor contact having low specific contact resistance. The contact layer can be substantially optically transparent layer in at least a portion of the visible light range.
Type:
Grant
Filed:
February 22, 2005
Date of Patent:
May 1, 2012
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Andrew Gabriel Rinzler, Stephen J. Pearton
Abstract: There are provided a method for epitaxial growth capable of securing stable optical and electrical characteristics by minimizing defects produced in a second epitaxial layer when growing the second epitaxial layer on a first epitaxial layer having defects formed therein, and an epitaxial layer structure using the method. The method includes preparing a first epitaxial layer having a defect formed therein, forming a metal quantum dot on the first epitaxial layer, allowing the metal quantum dot to be moved onto a step of the first epitaxial layer due to a difference of surface energy, converting the metal quantum dot into a metal quantum-dot semiconductor crystal having a lattice constant corresponding to that of the first epitaxial layer, and growing a second epitaxial layer on the first epitaxial layer.
Type:
Grant
Filed:
February 19, 2009
Date of Patent:
May 1, 2012
Assignee:
Industry-University Cooperation Foundation Hanyang University
Abstract: The present invention includes cold-adapted, acid-fast bacterium for use as a vaccine and a vaccine vector. In preferred embodiments, the cold-adapted, acid-fast bacterium is a Mycobacteria, for example, Mycobacteria shottsii.
Type:
Grant
Filed:
December 8, 2006
Date of Patent:
May 1, 2012
Assignee:
University of Georgia Research Foundation, Inc.
Inventors:
Frederick Quinn, Candace McCombs, Russell K. Karls
Abstract: A new and distinct cultivar of Southern highbush blueberry, ‘Southern Splendour’, is provided. ‘Southern Splendour’ is a Vaccinium hybrid, which is characterized by high vigor, short fruit ripening period, and high quality fruit suitable for mechanical harvesting.
Type:
Grant
Filed:
June 17, 2010
Date of Patent:
May 1, 2012
Assignee:
University of Georgia Research Foundation, Inc.