Abstract: The present invention relates to nuclear medicine using fluorescent silica nanoparticle and detecting method of optical dual imaging, and more particularly to radioisotope labeled fluorescent silica nanoparticles which are used for PET (positron emission tomography) and fluorescence detecting, and detecting method of PET and fluorescent dual imaging using thereof. Functionalized silica nanoparticles of this invention have promising potential as a role for organic lymphatic tracer in biomedical imaging such as pre- and intra-operative surgical guidance.

Abstract: A substrate formed of a suitable conductive-heat-transfer material is formed with small channels of a size selected to provide surface tension forces dominating a motion of a liquid-phase working fluid. A space above the channels of the substrate provides comparatively unobstructed space for the transport motion of a vapor phase of the working fluid effecting a heat-pipe effect in a multi-dimensional device. Channels may typically be formed in an orthogonal grid providing capillary return of liquids from a comparatively cooler condensation region to a comparatively warmer evaporation region, without any wicks other that the adhesion of the liquid phase working fluid to the vertices of the channels. Interference between the boundary layers of the liquid phase and the vapor phase of the working fluid are minimized by the depth of the channels, and the pedestals formed by the channel walls.

Abstract: A bidirectional equalizer and an equalization method using the bidirectional equalizer.

Abstract: A method of predicting sheet formability at a microscale level includes the steps of providing a grid pattern on a test sheet, bulging the test sheet to a hemispherical shape until a crack is initiated on the surface of the test sheet, detecting the initiation of the crack, acquiring two images of the surface adjacent to the crack and calculating surface strains on the test sheet.

Abstract: A surface-modified, magnetic nanoparticle has one or more multi-dentate ligands bound to a surface of a magnetic nanoparticle. The one or more multi-dentate ligands are bound to the surface of the magnetic nanoparticle through one or more dithiocarbamate groups. The one or more multi-dentate ligands may be a compound of Formula II: R2NCH2[CH2NR?CH2]m[CH2N(CS2?)CH2]q[CH2NHCH2]rCH2NR?2 ??(II) where each R, R?, and R? are independently H, a branched ethyleneimine unit, an unsubstituted or substituted alkyl, an unsubstituted or substituted alkenyl, or an unsubstituted or substituted aryl; and n is an integer from 1 to about 50.

Abstract: The invention is a method of making a hermetic via in a ceramic substrate that is comprised of noble metal powder in a glass-free paste that contains an admixture of a particulate phase of niobium pentoxide. The electrically conductive platinum provides excellent electrical conductivity while the niobium pentoxide phase prevents shrinkage of the paste during thermal processing and binds to both the ceramic and the noble metal particulates in the via, thus maintaining a hermetic seal around the via.

Abstract: Composite material and plunger-cast pipe manufacturing method and system wherein the composite material includes waste, chemically unmodified PET material, one or more waste filler materials (e.g. rock crusher fines, lime sludge or waste coal combustion by-products), and fiber reinforcement (e.g. glass, metal, ceramic, carbon, organic, and polymer fibers) and wherein the PET material is melted and mixed in a container to disperse filler material and fiber reinforcement in the PET material. The resulting mixture can be formed into a tubular pipe shape using the plunger-cast manufacturing method and system wherein a plunger piston and inner collapsible mold are pushed into the melted composite material contained in an outer mold. When cooled and solidified in the mold, a composite material having a matrix comprising PET with filler material and fiber reinforcement distributed in the matrix is formed in the shape of a tubular body.

Abstract: The invention provides for a spinal fixation support device to be used in conjunction with spinal fixation instrumentation. The invention further provides for methods of using the spinal fixation support device. In addition, the invention provides for a spinal fixation system that includes a spinal fixation support device of the invention and can further include spinal fixation instrumentation.

Abstract: Log likelihood ratios for data bits transmitted in a multi-dimensional signal are estimated using multiple Markov chain Monte Carlo simulations (MCMC). The MCMC simulations can include constraining symbols based on a most-likely symbol to improve the likelihood of finding distances for non-most-likely symbols. The log likelihood ratios can be calculated based on distances of the most-likely symbol and the non-most-likely symbols.

Abstract: The present invention relates to slitrk proteins as markers of stem and progenitor cells, including embryonic stem cells and hematopoietic stem and progenitor cells, and also as a marker of leukemia and lymphoma cells, and of endothelial cells. The invention provides, inter alia, methods for purifying slitrk-positive cells, methods for detecting slitrk-positive cells, purified preparations of slitrk-positive cells, therapeutic compositions containing purified slitrk-positive cells, methods for targeting therapeutic agents to slitrk-positive cells, and methods of treatment, including but not limited to, methods of administering slitrk-positive cells to subjects in need thereof.

Abstract: The present invention provides a bacterium having a genome that is genetically engineered to be at least 2 to 14% smaller than the genome of its native parent strain. A bacterium with a smaller genome can produce a commercial product more efficiently. The present invention also provides methods for deleting genes and other DNA sequences from a bacterial genome. The methods provide precise deletions and seldom introduces mutations to the genomic DNA sequences around the deletion sites. Thus, the methods can be used to generate a series of deletions in a bacterium without increasing the possibility of undesired homologous recombination within the genome. In addition, some of the methods provided by the present invention can also be used for replacing a region of a bacterial genome with a desired DNA sequence.

Abstract: Provided is a method of incremental SSTA (statistical static timing analysis) of a digital circuit, the method including a first step in which, when a gate is replaced in the digital circuit, delay propagation is performed from a node of a replaced gate to a virtual sink node based on SSTA; a second step in which, if a changed value of a gate timing yield at each gate which propagates delay toward the virtual sink node is smaller than a predetermined threshold value, delay propagation with respect to a fanout gate of the corresponding gate is stopped; and a third step in which, when a delay with respect to the node of the replaced gate is propagated to the virtual sink node, a new timing yield is calculated at the virtual sink node.

Abstract: The present invention provides a method of affecting physiological disorders by stimulating a specific location along the sympathetic nerve chain. Preferably, the present invention provides a method of affecting a variety of physiological disorders or pathological conditions by placing an electrode adjacent to or in communication with at least one ganglion along the sympathetic nerve chain and stimulating the at least one ganglion until the physiological disorder or pathological condition has been affected.

Abstract: A wave-guiding system and method for mode-selective transmission of a spatially coherent light beam is disclosed. The system comprises a wave-guide with an inlet and an outlet for transmitting one or more modes; a first mode-shaping optical element for shaping the spatially coherent light beam before it enters through the inlet of the wave-guide to a desired mode of the wave-guide; and a second mode-shaping optical element for shaping light beam after it exits from the outlet of the wave-guide for obtaining a desired vectorial field.

Abstract: The present invention relates to methods and systems for conducting three-dimensional image analysis and diagnosis and possible treatment relating thereto. The invention includes methods of handling signals containing information (data) relating to three-dimensional representation of objects scanned by a scanning medium. The invention also includes methods of making and analyzing volumetric measurements and changes in volumetric measurements which can be used for the purpose of diagnosis and treatment.

Abstract: The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.

Abstract: Mycobacterium strains that have an enhanced ability to elicit a MHC-Class I-restricted CD8+ T cell immune response are provided. The Mycobacterium strains are genetically engineered to express: a endosomalytic protein that is active at neutral pH (e.g. Perfringolysin O), permitting escape of the Mycobacterium from endosomes into the cytoplasm of the cell; and antigens of interest, such as tuberculosis antigens. The invention also provides vaccine preparations containing such Mycobacterium strains.

Abstract: An algorithm is disclosed for constructing nonlinear models from high-dimensional scattered data. The algorithm progresses iteratively adding a new basis function at each step to refine the model. The placement of the basis functions is driven by a statistical hypothesis test that reveals geometric structure when it fails. At each step the added function is fit to data contained in a spatio-temporally defined local region to determine the parameters, in particular, the scale of the local model. The proposed method requires no ad hoc parameters. Thus, the number of basis functions required for an accurate fit is determined automatically by the algorithm. The approach may be applied to problems including modeling data on manifolds and the prediction of financial time-series. The algorithm is presented in the context of radial basis functions but in principle can be employed with other methods for function approximation such as multi-layer perceptrons.

Abstract: Memory demands of large-memory applications continue to remain one step ahead of the improvements in DRAM capacities of commodity systems. Performance of such applications degrades rapidly once the system hits the physical memory limit and starts paging to the local disk. A distributed network-based virtual memory scheme is provided which treats remote memory as another level in the memory hierarchy between very fast local memory and very slow local disks. Performance over gigabit Ethernet shows significant performance gains over local disk. Large memory applications may access potentially unlimited network memory resources without requiring any application or operating system code modifications, relinkling or recompilation. A preferred embodiment employs kernel-level driver software.

Abstract: A safe and effective hemostatic is provided. The invention relates to a bioabsorbable synthetic nonwoven fabric holding thrombin as an effective ingredient and a hemostatic comprising said bioabsorbable synthetic nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention may be prepared by a process which comprises the steps of immersing a bioabsorbable synthetic nonwoven fabric into a solution containing thrombin and of lyophilizing the obtained nonwoven fabric. The bioabsorbable synthetic nonwoven fabric holding thrombin in accordance with the present invention allows for quicker and more effective hemostasis.