Abstract: Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions for potentiating T cell-mediated responses in mammalian cancer patients. They also have therapeutic uses in vitro.
Type:
Application
Filed:
August 5, 2009
Publication date:
July 22, 2010
Applicant:
South Alabama Medical Science Foundation
Inventors:
Joseph H. Coggin, JR., James W. Rohrer, Adel L. Barsoum
Abstract: A medical system comprising an implantable medical device and an external controller. The medical device includes a therapy administration subsystem, a telemetry subsystem, and a control subsystem which includes a microprocessor operable in response to data and/or code provided via said telemetry subsystem for producing an output signal for controlling said therapy administration subsystem. The controller includes a user input means and a telemetry subsystem responsive to said user input means for communicating data and/or code to said medical device telemetry subsystem. The medical device control subsystem includes program means for causing said microprocessor to separately execute at least two software processes to respectively produce separate therapy control output components. Combinatorial logic means responds to the separate output components to produce the output signal for controlling the therapy administration subsystem.
Type:
Grant
Filed:
July 7, 2005
Date of Patent:
July 20, 2010
Assignee:
The Alfred E. Mann Foundation for Scientific Research
Abstract: A method for preparing a site-specific peptide probe, wherein the peptide is specific to a receptor, includes modifying a marker to include a tether molecule and covalently binding the tether molecule to the peptide. The present invention also provides a labeled probe, comprising a peptide specific for a receptor and a marker. The marker is modified to include a tether molecule capable of covalently binding to the peptide. The peptide is typically derived from a bacteriophage or is a synthetic analog or derivative of the peptide. The receptor will typically be found on a surface of a bacterial cell. The method and probe of the invention are suitable for a rapid assay for a bacteria in a complex mixture.
Type:
Grant
Filed:
March 5, 2004
Date of Patent:
July 20, 2010
Assignee:
University of Kentucky Research Foundation
Abstract: A method, apparatus, and computer program product that provides, among other things, a procedure for the enhanced assessment of attention-related impairments of individuals. Further, the method, apparatus, and computer program product enhances existing assessment instruments by providing a way to reduce diagnostic error through the combining of the results of disparate assessment instruments. Potential users of this product will be any person or organization that diagnoses or treats persons with attentional or cognitive impairments. The method can be used for initial screening and diagnosis of disorders associated with impaired attention, such as ADHD, as well as for treatment and evaluation of the effects of treatments, such as medication or additional therapies.
Type:
Grant
Filed:
March 17, 2005
Date of Patent:
July 20, 2010
Assignee:
University of Virginia Patent Foundation
Inventors:
Daniel J. Cox, Boris P. Kovatchev, Rayna S. Robeva, Jennifer Kim Penberthy
Abstract: The present invention relates to a synthetic process for the preparation of a novel class of androgen receptor targeting agents (ARTA) which demonstrate androgenic and anabolic activity of a nonsteroidal ligand for the androgen receptor.
Type:
Grant
Filed:
February 23, 2005
Date of Patent:
July 20, 2010
Assignee:
University of Tennessee Research Foundation
Inventors:
James T. Dalton, Duane D. Miller, Donghua Yin, Yali He
Abstract: The invention discloses a method of maintaining hepatitis C virus (HCV) growing indefinitely in cell culture. The method includes providing a culture of cells susceptible to infection by HCV; introducing to the cell culture an inoculum containing an infective dose of HCV; contacting the inoculated cell culture with a growth medium containing an excess of uridine and cytidine; and changing spent growth medium with fresh growth medium containing the excess of uridine and cytidine on a predetermined schedule.
Type:
Grant
Filed:
September 28, 2006
Date of Patent:
July 20, 2010
Assignee:
The Florida State University Research Foundation, Inc.
Abstract: The invention is directed to formation and use of electroprocessed fibrin as an extracellular matrix and, together with cells, its use in forming engineered tissue. The engineered tissue can include the synthetic manufacture of specific organs or tissues which may be implanted into a recipient. The electroprocessed fibrin may also be combined with other molecules in order to deliver the molecules to the site of application or implantation of the electroprocessed fibrin. The fibrin or fibrin/cell suspension is electrodeposited onto a substrate to form the tissues and organs.
Type:
Grant
Filed:
January 26, 2004
Date of Patent:
July 20, 2010
Assignee:
Virginia Commonwealth University Intellectual Property Foundation
Inventors:
Gary L. Bowlin, Gary E. Wnek, David G. Simpson, Philippe Lam, Marcus E. Carr, Jr.
Abstract: The invention provides a CR2-FH molecule comprising a CR2 portion comprising CR2 protein or a fragment thereof and a FH portion comprising a factor H protein or a fragment thereof, and pharmaceutical compositions comprising a CR2-FH molecule. Also provided are methods of using the compositions for treatment diseases in which the alternative complement pathway is implicated, such as age-related macular degeneration, rheumatoid arthritis, and ischemia reperfusion.
Type:
Grant
Filed:
June 21, 2007
Date of Patent:
July 20, 2010
Assignees:
Regents of the University of Colorado, MUSC Foundation For Research Development
Inventors:
Gary Gilkeson, Stephen Tomlinson, V. Michael Holers, Baerbel Rohrer
Abstract: The present invention relates to an anti-cancer composition, which comprises a sulfur-containing compound thiacremonone as an active ingredient. The active ingredient induces the death of cancer cells by apoptosis through the action of specific inhibition of the activity of NF-?B. The composition can be effectively used in the treatment or prevention of cancer.
Type:
Grant
Filed:
August 6, 2008
Date of Patent:
July 20, 2010
Assignee:
Chungbuk National University Industry Academic Cooperation Foundation
Inventors:
Jin Tae Hong, Jung Ok Ban, Heon-Sang Jeong, Dae Joong Kim
Abstract: Systems and methods are provided for digital transport of paramagnetic particles. The systems and methods may include providing a magnetic garnet film having a plurality of magnetic domain walls, disposing a liquid solution on a surface of the magnetic garnet film, wherein the liquid solution includes a plurality of paramagnetic particles, and applying an external field to transport at least a portion of the paramagnetic particles from a first magnetic domain wall to a second magnetic domain wall of the plurality of magnetic domain walls.
Type:
Grant
Filed:
September 24, 2007
Date of Patent:
July 20, 2010
Assignee:
Florida State University Research Foundation
Inventors:
Thomas Fischer, Pietro Tierno, Lars Egil Helseth
Abstract: Embodiments of the present disclosure provide a system and method for improved distribution of content on a communication network. The system and method are adapted to receive a video request message from a client, identify a location of the client, identify a location of one or more overlay nodes nearest to the client, identify a location of one or more network servers nearest to the client, generate network organization information, and publish the network organization information to at least the client.
Abstract: The present invention relates to targeted killing of a cell utilizing a chimeric polypeptide comprising a cell-specific targeting moiety and a signal transduction pathway factor. In a preferred embodiment, the signal transduction pathway factor is an apoptosis-inducing factor, such as granzyme B, granzyme A, or Bax.
Abstract: The present invention provides a universal belay device for providing safety to mountain and rock climbers. The belay device allows a belayer to selectively operate the device in any of a plurality of modes. In an auto-locking mode, a fall by a climber automatically stops the rope without requiring the belayer manually apply any holding or stopping force. In a frictional mode, a fall by a climber is stopped by the belayer applying a minimal amount of pressure. The belay device includes a housing in which a rope pin and cam are contained. The cam is rotable to a first position which allows the rope pin to frictionally secure the rope against the housing and stop the rope. The cam is rotable to a second position which substantially prevents the rope pin from fully securing the rope and requires the user to apply a stopping force to stop the rope.
Type:
Grant
Filed:
May 5, 2006
Date of Patent:
July 20, 2010
Assignee:
The University of Utah Research Foundation
Abstract: A pixel including an organic light emitting diode for use in an organic light emitting display device and a method for driving the display device. First and second transistors are coupled with a current supply line and are turned-on by a scan signal supplied to a scan line to charge a first capacitor to a voltage corresponding to a current through the current supply line. A third transistor supplies a current corresponding to the voltage charged in the first capacitor to the diode. A fourth transistor coupled to a data line is turned-on by a select signal supplied to an address line to charge a second capacitor to a voltage corresponding to a current flowing in the data line. A fifth transistor is coupled between the third transistor and the diode, and is turned-on/off according to the voltage charged in the second capacitor.
Type:
Grant
Filed:
February 22, 2007
Date of Patent:
July 20, 2010
Assignees:
Samsung Mobile Display Co., Ltd., IUCF-HYU (Industry—University Cooperation Foundation Hanyang University)
Abstract: Nitrosamines are reduced in tobacco by treating a whole tobacco leaf with ferulic acid. Treatment is conducted by applying an aqueous solution of ferulic acid to the whole tobacco leaf immediately before, at, or after harvesting, or fire curing the whole tobacco leaf with wood smoke containing the ferulic acid.
Type:
Grant
Filed:
December 13, 2006
Date of Patent:
July 20, 2010
Assignees:
Swisher International, Inc., University of Kentucky Research Foundation
Inventors:
Terry Thomas, John Brandon, William A. Bailey, Thomas A. Losty
Abstract: The invention encompasses compositions and methods relating to viral polymerases having one or more substitutions of different amino acids at conserved regions of the polymerase yields enzymes with varying rates and fidelity of replication. A universally applicable, polymerase-mechanism-based strategy for production of attenuated viruses and anti-viral vaccines is disclosed.
Type:
Grant
Filed:
December 24, 2007
Date of Patent:
July 20, 2010
Assignee:
The Penn State Research Foundation
Inventors:
Craig E. Cameron, Christian Castro, Jamie J. Arnold
Abstract: Pulse detonation combustors of valveless construction. One valveless pulse detonation combustor, having a tube with a closed end and an open end, is constructed with a flame accelerator within the tube, adjacent the open end. A valveless, apertured flow restrictor is positioned between the flame accelerator and the closed end of the tube. A sparking device is positioned within the tube, between the flow restrictor and the flame accelerator. Valveless fuel and air ports are positioned between the flow restrictor and the closed end of the tube. Substantially right-angle manifold passageways are in communication with each of the ports.
Abstract: Antimicrobial agents that can serve as replacements to conventional pharmaceutical antibiotics are disclosed. The antimicrobial agents comprise conjugatively transmissible plasmids that kill targeted pathogenic bacteria, but are not harmful to donor bacteria. Two types of lethal transmissible plasmids are disclosed. One type kills recipient bacteria by unchecked (“runaway”) replication in the recipient cells and is prevented from occuring in donor cells. Another type kills recipient bacteria by expressing a gene that produces a product detrimental or lethal to recipient bacterial cells, that gene being prevented from expression in donor cells.
Abstract: An air-coupled transducer includes a ultrasonic transducer body having a radiation end with a backing fixture at the radiation end. There is a flexible backplate conformingly fit to the backing fixture and a thin membrane (preferably a metallized polymer) conformingly fit to the flexible backplate. In one embodiment, the backing fixture is spherically curved and the flexible backplate is spherically curved. The flexible backplate is preferably patterned with pits or depressions.
Type:
Grant
Filed:
May 24, 2006
Date of Patent:
July 20, 2010
Assignee:
Iowa State University Research Foundation, Inc.