Abstract: This invention provides for a method for inhibiting new tissue growth in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit new tissue growth in the subject's blood vessels. The invention also provides for method for inhibiting neointimal formation in blood vessels in a subject, wherein the subject experienced blood vessel injury, which comprises administering to the subject a pharmaceutically effective amount of an inhibitor of receptor for advanced glycation endproduct (RAGE) so as to inhibit neointimal formation in the subject's blood vessels.
Type:
Grant
Filed:
August 20, 2007
Date of Patent:
June 8, 2010
Assignees:
The Trustees of Columbia University in the City of New York, The Cleveland Clinic Foundation
Inventors:
David M. Stern, Ann Marie Schmidt, Steven Marso, Eric Topol, A. Michael Lincoff
Abstract: Methods, systems and computer program products determine and identify a favorable time to deliver cardiac compression to a subject to avoid a vulnerable period of a spontaneous intrinsic cardiac cycle.
Abstract: The present invention provides methods for stimulating mu-opioid receptors with agonist peptides in a mammal in need thereof. The methods comprise administering to the mammal an effective amount of a selective mu-opioid receptor agonist peptide that comprises at least two ?-amino acid residues. At least one of the amino acid residues has a positive charge. The amino acid residue in the first position is a tyrosine or tyrosine derivative. The amino acid in the second position is a D-?-amino acid. The present invention also provides methods of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the peptides.
Type:
Grant
Filed:
June 29, 2006
Date of Patent:
June 8, 2010
Assignees:
Cornell Research Foundation, Inc., Clinical Research Institute of Montreal
Abstract: In time-resolved contrast-enhanced magnetic resonance angiography, a measure quantifying image quality provides a basis for generating a linear filtered composite image by facilitating selection of a mask and an arterial phase image for subtraction. Filtering of individual pixels of a temporal series of images provides enhanced contrast in a single image by allowing the temporal behavior of the pixel intensity to denote representation as an artery, vein or background tissue. Motion artifacts are suppressed by re-registering sequential images, adjusting weighting before averaging and subtraction and filtering the Fourier data to eliminate data corrupted by motion or other phenomena.
Type:
Grant
Filed:
June 1, 2009
Date of Patent:
June 8, 2010
Assignee:
Cornell Research Foundation, Inc.
Inventors:
Martin R. Prince, Ramin Zabih, Yi Wang, Richard Watts, Junhwan Kim, Jeff Bezanson, Hale Ersoy
Abstract: A system for detecting explosive materials includes at least one deuterium/tritium neutron generator module, at least one germanium detector module, and an analysis module. The deuterium/tritium neutron generator module bombards an object with neutrons. The germanium detector module detects gamma rays emitted by the object in response to the neutrons. The analysis module analyzes the gamma rays detected by the germanium detector module for the presence of explosive materials on or within the object.
Type:
Grant
Filed:
August 29, 2007
Date of Patent:
June 8, 2010
Assignees:
Raytheon Company, Purdue Research Foundation
Inventors:
David S. Koltick, Yeong E. Kim, Jayson K. Bopp, Joseph C. Deno, Paul G. Jones
Abstract: A data aggregation method and data aggregation apparatus are provided. More particularly the data aggregation method includes: generating a plurality of data aggregation trees according to connection relationships between clusters that constitute a sensor network using a geographical code (GGC), selecting a single activation zone for each of the clusters which configures each of the plurality of data aggregation trees, selecting a maximum energy tree having a maximum total residual energy from the plurality of data aggregation trees, based on the single activation zone, and generating a tree list including activation zone information which corresponds to the maximum energy tree, and information about the maximum energy tree.
Type:
Grant
Filed:
August 23, 2007
Date of Patent:
June 8, 2010
Assignees:
Samsung Electronics Co., Ltd., Korea University Industrial & Academic Collaboration Foundation
Inventors:
Jin Wook Lee, Su-Myeon Kim, Sun Shin An, Won Keun Kong, Hun Lim, Kyung Soo Lim, Sang Bin Lee
Abstract: The present invention relates to a pair of primers specific to mycobacterial species, a polynucleotide of an hsp 65 gene fragment, and a method for the identification of mycobacterial species by using the same. More specifically, the 604-bp hsp 65 gene fragment can be applied to identification methods of mycobacteria such as the comparative sequence analysis method, the probe hybridization method, and PCR-RFLP, which can resolve the problems of a conventional identification method based on bio-chemical characteristics, where the genus mycobacterium covers various species and has a low growth rate, and of the problems of 16s rDNA. Thus, according to the identification method of the present invention, the mycobacterial species can be identified simply, economically, and accurately.
Type:
Grant
Filed:
January 21, 2003
Date of Patent:
June 8, 2010
Assignees:
Seoulin Bio Science Co., Ltd., Seoul National University Industry Foundation
Inventors:
Bum-Joon Kim, Yoon-Ho Kook, Jeong-Mi Kim
Abstract: Compositions and processes are disclosed for removing sulfur and sulfur compounds from hydrocarbon fuel feedstocks. The feedstock is contacted with a regenerable sorbent such as a compound of the formula TixCeyO2 where 0<x/y?1 and where 0<x?1 and 0<y?1 capable of selectively adsorbing sulfur compounds present in the hydrocarbon feedstock at about 0° C. to about 100° C. such as at about 25° C.
Type:
Grant
Filed:
September 7, 2007
Date of Patent:
June 8, 2010
Assignee:
The Penn State Research Foundation
Inventors:
Chunshan Song, Xiaoliang Ma, Shingo Watanabe, Fuxia Sun
Abstract: The present invention relates to a pharmaceutical composition for protecting neurons or for preventing and treating ischemic neuronal diseases comprising the extract of Lithospermum erythrorhizon Sieb. Et Zucc extracted with water, low-alcohols or their mixture or acetylshikonin separated therefrom as an effective ingredient. The extract of Lithospermum erythrorhizon Sieb. Et. Zucc or acetylshikonin separated therefrom of the present invention has neuronal protective effect, so that it not only interrupts the development of ischemic neuronal diseases but also is very safe, indicating that the extract or acetylshikonin can be used as a medicinal drug for prevention and treatment of degenerative brain disease caused by neuronal apoptosis such as stroke, apoplexy, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, Pick's disease and Creutzfeldt-Jakob disease and further can be developed as functional health food.
Type:
Grant
Filed:
June 13, 2007
Date of Patent:
June 8, 2010
Assignee:
Industry Academic Cooperation Foundation of Kyunghee University
Inventors:
Ho Cheol Kim, Ha Young Lee, Ni Na Ha, Min Jung Kong, Seung Ju Roh, Nak Sul Seong, Geum Soog Kim, Yun Tai Kim, Youngmin Bu
Abstract: Disclosed is the use of selective adenosine A1 allosteric enhancers to induce angiogenesis at a desired location for treating conditions in which increased angiogenesis is desired, such as stroke, heart disease and peripheral vascular disease.
Type:
Grant
Filed:
August 1, 2001
Date of Patent:
June 8, 2010
Assignee:
University of Virginia Patent Foundation
Inventors:
Joel Linden, Amy L. Tucker, Richard Price, Rebecca Youkey
Abstract: A variable tuned holder for machine tools that attaches to a machine tool to act in a manner similar to a dynamic absorber while the machine tool is used during machining. The natural frequency of the holder may be matched to the natural frequency of the machine tool as the tool is in use to reduce the amplitude of vibration at the cutting end of tool with a workpiece. The present invention is designed to provide an impedance match between the machine tool and the holder such that the cutting energy may escape and/or be dissipated. The flexible holder may be used as one part of an overall system. The system may be designed to be used with tools of different shapes and/or lengths. As the shape and/or length of the machine tool changes, the system may be easily modified to change the natural frequency of the flexible holder to enable the dynamic absorber effect of the flexible holder to occur.
Type:
Grant
Filed:
July 8, 2005
Date of Patent:
June 8, 2010
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Tony L. Schmitz, Lonnie A. Houck, III, Brian P. Mann, Kevin S. Smith
Abstract: The present invention is directed to liquid crystalline substrates useful in the culture of cells and methods of their use. In certain embodiments, the invention provides methods and devices for imaging changes (e.g., reorganization) of extracellular matrix components by living cells.
Type:
Grant
Filed:
November 30, 2006
Date of Patent:
June 8, 2010
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Nicholas L. Abbott, Jeffrey C. Mohr, Christopher J. Murphy, Elise Huang, Juan J. De Pablo, Sean P. Palecek, Nathan A. Lockwood
Abstract: This inventive discloses a method for transdifferentiating mesenchymal stem cells into neuronal cells, which comprises increasing the level of a basic helix-loop-helix (bHLH) transcription factor in the mesenchymal stem cells, said cells being useful in cell therapy or gene therapy for treating brain neurological diseases such as Parkinson's disease, Alzheimer disease, Hungtington's disease, amyotrophic lateral sclerosis, cerebral paralysis and brain ischemia; and spine disfunction caused by a traumatic injury.
Type:
Grant
Filed:
August 14, 2003
Date of Patent:
June 8, 2010
Assignee:
Ajoll University Industry Cooperation Foundation
Inventors:
Hae-Young Suh, Sung-Soo Kim, Ji-Won Kim, Young-Don Lee, Seung-Cheol Ahn
Abstract: The present invention relates to a TRPA1 activation inhibitor, more precisely a TRPA1 activity inhibitor containing isopentenyl pyrophosphate and a method for inhibiting pain containing the step of administering isopentenyl pyrophosphate to a subject. Isopentenyl pyrophosphate of the present invention can regulate pain caused by TRPA1, so that it can be effectively used for the development of a pain inhibitor which is effective but has less side effects.
Type:
Application
Filed:
February 18, 2009
Publication date:
June 3, 2010
Applicant:
Korea University Industry and Academic Collaboration Foundation
Abstract: A method of generating cultured chondrocytes/endochondral bone cells is provided. The method comprising isolating chondrocytes from mandibular condyle tissue, and culturing the isolated chondrocytes. A method of isolating chondrocytes from mandibular condyle tissue is further provided. The method comprises isolating mandibular condyle tissue from a mammal and treating the mandibular condyle tissue so as to selectively remove fibroblast-like cells and/or myocytes therefrom, the modified mandibular condyle tissue including chondrocytes, and selectively collecting the chondrocytes from the modified mandibular condyle tissue.
Type:
Application
Filed:
December 7, 2009
Publication date:
June 3, 2010
Applicant:
Technion Research & Development Foundation Ltd.
Abstract: The present invention relates to a method for activating TRPV3 (transient receptor potential vanilloid 3) using FPP (farnesyl diphosphate) and a method for screening a TRPV3 activity inhibitor. FPP of the present invention has TRPV3 specific activity and therefore it can be effectively used for the study on TRPV3 mechanism and functions and for the development of a TRPV3 based pain reliever.
Type:
Application
Filed:
February 18, 2009
Publication date:
June 3, 2010
Applicant:
Korea University Industry and Academic Collaboration Foundation
Abstract: An apparatus for reducing PAPR (Peack to Average Power Ratio) in an OFDM (Orthogonal Frequency Division Multiplexing) system includes: an IFFT (Inverse Fast Fourier Transform) unit for performing an IFFT on an input data stream modulated using a specific constellation to generate time-domain signals; a time-domain clipping unit for performing a time-domain clipping on the time-domain signals at a clipping level determined by characteristics of the time-domain signals; an FFT (Fast Fourier Transform) unit for performing an FFT on the clipped time-domain signals to generate frequency-domain signals; and a frequency-domain clipping unit for performing a frequency-domain clipping on the frequency-domain signals. The time-domain clipping reduces in the OFDM system, and the frequency-domain clipping reduces distortions generated by the time-domain clipping.
Type:
Application
Filed:
November 28, 2007
Publication date:
June 3, 2010
Applicants:
Electronics and Telecommunications Research Institute, Soongsil University Industry & Academy Collaboration Foundation
Inventors:
Jae-Ho Jung, Kwang Chun Lee, Sung Bin Im
Abstract: The present invention relates to a TRPV3 (transient receptor potential vanilloid 3) activity inhibitor, more precisely to a method for inhibiting TRPV3 activity including the step of treating isopentenyl pyrophosphate and a method for treating skin disease containing the step of administering isopentenyl pyrophosphate to a subject with skin disease or applying the same on the skin of the subject. Isopentenyl pyrophosphate of the present invention controls increase of sensory cell reactivity to current or migration and proliferation of skin cells induced by TRPV3, so that it can be effectively used for the development of a pain reliever or a therapeutic agent for skin disease.
Type:
Application
Filed:
February 18, 2009
Publication date:
June 3, 2010
Applicant:
Korea University Industry and Academic Collaboration Foundation
Abstract: Piezoelectric compounds of the formula xNamBinTiO3-yKmBinTiO3-zLimBinTiO3-pBaTiO3 where (0<x?1), (0?y?1), (0?z?1), (0.3?m?0.7), (0.3?n?0.7), (0<p?1) (0.9?m/n?1.1) as well as to doped variations thereof are disclosed. The material is suitable for high power applications.
Type:
Application
Filed:
September 24, 2009
Publication date:
June 3, 2010
Applicant:
The Penn State Research Foundation
Inventors:
Shujun Zhang, Hyeong Jae Lee, Thomas R. Shrout