Patents Assigned to Foundation
  • Tocopherols, tocotrienols, other chroman and side chain derivatives and uses thereof
    Patent number: 7718814
    Abstract: The present invention provides an antiproliferative compound having a structural formula where X and Y independently are oxygen, nitrogen or sulfur; R1 is alkyl, alkenyl, alkynyl, aryl, heteroaryl, carboxylic acid, carboxylate, carboxamide, ester, thioamide, thiolacid, thiolester, saccharide, alkoxy-linked saccharide, amine, sulfonate, sulfate, phosphate, alcohol, ethers or nitriles; R2 and R3 are hydrogen or R4; R4 is methyl, benzyl carboxylic acid, benzyl carboxylate, benzyl carboxamide, benzylester, saccharide or amine; and R1 is alkenyl; where when Y is nitrogen, said nitrogen is substituted with R6, wherein R6 is hydrogen or methyl. Also provided are methods for treating a cell proliferative disease and for inducing apoptosis in a cell comprising administering this compound is also provided.
    Type: Grant
    Filed: October 30, 2007
    Date of Patent: May 18, 2010
    Assignee: Research Development Foundation
    Inventors: Bob G. Sanders, Kimberly Kline, Weiping Yu
  • MHC-peptide complex binding ligands
    Patent number: 7718777
    Abstract: Disclosed are protein ligands comprising an immunoglobulin heavy chain variable (VH) domain and an immunoglobulin light chain variable (VL) domain, wherein the proteins bind a complex comprising an MHC and a peptide, do not substantially bind the MHC in the absence of the bound peptide, and do not substantially bind the peptide in the absence of the MHC, and the peptide is a peptide fragment of gp100, MUC1, TAX, or hTERT. Also disclosed are methods of using and identifying such ligands.
    Type: Grant
    Filed: October 18, 2006
    Date of Patent: May 18, 2010
    Assignee: Technion Research & Development Foundation Ltd.
    Inventors: Henricus Renerus Jacobus Mattheus Hoogenboom, Yoram Reiter
  • Method and system for controlling power in a communication system
    Patent number: 7720503
    Abstract: A method for controlling power in a communication system. In the power control method, a transmitter receives feedback information from receivers located in its own cell; determines data rates of the receivers according to the received feedback information, calculates a load of the cell by calculating an amount of data to be transmitted to the receivers; and calculates transmission power of the transmitter by comparing the load of the cell with a threshold.
    Type: Grant
    Filed: June 11, 2007
    Date of Patent: May 18, 2010
    Assignees: Samsung Electronics Co., Ltd., Seoul National University Industry Foundation
    Inventors: Ho-Joong Kwon, Byeong-Gi Lee, Han-Byul Seo, Won-Hyoung Park
  • Protective shield
    Patent number: 7717118
    Abstract: The subject invention provides a shield for protecting a patient's extremities when positioned on an arm or leg board or other surgical or examination table extension. The shield comprises essentially an inverted C-shaped or U-shaped covering with a channel therein. It may further comprise one or more flanges to aid in supporting and positioning the shield.
    Type: Grant
    Filed: December 13, 2006
    Date of Patent: May 18, 2010
    Assignee: University of Florida Research Foundation, Inc.
    Inventor: Harshdeep S. Wilkhu
  • Method of forming a dielectic film that contains silicon, oxygen and nitrogen and method of fabricating a semiconductor device that uses such a dielectric film
    Patent number: 7718484
    Abstract: In a film formation method of a semiconductor device including a plurality of silicon-based transistors or capacitors, there exist hydrogen at least in a part of the silicon surface in advance, and the film formation method removes the hydrogen by exposing the silicon surface to a first inert gas plasma. Thereafter a silicon compound layer is formed on the surface of the silicon gas by generating plasma while using a mixed gas of a second inert gas and one or more gaseous molecules, such that there is formed a silicon compound layer containing at least a pat of the elements constituting the gaseous molecules, on the surface of the silicon gas.
    Type: Grant
    Filed: October 31, 2007
    Date of Patent: May 18, 2010
    Assignee: Foundation for Advancement of International Science
    Inventors: Tadahiro Ohmi, Shigetoshi Sugawa, Masaki Hirayama, Yasuyuki Shirai
  • Universal biosensor and methods of use
    Patent number: 7718388
    Abstract: The present invention relates to methods for detecting or quantifying an analyte in a test sample including providing at least one test mixture including a test sample, at least one marker complex, wherein each marker complex includes a particle, a marker, and one member of a coupling group, a first binding material selected to bind to a portion of the analyte, a second binding material selected to bind with a portion of the analyte other than the portion of the analyte for which the first binding material is selected, analyte analog, and/or marker conjugate. The at least one test mixture is passed through a membrane. The amount of marker on the membrane is detected and correlated to the presence or amount of analyte in the test sample.
    Type: Grant
    Filed: November 10, 2006
    Date of Patent: May 18, 2010
    Assignee: Cornell Research Foundation, Inc.
    Inventor: Antje J. Baeumner
  • Bipolar spin transistors and the applications of the same
    Patent number: 7719071
    Abstract: A bipolar spin transistor is provided. In one embodiment of the present invention, the bipolar spin transistor includes a first semiconductor region having a first conductivity type, a second semiconductor region having a second conductivity type that is different from the first conductivity type and also having a spin polarization, and a third semiconductor region having a conductivity type that is the same conductivity type of the first semiconductor region. The first semiconductor region and the second semiconductor region are adjacent to each other so as to form a first charge depletion layer therebetween, the first charge depletion layer having a first side facing the first semiconductor region and an opposing second side facing the second semiconductor region.
    Type: Grant
    Filed: May 26, 2004
    Date of Patent: May 18, 2010
    Assignee: University of iowa Research Foundation
    Inventors: Michael Edward Flatté, Zhi Gang Yu, Ezekiel Johnston-Halperin, David Awschalom
  • One-way delay time estimation method and apparatus and clock synchronization method and apparatus using the same
    Patent number: 7720109
    Abstract: An apparatus for and method of estimating a one-way delay time between two hosts and an apparatus and method of clock synchronization using the same. The two hosts are connected to a network and communicate a predetermined packet; k-th, (k+1)-th, and (k+2)-th transmission times are measured at the first host, and k-th, and (k+1)-th transmission times are measured at the second host; a time difference of the m-th transmission time is measured at the first and second host, where m is k or k+1, and by using the measured transmission times, an m-th one-way delay time is calculated. If the time difference is identical to the calculated one-way delay time, a value equal to or less than the calculated one-way delay time is determined as the estimated one-way delay time. Accordingly, the estimation error of a one-way delay time is reduced for both symmetrically and asymmetrically connected hosts.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: May 18, 2010
    Assignees: Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation
    Inventors: Dong-keun Kim, Jai-yong Lee
  • (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs
    Patent number: 7718638
    Abstract: This invention discloses (20R)-23,23-difluoro-2-methylene-19-nor-bishomopregnacalciferol-vitamin D analogs, and specifically (20R)-23,23-difluoro-1?-hydroxy-2-methylene-19-nor-bishomopregnacalciferol, and pharmaceutical uses therefor. This compound exhibits pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as an anti-cancer agent and for the treatment of skin diseases such as psoriasis as well as skin conditions such as wrinkles, slack skin, dry skin and insufficient sebum secretion. This compound also has little, if any, calcemic activity and therefore may be used to treat autoimmune disorders or inflammatory diseases in humans as well as renal osteodystrophy. This compound may also be used for the treatment or prevention of obesity.
    Type: Grant
    Filed: December 24, 2008
    Date of Patent: May 18, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Margaret Clagett-Dame, Lori A. Plum, Rafal Barycki
  • Apparatus and method for high rate uniform coating, including non-line of sight
    Patent number: 7718222
    Abstract: A direct vapor deposition (DVD) apparatus and method is taught, that provides a carrier gas flow entraining vapor atoms for the coating of regions on a substrate that are not in line-of-sight. The degree of non line-of-sight (NLOS) coating, hence thickness uniformity around the substrate is a sensitive function of the flow conditions. For a fixed background pressure in the region of deposition, an increase in the uniformity of the coating thickness is accomplished as the flow velocity is reduced. This improvement in uniformity is a result of an increase in the fraction of vapor atoms which deposit in NLOS positions on the substrate such as backside (21) of fiber (65) as indicated by vapor streamlines (51). Vapor impact width (VIW) is the width of the vapor flux impacting on some area of the fiber. Front side coating (FSC) width is the vapor width of atoms impacting on the substrate frontside (22).
    Type: Grant
    Filed: April 25, 2003
    Date of Patent: May 18, 2010
    Assignee: University of Virginia Patent Foundation
    Inventors: Derek D. Hass, Douglas T. Queheillalt, Haydn N. G. Wadley
  • Preparation of metallic nanoparticles
    Patent number: 7718094
    Abstract: A method for the formation of metallic nanoparticles, such as gold and silver nanoparticles, which involves, combining in a single solution, solvent, metal ions and copolymers under conditions such that metal nanoparticles are formed. The copolymers have both reducing components and stabilizing components. The method can be used to form metal nanoparticles having a desired shape and size.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: May 18, 2010
    Assignee: The Research Foundation of State University of New York
    Inventors: Paschalis Alexandridis, Toshio Sakai
  • Granulysin and uses thereof
    Patent number: 7718378
    Abstract: Disclosed are uses of granulysin in methods of diagnosing or treating autoimmune disorders.
    Type: Grant
    Filed: June 22, 2007
    Date of Patent: May 18, 2010
    Assignees: Academia Sinica, Chang Gung Medical Foundation, Linkou Branch
    Inventors: Yuan-Tsong Chen, Wen-Hung Chung, Shuen-Iu Hung
  • Methods for determining particle size of metal nanocatalyst for growing carbon nanotubes
    Patent number: 7719265
    Abstract: Methods and processes for determining the particle size distribution of metal catalysts are provides. Superconducting Quantum Interference Device (SQUID) magnetometer is used to evaluate the magnetic catalyst particle sizes dispersed in the support material. Dependence on variation of the metal/support material ratio, which defines the metal particle sizes, the catalyst can show paramagnetic, superparamagnetic, and ferromagnetic behaviors.
    Type: Grant
    Filed: November 17, 2004
    Date of Patent: May 18, 2010
    Assignees: Honda Motor Co., Ltd., The Ohio State University Research Foundation
    Inventors: Avetik Harutyunyan, Elena Mora Fernandez, Toshio Tokune
  • Cancer vaccines containing epitopes of oncofetal antigen
    Patent number: 7718762
    Abstract: Disclosed are fragments of oncofetal antigen, otherwise known as immature laminin receptor protein that specifically stimulate one T cell subclass. The fragments may be formulated into compositions for potentiating T cell-mediated responses in mammalian cancer patients. They also have therapeutic uses in vitro.
    Type: Grant
    Filed: August 4, 2003
    Date of Patent: May 18, 2010
    Assignee: South Alabama Medical Science Foundation
    Inventors: Joseph H. Coggin, Jr., James W. Rohrer, Adel L. Barsoum
  • On-chip magnetic components
    Patent number: 7719112
    Abstract: An integrated circuit chip comprising a bond wire and a mass of magnetic material provided on the bond wire, wherein the mass of magnetic material increases the inductance of the bond wire.
    Type: Grant
    Filed: August 7, 2007
    Date of Patent: May 18, 2010
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Zheng John Shen
  • Use of 2-methylene-19-nor-20(S)-1alpha,25dihydroxy vitamin d3 to inhibit mammary tumor
    Patent number: 7718636
    Abstract: This invention provides pharmaceutical uses for 2-methylene-19-nor-20(S)-1?,25-dihydroxyvitamin D3. Administration of this compound increases the life expectancy of human beings, especially elderly human beings. In particular, it increases the survival rate of females lacking estrogen, especially post-menopausal females, and reduces mortality resulting from spontaneous development of malignant tumors in both males and females.
    Type: Grant
    Filed: June 21, 2006
    Date of Patent: May 18, 2010
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Hector F. DeLuca, Lori A. Plum, Margaret Clagette-Dame
  • Controlled fusion in a field reversed configuration and direct energy conversion
    Patent number: 7719199
    Abstract: A system and apparatus for controlled fusion in a field reversed configuration (FRC) magnetic topology and conversion of fusion product energies directly to electric power. Preferably, plasma ions are magnetically confined in the FRC while plasma electrons are electrostatically confined in a deep energy well, created by tuning an externally applied magnetic field. In this configuration, ions and electrons may have adequate density and temperature so that upon collisions they are fused together by the nuclear force, thus forming fusion products that emerge in the form of an annular beam. Energy is removed from the fusion product ions as they spiral past electrodes of an inverse cyclotron converter. Advantageously, the fusion fuel plasmas that can be used with the present confinement and energy conversion system include advanced (aneutronic) fuels.
    Type: Grant
    Filed: March 17, 2008
    Date of Patent: May 18, 2010
    Assignees: The Regents of the University of California, University of Florida Research Foundation
    Inventors: Hendrik J. Monkhorst, Norman Rostoker
  • Non-magnetic semiconductor spin transistor
    Patent number: 7719070
    Abstract: A nonmagnetic semiconductor device which may be utilized as a spin resonant tunnel diode (spin RTD) and spin transistor, in which low applied voltages and/or magnetic fields are used to control the characteristics of spin-polarized current flow. The nonmagnetic semiconductor device exploits the properties of bulk inversion asymmetry (BIA) in (110)-oriented quantum wells. The nonmagnetic semiconductor device may also be used as a nonmagnetic semiconductor spin valve and a magnetic field sensor. The spin transistor and spin valve may be applied to low-power and/or high-density and/or high-speed logic technologies. The magnetic field sensor may be applied to high-speed hard disk read heads. The spin RTD of the present invention would be useful for a plurality of semiconductor spintronic devices for spin injection and/or spin detection.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: May 18, 2010
    Assignee: University of Iowa Research Foundation
    Inventors: Kimberley C. Hall, Wayne H. Lau, Kenan Gündo{hacek over (g)}du, Michael E. Flatté, Thomas F. Boggess
  • Method of designing rotary thermal actuator and rotary thermal actuator
    Patent number: 7719161
    Abstract: Provided are a method of designing a rotary thermal actuator and a rotary thermal actuator. The method includes setting the shape of an entire design domain; dividing the entire design domain into a predetermined number of domains which are symmetrical to one another in a rotational direction from the center of the entire design domain; designing the domains using a topology optimization method which uses a driving stage disposed at the center of the entire design domain, an initial shape of thermal expansion members which connect electrodes disposed at outer boundaries of the entire design domain, material properties of the thermal expansion members, and boundary conditions of the domains; and designing the entire design domain such that the designed domains are symmetrical to one another in the rotational direction.
    Type: Grant
    Filed: July 5, 2007
    Date of Patent: May 18, 2010
    Assignee: Seoul National University Industry Foundation
    Inventors: Seok Heo, Yoon Young Kim
  • Proteins with repetitive bacterial-Ig-like (big) domains present in species
    Patent number: 7718183
    Abstract: The invention relates to three isolated DNA molecules that encode for proteins, BigL1, BigL2 and BigL3, in the Leptospira sp bacterium which have repetitive Bacterial-Ig-like (Big) domains and their use in diagnostic, therapeutic and vaccine applications. According to the present invention, the isolated molecules encoding for BigL1, BigL2 and BigL3 proteins are used for the diagnosis and prevention of infection with Leptospira species that are capable of producing disease in humans and other mammals, including those of veterinary importance.
    Type: Grant
    Filed: January 17, 2006
    Date of Patent: May 18, 2010
    Assignees: The United States of America represented by the Department of Veterans Affairs, The Regents of the University of California, Cornell Research Foundation, Inc., Fundação Oswaldo Cruz—FIOCRUZ
    Inventors: Albert I. Ko, Mitermayer Galvão Reis, Julio Henrique Rosa Croda, Isadora Cristina Siqueira, David A. Haake, James Matsunaga, Lee W. Riley, Michele Barocchi, Tracy Ann Young