Abstract: A scanning probe microscope includes a plate moveable in an x-axis direction, a y-axis direction, and a z-axis direction, and a probe tip coupled to the plate. A plurality of actuators cooperate to move the probe tip with three degrees of freedom of movement.
Abstract: The present invention concerns compounds derived from tunicates of the species Synoicum adareanum, as well as to pharmaceutical compositions comprising these compounds and methods of use. Extracts from tunicates show selective toxicity against several different cancer cell lines in the NCI 60 cell line panel. These compounds are useful in the effective treatment of cancers, particularly malignant melanomas, colon cancer, and renal cancer cell lines.
Type:
Application
Filed:
November 13, 2009
Publication date:
March 11, 2010
Applicants:
University of South Florida, The UAB Research Foundation
Inventors:
Bill J. Baker, Thushara Diyabalanage, James B. McClintock, Charles D. Amsler
Abstract: The invention provides methods and compositions for diagnosing risk of low BMD and risk of osteoporosis based on the detection of SNP identity for human chromosome 1p36 polymorphisms designated in the NCBI SNP database (dbSNP) as rs2794328, rs446529, rs397559 and rs1802353.
Type:
Application
Filed:
September 29, 2009
Publication date:
March 11, 2010
Applicant:
The Nemours Foundation
Inventors:
Marcella Devoto, Katia Sol-Church, Loretta D. Spotila
Abstract: A system for effectively pre-distributing keys for a distributed sensor network is disclosed, The system includes: a plurality of sensor nodes, each of which has a sensing function, a calculation function, and a wireless communication function; and a base station which is connected to the sensor nodes over a wireless network, receives data from the sensor nodes, acts as a data central station, and distributes keys for inter-sensornode security authentication to the sensor nodes. A key management unit contained in the base station, generates a set of the sensor nodes used for security authentication between the sensor nodes, decomposes the set of the sensor nodes into a plurality of matrices, distributes the matrices to the sensor nodes, and allows the sensor nodes to search for a common private key required for the security authentication using the received matrices. Therefore, the system can always search for a common private key between the sensor nodes.
Type:
Application
Filed:
December 4, 2006
Publication date:
March 11, 2010
Applicant:
Sungkyunkwan Univ. Foundation For Corporate Coll.
Abstract: The invention provides an isolated H3 equine influenza A virus, as well as methods of preparing and using the virus, and genes or proteins thereof.
Type:
Application
Filed:
July 15, 2009
Publication date:
March 11, 2010
Applicant:
Wisconsin Alumni Research Foundation
Inventors:
Christopher W. Olsen, Gabriele A. Landolt, Alexander I. Karasin
Abstract: The subject invention utilizes the characteristics of in vivo tissue impedances to provide an embodiment of a retinal rake capable of providing a visible and/or preferably an audible signal to a surgeon that more clearly indicates which type of tissue(s) is in contact with the retinal rake. A preferred embodiment comprises a handheld, battery operated retinal rake having two electrodes, wherein at least one electrode is the modified retinal rake. Upon contact with different optical tissues, e.g., epiretinal membranes, retinal tissue, vitreous humor, etc., the electrodes detect varying impedances which are translated by onboard circuitry into various signals that indicate what type of tissue, fluid, structure, etc. is in contact with the retinal rake.
Type:
Application
Filed:
September 12, 2007
Publication date:
March 11, 2010
Applicant:
University of Florida Research Foundation, Inc.
Inventors:
Shalesh Kaushal, Michael Darnall Furman, Jennifer Delight Simonotto, Abraham Miliotis
Abstract: A bulk thermoelectric material includes a matrix, the matrix including a crystalline thermoelectric material; and metal oxide particles disposed in the matrix at a grain boundary or within a crystal structure of the crystalline thermoelectric material.
Type:
Application
Filed:
September 4, 2009
Publication date:
March 11, 2010
Applicants:
SAMSUNG ELECTRONICS CO., LTD., Chungju National University Industry-Academic Cooperation Foundation
Inventors:
Sang-mock LEE, Eun-sung LEE, Kyu-hyoung LEE, Il-ho KIM
Abstract: Methods, systems and compositions for a green sorption media for bioretention soil amendments in drainfields for on-site waste water systems filled with the green sorption media to foster an anaerobic or anoxic environment saturated. The green sorption media includes one or more recycled materials, including tire crumb, sawdust, orange peel, coconut husks, leaf compost, oyster shell, soy bean hulls and one or more naturally occurring materials including peat, sands, zeolites, and clay. The wastewater filtration system for a passive drainfield includes the green sorption material mixture, a cell including baffled compartments and a riser, the cell filled with green sorption material mixture to provide an alternating cycle of aerobic and anoxic environments, an influent distribution system to distribute the influent over the cell, and a piping system arranged for dosing the cell to sustain the functionality of the green sorption material mixture to remove nutrient content in wastewater.
Type:
Application
Filed:
September 11, 2008
Publication date:
March 11, 2010
Applicant:
University of Central Florida Research Foundation, Inc.
Inventors:
Martin P. Wanielista, Ni-Bin Chang, Ammarin Makkeasorn
Abstract: Methods and pharmaceutical compositions for providing neuroprotection to the animal central nervous system against the effects of ischemia, and neurodegeneration. Patients at risk for certain diseases or disorders that are associated with cerebral ischemia may benefit, e.g., those at risk for Alzheimer's disease, Parkinson's disease, Wilson's disease or stroke or those patients having head or spinal cord injury. Patients undergoing certain medical procedures that may result in ischemia may also benefit. Initially, the possibility of ischemia or neurodegeneration is recognized. Intranasal therapeutic agents are administered to the upper third of the nasal cavity to bypass the blood-brain barrier and access the central nervous system directly to avoid unwanted and potentially lethal side effects. Therapeutic agents include those substances that interact with iron and/or copper such as iron chelators and copper chelators. A particular example of such therapeutic agents is the iron chelator deferoxamine (DFO).
Type:
Application
Filed:
November 16, 2009
Publication date:
March 11, 2010
Applicant:
HealthPartners Research Foundation
Inventors:
William H. Frey II, Samuel Scott Panter, Leah Ranae Bresin Hanson
Abstract: Provided is a pharmaceutical or food or drink composition for preventing or treating alcohol-induced fatty liver or steatohepatitis comprising metadoxine (pyridoxol 1-2-pyrrolidone-5-carboxylate) and garlic oil as active ingredients. The concurrent administration of metadoxine and garlic oil according to the present invention exhibits outstandingly superior effects of inhibiting the accumulation of triglyceride and increase of blood AST (aspartate aminotransferase) level in liver el tissue, inhibiting the expression of FAS (fatty acid synthase), CYP2E1 and iNOS (inducible nitric oxide synthase) and inhibiting the deactivation of AMPK (AMP-activated protein kinase), as compared to the administration of metadoxine or garlic oil only.
Type:
Application
Filed:
November 30, 2007
Publication date:
March 11, 2010
Applicant:
SUN R & D Foundation
Inventors:
Sang Geon Kim, Sung Hwan Ki, Jae Hoon Choi
Abstract: Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.
Type:
Grant
Filed:
January 30, 2004
Date of Patent:
March 9, 2010
Assignees:
University of Iowa Research Foundation, The United States of America as represented by the Department of Health and Human Services, Coley Pharmaceutical Group, Inc.
Inventors:
Arthur M. Krieg, Dennis Klinman, Alfred D. Steinberg
Abstract: A composition for human or animal consumption for supplying folate which includes a natural isomer of reduced folate, such as (6S)-tetrahydrofolic acid. 5-methyl-(6S)-tetrahydrofolic acid, 5-formyl-(6S)-tetrahydrofolic acid, 10-formyl-(6R)-tetrahydrofolic acid, 5,10-methylene-(6R)-tetrahydrofolic acid, 5,10-methenyl-(6R)-tetrahydrofolic acid, 5-formimino-(6S)-tetrahydrofolic acid, and their polyglutamyl derivatives is disclosed. Such compositions include multivitamin preparations (with or without minerals and other nutrients); breakfast foods such as prepared cereals, toaster pastries and breakfast bars; infant formulas; dietary supplements and complete diet and weight-loss formulas and bars; animal feed (for example pet foods) and animal feed supplements (such as for poultry feed). The amount of the natural isomer of a reduced folate in a composition for human consumption can range between about 5% and about 200% of the daily requirement for folic acid per serving or dose.
Type:
Grant
Filed:
February 3, 2007
Date of Patent:
March 9, 2010
Assignee:
South Alabama Medical Science Foundation
Abstract: A method for filtering a measurement of density of an object is described. The method includes filtering the measurement of the density and preserving a local average of the measurement and additional measurements when performing the filtering.
Type:
Grant
Filed:
September 12, 2005
Date of Patent:
March 9, 2010
Assignees:
Purdue Research Foundation, The University of Notre Dame du lac, General Electric Company
Inventors:
Ken David Sauer, Charles Addison Bouman, Jiang Hsieh, Jean-Baptiste Thibault
Abstract: Matrix metalloproteinases are major mediators of tissue destruction in various chronic inflammatory disorders. The present invention demonstrates that over-expression of intracellular isoform of IL-1 receptor antagonist confers to recipient cells resistance to signaling pathways of proinflammatory cytokines (such as tumor necrosis factor alpha and IL-1 beta) that induce matrix metalloproteinase and subsequent tissue degradation. Hence, over-expression of intracellular IL-1 receptor antagonist may inhibit tissue destruction in various inflammatory disorders such as rheumatoid arthritis, other arthritides, degenerative intervertebral disc disease and chronic skin ulcers that occurs in diabetes mellitus and bed-ridden patients.
Type:
Grant
Filed:
April 27, 2006
Date of Patent:
March 9, 2010
Assignee:
The University of Tennessee Research Foundation
Inventors:
Karen A. Hasty, Sivadasan Kanangat, Arnold Postlethwait
Abstract: An apparatus (10) for cutting bone includes a shaft member (12) having a central axis (14) and extending between a proximal end portion (16) and a distal end portion (18). The proximal end portion (16) has a first surface (32) adapted to receive repetitive impacts. The distal end portion (18) includes a cutting blade (40) extending in a first plane between a shield section (46) and a guide portion (60). The shield section (46) and the guide section (60) project axially beyond the cutting blade (40) to recess the cutting blade (40) in the distal end portion (18). The shield section (46) includes an inwardly facing shield surface (48) which extends in a second plane that is transverse to the first plane of the cutting blade (40). The apparatus (10) is a form of an osteotome that is particularly useful for certain spine-related surgical procedures.
Abstract: An apparatus and method for performing beamforming or transmitting a plurality of bit streams output through Adaptive Modulation and Coding (AMC) via a plurality of transmission antennas in a base station using a multi-antenna scheme. The apparatus and method include classifying the plurality of transmission antennas into a plurality of transmission antenna groups; selecting one of the transmission antenna groups depending on a group selection signal being fed back from a mobile station; and outputting each of the bit streams to its associated transmission antenna among the transmission antennas constituting the selected transmission antenna group.
Type:
Grant
Filed:
July 13, 2005
Date of Patent:
March 9, 2010
Assignees:
Samsung Electronics Co., Ltd, Seoul National University Industry Foundation
Inventors:
Ho-Jin Kim, Ju-Ho Lee, Kwang-Bok Lee, Hyoung-Woon Park, Ho Yang, Pandharipande Ashish, Sung-Jin Kim
Abstract: Methods are described for determining sulfonator status of a patient and determining dosages of drugs based on copy number of the SULT1A1 gene.
Type:
Grant
Filed:
November 14, 2006
Date of Patent:
March 9, 2010
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
Richard M. Weinshilboum, Araba A. Adjei, Scott J. Hebbring, Stephen N. Thibodeau
Abstract: The invention provides a method to C-terminally label proteins in a complex sample and identify those proteins, e.g., using mass spectrometry.
Abstract: Disclosed is a method for detection of ligand-cell membrane protein binding by solid state NMR spectroscopy. The method starts by forming a lipid bilayer inside nanopores of an anodic aluminum oxide (AAO) substrate, the lipid bilayer containing a membrane protein sample. The AAO substrate is treated with multiple candidate ligands having potential binding affinity for the membrane protein. Solid-state NMR analysis is performed on the treated AAO/lipid preparation so as to generate an NMR spectrum for the treated membrane protein. The solid-state NMR spectrum of the treated membrane protein is compared with the spectrum of the same preparation of membrane protein in the absence of the ligands. It is then determined whether the solid-state NMR spectrum of the treated membrane protein has shifted from the NMR spectrum of the untreated membrane protein, a shift being indicative of protein binding by the candidate ligand.
Type:
Grant
Filed:
February 5, 2009
Date of Patent:
March 9, 2010
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Timothy A. Cross, William W. Brey, Alexej Smirnov, Eduard Y. Chekmenev
Abstract: Hibiscus ‘Panama Bronze’ is an ornamental variety, crossed and cultivated in Georgia. The plants of the new Hibiscus variety display new growth with an intense bronze color in high light that matures to a green color with bronze edging, deeply cut foliage, stable foliage color, very large flowers, thrives in hot an humid conditions, and flowers heavily during short days (November to April) in zone 10. ‘Panama Bronze’ can be grown in the garden or in a container.
Type:
Grant
Filed:
July 30, 2007
Date of Patent:
March 9, 2010
Assignee:
University of Georgia Research Foundation