Patents Assigned to Foundation
  • METHOD OF CONSOLIDATING PRECIPITATION-HARDENABLE ALLOYS TO FORM CONSOLIDATED ARTICLES WITH ULTRA-FINE GRAIN MICROSTRUCTURES
    Publication number: 20060278308
    Abstract: A method by which consolidated articles can be produced from nanocrystalline materials to have mechanical properties that can be improved through thermal treatment. The method entails machining a body to produce polycrystalline chips having nanocrystalline microstructures, and then consolidating the chips to form a consolidated article having mechanical properties that exceed that of the body from which the chips were formed. In particular, consolidation of nanocrystalline chips formed by machining a supersaturated solid-solution body causes precipitation of a fine dispersion of precipitates in the consolidated article, with the potential for certain properties to even improve during consolidation or subsequent thermal treatment of the consolidated article.
    Type: Application
    Filed: May 3, 2006
    Publication date: December 14, 2006
    Applicant: Purdue Research Foundation
    Inventors: M. Shankar, Srinivasan Chandrasekar, W. Compton, Alexander King, Kevin Trumble
  • Processes for the preparation of paclitaxel
    Publication number: 20060281933
    Abstract: The present invention provides processes for the production of paclitaxel. Paclitaxel is produced by protecting the C(7) and the C(10) hydroxy groups of 10-DAB with a bridging silicon-based protecting group. The resulting 7,10-protected 10-DAB derivative is then derivatized and deprotected to form paclitaxel.
    Type: Application
    Filed: June 8, 2006
    Publication date: December 14, 2006
    Applicant: Florida State University Research Foundation, Inc.
    Inventors: Phong Vu, Robert Holton
  • In-Vitro fertilization systems with spermatozoa separated into X-chromosome and Y-chromosome bearing populations
    Publication number: 20060281176
    Abstract: An IVF system for successfully utilizing spermatozoa separated into X-chromosome bearing and into Y-chromosome bearing population for insemination. The IVF system includes fertilization medium that can shorten the time from insemination to cleavage and a portable incubator for the transportation of maturing oocytes and inseminated oocytes comprising a straw (19) and an incubation element (20) that can be sealed with a cap (22).
    Type: Application
    Filed: August 21, 2006
    Publication date: December 14, 2006
    Applicants: XY, Inc., Colorado State University through its agent Colorado State University Research Foundation
    Inventors: George Seidel, Kehuan Lu, Tae Suh
  • Composite of high melting polymer and nanoclay with enhanced properties
    Patent number: 7148282
    Abstract: A composite of a polyester, e.g., a polycarbonate, and a nanoclay (layered silicate) cation exchanged with a quaternized copolymer of styrene and 2-(dimethylamine) ethyl methacrylate is provided, the composite being useful for preparing injection molded objects and after injection molding being transparent and without coloration and has enhanced modulus and strength compared to neat polyester and does not have loss of elongation and toughness compared to neat polyester.
    Type: Grant
    Filed: December 19, 2003
    Date of Patent: December 12, 2006
    Assignee: Cornell Research Foundations, Inc.
    Inventors: Emmanuel P. Giannelis, Jin Zhu, Byoungkyeu Park, Kyung Hoon Seo
  • Chimeric retroviral gag genes and screening assays
    Patent number: 7148325
    Abstract: The subject invention provides novel and advantageous methods for identifying amino acid sequences in random peptide libraries that can bind to Gag polypeptides. The subject invention also establishes a novel in vitro system that can be used to test competitive inhibitors of retrovrial capsid assembly. Also provided are peptides, and compositions containing these peptides, which are inhibitors of the retrovirus Gag protein(s) function. Chimeric Gag polypeptides are also provided.
    Type: Grant
    Filed: September 28, 2001
    Date of Patent: December 12, 2006
    Assignee: The UAB Research Foundation
    Inventors: Michael Sakalian, Eric Hunter
  • Non-toxic immune stimulating enterotoxin compositions
    Patent number: 7148065
    Abstract: Pyrogenic toxins, such as staphylococcal enterotoxins, modified in the disulfide loop region are provided. The modified toxins retain useful biological properties but have substantially reduced toxicity compared to the corresponding unmodified native toxin. The native pyrogenic toxins are typically modified by deletions within the disulfide loop region to produce modified enterotoxins having 100-fold or greater decrease in toxicity.
    Type: Grant
    Filed: August 20, 2004
    Date of Patent: December 12, 2006
    Assignee: Idaho Research Foundation, Inc.
    Inventor: Gregory I. Bohach
  • Method of rapid production of hybridomas expressing monoclonal antibodies on the cell surface
    Patent number: 7148040
    Abstract: The present invention relates to genetically altered hybridomas, myelomas and B cells. The invention also relates to utilizing genetically altered hybridomas, myelomas and B cells in methods of making monoclonal antibodies. The present invention also provides populations of hybridomas and B cells that can be utilized to make a monoclonal antibody of interest.
    Type: Grant
    Filed: February 20, 2002
    Date of Patent: December 12, 2006
    Assignees: University of Georgia Research Foundation, Inc., Abeome Corporation
    Inventors: Richard B. Meagher, Vince Laterza
  • Magnetic resonance imaging with fat suppression
    Patent number: 7148685
    Abstract: A three-dimensional projection reconstruction pulse sequence acquires two half echoes in a steady state free precession (SSFP) scan. A method for combining the two echoes to suppress either fat or water in the reconstructed image is described includes shifting the phase of one echo and combining them in a regridding process used to transform the radial data to a Cartesian grid prior to image reconstruction.
    Type: Grant
    Filed: September 14, 2004
    Date of Patent: December 12, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Walter F. Block, Aiming Lu
  • Method of preparing catalyst for polymerization of aliphatic polycarbonate and method of polymerizing aliphatic polycarbonate using same
    Patent number: 7148317
    Abstract: Disclosed is a method of preparing a catalyst for polymerization of an aliphatic polycarbonate including oxidizing a dicarboxylic acid precursor and a zinc precursor under a pressurized condition, and a method for polymerizing the aliphatic polycarbonate.
    Type: Grant
    Filed: June 19, 2003
    Date of Patent: December 12, 2006
    Assignees: Posco, Postech Foundation
    Inventors: Seung-Jae Moon, Moon-Hor Ree, Jong-Sung Kim, Kie-Soo Kim
  • High sensitivity mechanical resonant sensor
    Patent number: 7148017
    Abstract: A system and method for detecting mass based on a frequency differential of a resonating micromachined structure, such as a cantilever beam. A high aspect ratio cantilever beam is coated with an immobilized binding partner that couples to a predetermined cell or molecule. A first resonant frequency is determined for the cantilever having the immobilized binding partner. Upon exposure of the cantilever to a solution that binds with the binding partner, the mass of the cantilever beam increases. A second resonant frequency is determined and the differential resonant frequency provides the basis for detecting the target cell or molecule. The cantilever may be driven externally or by ambient noise. The frequency response of the beam can be determined optically using reflected light and two photodetectors or by interference using a single photodetector.
    Type: Grant
    Filed: November 14, 2000
    Date of Patent: December 12, 2006
    Assignee: Cornell Research Foundation, Inc.
    Inventors: Harold G. Craighead, Bojan Ilic, David Alan Czaplewski, Robert H. Hall
  • Human cytomegalovirus glycoprotein O as a new drug target and subunit vaccine candidate
    Patent number: 7147861
    Abstract: A method of designing a new anti-CMV drug is disclosed. In one embodiment, the invention comprises (a) analyzing the binding of glycoprotein O to a glycoprotein O receptor and (b) designing a candidate drug that would competitively interfere with glycoprotein O binding to glycoprotein O receptor and (c) showing that the candidate drug competitively inhibits glycoprotein O binding to glycoprotein O receptor. A method of screening anti-CMV drugs, a vaccine effective to diminish CMV infection, and a method of diminishing CMV infection are also disclosed.
    Type: Grant
    Filed: June 26, 2002
    Date of Patent: December 12, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Teresa Compton, Mary T. Huber
  • Printing medium comprising aerogel materials
    Patent number: 7147701
    Abstract: New aerogels are disclosed which comprise silica, at least one organic polymer having polar functional groups, and at least one metal ion. Also disclosed are methods for making such aerogels. The present invention further concerns printable objects comprising these aerogels, specifically when the print media are imaged by the absorption of liquid and the spatial localization of pigments or dyes.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: December 12, 2006
    Assignee: Brown University Research Foundation
    Inventors: William M. Risen, Jr., Shuang Ji, Xiangjun Hu, Ruiyun Zhang
  • Portable surface plasmon resonance imaging instrument
    Patent number: 7148968
    Abstract: A surface plasmon resonant device provides practical portable operation through the use of a low power high efficiency LED source and a high-efficiency prism sample cell pre-loaded with probe molecules and sealed for field use. A simple mechanical control allows adjustment of angulation of the light and camera for accurate response outside of the laboratory.
    Type: Grant
    Filed: April 10, 2003
    Date of Patent: December 12, 2006
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Eric P. Codner, Robert M. Corn
  • Submucosa gel compositions
    Patent number: 7147871
    Abstract: A composition comprising enzymatically digested submucosa of a warm-blooded vertebrate and a method of making that composition is described. More particularly the submucosa is enzymatically digested and gelled to form a shape retaining gel matrix suitable for inducing cell proliferation and growth both in vivo and in vitro.
    Type: Grant
    Filed: September 3, 2002
    Date of Patent: December 12, 2006
    Assignee: Purdue Research Foundation
    Inventors: Sherry L. Voytik-Harbin, Andrew O. Brightman, Ryan M. Meixner, Beverly Z. Waisner
  • Recombinant poliovirus for the treatment of cancer
    Patent number: 7147848
    Abstract: The present invention is directed to non-pathogenic, oncolytic, recombinant polioviruses for the treatment of various forms of malignant tumors. The recombinant polioviruses of the invention are those in which the internal ribosomal entry site (IRES) of the wild type poliovirus was exchanged with the IRES of other picornaviruses, and optionally P1, P3 or the 3?NTR thereof was exchanged with that of poliovirus Sabin type. More particularly, the present invention is directed to the administration of the non-pathogenic, oncolytic, recombinant poliovirus to the tumor directly, intrathecally or intravenously to cause tumor necrosis. The method of the present invention is particularly useful for the treatment of malignant tumors in various organs, such as: breast, colon, bronchial passage, epithelial lining of the gastrointestinal, upper respiratory and genito-urinary tracts, liver, prostate and the brain.
    Type: Grant
    Filed: June 19, 2002
    Date of Patent: December 12, 2006
    Assignee: The Research Foundation of State University of New York
    Inventors: Matthias Gromeier, Eckard Wimmer
  • Orally administered small peptides synergize statin activity
    Patent number: 7148197
    Abstract: This invention provides novel peptides for the treatment of atherosclerosis.
    Type: Grant
    Filed: August 26, 2003
    Date of Patent: December 12, 2006
    Assignees: The Regents of the University of California, The University of Alabama Research Foundation
    Inventors: Alan M Fogelman, Gattadahalli M Anantharamaiah, Mohamad Navab
  • Hydrothermal synthesis of perovskite nanotubes
    Patent number: 7147834
    Abstract: A low-temperature hydrothermal reaction is provided to generate crystalline perovskite nanotubes such as barium titanate (BaTiO3) and strontium titanate (SrTiO3) that have an outer diameter from about 1 nm to about 500 nm and a length from about 10 nm to about 10 micron. The low-temperature hydrothermal reaction includes the use of a metal oxide nanotube structural template, i.e., precursor. These titanate nanotubes have been characterized by means of X-ray diffraction and transmission electron microscopy, coupled with energy dispersive X-ray analysis and selected area electron diffraction (SAED).
    Type: Grant
    Filed: August 11, 2004
    Date of Patent: December 12, 2006
    Assignee: The Research Foundation of State University of New York
    Inventors: Stanislaus Wong, Yuanbing Mao
  • System and method for performing a three-dimensional virtual segmentation and examination with optical texture mapping
    Patent number: 7148887
    Abstract: A system and method for generating a three-dimensional visualization image of an object such as an organ using volume visualization techniques and exploring the image using a guided navigation system which allows the operator to travel along a flight path and to adjust the view to a particular portion of the image of interest in order, for example, to identify polyps, cysts or other abnormal features in the visualized organ. An electronic biopsy can also be performed on an identified growth or mass in the visualized object. Virtual colonoscopy can be enhanced by electronically removing residual stool, fluid and non-colonic tissue from the image of the colon, by employing bowel preparation followed by image segmentation operations. Methods are also employed for virtually expanding regions of colon collapse using image segmentation results.
    Type: Grant
    Filed: October 10, 2001
    Date of Patent: December 12, 2006
    Assignee: The Research Foundation of State University of New York
    Inventors: Arie E. Kaufman, Zhengrong Liang, Mark R. Wax, Ming Wan, Dongquing Chen
  • Method and apparatus for microwave phosphor synthesis
    Patent number: 7148456
    Abstract: A method of microwave synthesis of phosphors includes a microwave furnace having a microwave chamber; providing starting material in the microwave chamber; and subjecting the starting material to microwaves, whereby the starting material is synthesized into phosphors. An insulation package for use in microwave synthesis is disclosed that includes an insulator having an opening therein, wherein the opening is substantially symmetrically disposed in relation to a central axis of the insulator, and wherein the opening is adapted to receive starting material. A susceptor configuration may be positioned within the cavity, wherein the insulator, the cavity, and the susceptor configuration are substantially symmetrically disposed in relation to an axis of rotation of the insulation package. A microwave furnace for continuous microwave synthesis of phosphors is also disclosed.
    Type: Grant
    Filed: September 15, 2004
    Date of Patent: December 12, 2006
    Assignee: The Penn State Research Foundation
    Inventors: Dinesh K. Agrawal, Christopher Y. Fang
  • Method and apparatus for tracking moving objects in spatial differential frame pictures
    Patent number: 7149328
    Abstract: Each frame of time-series pictures shot by a camera is converted to a spatial differential frame picture by the following equations: H(i,j)=?|G(i+di,j+dj)?G(i,j)|/(Gi,j,max/Gmax), I=Gmax/{1+exp(?0.02(H?80))}, where ? denotes a sum over di=?1 to 1 and dj=?1 to 1, Gi,j,max denotes the maximum pixel value of 3×3 pixels having its center at the i-th row and j-th column, and Gmax denotes the assumable maximum value 255 of the pixel value G(i, j). Moving objects at a time t is discriminated based on a correlation between spatial differential frame pictures at times (t?1) and t and a discrimination result of moving objects included in the spatial differential frame picture at the time (t?1).
    Type: Grant
    Filed: March 6, 2003
    Date of Patent: December 12, 2006
    Assignees: Fujitsu Limited, The Foundation for the Promotion of Industrial Science
    Inventors: Shunsuke Kamijo, Masao Sakauchi