Abstract: A method is provided for absorbing electromagnetic radiation using a polyaniline composition, wherein the radiation is infrared, visible light, ultraviolet, radar, or microwave radiation. Also provided is a method for reducing the detectability by radar of an object by increasing the absorption of radar waves and thereby decrease the reflection of the radar waves by applying to the object a polyaniline composition or a partially protonated salt thereof.
Type:
Grant
Filed:
July 27, 1992
Date of Patent:
March 15, 1994
Assignee:
The Ohio State University Research Foundation
Inventors:
Arthur J. Epstein, John M. Ginder, Mitchell G. Roe, Hamid Hajiseyedjavdi
Abstract: The present invention is directed to genetically engineered expression systems which encode a recombinant Hepatitis A virus (HAV) proteins capable of forming capsid particles. By way of example baculovirus vectors were utilized in order to express recombinant HAV proteins. The recombinant baculoviruses of the invention are formed by replacing regions of the polyhedrin structural gene coding sequences with HAV DNA by recombinant DNA techniques. Additionally, the polyhedrin transcriptional initiation site is altered in these recombinant baculoviruses such that only HAV proteins and not polyhedrin protein sequences are expressed from the polyhedrin promoter. The recombinant HAV capsid particles produced in accordance with the present invention can be particularly useful as vaccines.
Type:
Grant
Filed:
July 3, 1991
Date of Patent:
March 15, 1994
Assignees:
American Biogenetic Sciences, Inc, University of Iowa Research Foundation
Inventors:
James H. McLinden, Elliot D. Rosen, Patricia L. Winokur, Jack T. Stapleton
Abstract: A method for making a wound field for an electric motor, generator or alternator includes the steps continuously winding an insulated conductor into a coil, having a first plurality of windings wound in a first direction, and a second plurality of windings wound in a second direction opposite the first direction; flattening the coil into a two-layered flat web, and rolling the flat, two-layered web end-to-end into a cylindrical configuration. In one embodiment, a multiphase wound field can be made by winding a plurality of insulated conductors about a common axis to form a group of adjacent coil units. After the first group of coil units is wound, second and subsequent groups can be wound, in alternating directions of winding with respect to the first group, to form an elongate winding assembly. The entire assembly, is then flattened and rolled end-to-end.
Abstract: The pure isomers L-buthionine-S-sulfoximine and L-buthionine-R-sulfoximine are provided. The L-S-isomer has utility, for example, in causing the depletion of glutathione, a major protectant molecule in tumors and certain parasites. The L-R-isomer has utility as a compound decreasing further uptake and thus effect of the L-S-isomer and for causing glutathione depletion specific to the kidney. The isolation of pure isomers from L-buthionine-SR-sulfoximine enables treatment at lower dosages without cross effects.The pure L-buthionine-S-sulfoximine isomer is obtained from L-buthionine-SR-sulfoximine by recrystallization preferably by forming a solution of L-buthionine-SR-sulfoximine in water at a concentration of 0.
Abstract: Mouse monoclonal antibodies which will specifically recognize the pathogen Listeria monocytogenes were produced by fusion of spleen cells from an animal immunized with live L. monocytogenes to an NS-1 myeloma partner, and three hybridomas were identified upon subsequent subcloning, Mab 20-10-2, Mab 36-6-12 and Mab 56-9-16 which were preferentially reactive with L. monocytogenes in a direct binding ELISA assay. An indirect "sandwich" assay was developed and used to further confirm the reactivity of these hybridomas using four serotypes of L. monocytogenes and other common cross reacting bacteria.
Abstract: The reaction between a hydroxyacetic acid derivative bearing an oxygen protecting group and a chiral auxiliary group and an imine produces chiral .beta.-lactams. Hydrolysis of the chiral .beta.-lactams produces chiral amino acid analogs.
Type:
Grant
Filed:
February 27, 1992
Date of Patent:
March 15, 1994
Assignee:
The Research Foundation State University of New York
Abstract: Dormant seeds , e.g., of lettuce, tomatoes, peppers, carrots, onions, impatiens and primrose, are produced by soaking non-dormant seeds in a solution of gibberellin synthesis inhibitor, preferably tetcyclacis, preferably in the dark at 25.degree. C. to 350.degree. C. for at least 24 hours, washing to remove the inhibitor and drying to original seed weight. The dormancy can be released by application of a gibberellin, and in some cases by moist chilling, or exposure to light at 25.degree. C. to 35.degree. C.
Abstract: Pseudomorphic and dislocation free heteroepitaxial structures are formed in which pseudomorphic and heteroepitaxial layers of any desired thickness are grown on thin, free-standing substrates. In the case of pseudomorphic structures, the substrates are chosen to have a thickness less than the critical thickness above which misfit dislocations will form between the pseudomorphic layers and the substrate. Use of thin substrates in this manner prevents the overall strain energy between the two layers from ever becoming large enough to generate misfit dislocations, regardless of the pseudomorphic layer thickness. This concept can also be employed in the formation of defect free heteroepitaxial layers. If a heteroepitaxial layer is grown on a very thin substrate, an effect known as dislocation gettering will cause any dislocations between the two layers to propagate into the substrate, thus leaving the heteroepitaxial layer defect free.
Abstract: An ultrasound system that enables determination of layer thicknesses and contours of a multi-layer organic body includes a transmitter/receiver for obtaining a radio frequency signal from echoes over a plurality of points on the organic surface. Each radio frequency signal is then deconvolved to remove apparatus generated noise and filtered to create an analytic signal that exhibits a magnitude related to an instantaneous rate of arrival of total echo energy received by the transmitter/receiver. Analytic signals from adjacent parallel scans are then cross-correlated and magnitude detected to determine energy peaks to enable accurate determination of echo producing surfaces of each layer of the multi-layer organic body across the plurality of interrogation points. In the application of the invention to Corneal Epithelium Mapping, a pupil monitoring system is included that disables the measurement system if the pupil's gaze wanders so as to cause a diversion of the optical axis.
Type:
Grant
Filed:
July 9, 1993
Date of Patent:
March 15, 1994
Assignees:
Cornell Research Foundation Inc., Riverside Research Institute
Inventors:
Dan Z. Reinstein, Ronald H. Silverman, Donald J. Coleman, Frederic L. Lizzi
Abstract: A method of genetically evaluating animals by using mitochondrial DNA is disclosed. Polymorphisms in mitochondrial DNA are detected by isolating, fragmenting, and sequencing the DNA. The restriction patterns and nucleotide sequences of mitochondrial DNA of different animals are correlated to expressed traits in the animals. This may be confirmed by comparing results to expression of the trait in maternal lineages of animals. Further, effects of maternal lineages are determined by partitioning maternal genetic variation from nuclear variation.
Type:
Grant
Filed:
April 24, 1992
Date of Patent:
March 8, 1994
Assignee:
Iowa State University Research Foundation, Inc.
Inventors:
Donald C. Beitz, Albert E. Freeman, Michael M. Schutz, Gary L. Lindberg
Abstract: This invention relates to deliberately increasing growth hormone in swine during the last 2 weeks of pregnancy through a 3 week lactation. This has the effect of increasing fetal energy storage during late pregnancy which resulted in the newborn piglets having marked enhancement of the ability to maintain plasma concentrations of glucose and free fatty acids when fasted after birth. Likewise, treatment of the sow during lactation results in increased milkfat in the colostrum and an increased milk yield. These effects are important in enhancing survivability of newborn pigs and weight gain prior to weaning.
Type:
Grant
Filed:
April 6, 1992
Date of Patent:
March 8, 1994
Assignee:
Cornell Research Foundation, Inc.
Inventors:
R. Dean Boyd, Dale E. Bauman, Walter R. Butler
Abstract: Intact seed of rapeseed is added to compost at spawning to increase the yield of mushrooms similar to chemical-based delayed-release supplements. No chemicals, however, are needed in its preparation, only a treatment to destroy sprouting of the seed.
Abstract: A sequence directed reagent is constructed by conjugating a methyl naphthoquinone derivative to a hexamethylamino linker attached to the 5' terminus of an oligonucleotide. Annealing this modified fragment of DNA to its complementary sequence allows for target modification subsequent to photochemical activation. The product of this reaction is a covalent crosslink between the reagent and target strands resulting from an alkylation of DNA by the photoexcited quinone. The modified sequence is not labile to acid, base or reductants, and blocks the exonuclease activity of the Klenow fragment of DNA polymerase I. In another embodiment, a highly reactive moiety, such as Br is attached to the methyl group of the naphthoquinone derivative. This reagent is similarly linked to an oligonucleotide probe. Activation of this probe linked alkylating agent is by a reductive signal which may either naturally occur within the cell, such as an enzyme, or introduced into the media containing the target molecule.
Type:
Grant
Filed:
November 29, 1989
Date of Patent:
March 8, 1994
Assignee:
The Research Foundation of State University of New York
Abstract: A filter apparatus for filtering fluids such as gases or liquids includes a casing defining an inlet and an outlet, and having a peripheral wall extending between the inlet and outlet. The peripheral wall defines a chamber having a longitudinal axis and a cross-sectional area, when viewed in the direction of the longitudinal axis, which increases between the inlet and the outlet. A bed of particulate filtering media is disposed within the chamber, the media ranging in size between relatively large particles disposed adjacent the inlet and smaller particles disposed closer to the outlet. Preferably, the size of the particles is chosen based upon the relationship between the lifting force exerted on the particles by a fluid flowing upward through the chamber and the weight of the particles.
Type:
Grant
Filed:
May 13, 1992
Date of Patent:
March 8, 1994
Assignee:
Kansas State University Research Foundation
Abstract: Genetic material encoding luciferase from the marine coelenterate Renilla has been isolated and characterized. This genetic material allows the production of peptides for use as labels in bioluminescence assays or can itself be directly used to identify luciferase genes from related organisms.
Type:
Grant
Filed:
June 17, 1993
Date of Patent:
March 8, 1994
Assignee:
University of Georgia Research Foundation, Inc. Boyd Graduate Studies Research Center
Abstract: A method of treating pneumonia caused by a microorganism by administering directly into the lower respiratory tract of a host an amount of an anti-inflammatory agent effective to reduce inflammation is provided. The method may further include administering to a host an amount of an anti-infectious agent with activity against the microorganism effective to reduce the concentration of the microorganism.
Type:
Grant
Filed:
May 1, 1992
Date of Patent:
March 1, 1994
Assignee:
Henry M. Jackson Foundation for the Advancement of Military Medicine
Abstract: An aqueous cardioplegic solution providing significantly improved cardiac function after a period of exposure to cardioplegia, contains NaCl in the range of 70-110 mM; KCl in the range of 10-16 mM; CaCl.sub.2 in the range of 0.5-1.0 mM; MgCl.sub.2 in the range of 8-16 mM; NaHCO.sub.3 in the range of 10-20 mM; D-Glucose in the range of 5-15 mM; L-Aspartic acid in the range of 5-20 mM; and Lactobionic acid in the range of 0-15 mM.
Type:
Grant
Filed:
February 18, 1992
Date of Patent:
March 1, 1994
Assignee:
The National Heart Foundation of New Zealand
Abstract: A composition useful as a selective preemergence herbicide is provided, comprising an effective amount of a dipeptide selected from the group consisting of Gln-Gln, Ala-Asn, Ala-Gln, Gly-Ala, Ala-Ala and mixtures thereof, in combination with a compatible carrier vehicle.
Type:
Grant
Filed:
August 3, 1993
Date of Patent:
March 1, 1994
Assignees:
Iowa State University Research Foundation, Inc., Grain Processing Corporation
Inventors:
Nick E. Christians, John T. Garbutt, Dianna Liu
Abstract: A prefabricated, easily installable strain gage assembly (10) is provided which includes an elongated synthetic resin substrate (12) having adhesive (16) applied to the majority of one surface thereof while leaving a handling tab portion (18) adjacent one end of the substrate (12). A strain gage unit (28) is secured to the adhesive-bearing surface of substrate (12). A strippable protective film (56) is placed in covering, protective relationship to the strain gage (28) and the adhesive surface of substrate (12). Preferably, the substrate (12), adhesive (16) and film (56) are substantially transparent, and the substrate (12) is provided with perpendicular alignment marks (55, 55a) which are strategically located relative to the strain gage unit (28).
Type:
Grant
Filed:
April 27, 1992
Date of Patent:
March 1, 1994
Assignee:
Kansas State University Research Foundation