Abstract: Novel 6-pyridyl substituted pyrimidine derivatives are disclosed for use as antiviral agents, particularly for the treatment of retroviral infections such as HIV infections and related disorders, as well as for use in anti-cancer therapies to improve the efficacy of anti-cancer therapeutics. These compounds and their pharmacologically acceptable salts operate to disrupt viral replication an exhibit lower cell toxicity, thereby providing more efficient agents for use alone or in conjunction with other chemical or biological agents to provide prolonged antiviral therapy. In addition, the compounds can be used to increase the efficacy of anti-cancer therapeutics including 5-fluropyrimidines such as 5-fluorouracil, thereby reducing the dosage requirement of the therapeutic in anti-cancer therapies so as to decrease toxic effects to the host.

Abstract: Biological applications of synthetic and natural alkaloids derived from the tunicate Eudistoma sp. are disclosed. A method regulating cell growth includes contacting one or more cells with an effective concentration of a compound for regulating cell growth. These compounds include: Segoline A, Segoline B, Isosegoline A, Norosegoline, Debromoshermilamine, Eilatin, 4-methylpyrido[2,3,4-kl] acridine, pyrido[2,3,4-kl]acridine, 1-acetyl-2,6-dimethylpyrido[2,3,4-kl]acridine, and derivatives and combinations of these compounds. An effective concentration range for using these compounds can range from approximately 0.1 .mu.M to 100 .mu.M. The effective concentration range for Eilatin, the most potent of these compounds is from 0.01 .mu.M to 0.99 .mu.M, and the effective concentration range for the other compounds of the present invention is from about 1.0 .mu.M to 100 .mu.M.

Abstract: Device for separating and collecting ultrafine atomized powder from the gas stream of a gas atomizing apparatus comprises a housing having an interior wall oriented at an angle relative to horizontal so as to form a downwardly converging, conical expansion chamber, an inlet conduit communicated to the expansion chamber proximate an upper region thereof for receiving the gas stream, and an outlet proximate a lower region of the expansion chamber. The inlet conduit is oriented at a compound inclined angle (with respect to horizontal) selected to promote separation and collection of powder from the gas stream in the expansion chamber. The compound angle comprises a first entrance angle that is greater than the angle of repose of the powder on the housing interior wall such that any powder accumulation in the inlet conduit tends to flow down the wall toward the outlet.

Abstract: The present invention features low-temperature, self-encapsulated, copper interconnect lines on silicon substrates of Ultra-Large Scale Integration (ULSI) circuits. The interconnect lines are a product of a process that includes the following steps: (a) alloying the copper with titanium in an approximate 10 atomic weight percentage of titanium; (b) depositing a layer of the copper/titanium alloy upon a silicon dioxide/silicon substrate of a ULSI circuit; (c) patterning the copper/titanium layer to form interconnect lines on the substrate; (d) forming a titanium rich surface film on the copper interconnect lines by rapid heating of the copper/titanium interconnect lines at an approximate ramping rate of between 60.degree. and 80.degree. C./minute; and (e) nitriding the titanium rich surface of the interconnect lines in an ammonia atmosphere at low temperatures in an approximate range of between 450.degree. to 650.degree. C.

Abstract: The present invention provides a novel method of vasodilator therapy for treating a patient suffering from a condition, comprising long term, continuous administration of an organic nitrite to a patient suffering from the condition in a dosage form capable of delivering a sufficient therapeutic amount of nitrite to the blood stream of the patent thereby providing effective vasodilator therapy for at least 24 hours without development of tolerance in the patient. The method of the invention is useful in treating conditions such as, for example, angina, particularly chronic, stable angina pectoris, ischemic diseases, congestive heart failure, for controlling hypertension and/or impotence in male patients.Any conventional drug delivery system can be employed in carrying out the method of the invention. The drug delivery system can take virtually as many different forms as there are dosage forms available for delivery of nitrite to a patient.

Abstract: A method and compositions for reducing ischemic, inflammatory or septic injury in an animal that includes administration to the animal of an effective amount of a modified superoxide dismutase, wherein the modification comprises substituting a first amino acid residue located within 3-12 .ANG. of the active site of the superoxide dismutase with a second amino acid residue capable of reacting with a highly reactive nitrating species, such as nitronium ion, formed from the reaction of peroxynitrite and superoxide dismutase.

Abstract: An inbred corn line, designated LB159, is disclosed. The invention relates to the seeds of inbred corn line LH159, to the plants of inbred corn line LH159 and to methods for producing a corn plant produced by crossing the inbred line LH159 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH159 with another corn line.

Abstract: Compositions containing 1.alpha.-hydroxyvitamin D homolog compounds in a suitable carrier and methods employing such compositions are disclosed for cosmetic uses in the treatment of various skin conditions such as lack of adequate skin firmness, wrinkles, dermal hydration and sebum secretion. Various formulations of the compositions including creams, lotions and ointments are disclosed for use topically, orally or parenterally in accordance with this invention.

Abstract: An inbred corn line, designated LH210, is disclosed. The invention relates to the seeds of inbred corn line LH210, to the plants of inbred corn line LH210 and to methods for producing a corn plant produced by crossing the inbred line LH210 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH210 with another corn line.

Abstract: The present invention relates to a novel treatment for myocardial infarction which comprises administering a hapten-binding molecule capable of preventing reformation of fibrin-platelet clots and a thrombolytic agent capable of either dissolving fibrin-platelet clots or inhibiting their formation. The therapy of the invention is capable of increasing clot lysis while minimizing fibrinogen breakdown and preventing the reocclusion of the affected coronary artery. The therapy of the present invention is capable of achieving this goal even in the absence of heparin and when the concentration of thrombolytic agent is lower than that required by other potential therapies.

Abstract: An inbred corn line, designated LH172, is disclosed. The invention relates to the seeds of inbred corn line LH172, to the plants of inbred corn line LH172 and to methods for producing a corn plant produced by crossing the inbred line LH172 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH172 with another corn line.

Abstract: An inbred corn line, designated LH212, is disclosed. The invention relates to the seeds of inbred corn line LH212, to the plants of inbred corn line LH212 and to methods for producing a corn plant produced by crossing the inbred line LH212 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH212 with another corn line.

Abstract: Disclosed is a non-A, non-B hepatitis virus antigen peptide which exhibits antigen-antibody reaction specificity with at least one of sera from a convalescent patient having acute non-A, non-B hepatitis and sera from a patient having chronic non-A, non-B hepatitis. By the use of the antigen peptide of the present invention, not only the diagnosis of non-A, non-B hepatitis but also the screening of blood for transfusion can be achieved with ease and high reliability. The antigen peptide of the present invention may also be used as the basis for a vaccine against non-A, non-B hepatitis.

Abstract: A fabrication process polycrystalline silicon thin film transistors commences with the deposition of an ultra-thin nucleating-site forming layer onto the surface of an insulating substrate (e.g., 7059 glass). Next, an amorphous silicon film is deposited thereover and the combined films are annealed at temperatures that do not exceed 600.degree. C. By patterning the deposition of the nucleating site forming material on the glass substrate, the subsequently deposited amorphous film can be selectively crystallized only in areas in contact with the nucleating-site forming material.

Abstract: An herbal treatment for plant growth comprising a water solution of extracts of the type withdrawn at elevated temperature from Artemesia plants and the like, applicable to the root structure of plants and as an external spray.

Abstract: An inbred line, designated LH216, is disclosed. The invention relates to the seeds of inbred corn line LH216, to the plants of inbred corn line LH216 and to methods for producing a corn plant produced by crossing the inbred line LH216 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH216 with another corn line.

Abstract: An inbred corn line, designated LH213, is disclosed. The invention relates to the seeds of inbred corn line LH213, to the plants of inbred corn line LH213 and to methods for producing a corn plant produced by crossing the inbred line LH213 with itself or another corn line. The invention further relates to hybrid corn seeds and plants produced by crossing the inbred line LH213 with another corn line.

Abstract: The present invention relates to analgesic enkephalin derivatives represented by the following formula:Tyr-A.sub.1 -A.sub.2 -A.sub.3 -A.sub.4 SEQ ID NO:5 (1)and the acid salts thereof, wherein Tyr is L-tyrosine, A.sub.1 or A.sub.2 is a glycine, and that which is not a glycine is an optically active trifluoro amino acid of the formula: ##STR1## wherein n is an integer from 1-3 and m is 1 or 2; A.sub.3 is L-Phenylalanine, or N-methyl-(L)-phenylalanine, and A.sub.4 is L-Methionine, L-Met-OH, L-Met-ol or L-Met-NH.sub.2.

Abstract: A phantom for use in training persons in locating and aspirating tumors identified by X-ray in a human body part consists of a body of a tissue equivalent X-ray permeable material containing at least one aspiratable simulated tumor suspended in the interior of the body. A method of making the phantom also is disclosed.