Abstract: Provided is a method for detecting metastases of epithelial cancers, comprising detecting in non-primary tissue overexpression of a nucleic acid of KS1/4, or detecting in non-primary tissue overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx, the overexpression of a nucleic acid of KS1/4, or the overexpression of a combination of nucleic acids of KS1/4 and PIP, of nucleic acids of KS1/4 and mam, of nucleic acids of PIP and mam, of nucleic acids of KS1/4, PIP and mam, or of nucleic acids of KS1/4 and lunx in non-primary tissue being correlated with metastases of epithelial cancers.

Abstract: Disclosed herein is a method for the optimal design of an apodization function used for non-uniform weighted periodic sparse arrays for an ultrasound imaging system. The method includes the steps of (a) setting the interval PT of a transmit sparse array and the number LT of array elements within the interval PT so that common grating lobes are not generated in the beam patterns of the transmit sparse array and a receive sparse array; (b) setting the interval PR of the receive sparse array and the number LR of array elements within the interval PR so that common grating lobes are not generated in the beam patterns of the transmit sparse array and the receive sparse array; (c) setting a transmit apodization function WT(n) configured to be applied to the beam pattern of the transmit sparse array; and (d) setting a receive apodization function WR(n) configured to be applied to the beam pattern of the receive sparse array.

Abstract: Disclosed is a system and a method for detecting the presence of one or more objects in a turbid medium, the method including: illuminating at least a portion of the turbid medium with incident light having at least one wavelength which interacts with the one or more objects contained in the turbid medium differently than the incident light interacts with the turbid medium; measuring light that emerges from the turbid medium; and detecting and locating the one or more objects using Independent Component Analysis (ICA) of the emergent light from the turbid medium. The present invention is useful for medical applications, such as for finding and locating, a tumor(s) in body organs, or excised tissues. Moreover, the present invention can be used to locate objects in obscuring medium, such as, mines in shallow coastal water, a plane in fog, military targets under fog, smoke or cloud cover.

Abstract: The preferred embodiments generally relate to methods and compositions that affect the GTP-binding activity of members of the Rho family GTPases, preferably Rac (Rac1, Rac2 and/or Rac3), such compositions include compounds that modulate the GTP/GDP exchange activity, along with uses for the compounds including screening for compounds which recognize Rac GTPase, and methods of treating pathological conditions associated or related to a Rho family GTPase, including Rac. The preferred embodiments also relate to methods of using such compounds, or derivatives thereof, e.g., in therapeutics, diagnostics, and as research tools.

Abstract: Systems and methods for computing three-dimensional (3D) Euclidean Voronoi diagrams are disclosed. For some embodiments, a set of 3D objects is accessed, in which each 3D object is mathematically defined. Thereafter, a Voronoi region associated with each of the 3D objects is computed, thereby resulting in a complete Euclidean Voronoi diagram of the set of 3D objects. In some embodiments, the 3D objects are spheres, each of which is defined by a center and a radius. For other embodiments, the 3D objects are convex objects, each of which is mathematically-definable (e.g., cylinders, sphero-cylinders, etc.). Unlike prior approaches that suggested using a numerical approach to computing the Voronoi diagram, the present disclosure employs mathematical approaches for computing the Euclidean Voronoi diagram, thereby improving efficiency in the computation of the Euclidean Voronoi diagram.

Abstract: Materials, compositions, substances and methods and systems for stormwater treatment in wet ponds, dry ponds and a green roof system. A first embodiment provides in-situ treatment unit within the retention pond by withdrawing the stored stormwater to circulate the stored stormwater into the in-situ treatment unit to sorb nitrogen from the stored stormwater. A second embodiment provides uses a riprap apron, a perforated riser located at the bottom of the riprap apron and a geotextile media encased in a sorption media jacket around the perforated riser. A third embodiment provides a green roof stormwater treatment system that includes protection for waterproofing and insulating the roof, a pollution control media layer for filtration and sorption of solids and dissolved materials found in stormwater, a growing media for growing vegetation, and a cistern to store the runoff stormwater between irrigation events.

Abstract: A mobile brain-based device (BBD) includes a mobile platform with sensors and effectors, which is guided by a simulated nervous system that is an analogue of the cerebellar areas of the brain used for predictive motor control to determine interaction with a real-world environment. The simulated nervous system has neural areas including precerebellum nuclei (PN), Purkinje cells (PC), deep cerebellar nuclei (DCN) and an inferior olive (IO) for predicting turn and velocity control of the BBD during movement in a real-world environment. The BBD undergoes training and testing, and the simulated nervous system learns and performs control functions, based on a delayed eligibility trace learning rule.

Abstract: A computer-assisted method for identifying functionalities to add to an organism-specific metabolic network to enable a desired biotransformation in a host includes accessing reactions from a universal database to provide stoichiometric balance, identifying at least one stoichiometrically balanced pathway at least partially based on the reactions and a substrate to minimize a number of non-native functionalities in the production host, and incorporating the at least one stoichiometrically balanced pathway into the host to provide the desired biotransformation. A representation of the metabolic network as modified can be stored.

Abstract: A method for protein identification in complex mixtures that utilizes affinity selection of constituent proteolytic peptide fragments unique to a protein analyte. These “signature peptides” function as analytical surrogates. Mass spectrometric analysis of the proteolyzed mixture permits identification of a protein in a complex sample without purifying the protein or obtaining its composite peptide signature.

Abstract: A cross-linked polyazole, a method of preparing the cross-linked polyazole, an electrode and an electrolyte membrane for a fuel cell, which include the cross-linked polyazole, a method of manufacturing the electrolyte membrane, and a fuel cell including the cross-linked polyazole.

Abstract: The present invention provides an apparatus for measuring a Depth-Of-Interaction (DOI), comprising a crystal layer 10 of a mono layer in which a plurality of crystals for absorbing gamma rays are consecutively arranged, scintillation light detectors disposed at one end of the crystals and configured to detect scintillation light emitted from the crystal layer 10 by the gamma rays, change means included in the crystals and configured to linearly change transmittance in a length direction of the crystals, and a control unit 30 configured to calculate the DOI in the crystal layer 10 on a basis of the first output signal and the second output signal. The scintillation light detector outputs the first output signal in one direction and the second output signal in a direction at a right angle to the one direction.

Abstract: Compounds of formula I: wherein X is selected from oxygen, nitrogen and sulfur; n is 0 or 1; R1 is selected from alkyl, carboxylic acid, carboxylate, carboxamide, ester and combinations thereof; R2 is selected from alkyl, substituted alkyl, carboxylic acid, carboxylate, carboxamide, sulfonyl, sulfonamide and combinations thereof; and derivatives and metabolites thereof. Further provided are methods of using a compound of formula I to prevent and/or treat a subject having a condition characterized by unwanted cell proliferation. Also provided are pharmaceutical compounds comprising one or more compounds of formula I, or derivatives or pharmaceutically acceptable salts thereof.

Abstract: Walking auxiliary equipment 10 includes a walking unit 12 and a bogie 14. The walking unit 12 has a lumber frame 16 put onto the lumber region of a user, a below-knee frame 34 put onto the leg of a user, an above-knee frame 26 for coupling the lumber frame 16 to the below-knee frame 34, through a first joint K1 and a second joint K2, and an assistance force imparting device 102. The assistance force imparting device 102 includes a first actuator 104 for generating assistance force to flex the first joint K1, a second actuator 106 for generating assistance force to flex the second joint K2, a third actuator 108 for generating assistance force to extend the second joint K2, and a fourth actuator 110 for generating assistance force to extend the first joint K1.

Abstract: An apparatus and method for mitigating inter-cell interference in a macro Base Station (BS) of a wireless communication system having at least one femto cell are provided. The method includes restricting the use of at least one code among at least one available code when forming a beam by resource block, constructing a codebook set for each resource block, when feedback information is received from at least one Mobile Station (MS), allocating a resource to the MS in consideration of the feedback information, determining a weight for forming a beam to the MS in consideration of the codebook set for each resource block and the resource allocated to the MS, and forming the beam to the MS using the weight.

Abstract: A method for treating an ocular disorder characterized by the defect or absence of a normal gene in the ocular cells of a human or animal subject involves administering to the subject by subretinal injection an effective amount of a recombinant adeno-associated virus carrying a nucleic acid sequence encoding the normal gene under the control of a promoter sequence which expresses the product of the gene in the ocular cells. The ocular cells are preferably retinal pigment epithelial (RPE) cells, and the gene is preferably an RPE-specific gene, e.g., RPE65. The promoter is one that can express the gene product in the RPE cells. Compositions for subretinal administration are useful in this method.

Abstract: The present invention relates to a biomolecule-based electronic device in which the biomolecule with redox potential is directly immobilized on the substrate. The present invention enables to excellently exhibit the capability of a protein-based bio-memory device in which it is preferable to use the substrate on which cysteine-introduced recombinant proteins are effectively immobilized and a self-assembled layer (SAM) is fabricated. It becomes realized that a redox potential is regulated using intrinsic redox potential of the protein dependent on applied voltage. The present invention provides a novel operating method in which three potentials are applied throughout four steps. The present invention has some advantages of fabricating a protein layer in a convenient manner and inducing electron transfer by fundamental electrochemical or electronic operation.

Abstract: The invention relates to a method for aiding the diagnosis of a disorder in a subject, said method comprising; providing a sample from said subject wherein the sample comprises blood; assaying at least two characteristics of said sample, said characteristics selected from: the structural composition of a polypeptide comprised by said sample; a metabolite comprised by said sample; and a catalytic activity comprised by said sample, wherein each of said at least two characteristics is determined from a multiplexed analysis of the same sample. The invention also relates to certain compositions.

Abstract: Disclosed are high electron mobility transistors (HEMTs). In some embodiments, a HEMT includes a channel layer composed of a first compound semiconductor material and one or more barrier layers disposed on either one side or both sides of the channel layer and composed of a second compound semiconductor material.

Abstract: Microbial processes and systems are provided according to the present invention for desalination of saline materials, such as aqueous mixtures including dissolved salts. Microbial desalination devices according to embodiments of the present invention create hydrogen gas in a configuration referred to as a microbial electrolysis desalination cell (MEDC), or electricity in a configuration referred to as a microbial fuel desalination cell (MFDC) in addition to desalination of saline materials.

Abstract: Apparatuses and methods are provided for measuring the critical flicker fusion frequency of a subject. The apparatus in one aspect comprises two or more light sources, each flickering at a different predetermined frequency. The subject selects one light source from an array of light sources defining a first range of frequencies, the selection representing the light source of lowest frequency that appears as fused to the subject. The frequencies of the light sources are adjusted to second predetermined frequencies defining a second range. The subject selects the light source of lowest frequency that appears as fused to the subject. The frequency value of the second selection can be assigned as the subject's critical flicker fusion frequency.