Abstract: Provided herein are materials and methods for assessing ratios of lymphocyte to monocytes in cancer patients and, based on the ratios, treating the cancer patients with an immunotherapeutic.

Abstract: Methods and materials herein are useful for assessing and/or treating autoimmune ataxias associated with septin-specific autoantibodies septin-5-specific autoantibodies For example, septin-5 polypeptides are provided as well as methods for using septin-5 polypeptides to detect septin-5-specific autoantibodies and/or to treat a mammal having an autoimmune ataxia.

Abstract: Use of ligand-bound copper clusters (CuCs) and composition comprising the ligand-bound CuCs to treat liver cirrhosis in a subject. Use of ligand-bound copper clusters (CuCs) to manufacture a medication for the treatment of liver cirrhosis in a subject.

Abstract: Extensible shells and related methods for constructing a support pier are disclosed. An extensible shell can define an interior for holding granular construction material and define a first opening at a first end for receiving the granular construction material into the interior and a second opening at a second end. The extensible shell can be flexible such that the shell expands when granular construction material is compacted in the interior of the shell. A method may include positioning the extensible shell in the ground and filling at least a portion of the interior of the shell with the granular construction material. The granular construction material may be compacted in the interior of the extensible shell to form a support pier.

Abstract: Improved RNA interference (RNAi) efficiency in insects is disclosed herein. In particular, certain embodiments of the presently-disclosed subject matter relate to use of nanoformulations of double-stranded RNA (dsRNA) to limit nuclease degradation of the dsRNA, and enhance cellular update and intracellular transport to improve delivery of the dsRNA to enhance RNAi in insects.

Abstract: There may be provided a secure ledger network for executing cryptocurrency transactions, the secure ledger network includes at least one hardware processor, a non-transitory machine-readable storage medium having an executable computer readable program code, the at least one hardware processor configured to execute the computer-readable program code to: receive, by the secure ledger network, a request to validate a smart contract that determines at least one rule for performing a transaction related to a first cryptocurrency token, wherein an execution of the transaction comprising determining a price of the first cryptocurrency token based on a status of the first cryptocurrency token, and a status of an other cryptocurrency token; determine whether to validate the smart contract; when determining to validate the smart contract then updating a secure ledger maintained by the secure ledger network with the smart contract; receiving, by the secure ledger network, a request to execute a transaction related to t

Abstract: The present disclosure relates to an anode electrode active material for a secondary battery containing nickel cobalt molybdenum oxide, an anode electrode for a secondary battery including the same, a secondary battery including the anode electrode for a secondary battery, and a method for manufacturing the same. The novel anode electrode material for a sodium secondary battery containing nickel cobalt molybdenum oxide according to the present disclosure allows intercalation/deintercalation reaction of sodium ion during charge/discharge and does not undergo significant volume change during the intercalation reaction because structure is maintained stably during repeated charge/discharge. As a result, electrode damage and electric short circuit are decreased and, thus, improved electrochemical characteristics can be achieved in long-life and high-rate capability.

Abstract: Described herein are methods of increasing meat quantity and/or improving meat quality of domesticated meat animals using treatments of nicotinamide riboside. The nicotinamide riboside may be in the form of a chloride salt mixed or dissolved in a biologically-acceptable carrier. The treatments may be provided as an in ovo injection or orally administered to the live domesticated meat animal. The methods described herein advantageously increase the size and weight of the domesticated meat animals, reduce the incidences of transportation fatigue, and decrease meat discoloration over time.

Abstract: The present invention provides novel markers of treatment response in a subject infected with Mycobacterium, which allow for quantifying treatment impact on the physiologic state of the Mycobacterium.

Abstract: The ubiquitin ligase, RNF5, regulates the gut microbiota composition and influences the immune checkpoint response to tumors. RNF5 deficient animals exhibit significant inhibition of tumor development as well as an altered gut microbiota composition. Methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species are disclosed. Also disclosed are methods of treating cancer by administering to a subject one or more selected bacterial species and/or one or more prebiotics that promote the growth of one or more selected bacterial species in combination with one or more anti-cancer agents.

Abstract: Embodiments include controlling a processor to perform operations, the operations comprising accessing a digitized image of a region of tissue (ROT) demonstrating cancerous pathology; extracting a set of radiomic features from the digitized image, where the set of radiomic features are positively correlated with programmed death-ligand 1 (PD-L1) expression; providing the set of radiomic features to a machine learning classifier; receiving, from the machine learning classifier, a probability that the region of tissue will experience cancer recurrence, where the machine learning classifier computes the probability based, at least in part, on the set of radiomic features; generating a classification of the region of tissue as likely to experience recurrence or non-recurrence based, at least in part, on the probability; and displaying the classification and at least one of the probability, the set of radiomic features, or the digitized image.

Abstract: A magnetic-field-guidance system and methods of finishing a workpiece using a magnetic-field-guidance system are provided. The magnetic-field-guidance system comprises a workpiece holder, one or more tooling magnets each comprising a finishing tip, and one or more flexible bags containing magnetic media. The workpiece holder is configured to (a) be secured to a base and (b) secure a workpiece relative to the base. The flexible bag(s) are configured to be disposed on the opposite side and/or same side of the workpiece relative to the one or more tooling magnets. In collaboration with the tooling magnets, the magnetic media contained with the flexible bag(s) direct a magnetic field which thereby guides a magnetic-abrasive slurry to finish the workpiece using Magnetic Abrasive Finishing (MAF).

Abstract: Systems and methods for the optical control of qubits and other quantum particles with spatial light modulators (SLM) for quantum computing and quantum simulation are disclosed herein. The system may include a particle system configured to provide an ordered array comprising a multiplicity of quantum particles or a multiplicity of qubits, an optical source, a SLM configured to project a structured illumination pattern capable of individually addressing one or more quantum particles or qubits of the ordered array, and a SLM controller.

Abstract: Formamide group-containing monomers and polymers made by polymerizing the monomers are provided. Also provided are methods of polymerizing the monomers and methods of synthesizing functionalized polymers by pre- and/or post-polymerization functionalization. The monomers are non-toxic and can generate highly reactive isocyanate and isonitrile precursors in a one-pot synthesis that enables the incorporation of complex functionalities into the side-chain of the polymers that are synthesized from the monomers.

Abstract: A switching circuit for a current source inverter includes a first inverter leg, a second inverter leg, and a controller. The first inverter leg includes a first reverse-voltage-blocking (RB) switch, a second RB switch, and a third RB switch that are connected in series between a first bus line and a second bus line. The second inverter leg includes a fourth RB switch, a fifth RB switch, and a sixth RB switch are connected in series between the first bus line and the second bus line. The controller is configured to control a switch between an on-state and an off-state for each RB switch. When in the on-state, a reverse voltage is blocked by a respective RB switch, and a current with a positive polarity is conducted through the respective RB switch. When in the off-state, a voltage and the current are blocked by the respective RB switch.

Abstract: An ASG system for polygeneration with CC includes a devolatilizer that pyrolyzes solid fuel to produce char and gases. A burner adds exothermic heat by high-pressure sub-stoichiometric combustion, a mixing pot causes turbulent flow of the gases to heat received solid fuel, and a riser micronizes resulting friable char. A devolatilizer cyclone separates the micronized char by weight providing micronized char, steam and gases to a gasifier feed and oversized char to the mixing pot. An indirect fluid bed gasifier combustion loop includes a gasifier coupled to the gasifier feed, a steam input to provide oxygen for gasification and to facilitate sand-char separation, and an output for providing syngas. A burner provides POC to a mixing pot which provides hot sand with POC to a POC cyclone via a riser, where the POC cyclone separates sand and POC by weight and provides POC and sand for steam-carbon reaction.

Abstract: The present invention relates to a nitrogen-doped sulfide-based solid electrolyte for all-solid batteries. The a nitrogen-doped sulfide-based solid electrolyte for all-solid batteries includes a compound with an argyrodite-type crystal structure represented by the following Formula 1: LiaPSbNcXd??[Formula 1] wherein 6?a?7, 3?b?6, 0?c?1, 0?d?2, and each X is the same or different halogen atom selected from the group consisting of chlorine (Cl), bromine (Br), and iodine (I).

Abstract: A free standing liquid membrane is disclosed that can selectively separate objects based on the kinetic energy value of the objects such that either an object having a first kinetic energy value can pass through the free standing liquid membrane while retaining the membrane and/or an object having a second kinetic energy value is prevented from passing through the membrane while retaining the membrane. Advantageously, the free standing liquid membrane can remain intact for seconds to hours with multiple objects passing through the membrane.

Abstract: Devices that may couple two or more apparatuses, such as an organ-on-a-chip device and a microfluidic device. Devices that include an organ-on-a-chip device, a microfluidic device, and a cap that couples the organ-on-a-chip device and the microfluidic device. Systems that include the devices and a detection unit. Methods for quantitation of insulin.

Abstract: A nonvolatile memory device and a method of operating the same are provided. The nonvolatile memory device may include a memory cell array having a vertical stack-type structure, a control logic, and a bit line. The memory cell array may include memory cells that each include corresponding portions of a semiconductor layer and a resistance change layer. The control logic, in a read operation, may be configured to apply a first voltage to a non-select memory cell and a second voltage to a non-select memory cell. The first voltage turns on current only in the semiconductor layer portion of the non-select memory cell. The second voltage turns on current in both the semiconductor layer and resistance change layer portions of the select memory cell. The bit line may be configured to apply a read voltage to the select memory cell during the read operation.