Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.

Abstract: In some aspects, the disclosed technology relates to reducing respiratory-induced motion artifacts for accelerated imaging. In one embodiment, magnetic resonance data may be acquired for an area of a subject containing the heart. The acquired data may include motion-corrupted data due to respiration of the subject. From the acquired data, an image may be independently reconstructed for each of a plurality of time frames, with each time frame corresponding to one of a plurality of heartbeats. A region containing the heart of the subject may be automatically detected in the reconstructed images, and rigid motion registration may be performed on the region of the reconstructed images containing the heart. Based on the rigid motion registration, a linear phase shift for motion correction may be determined.

Abstract: Optogenetic and chemogenetic actuators are critical for deconstructing the neural correlates of behavior. However, these tools have several drawbacks, including invasive modes of stimulation or slow on/off kinetics. These disadvantages have been overcome by synthesizing a magnetically sensitive actuator, Magneto, comprised of the cation channel, TRPV4, fused to the paramagnetic protein, ferritin. Magneto permits non-invasive magnetic control over neuronal activity by showing remote stimulation of cells using in vitro calcium imaging assays, electrophysiological recordings in brain slices, in vivo electrophysiological recordings in freely moving mice, and behavioral outputs in zebrafish and mice. As proof of concept, the first magnetogenetic control of the nervous system was demonstrated by using Magneto to delineate a causal role of striatal dopamine receptor 1 neurons in mediating reward behavior in mice.

Abstract: A method of inhibiting the conversion of choline to trimethylamine (TMA) and lowering TMAO in an individual by providing a composition comprising a compound set forth in Formula (I):

Abstract: Disclosed herein are viral vectors based on modifications of the Citrus Tristeza virus useful for transfecting citrus trees for beneficial purposes. Included in the disclosure are viral vectors including one or more gene cassettes that encode heterologous polypeptide s. The gene cassettes are positioned at desirable locations on the viral genome so as to enable expression while preserving functionality of the virus. Also disclosed are methods of transfecting plants and plants transfected with viral vector embodiments.

Abstract: In one embodiment, the invention provides a method of purifying recombinant alpha-galactosidase A. The method includes obtaining a lysate from cells recombinantly expressing alpha-galactosidase A grown in a cell culture medium having non-precipitating phosphate; contacting said lysate with a first chromatography media that binds ?-D-mannopyranosyl or ?-D-glucopyranosyl; eluting alpha-galactosidase A from the first chromatography media to generate a first eluate having alpha-galactosidase A, wherein said eluting includes at least one elution pause between 4 and 16 hours; contacting the first eluate with a second chromatography media that binds galactose binding proteins; and eluting alpha-galactosidase A from said second chromatography media to generate a second eluate containing said recombinant alpha-galactosidase A.

Abstract: A method for hand pose identification in an automated system includes providing depth map data of a hand of a user to a first neural network trained to classify features corresponding to a joint angle of a wrist in the hand to generate a first plurality of activation features and performing a first search in a predetermined plurality of activation features stored in a database in the memory to identify a first plurality of hand pose parameters for the wrist associated with predetermined activation features in the database that are nearest neighbors to the first plurality of activation features. The method further includes generating a hand pose model corresponding to the hand of the user based on the first plurality of hand pose parameters and performing an operation in the automated system in response to input from the user based on the hand pose model.

Abstract: Described herein are embodiments of a system comprising an underground sensor network that measures soil moisture by quantifying how changes in soil water content affect the attenuation of radio signals between buried sensor nodes. Also disclosed herein are methods of using the described system for measuring soil moisture and using the measurement for various control aspects including for example controlling irrigation in agricultural and urban settings.

Abstract: This document provides methods and materials related to treating cancer. For example, methods and materials for using nucleic acid libraries to treat cancer are provided.

Abstract: Described herein are mass spectrometry systems and methods which improve the accuracy of isobaric tag-based quantification by alleviating the pervasive problem of precursor interference and co-isolation of impurities through gas-phase purification. During the gas-phase purification, the mass-to-charge ratios of precursor ions within at least a selected range are selectively changed allowing ions having similar unmodified mass-to-charge ratios to be separated before further isolation, fragmentation or analysis.

Abstract: The present application discloses a novel fusion peptide of IL-2 and IL-33 and its use. It comprises a biologically active domain of Interleukin-2 (IL-2) or a biologically active fragment or homolog thereof, and a biologically active domain of Interleukin-33 (IL-33) or a biologically active fragment or homolog thereof. The two portions can be linked by a linker sequence. The application discloses that combination therapies using IL-2 and IL-33 or a therapy using the IL233 fusion protein are effective in preventing or treating diseases and disorders such as autoimmune diseases and disorders, inflammation, etc. Depending on the subject's disease or disorder, the compositions of the invention are useful for preventing certain symptoms, treating the disease, and alleviating at least some of the symptoms.

Abstract: A polyHIPE-templated composition-of-matter afforded by interfacial polymerization, comprising a polymer of alternating residues of hydrophobic and hydrophilic monomers. The described composition-of-matter is characterized by an open-, quasi-closed- or a truly closed-cell microstructure, whereas the latter is capable of non-releasably or releasably encapsulating an organic or aqueous composition therein for extended periods of time, as well as various uses thereof.

Abstract: A multichannel microphone-based reverberation time estimation method and device which use a deep neural network (DNN) are disclosed. A multichannel microphone-based reverberation time estimation method using a DNN, according to one embodiment, comprises the steps of: receiving a voice signal through a multichannel microphone; deriving a feature vector including spatial information by using the inputted voice signal; and estimating the degree of reverberation by applying the feature vector to the DNN.

Abstract: Provided is a Single Pole N Throw (SPNT) switch including: a transmission line unit including a plurality of transmission lines each connected between a plurality of selection terminals and a single common terminal; and a SPST switch unit including a plurality of SPST switches for grounding each of the plurality of transmission lines, wherein the SPST switches allows at least a part of the plurality of transmission lines and other transmission lines to operate as open nodes at the common terminal for different frequencies.

Abstract: A fabrication method for stretchable/conformable electronic and optoelectronic circuits and the resulting circuits. The method may utilize a variety of electronic materials including, but not limited to Silicon, GaAs, InSb, PbSe, CdTe, organic semiconductors, metal oxide semiconductors and related alloys or hybrid combinations of the aforementioned materials. While a wide range of fabricated electronic/optoelectronic devices, circuits, and systems could be manufactured using the embodied technology, a hemispherical image sensor is an exemplary advantageous optoelectronic device that is enabled by this technology. Other applications include but are not limited to wearable electronics, flexible devices for the internet-of-things, and advanced imaging systems.

Abstract: Magnet microstructure manipulation in the solid state by controlled application of a sufficient stress in a direction during high temperature annealing in a single-phase region of heat-treatable magnet alloys, e.g., alnico-type magnets is followed by magnetic annealing and draw annealing to improve coercivity and saturation magnetization properties. The solid-state process can be termed highly controlled abnormal grain growth (hereafter AGG) and will make aligned sintered anisotropic magnets that meet or exceed the magnetic properties of cast versions of the same alloy types.

Abstract: A hand-held tool is provided for retraction of internal organs during transhiatal mediastinal surgery. The tool includes a handle and a blade extending forwardly from the handle. The blade has an acute end extending rearwardly and then curves forwardly and upwardly to form an open mouth for receiving the organ.

Abstract: The present invention is related to novel methods for identifying a population of subjects that are at risk for developing of atopic allergic diseases, and to the prevention of these allergic diseases.

Abstract: Various methods and systems are provided for cerebral diagnosis. In one example, among others, a method includes obtaining EEG signals from sensors positioned on a subject; conditioning data from the EEG signals to remove artifacts; generating a cerebral network model based at least in part upon the conditioned data; determining network features based upon the cerebral network model; and determining a cerebral condition of the subject based at least in part upon the network features. In another example, a method includes determining a recording condition of a positioned EEG sensor and providing an indication of an unacceptable recording condition of the EEG sensor. In another example, a system includes an EEG recording module to acquire signals; a signal conditioning module to condition signal data; a signal analysis module to determine signal features and cerebral network features; and a condition classification module to determine a cerebral condition of the subject.

Abstract: An assay and a method for identifying a prebiotic to treat a subject in need thereof to promote intestinal barrier integrity or to blunt an inflammatory response are provided.