Patents Assigned to Foundation
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Publication number: 20200402309Abstract: A system, method, and chip, which may be used for attaching digital reality applications to and enabling interactions with dynamic objects in a virtual world. The system comprises a server comprising a persistent virtual world system storing virtual replicas of static and dynamic real world objects. A client device connected to the server via a network enables interaction with one or more digital reality applications virtually attached to dynamic objects of the real world. Chips installed on dynamic objects of the real world store dynamic object data comprising at least geo-location data of the host dynamic objects. Combining static object data stored in the server and the dynamic object data generates a persistent virtual world system that can be streamed to the client device for interaction with users while accurately tracking the dynamic objects and client devices.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200397788Abstract: Materials and methods for modulating protease activated receptor 1 (PAR1) activity to alter myelination are provided.Type: ApplicationFiled: January 29, 2020Publication date: December 24, 2020Applicant: Mayo Foundation for Medical Education and ResearchInventors: Isobel A. Scarisbrick, Hye-Sook Yoon, Kristen L. Drucker
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Publication number: 20200397235Abstract: Disclosed are an optical fiber probe and a method for manufacturing an optical fiber probe which can reduce astigmatism. The disclosed optical fiber probe comprises: an optical fiber configured to receive light inputted from a light source; a reflection part configured to reflect the inputted light in the direction of a cylindrical surface; and a transparent window comprising an incidence surface and an output surface, the incidence surface coupled to the cylindrical surface of the reflection part, the output surface comprising a curvature thereof different from a curvature of the cylindrical surface.Type: ApplicationFiled: October 23, 2018Publication date: December 24, 2020Applicant: Industry-University Cooperation Foundation Hanyang UniversityInventors: Hong Ki YOO, Min Woo LEE, Jingchao XING
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Publication number: 20200397900Abstract: The present disclosure relates to novel radiation-triggered controlled release drug compositions, and methods to make and use the radiation-triggered controlled release drug compositions. The radiation-triggered controlled drug release nanoparticle formulations may be used to achieve maximum bioavailability and minimum adverse effects of the chemo drugs in chemo radio combination therapy treatment of locally advanced solid tumors.Type: ApplicationFiled: September 7, 2018Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: You-Yeon WON, Jaewon LEE, Rahul MISRA, Vincenzo PIZZUTI, Kaustabh SARKAR
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Publication number: 20200397864Abstract: This document provides methods and materials related to treating rotator cuff conditions (e.g., rotator cuff tendonitis or rotator cuff injuries such as partial rotator cuff tears). For example, methods and materials for using BMP-5 polypeptides to treat rotator cuff conditions as well as methods and materials for using inhibitors of SIRT6, SIRT7, and/or HDAC10 polypeptide expression or activity to treat rotator cuff conditions are provided.Type: ApplicationFiled: April 3, 2020Publication date: December 24, 2020Applicant: Mayo Foundation for Medical Education and ResearchInventors: Scott M. Riester, John W. Sperling, Andre J. van Wijnen
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Publication number: 20200402799Abstract: The present invention generally relates to a method for preparing structurally unique nanomaterials and the products thereof. In particular, the present invention discloses a method for preparing an array of ultra-narrow nanowire or nanorod on a patterned monolayer supported by a 2D material substrate in a controlled environment, wherein said pattered monolayer comprises a polymerizable amphiphiles such as phospholipid with a terminal amine and wherein said controlled environment comprises a major nonpolar solvent, a trace amount of polar solvent, and a unsaturated aliphatic amine. Gold nanowires (AuNWs) so prepared have a highly controlled diameter of about 2 nm, a length up to about 1000 nm, and an AuNW ordering over an area >100 ?m2.Type: ApplicationFiled: March 13, 2020Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: Shelley A. Claridge, Ashlin Porter
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Publication number: 20200403825Abstract: A system for authenticating messages transmitted on a bus based on physical location of transmitting units, comprising a reflector adapted to inject a plurality of reflection signals at a first point of a line topology bus, each in response to each of a plurality of messages transmitted by a plurality of bus connected units and a probe adapted to intercept the messages and the reflection signals at a second point of the bus. The probe calculates propagation timing between a reception time of the message and a reception time of an associated reflection signal transmitted in response to the message and determines validity of the message according to a match between the calculated propagation timing and a predefined propagation timings associated with the bus connected units. Wherein the bus connected units are statically connected to the bus between the first point and the second point.Type: ApplicationFiled: December 18, 2018Publication date: December 24, 2020Applicant: Technion Research & Development Foundation LimitedInventors: Eli BIHAM, Eli GAVRIL, Sara BITAN-ERLICH
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Publication number: 20200400563Abstract: A system for the identification of micro-organisms includes an irradiation unit adapted to sequentially provide coherent electromagnetic radiation of one or more wavelengths along a common optical path. A holder is adapted to retain a substrate having a surface adapted for growth of a micro-organism colony. A beamsplitter is adapted to direct the coherent electromagnetic radiation from the common optical path towards the retained substrate. An imager is arranged opposite the beamsplitter from the retained substrate and is adapted to obtain images of backward-scattered light patterns from the micro-organism colony irradiated by the respective wavelengths of the directed coherent electromagnetic radiation. Some examples provide radiation of multiple wavelengths and include an imager arranged optically downstream of the retained substrate to obtain images of forward-scattered light patterns from the micro-organism colony irradiated by the wavelengths of radiation.Type: ApplicationFiled: September 2, 2020Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: Euiwon Bae, Arun Bhunia, Edwin Daniel Hirleman, Huisung Kim, Bartlomiej Rajwa, Joseph Paul Robinson, Valery Patsekin
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Publication number: 20200402580Abstract: A method of accessing a nonvolatile memory device which includes a memory block where semiconductor layers including word lines are stacked includes receiving a write request for the memory block, determining whether the write request corresponds to one or more leading word lines, programming, in response to the write request determined as corresponding to the leading word lines, memory cells connected thereto in a first program mode, and programming, when the write request is determined as corresponding to a following word line different from the leading word lines, memory cells connected to the following word line in a second program mode. The second program mode is performed with a second program parameter including at least one of a number of program pulses, a number of program verify pulses, a program start voltage, and a program end voltage that is different from a corresponding first parameter of the first program mode.Type: ApplicationFiled: January 8, 2020Publication date: December 24, 2020Applicants: Samsung Electronics Co., Ltd., Seoul National University R&DB FoundationInventors: JIHONG KIM, KYUNGDUK LEE, YOUNG-SEOP SHIM, KIROCK KWON, MYOUNG SEOK KIM
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Publication number: 20200402315Abstract: A merged reality system comprises at least one server storing a virtual world system comprising one or more virtual objects, the virtual objects including virtual replicas of at least a first location, a second location, and real world elements in the at least first and second locations. The at least one server is configured to receive, from a plurality of connected devices communicating with the at least one server through a network, real-world data from real-world elements in the first and second locations; use the real-world data from the first and second locations in the virtual world system to enrich and synchronize the virtual replicas with corresponding real-world elements; and overlap and stream at least one portion of the real-world data from the second location onto, e.g., one or more surfaces of the virtual replica of the first location.Type: ApplicationFiled: June 17, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200401284Abstract: A system and method for providing a virtual collaborative creation of real-world projects. The system comprises a server configured to store and process input data, the server comprising a memory and a processor, wherein the memory further comprises a database with structured data storing virtual replicas of real-world elements forming a virtual world system, and wherein the processor is configured to execute data and instructions stored in the memory. A plurality of devices connect the server via a network, each device comprising sensing mechanisms configured to capture multi-source data from real-world elements that serve to enrich and synchronize the virtual replicas with corresponding real-world elements. Collaborative platforms stored in the memory and accessed via user devices enable the creation, tender offering, and administrative reviewing and approval or rejection of real-world projects. Methods thereof are also described.Type: ApplicationFiled: June 17, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200404079Abstract: A system and method enabling location-based activation of applications.Type: ApplicationFiled: June 15, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200398163Abstract: A system for developing and deploying virtual replicas of real-world elements into a persistent virtual world system. The development of the virtual replicas is performed in a virtual environment that enables development and configuration of the virtual replicas that mirror the behavior and appearance of the corresponding real elements. The virtual replicas are enriched through data captured by sensing mechanisms that synchronize in real-time the virtual replicas with the real-world elements. The virtual replicas are shared in a virtual world-based quality assurance system where they can be either approved or rejected for subsequent adjustments, when necessary. After approval and deployment, the replicas are shared in a deployed persistent virtual world system that is viewable to end users for management and interaction of the virtual replicas. Methods thereof are also disclosed.Type: ApplicationFiled: June 15, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200397283Abstract: The invention relates to a method to quantify human corneal tissue parameters to improve biomechanical modelling of refractive and therapeutic procedures to reduce or eliminate refractive errors and unwanted wavefront aberrations. The analysis of the preoperative biomechanical properties of cornea assists in predicting the postoperative biomechanical response of cornea. The computational models of extreme properties of the corneal tissue are conducted and the 3-D finite element models are populated with tomographic information of the cornea and artificial intelligence is trained to consider the pre-operative characteristics of the corneal tissue. The post-operative refractive procedures are simulated using the said finite element models. Finally, biomechanical deformations are prospectively estimated and method builds a deep learning approach to link clinical features to changes in biochemical outcomes.Type: ApplicationFiled: January 18, 2019Publication date: December 24, 2020Applicant: Narayana Nethralaya FoundationInventors: Abhijit Sinha Roy, Rohit Shetty, Mathew Francis, Rachana Chandapura
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Publication number: 20200397894Abstract: Provided are compositions for inhibiting cellular proliferation comprising one or more CRL4CDT2 ubiquitin ligase inhibitors. Also provided are uses of the disclosed compositions to prepare medicaments, for treating and/or preventing diseases, disorders, and conditions, particularly for treating cancer, inducing apoptosis and/or rereplication in cells, inhibiting undesirable neddylation, overcoming vemurafenib-resistance in cells, treating melanoma, breast cancer, head and neck squamous carcinoma cell (HNSCC) cancer, a solid tumor, hepatocellular carcinoma, colorectal cancer, a non-small-cell lung cancer, serous ovarian cancer, papillary thyroid carcinoma, or ameloblastoma, and pharmaceutical compositions comprising the same.Type: ApplicationFiled: April 27, 2017Publication date: December 24, 2020Applicant: University of Virginia Patent FoundationInventor: Tarek Abbas
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Publication number: 20200399336Abstract: A heterodimeric Fc-fused protein and a pharmaceutical composition comprising the heterodimeric Fc-fused protein are disclosed. The heterodimeric Fc-fused protein includes first and second Fc regions of an immunoglobulin heavy chain constant region (Fc) pair and in which IL-21 is bound to at least one of the N-terminus or the C-terminus of the first Fc region and/or the second Fc region, wherein CH3 domains of the first Fc region and the second Fc region are mutated such that the formation of a heterodimer is promoted. When the heterodimeric Fc-fused protein is used, an in vivo half-life of IL-21 included in the heterodimeric Fc-fused protein may be significantly increased.Type: ApplicationFiled: September 9, 2020Publication date: December 24, 2020Applicants: Korea University Research and Business Foundation, AJOU UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATIONInventors: Kyung-Mi LEE, Seon Ah LIM, Yong Sung KIM, Ye Jin KIM
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Publication number: 20200399308Abstract: Non-antimicrobial compounds, methods and compositions comprising the same for treating medical conditions associated with pathogenic microorganism in a subject, as well as drug-resistant strains thereof, which are effective in immunopotentiating the pathogenic microorganism to the antimicrobial systems in the subject, and/or act in synergism with exogenous antimicrobial drugs.Type: ApplicationFiled: March 2, 2018Publication date: December 24, 2020Applicant: Technion Research & Development Foundation LimitedInventor: Amram MOR
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Publication number: 20200399589Abstract: A collagen-fibronectin-based method enables the production of tumors of centimeter size with recognizable pathological traits. The method supports reproducing tumor heterogeneity with preinvasive and invasive phenotypes and stacking of tumor portions using a paper-scaffold with 80 ?m-punched holes for larger nodule creation and easy separation of tumor portions for analysis. Macrotumors are convenient for testing drug delivery and therapeutic tools that necessitate a minimum tumor size relevant to in vivo.Type: ApplicationFiled: June 9, 2020Publication date: December 24, 2020Applicant: Purdue Research FoundationInventors: Sophie Andree Lelievre, Rahim Rahimi, Tim Kwok
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Publication number: 20200401576Abstract: A system comprises at least one cloud server of a cloud server computer system comprising at least one processor and memory storing a persistent virtual world system comprising one or more virtual objects including virtual data and models. The virtual objects comprise one or more of a virtual twin, a pure virtual object, or an application, wherein at least one of the virtual objects represents a store of real-world items connected to a periodically-updated database associated to the products of the at least one store. Users may access the store through the persistent virtual world system via a user device enabling interactions with and between elements within the store.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli
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Publication number: 20200402313Abstract: A system and method for attaching digital reality applications and interactions to static objects are disclosed. The system comprises a server configured to store and process input data, the server comprising a memory and a processor; and a plurality of client devices connected to the server via a network configured enable interaction with digital reality applications. The memory contains a database with structured data containing a persistent virtual world system storing virtual replicas of static objects. The virtual replicas are configured based on the static objects, comprising location and space, physics, and 3D structure. The system enables application developers to attach digital reality applications on the virtual replicas. When users employing client devices approach a digital reality application, the digital reality application detects the physical position and orientation of the client device, triggering the server to share digital reality application content with the client devices.Type: ApplicationFiled: June 16, 2020Publication date: December 24, 2020Applicant: TMRW Foundation IP & Holding S. À R.L.Inventor: Cevat Yerli