Patents Assigned to Foundation
  • Publication number: 20200009088
    Abstract: Compositions and methods are provided herein for the prevention and treatment of cancer, including prostate cancer, breast cancer, and androgen-independent cancer. In one aspect, the present invention provides a composition comprising a niclosamide analog and an antiandrogen drug. In some embodiments, the compositions and methods provided herein inhibit a mutant or splice variant androgen receptor. In particular embodiments, the compositions and methods provided herein reduce the androgen independence of a cancer. Kits are also provided herein.
    Type: Application
    Filed: July 12, 2019
    Publication date: January 9, 2020
    Applicants: The Regents of the University of California, Ohio State Innovation Foundation, U.S. Government represented by the Department of Veterans Affairs
    Inventors: Allen Gao, Pui-Kai Li
  • Publication number: 20200010510
    Abstract: Provided herein are modified recombinant adeno-associated virus (rAAV) capsid proteins, such as modified rAAV1, rAAV5, and rAAV6 capsid proteins, rAAV particles comprising such capsid proteins, nucleic acid molecules encoding such capsid proteins, as well as compositions, kits and methods of use thereof.
    Type: Application
    Filed: September 9, 2019
    Publication date: January 9, 2020
    Applicant: University of Florida Research Foundation, Incorporated
    Inventors: George Vladimirovich Aslanidi, Kim M. Van Vliet, Mavis Agbandje-McKenna, Arun Srivastava
  • Patent number: 10527540
    Abstract: An imaging system for a smartphone includes a housing configured to rigidly attach to a handheld smartphone device. The system further includes an arm extending from the housing, wherein the arm is configured to be adjustable such that the arm is movable toward and away from the housing. Additionally, the system includes a sample mounting portion attached to the arm, the mounting portion having a retaining device, wherein the retaining device is configured to secure a target sample, the mounting portion configured to direct an image of the target sample to a first camera in the handheld smartphone device.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: January 7, 2020
    Assignee: Purdue Research Foundation
    Inventor: Jian Jin
  • Patent number: 10529879
    Abstract: A photoelectric conversion device may include a substrate, a photoactive layer disposed on the substrate, and a first electrode and a second electrode respectively connected to corresponding edges of the photoactive layer. The photoactive layer may include a first oxide semiconductor layer on the substrate, and a plurality of quantum dot layers and a plurality of second oxide semiconductor layers that are alternately formed on the first oxide semiconductor layer.
    Type: Grant
    Filed: May 25, 2018
    Date of Patent: January 7, 2020
    Assignees: SAMSUNG ELECTRONICS CO., LTD., CHEONGJU University Industry & Academy Cooperation Foundation
    Inventors: Kyungsang Cho, Sangyeol Lee, Chanwook Baik
  • Patent number: 10525502
    Abstract: This invention discloses a method for controlling nanoscopic wetting near or at a molecular scale for synthetic material applications. In particular this invention relates to a method for preparing a monolayer or thin film with a patterned nanoscopic wetting surface using a ‘sitting’ phase of polymerizable amphiphile, wherein hydrophobic alkyl chains of the amphiphile extend along the supporting surface and the amphiphile molecules align side-to-side, effectively forming a repeating cross-section of bilayer with alternating hydrophilic and hydrophobic stripes of a ˜6 nm pitch tunable based on the chain length of the amphiphile. Products prepared according to the methods disclosed herein are within the scope of this invention. In some embodiments, monolayers or thin films so prepared are transferable.
    Type: Grant
    Filed: January 19, 2018
    Date of Patent: January 7, 2020
    Assignee: Purdue Research Foundation
    Inventors: Shelley A Claridge, Shi Wah Choong, Jae Jin Bang, Shane Richard Russell
  • Patent number: 10526694
    Abstract: A method of preparing an ultra-flat metal surface involves providing a layer of a crystalline metallic material on an ultra-flat substrate surface that is relatively harder than the metallic material layer and then impinging the metallic material layer with incoming metal atoms that are deposited as an additive crystalline layer thereon, wherein at least a lattice constant of the additive crystalline layer is different enough from a lattice constant of the crystalline metallic material layer resulting in a reduction of roughness of the surface of the metallic material layer adjacent to the substrate surface. The metallic material layer having an ultra-flat surface then is separated by template stripping or other technique from the substrate surface for further use of the ultra-flat surface.
    Type: Grant
    Filed: April 26, 2016
    Date of Patent: January 7, 2020
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Martin Thuo, Jiahao Chen, Ian D. Tevis
  • Patent number: 10526606
    Abstract: Materials and methods for treating cancer (e.g., by reducing metastasis) are provided herein. For example, materials and methods for treating cancer by targeting WSB1 and/or pVHL are provided.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: January 7, 2020
    Assignee: Mayo Foundation for Medical Education and Research
    Inventors: Zhenkun Lou, JungJin Kim, SeungBaek Lee
  • Patent number: 10524683
    Abstract: A brain-machine interface apparatus and a method of the same are provided. To elaborate the brain-machine interface apparatus may include a display where a plurality of light-emitting points (or lines) flickering with their individual set frequencies are arranged a flickering controller that divides the plurality of the light-emitting points (or lines) into a plurality of groups, and sets the set frequencies for the groups; an EEG measurement unit that detects EEG signals of a user who watches the display without gaze-shift; a frequency detector that detects one or more (their harmonic or combination) frequency components from the measured EEG signals; a shape analysis unit that decodes an originally intended shape according to the user's imagination based on the one or more detected frequency components and the set frequencies; and a result output unit that outputs information of the embodied originally intended shape.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: January 7, 2020
    Assignee: Korea University Research and Business Foundation
    Inventor: Byoung-Kyong Min
  • Patent number: 10530967
    Abstract: Certain examples described herein relate to the halftoning of a color image. In one example, a set of clusters are determined based on the color image. A set of edges are also detected in the color images. Clusters within these edges are then merged. A set of screens for halftoning are assigned to the set of clusters. This assignment is based on color property metrics for the set of clusters. The color image is halftoned using the set of screens assigned to the merged clusters.
    Type: Grant
    Filed: April 4, 2019
    Date of Patent: January 7, 2020
    Assignees: Purdue Research Foundation, Hewlett-Packard Development Company, L.P.
    Inventors: Tal Frank, Altyngul Jumabayeva, Robert Ulichney, Jan Allebach, Yotam Ben-Shoshan
  • Patent number: 10526278
    Abstract: Modulation of quorum sensing in Gram-negative bacteria, particularly strains of Pseudomonas which form biofilms, by compounds including those of formula I and formula II: where: AR is optionally substituted phenyl, cycloalkyl or cycloalkenyl or heterocyclic, and R1 is optionally substituted alkyl, alkenyl, alkoxyalkyl, or alkylthioalkyl or alkyl substituted at the omega position with optionally substituted phenyl, cyclohexyl or cyclohexenyl. In particular compounds inhibit quorum sensing and biofilm formation. Pharmaceutical compositions for treatment of bacterial infections and methods of treatment of such infections are provided.
    Type: Grant
    Filed: October 11, 2018
    Date of Patent: January 7, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Helen Blackwell, Daniel Manson
  • Patent number: 10526605
    Abstract: The invention provides siRNA compositions that specifically downregulates expression of a variant of the PNPLA3 gene and methods of use thereof for treating a chronic liver disease or alcoholic liver disease (ALD).
    Type: Grant
    Filed: July 3, 2018
    Date of Patent: January 7, 2020
    Assignee: Purdue Research Foundation
    Inventors: Wanqing Liu, Yoon Yeo
  • Patent number: 10526575
    Abstract: The present invention relates to a cell culture medium additive comprising a xanthan polysaccharide and a mannan polysaccharide, such as a glucomannan or a galactomannan, that supports the growth of cells in suspension, and to a cell culture medium containing the additive. More particularly, but not exclusively, the present invention relates to a cell culture medium additive that supports the formation of multicellular bodies such as spheroids, and prevents sedimentation of cells without adversely affecting the physical properties of the cell culture medium.
    Type: Grant
    Filed: April 2, 2013
    Date of Patent: January 7, 2020
    Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of the Board of the College of the Holy and Undivided Trinity of Queen Elizabeth
    Inventor: Anthony Davies
  • Patent number: 10531243
    Abstract: A method for transmitting data in a mobile device includes transmitting, to a reception device, a connection request message comprising information indicating whether the transmission device supports message transmission having temporal correlation; receiving, from the reception device, a connection response message comprising information indicating whether the reception device supports the message transmission in response to the connection request message; and if both the transmission device and the reception device support the message transmission, transmitting, to the reception device, at least two of messages having temporal correlation, the at least two of messages comprising identification information, wherein the identification information indicates that the at least two of messages have temporal correlation.
    Type: Grant
    Filed: November 4, 2016
    Date of Patent: January 7, 2020
    Assignees: Samsung Electronics Co., Ltd., Seoul National University R&DB Foundation
    Inventors: Yong-Seok Park, Soo-Young Jang, Daedong Park, Seongsoo Hong, Sangwook Kim
  • Patent number: 10525286
    Abstract: A sharpening filter for orthovoltage x-ray beams employs a substantially planar filter disk supporting a set of radial symmetric features controlling attenuation of x-ray transmission in concentric circular regions providing increased sharpness of the pencil beams in a compact filter structure that may be tailored to different beam sizes and focus depths.
    Type: Grant
    Filed: May 18, 2017
    Date of Patent: January 7, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Jessica Fagerstrom, Edward Bender, Wesley Culberson, Michael Lawless, Benjamin R. M. Palmer, Larry DeWerd
  • Patent number: 10530663
    Abstract: Provided is an opportunistic forwarding method and apparatus for a content-based information centric network in a delay tolerant network environment. The opportunistic forwarding method for a content-based information centric network in a delay tolerant network environment having a processor and a memory includes when a first node contacts a second node, updating a first delivery predictability and a second delivery predictability of the first node based on contact record information between the first node and the second node and data that the second node has, updating a first message of the first node by comparing the first message including first interest information and first data that the first node has with a second message including second interest information and second data that the second node has, and delivering the first message of the first node to the second node based on the first and second delivery predictabilities of the first node.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: January 7, 2020
    Assignee: Foundation of Soongsil University-Industry Cooperation
    Inventors: Yun Won Chung, Younghan Kim, Min Wook Kang
  • Patent number: 10526408
    Abstract: In some aspects, mutant or variant Fc domains are provided that can exhibit increased affinity or selectivity for Fc?RIIB. The variant Fc domain may be a mutant IgG1 Fc domain. In some embodiments, a mutant or variant Fc domain may be present in a therapeutic antibody such as, e.g., an agonistic antibody. Additional methods for using and identifying mutant Fc domains are also provided.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: January 7, 2020
    Assignee: Research Development Foundation
    Inventors: George Georgiou, Chang-Han Lee
  • Patent number: 10528532
    Abstract: A computer implemented method for integrating data into a target database may include: providing a plurality of source databases which each may include a relational schema and data for integration into the target database; generating at least one complexity model based on the relational schema and data of each source database, each complexity model indicating at least one inconsistency between two or more of the data sources which may be require to be resolved to integrate the data from the data sources into the target database; and generating an effort model that may include an effort value for each inconsistency indicated by each complexity model, each effort value indicating at least one of a time period and a financial cost to resolve the inconsistency to integrate data from the data sources into the target database.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: January 7, 2020
    Assignees: Qatar Foundation, Hasso-Plattner-Institut Für Softwaresystemtechnik GmbH
    Inventors: Paolo Papotti, Felix Naumann, Sebastian Kruse, El Kindi Rezig
  • Patent number: 10525831
    Abstract: A vehicle includes a first battery configured to output power at a first voltage, a second battery configured to output power at a second voltage, and a direct current (DC)-DC converter configured to convert the first voltage of the first battery to the second voltage and supply power at the second voltage to the second battery. The DC-DC converter includes a transformer, at least one switch, at least one rectifying diode, and a snubber circuit. The transformer is configured to transform the first voltage to the second voltage. The at least one switch is configured to control a first current input to the transformer from the first battery. The at least one rectifying diode is configured to rectify an alternate current (AC) output from the transformer. The snubber circuit is configured to prevent overvoltage from being applied to the at least one rectifying diode.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: January 7, 2020
    Assignees: HYUNDAI MOTOR COMPANY, KIA MOTORS CORPORATION, Korea University Research and Business Foundation
    Inventors: JinYoung Yang, Taejong Ha, Youngjin Kim, Yong Sin Kim, Sang-hun Lee
  • Patent number: 10525628
    Abstract: Systems and methods for controlling support structures in manufacturing are provided. In particular, the present disclosure provides systems and methods for characterizing the support volume in the design phase based on a perimeter length of a boundary with undercut, projected along a build direction, referred to as a projected undercut perimeter (PUP). By constraining this PUP, the amount of support structures in resulting designs are effectively controlled. By constraining overhang able based PUP, the resulting designs can self support.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: January 7, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventor: Xiaoping Qian
  • Patent number: PP31316
    Abstract: The new variety ‘TH-1321’ ripens around mid-April in southeastern Georgia. The fruit of the new variety ‘TH-1321’ are very large, firm, have good flavor and scar. The new variety ‘TH-1321’ is vigorous with an estimated chilling requirement of about 50 to 100 hours at or below approximately 7° C. The asexually reproduced variety is reliably propagated vegetatively.
    Type: Grant
    Filed: January 17, 2019
    Date of Patent: January 7, 2020
    Assignee: University of Georgia Research Foundation, Inc.
    Inventor: D. Scott NeSmith