Abstract: This document provides methods and materials related to insulin secreting polypeptides. For example, polypeptides having the ability to induce insulin secretion and methods and materials for using use such polypeptides to induce insulin secretion and to treat diabetes are provided.
Type:
Grant
Filed:
March 22, 2018
Date of Patent:
July 2, 2019
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: VM-to-VM switching is an enhancement to Ethernet card technology that enables virtual machines on the same hardware server platform to switch Ethernet Frames (or IP Packets) directly without exiting the server or using a slower and bandwidth limited software process in the hypervisor. The method does not require new network switch hardware. The invention creates a unique switching ability that allows users to modify parameters applied to Ethernet Frames passing between Virtual Machines, such as quality of service or firewall rules without adding considerable latency to the switching process. The hardware switching method enriches the functionality of the Ethernet Card and permits more advanced switching architectures in servers and thus increases density of VMs and reduces complexity of planning the location of virtual machines in a virtualized infrastructure.
Type:
Grant
Filed:
June 27, 2016
Date of Patent:
July 2, 2019
Assignee:
University of Central Florida Research Foundation, Inc.
Abstract: An ultrafast electromechanical switch having a drive mechanism comprising two non-movable contacts connected to electrical feedthroughs, one actuator and one movable contact. The provided ultrafast electrical (e.g., transfer, disconnect, etc.) switch is simple, compact, clean, exhibits ultralow loss, does not require high energy to operate and is capable of being automatically reset.
Type:
Grant
Filed:
November 20, 2018
Date of Patent:
July 2, 2019
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Lukas Graber, Christopher Widener, Samantha Smith, Michael Steurer
Abstract: An improved system and method for estimating and compensating for motion by reducing motion artifacts produced during image reconstruction from helical computed tomography (CT) scan data. In a particular embodiment, the reconstruction may be based on helical partial angle reconstruction (PAR).
Type:
Grant
Filed:
November 16, 2017
Date of Patent:
July 2, 2019
Assignees:
University of Central Florida Research Foundation, Inc., iTomography Corporation
Abstract: A system for beam training including a transmitter forming a transmission beam using a transmission array and a receiver forming a receiving beam using a receiving array is disclosed. The transmitter transmits an identifier of a transmission training beam selected from the transmission beams using a secondary synchronization signal or a common reference signal, etc. The identifier of the transmission training beam is used for the beam training.
Type:
Grant
Filed:
October 26, 2015
Date of Patent:
July 2, 2019
Assignee:
Chung-Ang University Industry—Academy Cooperation Foundation
Abstract: A method of estimating land surface temperature lapse rate using an infrared image is disclosed. In the method of estimating land surface temperature lapse rate using an infrared image, a target area for the estimation of land surface temperature lapse rate is selected. The atmospheric transmittance of the target area is calculated. Reference temperature is estimated at a reference location set in the target area as desired. A temperature difference is calculated from the atmospheric transmittance and the estimated reference temperature, and then a temperature difference image is generated. Land surface temperature lapse rate is estimated from the temperature difference image and a Digital Elevation Map (DEM) in an identical area using an elevation-based temperature difference distribution.
Type:
Grant
Filed:
December 11, 2015
Date of Patent:
July 2, 2019
Assignee:
University of Seoul Cooperation Foundation
Abstract: The treatment of abnormal hyperphosphorylation of tau in brains of patients with metabotropic glutamate receptor 5 (mGluR5) antagonists. The treatment uses the signaling pathway in which the inhibition of protein phosphatase 2A (PP2A) through phosphorylation of its catalytic subunit PP2Ac at Tyr307 is induced by the activation of metabotropic glutamate receptor 5 (mGluR5) and leads to hyperphosphorylation of tau. The mGluR5-PP2A axis has a central role in neurofibrillary degeneration and thus is be a therapeutic target for the treatment of tauopathies.
Type:
Grant
Filed:
August 5, 2015
Date of Patent:
July 2, 2019
Assignee:
The Research Foundation for Mental Hygiene, Inc.
Abstract: A method of generating soluble polyphosphides using solution chemistry is presented. A reaction between potassium ethoxide and shelf stable red phosphorus generated soluble polyphosphides in a variety of organic solvents with the 31P NMR spectrum being used to detect the species of polyphosphides produced.
Type:
Grant
Filed:
October 10, 2018
Date of Patent:
July 2, 2019
Assignee:
The Florida State University Research Foundation, Inc.
Inventors:
Michael Shatruk, David Tyler McQuade, Alina Dragulescu-Andrasi, Levi Zane Miller, Chongin Pak
Abstract: Biocompatible stiffness enhanced pliable electrically conductive filaments configured for contact with living tissue and electrical communication with such tissue. The pliability of the filaments allows the distal end of the filaments to remain at the original site of penetration into the tissue despite the movement of the tissue relative to their surrounding environment. To temporarily stiffen the filaments, a soluble stiffness enhancing coating is disposed over the filaments. The coating may be in the form of a liquid which dries to a solid state after being applied to the filaments and renders the filaments sufficiently rigid such that under appropriate force, the filaments are capable of penetrating into dense tissue. Once in place, the stiffness enhancing coating dissolves due to contact with body fluids, the filaments, in the absence of such a coating, return to their initial pliability.
Type:
Grant
Filed:
October 14, 2016
Date of Patent:
July 2, 2019
Assignee:
The Alfred E. Mann Foundation for Scientific Research
Abstract: Disclosed are recombinant polypeptides that include (a) a filaggrin amino acid sequence and (b) a cell importation signal sequence that includes a motif of two to fifteen amino acids, wherein the motif includes at least one arginine residue and at least one methionine residue. Also disclosed are nucleic acids encoding the recombinant polypeptides of the present invention, and compositions that include the recombinant polypeptides and nucleic acids of the present invention. Methods of treating or preventing a skin disease or skin disorder using the compositions of the present invention are also included, as well as kits that include a sealed containing that includes a recombinant polypeptide of the present invention.
Type:
Grant
Filed:
November 22, 2010
Date of Patent:
July 2, 2019
Assignee:
Research Development Foundation
Inventors:
J. Timothy Stout, Binoy Appukuttan, Trevor McFarland
Abstract: A microfluidic detection system for micrometer-sized entities, such as biological cells, includes a detector component incorporating a plate with a plurality of opening, the plate separating two chambers, one in communication with a fluid source containing target cells bound to magnetic beads. The openings are sized to always permit passage of the magnetic beads therethrough into a lower one of the chambers and are further sized to always prevent passage of the target cells from the upper one of the chambers. The detector component further includes a magnet positioned to pull unbound magnetic beads through the openings and to capture target cells bound to magnetic beads on the surface of the plate. The microfluidic detection system includes a pump flowing the fluid through the detector component at high flow rates of milliliters per minute for high throughput detection of target cells.
Type:
Grant
Filed:
November 4, 2016
Date of Patent:
July 2, 2019
Assignee:
Purdue Research Foundation
Inventors:
Cagri Abdullah Savran, Philip S. Low, Chun-Li Chang
Abstract: A mechanism is disclosed for reconstructing trimmed surfaces whose underlying spline surfaces intersect in model space, so that the reconstructed version of each original trimmed surface is geometrically close to the original trimmed surface, and so that the boundary of each respective reconstructed version includes a model space trim curve that approximates the geometric intersection of the underlying spline surfaces. Thus, the reconstructed versions will meet in a continuous fashion along the model space curve. The mechanism may operate on already trimmed surfaces such as may be available in a boundary representation object model, or, on spline surfaces that are to be trimmed, e.g., as part of a Boolean operation in a computer-aided design system.
Type:
Grant
Filed:
February 15, 2017
Date of Patent:
July 2, 2019
Assignees:
Board of Regents of the University of Texas Systems, University of Utah Research Foundation
Inventors:
Benjamin Urick, Thomas J. R. Hughes, Richard H. Crawford, Elaine Cohen, Richard F. Riesenfeld
Abstract: A time synchronization method performed by a communication node in a vehicle includes: receiving, from a road side unit (RSU), a first frame including time information of a first domain to which the RSU belongs; setting a time of the vehicle based on a time indicated by the time information of the first domain; and transmitting a second frame including the time information of the vehicle.
Type:
Grant
Filed:
December 28, 2016
Date of Patent:
July 2, 2019
Assignees:
Hyundai Motor Company, Kia Motors Corporation, Industry-University Cooperation Foundation Hanyang University
Inventors:
Seong Jin Park, Woo Sub Kim, SungKwon Park, Ju Ho Lee
Abstract: Disclosed is a system for recognizing a user location using sensor-based activity recognition. The system includes a mobile device which includes a sensor module configured to sense information about at least one of a user state and surrounding environments, a first processor configured to extract activity information based on the sensed information, and a first communication module configured to transmit the extracted activity information; and a user terminal device which includes a second communication module configured to receive the activity information from the first communication module, and a processor configured to determine a user location in a user space corresponding to a user activity based on the received activity information. By determining a user's location in a user space corresponding to a user activity, it is possible to control electronic devices corresponding to the user activity or provide a service of monitoring activities of the old and weak and the child.
Type:
Grant
Filed:
July 12, 2016
Date of Patent:
July 2, 2019
Assignees:
Samsung Electronics Co., Ltd., Industry-Academic Cooperation Foundation, Yonsei University
Inventors:
Seung-hak Yu, Seung-woo Lee, Ho-jung Cha, Yo-han Ko, Soo-hwan Kim, Hyun-choong Kim, Jong-hoon Shin, Kyoung-woo Lee, Seong-il Hahm
Abstract: An apparatus for recognizing a user's motions based on sensor information and label information, a method for establishing an ONMF-based basis matrix, and a method for establishing an OSSNMF-based basis matrix are provided, where the basis matrices are used to extract motion features of the user. The apparatus for recognizing the user's motions may include a feature vector extractor configured to multiply a transposed matrix of an orthogonalized basis matrix by a sensor data matrix of frequency domain sensor data acquired from sensors to extract an ONMF-based feature vector and a multi-class classifier configured to use the extracted ONMF-based feature vector to classify the user's motion into a type from among types of a user's motions.
Type:
Grant
Filed:
January 21, 2014
Date of Patent:
July 2, 2019
Assignees:
Samsung Electronics Co., Ltd., Postech Academy-Industry Foundation
Inventors:
Jae-Mo Sung, Won-Keun Kong, Sae-Hun Kim, Seung-Jin Choi
Abstract: Recent studies in computer vision have shown that, while practically invisible to a human observer, skin color changes due to blood flow can be captured on face videos and, surprisingly, be used to estimate the heart rate (HR). While considerable progress has been made in the last few years, still many issues remain open. In particular, state-of-the-art approaches are not robust enough to operate in natural conditions (e.g. in case of spontaneous movements, facial expressions, or illumination changes). Opposite to previous approaches that estimate the HR by processing all the skin pixels inside a fixed region of interest, we introduce a strategy to dynamically select face regions useful for robust HR estimation. The present approach, inspired by recent advances on matrix completion theory, allows us to predict the HR while simultaneously discover the best regions of the face to be used for estimation.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
July 2, 2019
Assignees:
Universita degli Studi Di Trento, Fondazione Bruno Kessler, The Research Foundation for the State University of New York, University of Pittsburgh of the Commonwealth of Higher Education
Abstract: A system for determining a travel path, including a network of at least one camera, a communication hub coupled to the network of at least one camera, at least one electronic communication device, and a data processing system coupled to the communication hub, the data processing system comprising one or more processors configured to calculate a travel path based on user-specified criteria including maximum camera coverage, where the system is adapted to dynamically identify a plurality of cameras.
Type:
Grant
Filed:
March 23, 2017
Date of Patent:
July 2, 2019
Assignee:
Purdue Research Foundation
Inventors:
Abish Malik, David Scott Ebert, Hanye Xu, James Tay, Shehzad Afzal, Yung-hsiang Lu
Abstract: An apparatus comprises a system on a chip (SoC). In some embodiments, the SoC includes a power supply circuit, a power management circuit operatively coupled to the power supply circuit, a first wireless communications circuit and a second wireless communications circuit. The first wireless communications circuit is configured to receive an RF signal and is operatively coupled to the power supply circuit and the power management circuit. The first wireless communications circuit has a net radio frequency (RF) power gain no more than unity before at least one of downconversion of the RF signal or detection of the RF signal. The second wireless communications circuit is operatively coupled to the power supply circuit and the power management circuit.
Type:
Grant
Filed:
August 7, 2017
Date of Patent:
July 2, 2019
Assignees:
University of Virginia Patent Foundation, The Regents of the University of Michigan
Inventors:
Benton H. Calhoun, Yousef Shakhsheer, Yanqing Zhang, Alicia Klinefelter, David D. Wentzloff, Nathan E. Roberts, Seunghyun Oh