Abstract: Provided herein are HER-3, HER-1 and IGF-1R B cell epitopes, peptide mimics, chimeric peptides and multivalent peptides. In some embodiments, the chimeric peptides include one or more HER-3, HER-1 and/or IGF-1R B cell epitopes, a linker, and a T helper cell (Th cell) epitope. Pharmaceutical compositions are also provided that contain one or more HER-3, HER-1 and/or IGF-1R chimeric peptides, and optionally, one or more HER-2 chimeric peptides and/or VEGF peptides. Also included herein are methods of treating a cancer using the HER-3, HER-1 and IGF-1R B cell epitopes, chimeric peptides and multivalent peptides.

Abstract: Sensing voltage based on a supplied to magneto-resistive random access memory (MRAM) bit cells in an MRAM for tracking write operations. Sensing voltage based on supply voltage applied to an MRAM bit cell in a write operation can be used to detect completion of magnetic tunnel junction (MTJ) switching in an MRAM bit cell to terminate the write operation to reduce power and write times. In exemplary aspects provided herein, reference and write operation voltages sensed from the MRAM bit cell in response to the write operation are compared to each other to detect completion of MTJ switching of voltage based on the supply voltage applied to the MRAM bit cell regardless of whether the write operation is logic ‘0’ or logic ‘1’ write operation. This provides a higher sensing margin, because the change in MTJ resistance after MTJ switching completion is larger at the supply voltage rail.

Abstract: Systems and methods for improved data transmission utilizing a communication facilitator are described in accordance with embodiments of the invention. One embodiment includes a plurality of nodes, that each comprise: a transmitter; a receiver; and an encoder that encodes message data for transmission using a plurality of codewords; a cooperation facilitator node comprising: a transmitter; and a receiver; wherein the nodes are configured to transmit data parameters to the cooperation facilitator; wherein the cooperation facilitator is configured to generate cooperation parameters based upon the data parameters received from the nodes; wherein the cooperation facilitator is configured to transmit cooperation parameters to the nodes; and wherein the encoder in each of the nodes selects a codeword from the plurality of codewords based at least in part upon the cooperation parameters received from the communication facilitator and transmit the selected codeword via the multiple access channel.

Abstract: Metal halide scintillators are described. More particularly, the scintillators include Tl and/or In-based ternary metal halides, such as those of the formulas A2BX4 and AB2X5, wherein A is an alkali metal, such as Li, Na, K, Rb, Cs or any combination thereof; B is an alkali earth metal, such as Be, Mg, Ca, Sr, Ba or any combination thereof; X is a halide, such as Cl, Br, I, F or any combination thereof; some or all of A has been replaced by Tl and/or In, and some or all of B has been replaced by another dopant, such as Eu, Ce, Tb, Yb, and Pr. Radiation detectors comprising the metal halide scintillators are also described.

Abstract: Various examples are provided for multiferroic thin films. In one example, a multiferroic thin film device includes a thin film of multiferroic material and an electrode disposed on a side of the thin film of multiferroic material. The multiferroic material can be (Fex,Sr1-x)TiO3 In another example, a method for producing a multiferroic thin film includes forming a multiferroic precursor; disposing the multiferroic precursor on a substrate to form a multiferroic coating; pre-baking the multiferroic coating on the substrate to form a pre-baked multiferroic thin film; and annealing the pre-baked multiferroic thin film under an oxygen atmosphere to form a crystalized multiferroic thin film. One or more electrodes can be formed on the crystalized multiferroic thin film.

Abstract: Disclosed are a method and apparatus for tiling light sheet selective plane illumination microscopy (TLS-SPIM) with real-time light sheet optimization. The method and apparatus image multi-cellular specimens in 3D, with an improved 3D imaging ability of SPIM in resolving complex structures and optimizes SPIM live imaging performance by using a real-time adjustable tiling light sheet and creating a flexible compromise between spatial and temporal resolution. A 3D live imaging ability is provided of the TLS-SPIM by real-time imaging cellular and sub-cellular behaviors.

Abstract: In some embodiments, a method that includes capturing sound in a natural language environment using at least one sound capture device that is located in the natural language environment. The method also can include analyzing a sound signal from the sound captured by the at least one sound capture device to determine at least one characteristic of the sound signal. The method additionally can include reporting metrics that quantify the at least one characteristic of the sound signal. The metrics of the at least one characteristic can include a quantity of words spoken by one or more first persons in the natural language environment. Other embodiments are provided.

Abstract: The present invention proposes an apparatus and a method capable of forming M*N number of beams by a base station, which supports signal transmission/reception of the macro service area in heterogeneous networks in which a macro service area is formed with the M*N number of beams through a two-dimensional arrangement simultaneously considering the horizontal dimension and the vertical dimension and at least one small service is formed in the macro service area. To this end, at least one interference prediction beam formed to transmit signals interfering in transmission signals in at least one small service area from among the signals to be transmitted by the M*N number of beams is selected, and each of the M*N number of beams is formed in consideration of the inter-cell interference in at least one small service area due to the signals to be transmitted by at least one selected interference prediction beam.

Abstract: Disclosed herein are methods and apparatus for making a determination about an eye in ambient lighting conditions comprising detecting ambient light reflected out of an eye of a subject from a retina of the eye of the subject and making a determination about the eye of the subject based upon the reflected ambient light.

Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.

Abstract: Provided herein are Mycobacterium smegmatis porin nanopores, systems that comprise these nanopores, and methods of using and making these nanopores. Such nanopores may be wild-type MspA porins, mutant MspA porins, wild-type MspA paralog porins, wild-type MspA homolog porins, mutant MspA paralog porins, mutant MspA homolog porins, or single-chain Msp porins. Also provided are bacterial strains capable of inducible Msp porin expression.

Abstract: A water curtain head according to the present invention may comprise: a head body which is connected to a water supply pipe installed in an inner side of a building and has a water-releasing opening; and a deflector arranged adjacent to the water-releasing opening to allow water discharged by the water-releasing opening to pass therethrough. The deflector may comprise: a first spray nozzle formed on the front surface of the deflector to penetrate the front surface of the deflector; and a second spray nozzle formed to be recessed inward from a side surface of the deflector by a predetermined section.

Abstract: The invention generally relates to systems and methods for precursor and neutral loss scan in an ion trap. In certain aspects, the invention provides a system that includes a mass spectrometer having an ion trap, and a central processing unit (CPU). The CPU includes storage coupled to the CPU for storing instructions that when executed by the CPU cause the system to excite a precursor ion and eject a product ion in the single ion trap.

Abstract: The methods and systems provided can automatically determine an Arteriolar-to-Venular diameter Ratio, AVR, in blood vessels, such as retinal blood vessels and other blood vessels in vertebrates. The AVR is an important predictor of increases in the risk for stroke, cerebral atrophy, cognitive decline, and myocardial infarct.

Abstract: The present invention relates to a method and tools for manufacturing of seamless tubular shapes, especially tubes and canisters. In the method of the invention the tubular shape is extracted from the flash (1) continuously produced during the plunging of a consumable rod (2) against a rigid anvil (3). The tools of the invention include a consumable rod (2); a non-consumable or consumable rigid anvil (3); first means for rotating the consumable rod (2) and the non-consumable or consumable rigid anvil (3) relatively with respect of each other; second means for plunging the consumable rod (2) and the non-consumable or consumable rigid anvil (3) relatively against each other; open die condition configuration for continuous production of flash (1) during said plunging.

Abstract: Methods capable of forming holes in, etching the surface of, or otherwise ablating substrates, and substrates formed thereby. A first method includes directing a first laser beam pulse towards a substrate to form a hole in a surface thereof and to form a plasma plume at least partially within the hole wherein the plasma plume has insufficient thermal energy and expansion velocity to etch sidewall of the hole, and directing a second laser beam pulse into the plasma plume to increase the temperature and expansion velocity of the plasma plume such that the sidewall is etched causing an increase in the cross-sectional dimension of the hole. A second method includes applying a liquid to a surface of a substrate, and directing a laser beam pulse into the liquid to create plasma on the surface of the substrate that etches portions of the surface of the substrate.

Abstract: Disclosed herein are embodiments of methods for encoding, decoding, and matching patterns in collections of signals. These methods use weighting functions to scale the signals. This scaling enables the use of signals of arbitrary duration, wherein the signals may include discrete sequences and spike trains. In the most general case, the signals can be represented using functionals, which extends the expressive power of the methods. Further disclosed herein are embodiments of a system that performs these methods.

Abstract: The present invention provides a compound, and method of inhibiting the activity of a Fatty Acid Binding Protein (FABP) comprising contacting the FABP with a compound, said compound having the structure: Formula (I)

Abstract: An unmanned aerial vehicle (UAV) system is disclosed. The UAV system includes a chassis, a plurality of propeller assemblies configured to provide vertical take-off and landing (VTOL) for the chassis with propulsion in 6 degrees of freedom including along a cartesian coordinate system (X, Y, Z) and provide yaw, pitch, and roll, the plurality of propeller assemblies are selected from the group consisting of (i) two fixed propeller assemblies and a tiltable propeller assembly, and (ii) four fixed propeller assemblies, a boom having a boom propeller assembly, configured to selectively provide positive and negative rectilinear thrust vectors, and an end-effector coupled to a distal end of the boom, the end-effector having a force sensor configured to provide contact force between the end-effector and an object.

Abstract: Ritanserin is shown to be an inhibitor of diacylglycerol kinase alpha (DGK?) and to be cytotoxic to glioblastoma and melanoma cells. Ritanserin treatment also provides chemo- and radiosensitization in cancer cells, prolonged survival in mouse models of glioblastoma, decreased melanoma tumor burden in mice, and shows synergistic cytotoxic effects with temozolomide and chloroquine, both singly and in combination. DGK? inhibition with ritanserin shows particular toxicity to the treatment-resistant mesenchymal subtype in glioblastoma and other cancers.