Abstract: One aspect of the present invention relates to a method of modifying thermoplastic properties of lignin rich biomass to reduce agglomeration during any subsequent pyrolysis. The method comprises providing a lignin rich biomass and treating the lignin rich biomass with an alkali metal hydroxide or an alkaline earth metal hydroxide under conditions effective to reduce agglomeration, during any subsequent pyrolysis, compared to when the lignin rich biomass is not subjected to said treating. Also disclosed is a method of fast pyrolysis using the product of this method of modifying the thermoplastic properties of lignin rich biomass.
Type:
Grant
Filed:
February 14, 2017
Date of Patent:
January 29, 2019
Assignee:
Iowa State University Research Foundation, Inc.
Abstract: Disclosed herein are methods and compositions useful in targeting a payload to, or editing a target nucleic acid, where a governing gRNA molecule is used to target, optionally inactivate, a Cas9 molecule or a Cas9 molecule/gRNA complex.
Type:
Grant
Filed:
November 29, 2017
Date of Patent:
January 29, 2019
Assignees:
Editas Medicine, Inc., The Broad Institute Inc., Massachusetts Institute of Technology, University of Iowa Research Foundation
Abstract: An unmanned aerial vehicle (UAV) is provided. The UAV includes a main body, a plurality of motors connected to the main body, each of the plurality of motors having a rotor blade, a plurality of ultrasonic sensors located at least one of the plurality of motors and the main body, and transmitting and receiving ultrasonic waves to and from a ground surface, and measuring distances from the ground surface, a gyro sensor disposed at the main body and maintaining the UAV in a horizontal state, and a controller disposed at the main body, detecting an unevenness of the ground surface based on the distances from the plurality of ultrasonic sensors to the ground surface, generating a control signal whether to land on the ground surface or not in response to the detection of the unevenness, and transmitting the control signal to the plurality of motors.
Type:
Grant
Filed:
April 20, 2017
Date of Patent:
January 29, 2019
Assignee:
Foundation of Soongsil University-Industry Cooperation
Abstract: The present disclosure relates to a current memory circuit for minimizing clock feedthrough, the circuit including: a first memory capacitor implemented as a first conductive type MOS; a second memory capacitor implemented as a second conductive type MOS; and a dummy capacitor for connecting the first memory capacitor and the second memory capacitor to each other, wherein the first memory capacitor and the second memory capacitor are current mirrors. Accordingly, a current memory circuit with a more accurate performance, low power consumption, and an integration capability can be provided.
Type:
Grant
Filed:
September 1, 2015
Date of Patent:
January 29, 2019
Assignee:
Foundation of Research and Business, Seoul National University of Science and Technology
Abstract: A data driver capable of displaying images with a substantially uniform brightness, an organic light emitting display device using the same, and a method of driving the organic light emitting display device. The data driver includes a plurality of current sink units for controlling predetermined currents to flow through data lines, a plurality of voltage generators for resetting values of gray scale voltages using compensation voltages generated when the predetermined currents flow, a plurality of digital-to-analog converters for selecting one gray scale voltage among the gray scale voltages as a data signal in response to bit values of the data supplied from the outside, and a plurality of switching units for supplying the data signal to the data lines. The predetermined currents may be set equal to pixel currents that correspond to a maximum brightness.
Abstract: This document provides methods and materials for treating cancer. For example, methods and materials for identifying antigens and combinations of antigens that can be used to treat cancer as well as combinations of antigens having the ability to reduce established tumors (e.g., gliomas) within a mammal (e.g., a human) are provided. In general, one aspect of this document features a composition comprising, or consisting essentially of, nucleic acid encoding HIF-2a, SOX-10, C-MYC, and TYRP-1, wherein the composition comprises less than 100 separate nucleic acid molecules.
Type:
Grant
Filed:
March 19, 2015
Date of Patent:
January 29, 2019
Assignees:
Mayo Foundation for Medical Education and Research, University of Leeds
Inventors:
Richard G. Vile, Timothy J. Kottke, Jill M. Thompson, Jose S. Pulido, Alan A. Melcher, Peter Selby
Abstract: A method (400) for producing a titanium product is disclosed. The method (400) can include obtaining TiO2-slag (401), and producing a titanium product from the TiO2-slag using a metallic reducing agent (402) at a moderate temperature and a pressure to directly produce a titanium product chemically separated from metal impurities in the TiO2 slag (403). The titanium product can comprise TiH2 and optionally elemental titanium. Impurities in the titanium product can then removed (404) by leaching, purifying and separation to form a purified titanium product.
Type:
Grant
Filed:
August 19, 2014
Date of Patent:
January 29, 2019
Assignee:
University of Utah Research Foundation
Inventors:
Zhigang Zak Fang, Peng Fan, Scott Middlemas, Jun Guo, Ying Zhang, Michael Free, Amarchand Sathyapalan, Yang Xia
Abstract: A multidirectional control system with shear feedback, comprising at least one stationary body, a plurality of tactors disposed within the at least one movable body or the at least one stationary body. In some embodiments, a moveable body is included, such that the tactors have at least one degree of freedom of motion with respect to the stationary body or the moveable body within which they are disposed and are operable to engage target areas of a user's skin; and a plurality of actuators capable of moving the tactors.
Abstract: Systems and methods for relocating executable instructions to arbitrary locations are described, in which the relocation of the instructions may be arbitrary or random, and may operate on groups of instructions or individual instructions. Such relocation may be achieved through hardware or software, and may use a virtual machine, software dynamic translators, interpreters, or emulators. Instruction relocation may use or produce a specification governing how to relocate the desired instructions. Randomizing the location of instructions provides defenses against a variety of security attacks. Such systems and methods may provide many advantages over other instruction relocation techniques, such as low runtime overhead, no required user interaction, applicability post-deployment, and the ability to operate on arbitrary executable programs.
Type:
Grant
Filed:
February 27, 2013
Date of Patent:
January 29, 2019
Assignee:
University of Virginia Patent Foundation
Inventors:
Jason D. Hiser, Anh Nguyen-Tuong, Michele Co, Jack W. Davidson
Abstract: Cytisine-linked isoflavonoids, or pharmaceutically acceptable salts thereof or pharmaceutically acceptable compositions thereof, are useful for the treatment of conditions in which cells have a reliance on peroxisomal HSD17B4 to degrade very long chain fatty acids and provide necessary energy for cell proliferation, such as is seen in colorectal cancer and prostate cancer, for example.
Type:
Grant
Filed:
September 25, 2017
Date of Patent:
January 29, 2019
Assignee:
University of Kentucky Research Foundation
Inventors:
Chunming Liu, David S. Watt, Mykhaylo S. Frasinyuk, Vitaliy M. Sviripa, Wen Zhang, Svitlana P. Bondarenko
Abstract: A method of detecting a substance, wherein the method includes functionalizing a plurality of sensors, wherein the functionalizing the plurality of sensors comprises depositing a first material using a piezoelectrically actuated pipette system, wherein the first material includes a polymer, a receptor, and a solvent, wherein the solvent comprises dimethylformamide. The method further includes evaporating a solution of the first material wherein a residue after the evaporation comprises a functionalized chemical. Additionally, the method includes introducing a control material to a first set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system. Further, the method includes introducing a test material to a second set of sensors of the plurality of sensors using the piezoelectrically actuated pipette system, wherein the test material comprises an analyte.
Type:
Application
Filed:
July 19, 2018
Publication date:
January 24, 2019
Applicant:
Purdue Research Foundation
Inventors:
Jeffrey Frederick Rhoads, Eric A. Nauman, Mackenzie Tweardy, Michael Wadas, Allison Kelly Murray, George Tsu-Chih Chiu, Nikhil Bajaj
Abstract: Indirect ELISAs to detect exposure to Felis catus gammaherpesvirus 1 (FcaGHV1) in domestic cats. These ELISAs detect feline serum antibodies to ORF52 and ORF38 of FcaGHV1. The ELISA assays are sensitive, specific, and adaptable for scale up use in high throughput diagnostics.
Type:
Application
Filed:
July 19, 2018
Publication date:
January 24, 2019
Applicant:
Colorado State University Research Foundation, Inc .
Inventors:
Susan VandeWoude, Kathryn R. Stutzman-Rodriguez, Ryan M. Troyer
Abstract: Scoliosis can be treated by systems for anterior vertebral body tethering described herein. In some embodiments, installation tools of a system for anterior vertebral body tethering can be used to sequentially tension segments of a tether between adjacent vertebral screws in a controllable and user-friendly manner.
Type:
Application
Filed:
July 10, 2018
Publication date:
January 24, 2019
Applicant:
Mayo Foundation for Medical Education and Research
Inventors:
Todd A. Milbrandt, A. Noelle Larson, Stephen D. Cassivi
Abstract: This invention generally relates to a device for preparing and transferring a monolayer or thin film. In particular this present invention is a device for preparing and transferring a monolayer or thin film to a substrate using an improved version of the Langmuir-Schaefer technique, which incorporates in situ thermal control, for instance to heat the supporting substrate before and/or during the transfer process.
Type:
Application
Filed:
July 18, 2018
Publication date:
January 24, 2019
Applicant:
Purdue Research Foundation
Inventors:
Shelley A. Claridge, Tyler Hayes, David McMillan
Abstract: A microparticle for cell encapsulation is provided, having a core which comprises continuous fibers of decellularized extracellular matrix (ECM) and, optionally, an outer layer. Also provided are methods of encapsulating cells in the microparticle, pharmaceutical compositions comprising the microparticle, and methods of treating disease in animals employing the microparticles of the invention, for example, treating Diabetes.
Type:
Application
Filed:
September 25, 2018
Publication date:
January 24, 2019
Applicant:
Technion Research & Development Foundation Limited
Abstract: Disclosed is a real-time nucleic acid amplification measurement apparatus using a surface measurement technique, the apparatus including: a microfluidic chip having a closed loop shaped-microfluidic channel; a sample injecting and closing part communicating with the microfluidic channel, and operating in an injecting mode in which a reaction sample is injected to the microfluidic channel or operating in a closed mode in which the microfluidic channel forms a closed-loop in a state that the reaction sample has been injected to the microfluidic channel; a fluid movement generating part inducing the reaction sample to circulate inside the microfluidic channel; a plurality of heating parts individually heating a plurality of heating areas with different temperatures to amplify nucleic acid in the reaction sample; and a surface measurement part detecting the nucleic acid in the reaction sample at a predetermined area inside the microfluidic channel.
Type:
Application
Filed:
December 21, 2016
Publication date:
January 24, 2019
Applicant:
Korea University Research and Business Foundation
Abstract: This invention generally relates to a method for preparing and transferring a monolayer or thin film. In particular this present invention is an improved version of the Langmuir-Schaefer technique for preparing and transferring a monolayer or thin film, incorporating in situ thermal control of the substrate during the transfer process.
Type:
Application
Filed:
July 18, 2018
Publication date:
January 24, 2019
Applicant:
Purdue Research Foundation
Inventors:
Shelley A. Claridge, Tyler Hayes, David McMillan
Abstract: Multilayer UAS image ortho-mosaics is used to help remote sensing, agronomy and plant breeding (especially field-based high-throughput phenotyping).
Type:
Application
Filed:
July 20, 2018
Publication date:
January 24, 2019
Applicant:
Purdue Research Foundation
Inventors:
Katherine Martin Rainey, Keith Cherkauer, Anthony A. Hearst
Abstract: A geometrical error measurement method for a feed drive system includes entering coordinate values of four vertices of a virtual regular tetrahedron, mounting a position indicator to an end of a main shaft of a feed drive system, mounting three center mounts at three respective vertices of the four vertices except for the remaining vertex at which the main shaft is positioned while moving the main shaft of the feed drive system sequentially from one vertex to another according to the entered coordinate values, measuring distances between each of the four vertices indicated by the three center mounts and the position indicator with a double ballbar, and calculating a geometrical error from the measured distances.
Type:
Application
Filed:
July 17, 2018
Publication date:
January 24, 2019
Applicants:
Kyungil University Industry-Academic Cooperation Foundation, Kyungpook National University Industry-Academic Cooperation Foundation
Inventors:
Kwang Il LEE, Seung Han YANG, Hoon Hee LEE
Abstract: An object is to provide a novel polycyclic aromatic compound and an organic electroluminescent element using the same. By providing a novel polycyclic aromatic compound having a diarylamino group and having a plurality of aromatic rings linked to each other via a boron atom, an oxygen atom, or the like, options of a material for an organic EL element are increased. In addition, by using the novel polycyclic aromatic compound as a material for an organic electroluminescent element, an excellent organic EL element is provided.