Abstract: This invention relates to a complex for cancer cell chemotherapy and, more particularly, to an AGTR1 aptamer-anticancer drug complex for chemotherapy of cancer cells, which includes a nucleic acid aptamer specifically binding to AGTR1 and an anticancer drug linked with the nucleic acid aptamer, so that AGTR1-positive (overexpressed) breast cancer cells are selectively targeted and killed.

Abstract: An omnidirectional electromagnet (100) is disclosed. The omnidirectional electromagnet (100) comprises a ferromagnetic core (110) and three orthogonal solenoids (120, 130, 140) disposed about the core (110). Each solenoid (120, 130, 140) is adapted to receive a current from a current source to control an orientation and a magnitude of a magnetic field generated by the omnidirectional electromagnet (100). One or more omnidirectional electromagnets (100) can be used as a single magnetic manipulation system. The magnetic field generated by the omnidirectional electromagnet system can be used to control at least one of a force, a torque, an orientation, and a position of an adjacent magnetic object.

Abstract: A technique for forming a material including nanotwinned silver crystals in solid solution with a solute that exhibits enhanced strength and desirable electrical conductivity, as compared to coarse-grained material. Synthesis of nanotwinned silver alloy material is achieved by cooling of a substrate and co-deposition of silver and the solute. Controlling the processing conditions of synthesis allows for tailoring of the nanostructure and mechanical properties of the nanotwinned silver alloy material. A material including nanotwinned silver crystals in solid solution with a solute also is described.

Abstract: A system for use in a lecture environment in which a lecturer delivers a lecture to students. The lecturer can broadcast questions to the students to test their understanding of the subject matter of the lecture, and the students' answers to those question are made available to the lecturer in real time. This makes it possible for the lecturer to adapt the lecture to the students' level of understanding of the subject matter of the lecture.

Abstract: Cell-free translation and assembly systems allow for HBV capsid assembly under cell-free conditions that also mimic the physiological salt and protein concentrations. These hepatitis virus capsid assembly systems utilize the C-terminal domain (CTD) and N-terminal domain (NTD) of the hepatitis capsid protein in capsid assembly. Uses of the system include the identification of potential new therapeutic strategies and screening of potential therapeutic agents which target these domains and modulate capsid assembly and/or disassembly and other functions of these domains in HBV replication and pathogenesis.

Abstract: An internally ventilated brake disc with a disc coning reducing arrangement is provided in which temperature differences between inboard and outboard sides of the brake disc are minimized in order to reduce coning-causing differential thermal expansion. Between a radially inner region of a brake disc that includes brake disc-to-axle hub mounting features and a radially outer region the mass of the inboard side of the brake disc is distributed in a manner that reduces the amount of differential thermal expansion occurring during brake application between the inboard and outboard sides of the brake disc, thereby minimizing thermally-induced coning effects. The inboard side disc plate portion may having an increasing axial thickness in the direction from the radially outer region to the radially inner region, providing additional material mass to receive and dissipate heat energy received during a braking event.

Abstract: The following description related to a reduced titanium dioxide, which is formed by reducing rutile titanium dioxide and includes a disordered surface, a preparing method the same, and a photocatalyst including the reduced titanium dioxide.

Abstract: Patterned hydrogel arrays and methods of preparing patterned hydrogel arrays are disclosed. Advantageously, the methods used to prepare the patterned hydrogel arrays allow for controlling individual hydrogel spot conditions such as hydrogel spot modulus, hydrogel spot ligand identity and hydrogel spot ligand density, which allows for preparing a wide range of hydrogel spots in a single array format. Patterned hydrogel arrays can also be formed to include hydrogel-free pools surrounded by hydrogel. Additionally, the patterned hydrogel arrays of the present disclosure support the culture of a range of cell types. The patterned hydrogel arrays offer the ability to rapidly screen substrate components for influencing cell attachment, spreading, proliferation, migration, and differentiation.

Abstract: A method of enhancing transmittance of waves according to the invention comprises the following steps: (a) generating a plurality of waves each of which has random phase; (b) grouping randomly the plurality of waves into a first group and a second group; (c) introducing the waves onto a disordered medium by fixing phase of waves constituting the first group and varying phase of waves constituting the second group; (d) measuring intensity of the waves based on overlapped waves of the first group and the second group which penetrated the disordered medium according to the phase variation of waves constituting the second group; (e) obtaining phase having the maximum intensity according to the phase variation among intensities measured at the step (d); and (f) adjusting phase of the waves constituting the second group based on phase obtained at the step (e).

Abstract: In one aspect, the disclosed technology relates to a method which, in one example embodiment, includes acquiring magnetic resonance imaging data for a plurality of images of the heart of a subject during free breathing of the subject. The method also includes generating an additional plurality of images with high tissue-blood contrast over the region of interest, and selecting a subset of images from the plurality of images, based upon a pre-determined quality metric of image similarity, to be used for non-rigid image registration. The method also includes aligning the subset of images by non-rigid image registration using a combination of the plurality of images and the additional plurality of images, and creating a parametric map from the aligned images.

Abstract: A system and method employing a hybrid method for predicting sub-seasonal forecasts of winter storms and cold air outbreaks (CAOs). In various embodiments, the method includes, deriving a lead-time series of forecasted indices describing a state of stratospheric mass circulation from a plurality of forecasts generated by an operational numerical model for seasonal weather forecasts, detecting one or more PULSE events in the lead-time series of forecasted indices describing a state of stratospheric mass circulation to determine a state of the stratospheric mass circulation during the detected PULSE events and generating a sub-seasonal forecast of winter snowstorms and cold air outbreaks (CAOs) by linking the state of stratospheric mass circulation during the detected PULSE events to one or more maps of surface temperature and wintery precipitation based on historical observation data.

Abstract: An altered avian NDV that contains the coding sequence of avian interleukin-4 (IL-4), or a portion thereof, in the reverse orientation suppresses in-ovo IL-4 production via RNAi when administered to embryonic birds. An immunogenic composition containing this altered NDV is included in this invention. The altered avian NDV can, optionally contain a polynucleotide encoding a heterologous antigen from a heterologous avian pathogen and can produce said heterologous antigen in-ovo.

Abstract: Systems and methods for producing biologic tissues are described. For example, this document provides electrospinning systems and culturing techniques to make biologic heart valve leaflets and fibrosa layers of native valve leaflet having nanofibrous substrate layer(s). In some implementations, a tri-layered leaflet with circumferentially, randomly, and radially oriented nanofibers that mimics morphologies of native leaflets.

Abstract: An electrical capacitance tomography sensor including a sensor having a plurality of electrodes, where each electrode is formed from a plurality of capacitance segments. Each of the capacitance segments of each electrode can be individually addressed to focus the electric field intensity or sensitivity to desired regions of the electrodes and the sensor.

Abstract: A semiconductor photonic device includes a substrate, facet(s), and optical coupler(s) associated with the facet(s). Each optical coupler can couple an electromagnetic field incident on the respective facet towards the substrate as the electromagnetic field proceeds into the semiconductor photonic device. In some examples, each coupler has waveguides extending in a longitudinal direction and at least partly encapsulated within corresponding cladding layers. A first waveguide extends farther from the facet in the longitudinal direction than does a second waveguide. The second waveguide is located farther above the silicon substrate than is the first waveguide. The coupler can include a stack of waveguide assemblies. A lower waveguide assembly can include one waveguide. An intermediate or upper waveguide assembly can include multiple waveguides. In some examples, at least one waveguide tapers along its length.

Abstract: The invention generally relates to methods of analyzing crude oil. In certain embodiments, methods of the invention involve obtaining a crude oil sample, and subjecting the crude oil sample to mass spectrometry analysis. In certain embodiments, the method is performed without any sample pre-purification steps.

Abstract: There is provided a method for manufacturing a flexible electrode, the method comprising: cleaning a plastic substrate; forming a metal-oxide seed layer on the plastic substrate by sputtering a metal oxide on the plastic substrate; and forming a metal plating layer on the metal oxide seed layer using an electroless plating.

Abstract: Disclosed is a method of managing a memory of an electronic device, including: dividing a physical memory into one or more regions including consecutive pages; when there is a memory allocation request of a process or an operating system, allocating a physical memory space to a region including a free page; and configuring a domain by collecting one or more regions having the same characteristic among the regions, to which the memory is allocated.

Abstract: A process is disclosed for removing impurities from a carbon nanotube structure and then orienting the nanotubes within the structure. The process may use environmentally benign materials and minimize damage to the carbon nanotubes. The process may provide a cost-effective way to manufacture nanomaterials based macroscopic parts and components, whose properties approach to those of the individual nanoparticles.

Abstract: A secondary alkaline battery using manganese dioxide is described. The battery includes a mixed cathode material with birnessite-phase manganese dioxide or electrolytic manganese dioxide (EMD), a bismuth compound and a copper compound selected from the group consisting of elemental copper and a copper salt. In some embodiments, a conductive carbon and/or a binder may also be included.