Abstract: This invention provides novel indole, indazole, benzimidazole, benzotriazole, indoline, quinolone, isoquinoline, and carbazole selective androgen receptor degrader (SARD) compounds, pharmaceutical compositions and uses thereof in treating hyperproliferations of the prostate including pre-malignancies and benign prostatic hyperplasia, prostate cancer, advanced prostate cancer, castration resistant prostate cancer, other AR-expressing cancers, androgenic alopecia or other hyper androgenic dermal diseases, Kennedy's disease, amyotrophic lateral sclerosis (ALS), abdominal aortic aneurysm (AAA), and uterine fibroids, and to methods for reducing the levels (through degradation) and/or activity (through inhibition) of any androgen receptor including androgen receptor-full length (AR-FL) including pathogenic and/or resistance mutations, AR-splice variants (AR-SV), and pathogenic polyglutamine (polyQ) polymorphisms of AR in a subject.

Abstract: A method fits reversing immune suppression or immune exhaustion or for treating a disease associated with immune suppression includes: administering a co position to a subject in need of such treatments wherein the composition contains a CD11b modulator that binds specifically to CD11b on a cell to inhibit PD-L1 expression. The CD11b modulator is an antibody or an antigen-binding portion thereof, or a compound as described.

Abstract: Provided herein are biomarkers that can be altered in the gut of a mammal having CDI. One or more biomarkers can be used to predict Clostridium difficile infection (CDI) treatment outcome (e.g., response to primary CDI treatment and/or risk of recurrence after primary CDI treatment) in a mammal (e.g., a human) having CDI. Methods for using one or more biomarkers can be used to predict response to primary CDI treatment in a mammal having CDI. Methods for using one or more biomarkers can be used to predict risk of recurrence in a mammal having CDI. Also provided are methods of treating CDI.

Abstract: This document relates to materials and methods involved in assessing inflammatory bowel disease patients at risk for developing cancer. For example, materials and methods for monitoring colorectal cancer risk in ulcerative colitis patients are provided.

Abstract: The present invention provides 5-nitrofuran-2-amide derivatives and methods of using the same in the treatment of cancer and induction of apoptosis by activating C/EBP-homologous protein expression.

Abstract: The present disclosure generally relates to compositions comprising substrate-free 2D tellurene crystals, and the method of making and using the substrate-free 2D tellurene crystals. The 2D tellurene crystals of the present disclosure are characterized by an X-ray diffraction pattern (CuK? radiation, ?=1.54056 A) comprising a peak at 23.79 (2?±0.1°) and optionally one or more peaks selected from the group consisting of 41.26, 47.79, 50.41, and 64.43 (2?±0.1°).

Abstract: A threshold switching device is provided. The threshold switching device includes a first electrode and a second electrode spaced apart from each other, and a switching layer disposed between the first electrode and the second electrode. The switching layer includes an internal electric field.

Abstract: A flip-flop includes a conditional boosting stage, a pulse generator and a latch. The conditional boosting stage includes a boosting capacitor, and is configured to pre-charge the boosting capacitor in accordance with a previous output signal and boost a node connected to the boosting capacitor upon a level of the previous output signal being different from a level of a current input signal. The pulse generator is configured to generate a pulsed signal in accordance with transitions of a clock signal. The latch configured is to latch the current input signal to a current output signal in accordance with the pulsed signal.

Abstract: The present invention relates to series of compounds as an inhibitor targeting Proliferating Cell Nuclear Antigen (PCNA). Pharmaceutical compositions of those compounds and methods of using them in the treatment of cancer are within the scope of this disclosure.

Abstract: Aspects of the present disclosure involve systems, methods, and computer program products for obtaining and displaying a large image file over a network. In one embodiment, a user utilizes a computing device to obtain a large image file over a network, such as the Internet. The large image file may be stored in and available from a network device, such as an application server or database. To obtain the image file, a user interface executed on the user's computing device determines which portions of the overall image file are to be displayed in the interface. The interface may utilize one or more image variables to create or generate one or more network addresses at which the image tiles are stored or otherwise available. To retrieve the image tiles, the computing device uses the generated network addresses of the identified image tiles to request and obtain the image tiles.

Abstract: An approximate cache system is disclosed. The system includes a quality aware cache controller (QACC), a cache, a quality table configured to receive addresses and a quality specification from the processor associated with each address and further configured to provide the quality specification for each address to the QACC, wherein the QACC controls approximation is based on one or more of i) approximation through partial read operations; ii) approximation through lower read currents; iii) approximation through skipped write operations; iv) approximation through partial write operations; v) approximations through lower write duration; vi) approximation through lower write currents; and vii) approximations through skipped refreshes.

Abstract: Devices and methods for the treatment of heart conditions, hypertension, and other medical disorders are described. For example, this document describes devices and methods for treating atrial fibrillation by performing thoracic vein ablation procedures, including pulmonary vein myocardium ablation. In some embodiments, the ablation is performed in coordination with the delivery a pharmacological agent that can abate the formation of tissue stenosis or neointimal hyperplasia caused by the ablation. Additionally, in some embodiments, particulate matter, such as thrombus or crystalline drug compounds, created during the ablation is captured and removed from the patient using devices and methods provided herein. Further, devices and methods for non-thermal methods of causing cell death, such as tissue suction and tissue stretching, are also described.

Abstract: Xerogels and compositions comprising xerogels comprising a transition metal oxide and silicon oxide xerogel matrix. The xerogels and compositions can be made from mixtures of transition metal alkoxide(s) and tetraalkoxysilane(s) and, optionally, alkyltrialkoxysilane(s), aminoalkyl-, alkylaminoalkyl-, dialkylaminoalkyltrialkoxysilane(s), or a combination thereof. The xerogels and compositions can be used as antifouling coatings on, for example; boats.

Abstract: A strength and endurance training system.

Abstract: Devices and methods are provided for the treatment of pathological conditions including arrhythmias and trauma using temperature modulation via implantable or worn devices. For example, in one example embodiment this document relates to devices and methods for treating atrial or ventricular fibrillation by cooling the epicardium. The devices and methods can also be used to treat other disorders by applying heating and/or cooling to a patient in a number of different manners.

Abstract: The present disclosure relates to a nanofiber structure for cell culture, a method for manufacturing the structure, and a cell analysis device including the nanofiber structure for cell culture. The structure includes a cell culture layer made of nanofibers; and a spacer protruding upward from a surface of the cell culture layer, wherein the spacer divides a region on the cell culture layer into at least two culturing regions, wherein the spacer is made of the same nanofibers as the cell culture layer and thus has a cell migration channel defined therein.

Abstract: An electrode for electrical discharge machining (EDM) may comprise a diffuser portion and a tapered portion defining the tip of the electrode. A method for forming a film cooling hole may comprise moving a tool with respect to a film cooled gaspath component, forming a diffuser of the film cooling hole in response to the moving, and forming a tapered surface between a metering section and the diffuser of the film cooling hole.

Abstract: A building framing system includes a floor portion or floor framing system, a wall portion or wall framing system, and a roof portion or roof framing system. Each framing system comprises a plurality of components. Each component defines a connection geometry for connecting one component to another. The connection geometries are such that mechanical or other similar fasteners are not required to hold the various components together; rather, the connection geometries connect the components and hold them in place with respect to one another. Further, the framing systems utilize pre-cut components such that the components of each framing system arrive onsite cut to a needed length and width and with the appropriate connection geometry.

Abstract: The present disclosure includes: a data processing method of a software defined network (SDN) controller included in a SDN, wherein the SDN controller is connected to legacy network access equipment, an edge switch, and base network access equipment, and includes: (a) receiving an access request of user equipment transmitted by the legacy network access equipment through the edge switch connected to the legacy network access equipment; (b) setting initial access of the user equipment through a legacy network service module included in the SDN controller in response to the access request of the user equipment; (c) generating an access path for a base network on the basis of a base network service module included in the SDN controller upon completion of the initial access setup; and (d) requesting the edge switch to generate an entry for the access path upon generation of the access path.

Abstract: Disclosed are methods of delivering an agent to the lumen of the vas deferens under guidance of ultrasound imaging. The methods include vas-occlusive contraception in which the vas deferens is non-surgically isolated and an occlusive substance is percutaneously administered into the lumen of the vas deferens under ultrasound. Also disclosed are methods of reversal of vas-occlusive contraception and methods of delivering an agent to the lumen of the vas deferens. Also disclosed are compositions for use in the methods of the invention.