Abstract: An approach is provided for configuring multiple interferers. An interference effect minimum protective distance is calculated in response to detection of an input of an interferer parameter. Physical (PHY) layer modeling is performed to individually apply a pathloss caused by a separation distance between an interferer node and a victim and apply a pathloss of each node to an attenuator and a transmitter amplifier in an HW manner. MAC layer modeling is performed to determine a transmission node and a transmission time using Markov chain or determine a transmission node and a transmission time using a result log file of an external MAC simulator and a transmission/reception time is reflected in an HW manner by turning ON/OFF a switch. Multiple correlated interferer signals are generated for analyzing an effect of frequency interference in view of both of PHY and MAC layers.
Type:
Grant
Filed:
June 7, 2016
Date of Patent:
December 25, 2018
Assignee:
Kookmin University Industry Academy Cooperation Foundation
Inventors:
Byungjun Jang, Jinsoo Park, Hyungoo Yoon
Abstract: A new class of paromomycin-derived aminoglycosides, which exhibit efficient stop-codon mutation suppression activity, low toxicity and high selectivity towards eukaryotic cells are provided. Also provided are chemical and chemo-enzymatic processes of preparing these paromomycin-derived aminoglycosides and intermediates thereof, as well as pharmaceutical compositions containing the same, and uses thereof in the treatment of genetic disorders.
Type:
Grant
Filed:
November 20, 2017
Date of Patent:
December 25, 2018
Assignee:
Technion Research & Development Foundation Limited
Inventors:
Timor Baasov, Tamar Ben-Yosef, Igor Nudelman, Annie Rebibo-Sabbah, Dalia Shallom-Shezifi, Mariana Hainrichson
Abstract: Isolated polypeptides are provided that comprise a cholera toxin B subunit variant having one or more modifications to increase the expression of the polypeptide in a plant cell. Nucleic acids sequences, vectors, and plant cells for expressing the cholera toxin B subunit variant polypeptides are also provided. Further provided are methods for producing the cholera toxin B subunit variant polypeptides that include the steps of transforming a plant cell with a nucleic acid encoding the cholera toxin B subunit variant polypeptides; expressing the variant polypeptides; and purifying the polypeptides. Still further provided are methods of isolating the variant polypeptides that include the steps of obtaining a plant cell expressing the cholera toxin B subunit variant polypeptides; extracting the cholera toxin B subunit variant polypeptides from the plant cell; and purifying the cholera toxin B subunit variant polypeptides. Methods of eliciting an immune response are also provided.
Type:
Grant
Filed:
March 14, 2012
Date of Patent:
December 25, 2018
Assignee:
University of Louisville Research Foundation, Inc.
Abstract: This document provides methods and materials for treating cancers including renal cancer (e.g., renal cell carcinoma) as well as ovarian, breast, prostate, colon, pancreatic, bladder, liver, lung, and thyroid cancers and melanoma. For example, methods and material for using one or more inhibitors of an SCD1 polypeptide to treat renal cell carcinoma (e.g., clear cell renal cell carcinoma (ccRCC)) or to increase the efficacy of a renal cell carcinoma treatment are provided. In addition, this document provides methods and materials for using elevated SCD1 expression levels in diseased tissues as an indication that an SCD1 inhibitor can be used as an appropriate therapeutic to ameliorate the disease.
Type:
Grant
Filed:
August 31, 2017
Date of Patent:
December 25, 2018
Assignee:
Mayo Foundation for Medical Education and Research
Inventors:
John A. Copland, III, Laura Ann Marlow, Christina Von Roemeling
Abstract: The present disclosure illustrates new synthetic ALK-specific biosensors used to measure the activity or ALK, and methods of using the synthetic ALK-specific biosensors in assays, including high throughput assays.
Abstract: A system and method for generating magnetic resonance imaging (MRI) images is provided. The MRI system is directed to perform the dynamic contrast enhanced imaging study of the subject by exciting a two-dimensional (2D) slice within a portion of a field of view (FOV) of the MRI system and acquiring imaging data from the 2D slice by sampling k-space in a pseudorandom manner using sampling trajectories extending between a center of k-space and peripheral areas of k-space. Thereafter, the 2D slice is slid to another portion of the FOV at a velocity selected to be greater a velocity of the motion of the subject and the process is repeated for each of a plurality of 2D slices to create images of the subject where artifacts induced by the motion of the subject are reflected as geometric distortions.
Abstract: The invention provides a nutrient medium composition and associated methods for lengthening the useful life of a culture of muscle cells. Disclosed is a method of culturing mammalian muscle cells, including preparing one or more carriers coated with a covalently bonded monolayer of trimethoxy-silylpropyl-diethylenetriamine (DETA); verifying DETA monolayer formation by one or more associated optical parameters; suspending isolated fetal rat skeletal muscle cells in serum-free medium according to medium composition 1; plating the suspended cells onto the prepared carriers at a predetermined density; leaving the carriers undisturbed for cells to adhere to the DETA monolayer; covering the carriers with a mixture of medium 1 and medium 2; and incubating.
Type:
Grant
Filed:
October 19, 2015
Date of Patent:
December 25, 2018
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
James J. Hickman, Mainak Das, John W. Rumsey
Abstract: In an aspect, the invention relates to compositions and methods for permeabilizing membranes of cells. In an aspect, the invention relates to compositions and methods for killing cells. In an aspect, the invention relates to compositions and methods of permeabilizing the membranes of cancer cells or microbial cells.
Type:
Grant
Filed:
May 20, 2015
Date of Patent:
December 25, 2018
Assignee:
University of Central Florida Research Foundation, Inc.
Inventors:
Annette Khaled, Rebecca Boohaker, Michael Lee, Jesus Perez Figueroa
Abstract: The optimized inequality join method is a method for joining relational tables on input inequality conditions. The optimized inequality join method is a relatively fast inequality join method using permutation arrays to store positional information for sorted attributed values. Additionally, space efficient bit arrays are used to enable optimization, such as Bloom filter indices, thus providing faster computation of the join results. The method may be used, for example, for joining various inequalities associated with a variety of measured environmental conditions for raising an alarm when certain conditions are met.
Type:
Grant
Filed:
August 15, 2016
Date of Patent:
December 25, 2018
Assignee:
Qatar Foundation For Education, Science and Community
Inventors:
Zuhair Khayyat, William Lucia, Mourad Ouzzani, Paolo Papotti, Jorge-Arnulfo Quiane-Ruiz, Nan Tang
Abstract: A method and apparatus for photon, ion or particle counting described that provides seven orders of magnitude of linear dynamic range (LDR) for a single detector. By explicitly considering the log-normal probability distribution in voltage transients as a function of the number of photons, ions or particles present, the binomial distribution of observed counts for a given threshold, the mean number of photons, ions or particles can be determined well beyond the conventional limit.
Type:
Grant
Filed:
September 12, 2017
Date of Patent:
December 25, 2018
Assignee:
Purdue Research Foundation
Inventors:
Garth Jason Simpson, Ryan Douglas Muir, David Joseph Kissick
Abstract: Disclosed is a glass composition for sealing a large-area dye-sensitized solar cell, and more particularly, to a glass composition which may be uniformly bonded to a large-area without reacting with an electrolyte.
Type:
Grant
Filed:
May 8, 2017
Date of Patent:
December 25, 2018
Assignees:
Kongju National University Industry-University Cooperation Foundation, Orion Co., Ltd.
Inventors:
Woon Jin Chung, Han Sol Lee, Jae Kwun Hwang, Jae Hyoung Park
Abstract: Methods, kits, and compositions of matter suitable for use in RNA Tagging are disclosed. In one embodiment, a method includes: expressing a fusion protein within the cellular environment, the fusion protein including at least part of the protein of interest and a tagging domain, the tagging domain introducing a selective tag to an RNA to which the fusion protein selectively binds, the selective tag including a selective tag sequence or a selective covalent modification; allowing the tagging domain to tag the RNA to which the protein of interest selectively binds by waiting for about 1 minute to about 28 days; and identifying the tagged RNA.
Type:
Grant
Filed:
November 19, 2015
Date of Patent:
December 25, 2018
Assignee:
Wisconsin Alumni Research Foundation
Inventors:
Marvin P. Wickens, Christopher P. Lapointe, Melanie A. Preston
Abstract: A system for providing continuous passive motion of a subject's leg through hip extension and flexion. The system may have an actuator, a leg support member, a retention surface, and a base. The leg support member may be a support frame with a proximal member and a distal member. The subject places his/her leg on the leg support and the actuator provides a moment of force to the subject's upper leg to move the upper leg through the desired range of motion. The system may be controlled allowing the device to operate at different speeds and for different ranges of motion.
Type:
Grant
Filed:
July 7, 2011
Date of Patent:
December 25, 2018
Assignee:
University of Virginia Patent Foundation
Inventors:
Laura W. Lee, Kenneth A. Garrett, Muhaimeinul Khan
Abstract: Methods for expanding proliferating populations of neuronal subtype-specific progenitors and creating substantially pure populations of motor neurons are provided herein. In particular, the present invention provides methods for maintaining the unique gene profile and differentiation potential of neuronal subtype-specific progenitors, such as motor neuron progenitors and hindbrain serotonergic neural progenitors.
Abstract: Ultrasonic imaging apparatus or techniques can include obtaining at least an approximation of samples of reflected ultrasonic energy and constructing a representation of an imaging plane within the tissue region. Such apparatus or techniques can include separately determining, for respective focusing locations respective first sums of at least approximated complex samples of reflected ultrasonic energy obtained via respective first lines of transducers, and separately determining, for the specified focusing location, a second sum of at least some the respective first sums of at least approximated complex samples of reflected ultrasonic energy, the second sum corresponding to a second line of transducers in the ultrasonic transducer array. The separately determining the first or second sums of at least approximated complex samples can include phase-rotating at least some of the complex samples. The second line of transducers can be orthogonal to respective first lines in the transducer plane.
Type:
Grant
Filed:
September 2, 2016
Date of Patent:
December 25, 2018
Assignee:
University of Virginia Patent Foundation
Abstract: Disclosed herein is a tissue harvester comprising a substrate having an airfoil shape; and a textured surface disposed upon the substrate, where the textured surface comprises a spatial array of nanometer or micrometer sized pillars of varying cross-sections. Disclosed herein too is method comprising disposing upon a substrate a textured surface; where the substrate has an airfoil shape and where the textured surface where the textured surface comprises nanometer or micrometer sized pillars; contacting the tissue harvester with biological cells whose proliferation under different conditions is desired; and disposing the tissue harvester in a flow field such that cells disposed on the tissue harvester at different locations may experience different flow fields.
Type:
Grant
Filed:
September 12, 2014
Date of Patent:
December 25, 2018
Assignee:
University of Florida Research Foundation, Inc.
Inventors:
Mina-Elraheb Saad Hanna, Juan Claudio Nino
Abstract: The present invention relates a novel compound represented by the following Formula 3 or Formula 5, and a pharmaceutical composition having superior anti-inflammatory effect comprising the above. The above compound inhibits the translocation of HMGB1 form nucleus to cytosol, and then has remarkable effect of treating or preventing inflammatory disease, especially sepsis.
Type:
Grant
Filed:
November 1, 2017
Date of Patent:
December 25, 2018
Assignees:
Spark Biopharma, Inc., Seoul National University R&DB Foundation
Inventors:
Seung Bum Park, Wan Sang Cho, Ja Young Koo
Abstract: An organic semiconductor compound and a method for manufacturing the same is provided. The method for manufacturing the organic semiconductor compound may include stirring a solated organic semiconductor and a solated organometallic precursor. Herein, the manufacturing the organic semiconductor compound includes: forming a three-dimensional organic semiconductor compound by allowing the solated organic semiconductor to orthogonally penetrate one or more gaps in a lattice structure of a gelated organometallic precursor formed by stirring the solated organometallic precursor.
Type:
Grant
Filed:
January 4, 2016
Date of Patent:
December 25, 2018
Assignees:
SOONGSIL UNIVERSITY RESEARCH CONSORTIUM TECHNO-PARK, Industry-University Cooperation Foundation Hanyang University
Inventors:
Do Hwan Kim, Hojin Lee, Han Wool Park, Keun-Yeong Choi
Abstract: A new and distinct muscadine grape plant characterized by purple berries; self-fertile flowers; berries that separate with a high percentage of dry stem scars; berries that are very large in size; and very productive vines with high total and usable yields.
Type:
Grant
Filed:
May 22, 2017
Date of Patent:
December 25, 2018
Assignee:
University of Georgia Research Foundation, Inc.
Abstract: A magnetic resonance imaging “MRI” method and apparatus for lengthening the usable echo-train duration and reducing the power deposition for imaging is provided. The method explicitly considers the t1 and t2 relaxation times for the tissues of interest, and permits the desired image contrast to be incorporated into the tissue signal evolutions corresponding to the long echo train. The method provides a means to shorten image acquisition times and/or increase spatial resolution for widely-used spin-echo train magnetic resonance techniques, and enables high-field imaging within the safety guidelines established by the Food and Drug Administration for power deposition in human MRI.
Type:
Grant
Filed:
May 11, 2015
Date of Patent:
December 25, 2018
Assignee:
University of Virginia Patent Foundation
Inventors:
John P. Mugler, III, James R. Brookeman