Abstract: Provided herein are materials and methods for delivering immunoglobulins (e.g. therapeutic immunoglobulins) across the blood-brain barrier.

Abstract: The present invention is directed to small interfering RNA molecules (siRNA) targeted against nucleic acid sequence that encodes huntingtin or ataxin-1, and methods of using these siRNA molecules.

Abstract: This invention provides a device for implantation directly into the spinal cord for the purpose of treating back pain. Electrodes on a backing that conforms directly to the spinal cord are installed as a source of electrical stimulation and pain relief. The floating electrodes can be flexibly mounted to the substrate such that when the electrode array is implanted into the subject, individual electrodes float or move resiliently relative to the substrate to an extent sufficient to accommodate pulsations of the surface of the spinal cord within the dura.

Abstract: A condensed cyclic compound and an organic light-emitting device, the compound being represented by Formula 1 below:

Abstract: Isolated non-naturally occurring, mutant-human islet amyloid polypeptides (hIAPP) are disclosed. These polypeptides can be formulated or co-formulated at physiological pH, which enable the polypeptides of the instant disclosure to be delivered to a subject having an amyloid-based disease in a single injection with an insulin agent. Methods and compositions for treating amyloid-based disease in a subject in need thereof, by administering an effective amount of an isolated, mutant-hIAPP polypeptide, including formulations or co-formulations thereof are also disclosed.

Abstract: A system and method of dynamically localizing a measurement of parameter characterizing tissue sample with waves produced by spectrometric system at multiple wavelengths and detected at a fixed location of the detector of the system. The parameter is calculated based on impulse response of the sample, reference data representing characteristics of material components of the sample, and path lengths through the sample corresponding to different wavelengths. Dynamic localization is effectuated by considering different portions of a curve representing the determined parameter, and provides for the formation of a spatial map of distribution of the parameter across the sample. Additional measurement of impulse response at multiple detectors facilitates determination of change of the measured parameter across the sample as a function of time.

Abstract: A memory capable of carrying out compute-in-memory (CiM) operations is disclosed. The memory includes a matrix of bit cells having a plurality of bit cells along one or more rows and a plurality of bit cells along one or more columns, each bit cell having a value stored therein, an address decoder configured to receive addresses and activate two or more of the rows associated with the addresses, and a sensing circuit coupled to each column of bit cells, and configured to provide two or more outputs, wherein each output is associated with at least one compute operation performed on values stored in the bit cells in the column.

Abstract: The present invention relates to a method for preparing 3,6-anhydro-L-galactose, and use thereof. More specifically, 3,6-anhydro-L-galactose, which is a monosaccharide constituting agar, is produced in a high yield through chemical and enzymatic methods, and the physiological activities thereof such as whitening, moisturizing, antioxidant, anti-inflammatory activities and the like are displayed, thereby enabling industrial use thereof.

Abstract: A pulse width modulation resonance converter is provided that includes a transformer and a switching unit including first to fourth switches electrically connected to a primary coil of the transformer and configured to convert a DC voltage into an AC voltage by a switching operation of the first to fourth switches in which each switch is switched from an off state to an on state when a voltage difference between both ends is about 0. Additionally, a rectifying unit includes an output capacitor, first to fourth diodes electrically connected to a secondary coil of the transformer, and a resonance tank having a resonance capacitor and a resonance inductor which are electrically connected to the secondary coil of the transformer. The plurality of switches connected to the primary side of the transformer perform the zero-voltage switching using the magnetized inductance of the primary side to minimize the switching loss.

Abstract: A wearable paper-based platform with simultaneous passive and active feedback for monitoring perspiration is provided. The sensor platform comprises two modules: a disposable wicking-based sweat collection patch with discrete colorimetric feedback, and a reusable electronic detachable module for active feedback. The disposable patch comprises a hygroscopic wicking material laminated between two polymeric films. The wicking material is patterned with a radial finger design that offers discretized visual readout of the sensor. The active module attaches to the film and alerts the user when the film collects a pre-determined volume of sweat. The multi-feedback system allows high-performance athletes who value objective quantification of perspiration to better assess their sweat loss during physical activities.

Abstract: The present invention provides oxygenized nanobubbles and their uses in imaging and cancer treatment when combined with therapeutic drugs and precise ultrasound beam steering.

Abstract: A video analytics algorithm, system, and method for use in real time allowing accurate, reliable, and timely warnings that facilitate traffic safety and efficiency. The system and method are readily implemented with minimal computational resources, providing broad applicability. In an embodiment, a video analytics method may include (a) obtaining a sequence of real-time images as input from a traffic monitoring system; (b) identifying a plurality of vehicles within a pre-defined region of interest; (c) tracking vehicles within the predefined region of interest; and (d) detecting a conflict event when the vehicles are located within a pre-determined maximum separation threshold based on each vehicles coordinates in a spatial-temporal domain.

Abstract: The present disclosure provides novel cell compositions engineered to express at least a chimeric antigen receptor and a survival factor. Methods of using such cell compositions are also described.

Abstract: A vertical field-effect transistor is provided, comprising a first electrode, a porous conductor layer formed from a layer of conductive material with a plurality of holes extending through the conductive material disposed therein, a dielectric layer between the first electrode and the porous conductor layer, a charge transport layer in contact with the porous conductor layer, and a second electrode electrically connected to the charge transport layer. A photoactive layer may be provided between the dielectric layer and the first electrode. A method of manufacturing a vertical field-effect transistor may also be provided, comprising forming a dielectric layer and depositing a conductor layer in contact with the dielectric layer, wherein one or more regions of the dielectric layer are masked during deposition such that the conductor layer includes a plurality of pores that extend through the conductor layer.

Abstract: The effects of hepcidin treatment on mitigating IRI and acute kidney injury by decreasing iron availability and ROS-mediated cell death were tested. C57Bl/6 (WT) and hepcidin knock out (Hamp?/?) mice were treated with saline or 50 ?g of hepcidin i.p. prior to bilateral renal IRI. Renal function, injury markers, histopathology, and inflammation were examined after 24 hours of reperfusion. In WT mice, IRI induced increases in serum and kidney non-theme iron levels, but hepcidin treatment induced sequestration of iron in the spleen and liver and prevented IRI-associated increases in serum and kidney non-heme iron. Kidney function was significantly better in hepcidin-treated mice, accompanied by less acute tubular necrosis and reduced infiltration of immune cells. Hepcidin treatment decreased kidney ferroportin expression and induced the expression of cytoprotectant, H-Ferritin, and was associated with less ROS and tubular epithelial apoptosis.

Abstract: The present invention relates to a triblock copolymer having a polyethylene glycol-poly(D,L-lactide)-polyethylene glycol skeleton.

Abstract: A battery packaging arrangement. The battery packaging arrangement includes a first base configured to be fixedly coupled to a frame of a vehicle, a second base moveable with respect to the first base, and a plurality of cooling columns inter-disposed between the first base and the second base. Each of the plurality of cooling columns includes a plurality of receiving surfaces for receiving a corresponding plurality of battery cells. Each of the plurality of cooling columns is further configured to deform when the second base in response to a force moves towards the first base.

Abstract: A neural network processor and method include a fetch controller configured to receive input feature information, indicating whether each of a plurality of input features of an input feature map includes a non-zero value, and weight information, indicating whether each of a plurality of weights of a weight map includes a non-zero value, and configured to determine input features and weights to be convoluted, from among the plurality of input features and the plurality of weights, based on the input feature information and the weight information. The neural network processor and method also include a data arithmetic circuit configured to convolute the determined weights and input features to generate an output feature map.

Abstract: This document provides methods and materials involved in reducing suppression of immune function in mammals. For example, methods and materials for (a) identifying a mammal as having an elevated level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and (b) administering RU486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that change the ratio of CD14+/HLA-DR? cells to CD14+/HLA-DR? cells as well as methods and materials for (a) identifying a mammal as being likely to experience an elevated level of CD14+/DR? cells (e.g., CD14+/DR? monocytes) and (b) administering RU486 (mifepristone; or drugs with a similar functional profile) to the identified mammal under conditions that reduce the degree to which the mammal develops CD14+/DR? cells are provided.

Abstract: The present disclosure relates to the identification and use of biomarkers (e.g., analytes, analyte profiles, or markers (e.g., gene expression and/or protein expression profiles)) with clinical relevance to cytokine release syndrome (CRS).