Abstract: A method for analyzing incoming data, comprising the steps of processing the incoming data in segments to output a sequence of segment types by extracting one or more properties of an incoming data segment and forming an Unknown Property Vector for each segment of data in the incoming data, and processing the sequence of segment types to identify events in the incoming data. The sequence of segment types is determined, for each segment, by analyzing the Unknown Property Vector by reference to one or more collections of vectors obtained from a set of Reference Property Vectors. This may each of the one or more collections of vectors being selected from the set of Reference Property Vectors randomly or based on relevance or clustering.

Abstract: Abstract of the Disclosure Disclosed herein are methods and compounds for screening and identifying ligands of G protein-coupled receptors (GPCRs). Also disclosed are chimeric G proteins and methods for detecting the activation or inhibition of GPCRs.

Abstract: A method for analyzing incoming data, comprising the steps of processing the incoming data in segments to output a sequence of segment types by extracting one or more properties of an incoming data segment and forming an Unknown Property Vector for each segment of data in the incoming data, and processing the sequence of segment types to identify events in the incoming data. The sequence of segment types is determined, for each segment, by reference to a set of Reference Property Vectors that are relevant to the Unknown Property Vector. This may involve application of first and/or second and/or further functions to identify at least a first subset of Reference Property Vectors that are relevant to the Unknown Property Vector. Alternatively, a logistic regression algorithm, derived using clustering or classification methods for identifying candidate vectors, may be used.

Abstract: The invention provides HSV antigens that are useful for the prevention and treatment of HSV infection, including epitopes confirmed to be recognized by T-cells derived from herpetic lesions. T-cells having specificity for antigens of the invention have demonstrated cytotoxic activity against cells loaded with virally-encoded peptide epitopes, and in many cases, against cells infected with HSV. The identification of immunogenic antigens responsible for T-cell specificity provides improved anti-viral therapeutic and prophylactic strategies. Compositions containing antigens or polynucleotides encoding antigens of the invention provide effectively targeted vaccines for prevention and treatment of HSV infection.

Abstract: A hot-mix asphalt paving mixture includes the use of a hard, angular, non-carbonate ½? minus igneous crushed rock, washed rounded No. 100 sieve silica sand particles, ½? minus recycled asphalt pavement particles, and a performance-graded bituminous liquid asphalt binder, thereby to produce an environmentally-friendly hot asphalt mixture that is laid with minimal compaction effort, and without the use of conventional compaction-aiding additives that chemically alter the viscosity of the liquid asphalt binder. During compaction, the rounded silica sand particles react with the igneous rock particles as a mechanical compaction aid, thereby allowing the angular particles to achieve proper aggregate interlock with minimal compactive effort. The aggregate composition comprises about 75% igneous crushed rock, about 5% processed round silica sand particles, about 20% recycled asphalt pavement, and about 5% binder. The resultant pavement is skid-resistant, resists rutting, and has a permanent dark color.

Abstract: An architecture is provided for a widely distributed security system (SDI-SCAM) that protects computers at individual client locations, but which constantly pools and analyzes information gathered from machines across a network in order to quickly detect patterns consistent with intrusion or attack, singular or coordinated. When a novel method of attack has been detected, the system distributes warnings and potential countermeasures to each individual machine on the network. Such a warning may potentially include a probability distribution of the likelihood of an intrusion or attack as well as the relative probabilistic likelihood that such potential intrusion possesses certain characteristics or typologies or even strategic objectives in order to best recommend and/or distribute to each machine the most befitting countermeasure(s) given all presently known particular data and associated predicted probabilistic information regarding the prospective intrusion or attack.

Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing or treating hearing loss. The compounds and pharmaceutical compositions described herein prevent or treat hair cell death. In addition, the compounds and pharmaceutical compositions described herein protect against kidney damage in an individual receiving an aminoglycoside antibiotic. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Abstract: A method of carrying out adoptive immunotherapy by administering a subject an antigen-specific cytotoxic T lymphocytes (CTL) preparation in a treatment-effective amount is described. In the method, the CTL preparation is preferably administered as a preparation of an in vitro antigen-stimulated and expanded primate CTL population, the CTL population: (i) depleted of FoxP3+ T lymphocytes prior to antigen stimulation; (ii) antigen-stimulated in vitro in the presence of interleukin-21; or (iii) both depleted of FoxP3+ T lymphocytes prior to antigen stimulation and then antigen-stimulated in vitro in the presence of interleukin-21. Methods of preparing such compositions, and compositions useful for carrying out the adoptive immunotherapy, are also described.

Abstract: The present invention provides methods for treating cancers having a mutation in one or more tumor suppressor genes, comprising providing to a subject in need thereof an inhibitor of a kinase, as well as related methods and compositions.

Abstract: Described herein are methods for treating hematological malignancies and/or solid tumors in a subject using inhibitors of integrin alpha 6. In some embodiments, the inhibitors are monoclonal antibodies. The antibodies may be conjugated to additional therapeutic agents. The antibodies may be co-administered sequentially or simultaneously with additional therapeutic agents.

Abstract: In order to inhibit thrombotic processes locally rather than systemically, higher levels of antithrombotic drugs in the deep veins of the legs than in the systemic circulation are obtained using devices and methods that provide venous cannulation in the dorsum of the foot of a patient while applying pressure to the foot proximal to the venous cannulation, potentially as far up the leg as the knee, in an amount sufficient to compress the superficial veins and divert the venous drainage in the deep venous system into the venous plexus.

Abstract: A distributed multi-agent system and method is implemented and employed across at least one intranet for purposes of real time collection, monitoring, aggregation, analysis and modeling of system and network operations, communications, internal and external accesses, code execution functions, network and network resource conditions as well as other assessable criteria within the implemented environment. Analytical models are constructed and dynamically updated from the data sources so as to be able to rapidly identify and characterize conditions within the environment (such as behaviors, events, and functions) that are typically characteristic with that of a normal state and those that are of an abnormal or potentially suspicious state. The model is further able to implement statistical flagging functions, provide analytical interfaces to system administrators and estimate likely conditions that characterize the state of the system and the potential threat.

Abstract: Disclosed herein are compounds, and pharmaceutical compositions that include such compounds, for preventing, treating, and/or protecting against sensory hair cell death. Methods of using the compounds, alone or in combination with other therapeutic agents, are also disclosed.

Abstract: The present invention provides nanoparticles having a core comprising a magnetic material and having a surface, where the surface may be operatively linked to an antigenic peptide-major histocompatibility complex (MHC) monomer. The antigenic peptide-MHC monomer may then be recognized by a T cell receptor. These nanoparticles may further comprise a signal-generating label, such as a fluorophore. Methods employing nanoparticles of the present invention may involve magnetic resonance imaging and/or fluorescence detection, such that cell imaging and localization are performed.

Abstract: In one aspect, the present invention provides an intron-modified capsid expression cassette useful for generating adeno-associated virus (AAV) vector particles. In another aspect, the present invention provides a method of reducing the immune response in a mammalian subject undergoing treatment with an AAV vector.

Abstract: In one embodiment, a gene expression signature for predicting risk of developing therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) after autologous hematopoietic cell transplantation (aHCT) is provided. In another embodiment, a method for predicting a risk for development of t-MDS/AML after aHCT is provided. Such a method may include providing a biological sample that contains CD34 cells from a subject; detecting a test expression level of a set of two or more genes of a gene expression signature; comparing the test expression level of a set of corresponding training expression levels that include a training case expression level and a training control expression level; and predicting a high risk of developing t-MDS/AML when the test expression level is at or about the training case expression level or predicting a low risk of developing t-MDS/AML when the test expression level is at or about the training control expression level.

Abstract: A sensor device for sensing wetness in an absorbent article worn by a subject includes one or more sensing elements; and a coupling for communicating sensor signals between the one or more sensing elements and a receiver. A change in environmental parameter causes a change in electrical behavior of at least one of the sensing elements, which behavior can be analyzed to determine occurrence of a wetness event in the absorbent article. The changes in electrical behavior are communicated in the sensor signals to the receiver. The analysis may be by the receiver or a processor in communication with the receiver. Ideally, the sensing elements include capacitive elements and preferably, resonance circuits.

Abstract: A system for monitoring incontinence in one or more subjects comprises display means; input means operable by a user; one or more transmitters, each transmitter being associated with one or more subjects being monitored; the one or more transmitters being configured to transmit signals containing continence-related data for the one or more subjects, wherein the continence-related data has been obtained over time from a continence sensor associated with an absorbent article worn by each respective subject; a receiver unit configured to receive signals from the one or more transmitters; and processing means in communication with at least the receiver unit, the processing means including a display processor configured to process the received signals and communicate display information to the display means for display of a visual representation of continence-related information derived from continence sensors in the absorbent articles worn by the one or more subjects being monitored.

Abstract: Compositions and methods are described for highly sensitive quantification of the relative representation of DNA from adaptive immune cells (e.g., T and/or B lymphocytes) in DNA extracted from complex mixtures of cells that include cells which are not adaptive immune cells. Included are methods for determining the relative presence in a tumor of tumor infiltrating lymphocytes (TIL), the relative presence of lymphocytes infiltrating a somatic tissue that is the target of an autoimmune disease, and the relative presence of lymphocytes infiltrating a transplanted organ.

Abstract: The invention generally relates to methods for identifying and using anticancer therapeutic agents and, more particularly, to methods for identifying and using inhibitors of genes for inhibiting the growth and/or proliferation of MYC-driven tumor cells relative to normal cells.