Patents Assigned to FRED
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Patent number: 8450334Abstract: Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.Type: GrantFiled: May 21, 2009Date of Patent: May 28, 2013Assignee: Fred Hutchinson Cancer Research CenterInventors: Valeri I. Vasioukhin, John R. Chevillet
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Patent number: 8450059Abstract: Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample to generate an amplicon that includes a region of an Aspergillus spp. ribosomal RNA (rRNA) gene, and detecting the PCR amplicon. The present disclosure also provides primers and primer sets for specifically detecting an Aspergillus spp. fungal pathogen in the presence of human ribosomal DNA (rDNA).Type: GrantFiled: April 27, 2010Date of Patent: May 28, 2013Assignee: Fred Hutchinson Cancer Research CenterInventors: David N. Fredricks, Prasanna D. Khot, Daisy L. Ko
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Publication number: 20130115232Abstract: The disclosure relates to the development of methods for detecting or predicting graft-versus-host disease (GVHD) and for detecting or predicting response to treatment for GVHD. More particularly, the disclosure provides new biomarkers and combinations of biomarkers for detecting or predicting gastrointestinal GI GVHD and for predicting and analyzing response to treatment for acute GVHD.Type: ApplicationFiled: October 3, 2012Publication date: May 9, 2013Applicants: FRED HUTCHINSON CANCER RESEARCH CENTER, The Regents Of The University Of MichiganInventors: The Regents Of The University Of Michigan, Fred Hutchinson Cancer Research Center
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Publication number: 20130115309Abstract: In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the tumor cells with a CSNK1? inhibitor. In another aspect, the invention provides a method of treating a subject suffering from a tumor comprising myc-driven tumor cells, comprising administering to the subject an amount of a composition comprising a CSNK1? inhibitor effective to inhibit the growth and/or proliferation of the tumor cells.Type: ApplicationFiled: April 6, 2011Publication date: May 9, 2013Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: Carla Grandori, Masafumi Toyoshima
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Publication number: 20130108657Abstract: What is described is a novel genetic screen, involving recombinant technology and class I antigen cross-presentation, to search for supraoptimal superagonists of the 27L MART-1 mutant selecting for single amino acid substitution mutants of 27L that activate human antigen-specific CTL clones recognizing the wild-type MART-126-35 epitope. Three novel mutant epitopes are identified with superagonist properties that are functionally superior to 27L. The ability of a given analog to act as superagonist varies among patients. Also described is the use of methods to establish panels of potential superagonist APLs to individualize tumor peptide vaccines among patients. The methodology is replicated to identify APL to NY-ESO-1157-165 and NY-ESO-1157-170 tumor epitopes. A general method is described that is useful to produce a tumor vaccine to any tumor epitope.Type: ApplicationFiled: November 10, 2011Publication date: May 2, 2013Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: Cassian Yee, Yongqing Li, C. Siddiq Abdul-Alim
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Publication number: 20130095079Abstract: The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.Type: ApplicationFiled: April 11, 2011Publication date: April 18, 2013Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: Irwin D. Bernstein, Colleen Delaney
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Publication number: 20130095080Abstract: The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/pro-genitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.Type: ApplicationFiled: April 11, 2011Publication date: April 18, 2013Applicant: Fred Hutchinson Cancer Reserach CenterInventors: Irwin D. Bernstein, Colleen Delaney
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Publication number: 20130081371Abstract: A mowing finger arrangement has a lower element and an upper element connected to each other and forms two mowing fingers. A space is formed to accommodate a cutting device between the lower element and the upper element. The two mowing fingers are connected to each other via, respectively, a connection web on the upper element and on the lower element on a rear end of the mowing finger, when viewed in working direction. At least one of the connection webs has, at least portion wise, an off-set to provide an enlarged distance between the connection webs.Type: ApplicationFiled: September 24, 2012Publication date: April 4, 2013Applicant: Erfindergemeinschaft Gustav und Fred Schumacher GbRInventor: Erfindergemeinschaft Gustav und Fred Schumach
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Patent number: 8349554Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.Type: GrantFiled: August 14, 2008Date of Patent: January 8, 2013Assignee: Fred Hutchinson Cancer Research CenterInventors: S. Bahram Bahrami, Mandana Veiseh, James Olson
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Patent number: 8333410Abstract: A multi-piece swivel coupling kit with a snap connection for ready and rapid assembly with the capability to be disassembled and reconfigured as required by the specific installation. The swivel coupling kit includes a tubular socket member having a line connecting end and multiple coupling ends and multiple tubular stem members each having a line connecting end and a coupling end connectable to one of the coupling ends of the tubular socket member. The multiple coupling ends including integral complementing annular projections and recesses which define a close fitting bearing unit creating forced engagement between the projections and recesses to establish smooth engagement and rotational support of the socket member and each of the stem members. The multiple coupling ends of the tubular socket member are configured to allow releasable configuration, reconfiguration and expansion of the multiple tubular stem members along a X axis, a Y axis and a Z axis and in a X plane, a Y plane and a Z plane.Type: GrantFiled: May 7, 2009Date of Patent: December 18, 2012Assignee: Fred Knapp Engraving Company, Inc.Inventor: John A. Boticki
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Patent number: 8309315Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.Type: GrantFiled: August 25, 2008Date of Patent: November 13, 2012Assignees: Van Andel Research Institute, Fred Hutchinson Cancer Research CenterInventors: Boliang Cao, George F. Vande Woude, Beatrice S. Knudsen, Ping Xu Zhao
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Publication number: 20120282353Abstract: The present invention generally relates to the modulation of hypoxia-inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis.Type: ApplicationFiled: March 26, 2012Publication date: November 8, 2012Applicant: Fred Hutchinson Cancer Research CenterInventors: Mark B. Roth, Mark Budde
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Publication number: 20120268278Abstract: A system for monitoring incontinence in one or more subjects comprises display means; input means operable by a user; one or more transmitters, each transmitter being associated with one or more subjects being monitored; the one or more transmitters being configured to transmit signals containing continence-related data for the one or more subjects, wherein the continence-related data has been obtained over time from a continence sensor associated with an absorbent article worn by each respective subject; a receiver unit configured to receive signals from the one or more transmitters; and processing means in communication with at least the receiver unit, the processing means including a display processor configured to process the received signals and communicate display information to the display means for display of a visual representation of continence-related information derived from continence sensors in the absorbent articles worn by the one or more subjects being monitored.Type: ApplicationFiled: November 5, 2010Publication date: October 25, 2012Applicant: FRED BERGMAN HEALTHCARE PTY LTDInventors: Philippa Mary Lewis, Karen Maree Carey, Alan Michael Cottenden, David Albert Barda, Peter Curran, Don Black
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Patent number: 8285619Abstract: A method of using natural language processing (NLP) techniques to extract information from online news feeds and then using the information so extracted to predict changes in stock prices or volatilities. These predictions can be used to make profitable trading strategies. Company names can be recognized and simple templates describing company actions can be automatically filled using parsing or pattern matching on words in or near the sentence containing the company name. These templates can be clustered into groups which are statistically correlated with changes in the stock prices. The system is composed of two parts: message understanding component that automatically fills in simple templates and a statistical correlation component that tests the correlation of these patterns to increases or decreases in the stock price.Type: GrantFiled: January 22, 2002Date of Patent: October 9, 2012Assignee: Fred Herz Patents, LLCInventors: Frederick S. M. Herz, Lyle H. Ungar, Jason M. Eisner, Walter Paul Labys
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Publication number: 20120252839Abstract: Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.Type: ApplicationFiled: April 2, 2012Publication date: October 4, 2012Applicant: FRED HUTCHINSON CANCER RESEARCH CENTERInventors: David HOCKENBERY, Julian SIMON
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Publication number: 20120244067Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.Type: ApplicationFiled: March 22, 2012Publication date: September 27, 2012Applicant: Fred Hutchinson Cancer Research CenterInventors: Mark B. Roth, Pamela A. Padilla
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Patent number: 8272908Abstract: A swim ring, including: at least one ring stabilizing a swim position of the swim ring; wings protruding upward from a base component or from the ring and configured with disengageable wing connectors; and suspenders configured to be attached on one side at the base component or at the ring and on the other side at the wings, wherein the ends of the suspenders are configured to be connected to the wings through disengageable suspender connectors, wherein a wing side suspender connector and a wing connector of a first wing are integrally combined to form a combined one piece wing side connector, wherein the combined one piece wing side connector, a suspender side suspender connector and a wing connector of a second wing are configured, so that establishing disengageable connections of the connectors with one another is only possible in a single connection configuration.Type: GrantFiled: September 7, 2010Date of Patent: September 25, 2012Assignee: Freds Swim Academy GmbHInventor: Michaela Warmuth-Rued
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Patent number: 8232314Abstract: The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.Type: GrantFiled: January 15, 2008Date of Patent: July 31, 2012Assignees: University of Washington, Fred Hutchinson Cancer Research CenterInventors: Henry C. Ou, Felipe Santos, Edwin W. Rubel, David W. Raible, Julian A. Simon
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Publication number: 20120192314Abstract: The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprises the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided.Type: ApplicationFiled: June 8, 2007Publication date: July 26, 2012Applicant: Fred Hutchinson Cancer Research CenterInventors: James M. Roberts, Beth L. Kelly
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Publication number: 20120164118Abstract: Provided herein are Cocal vesiculovirus envelope pseudotyped retroviral vectors that exhibit high titers, broad species and cell-type tropism, and improved serum stability. Disclosed Cocal vesiculovirus envelope pseudotyped retroviral vectors may be suitably employed for gene therapy applications and, in particular, for the ex vivo and in vivo delivery of a gene of interest to a wide variety of target cells.Type: ApplicationFiled: May 4, 2010Publication date: June 28, 2012Applicant: Fred Hutchinson Cancer Research CenterInventors: Grant D. Trobridge, Hans-Peter Kiem