Patents Assigned to FRED
  • Patent number: 8450334
    Abstract: Compositions and methods are provided for preventing or attenuating cancer progression or blocking metastasis in prostate cancer and other cancers (e.g., ovarian carcinoma, endometrial cancer, renal cell carcinoma) that are characterized by overexpression of the type II cell surface serine protease hepsin, based on the discovery of multiple disclosed compounds having activity as specific hepsin inhibitors.
    Type: Grant
    Filed: May 21, 2009
    Date of Patent: May 28, 2013
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Valeri I. Vasioukhin, John R. Chevillet
  • Patent number: 8450059
    Abstract: Provided are quantitative PCR-based compositions and methods for the diagnosis of invasive pulmonary aspergillosis (IPA) in a patient sample, such as bronchoalveolar lavage (BAL) fluid. The methods presented herein involve isolating a patient sample, optionally extracting DNA from the sample, carrying out a quantitative PCR (qPCR) reaction on the sample to generate an amplicon that includes a region of an Aspergillus spp. ribosomal RNA (rRNA) gene, and detecting the PCR amplicon. The present disclosure also provides primers and primer sets for specifically detecting an Aspergillus spp. fungal pathogen in the presence of human ribosomal DNA (rDNA).
    Type: Grant
    Filed: April 27, 2010
    Date of Patent: May 28, 2013
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: David N. Fredricks, Prasanna D. Khot, Daisy L. Ko
  • Publication number: 20130115232
    Abstract: The disclosure relates to the development of methods for detecting or predicting graft-versus-host disease (GVHD) and for detecting or predicting response to treatment for GVHD. More particularly, the disclosure provides new biomarkers and combinations of biomarkers for detecting or predicting gastrointestinal GI GVHD and for predicting and analyzing response to treatment for acute GVHD.
    Type: Application
    Filed: October 3, 2012
    Publication date: May 9, 2013
    Applicants: FRED HUTCHINSON CANCER RESEARCH CENTER, The Regents Of The University Of Michigan
    Inventors: The Regents Of The University Of Michigan, Fred Hutchinson Cancer Research Center
  • Publication number: 20130115309
    Abstract: In one aspect, the invention provides a method for inhibiting the growth and/or proliferation of a myc-driven tumor cell comprising the step of contacting the tumor cells with a CSNK1? inhibitor. In another aspect, the invention provides a method of treating a subject suffering from a tumor comprising myc-driven tumor cells, comprising administering to the subject an amount of a composition comprising a CSNK1? inhibitor effective to inhibit the growth and/or proliferation of the tumor cells.
    Type: Application
    Filed: April 6, 2011
    Publication date: May 9, 2013
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Carla Grandori, Masafumi Toyoshima
  • Publication number: 20130108657
    Abstract: What is described is a novel genetic screen, involving recombinant technology and class I antigen cross-presentation, to search for supraoptimal superagonists of the 27L MART-1 mutant selecting for single amino acid substitution mutants of 27L that activate human antigen-specific CTL clones recognizing the wild-type MART-126-35 epitope. Three novel mutant epitopes are identified with superagonist properties that are functionally superior to 27L. The ability of a given analog to act as superagonist varies among patients. Also described is the use of methods to establish panels of potential superagonist APLs to individualize tumor peptide vaccines among patients. The methodology is replicated to identify APL to NY-ESO-1157-165 and NY-ESO-1157-170 tumor epitopes. A general method is described that is useful to produce a tumor vaccine to any tumor epitope.
    Type: Application
    Filed: November 10, 2011
    Publication date: May 2, 2013
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Cassian Yee, Yongqing Li, C. Siddiq Abdul-Alim
  • Publication number: 20130095079
    Abstract: The present invention relates to methods and compositions for providing hematopoietic function in immunodeficient human patients, by selecting an expanded human umbilical cord blood stem/progenitor cell sample without taking into account the HLA-type of the expanded human cord blood stem/progenitor sample or the HLA-type of the patient; and administering the selected expanded human cord blood stem/progenitor cell sample to the patient. Methods for obtaining the expanded human cord blood stem/progenitor cell samples, banks of frozen expanded human cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
    Type: Application
    Filed: April 11, 2011
    Publication date: April 18, 2013
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: Irwin D. Bernstein, Colleen Delaney
  • Publication number: 20130095080
    Abstract: The present invention relates to methods and compositions for providing hematopoietic function to human patients in need thereof, by selecting a pool of expanded human cord blood stem/progenitor cell samples for administration to the patient, wherein the samples in the pool collectively do not mismatch the patient at more than 2 of the HLA antigens or alleles typed in the patient; and administering the selected pool of expanded human cord blood stem/progenitor cell samples to the patient. Methods for obtaining the pools of expanded human cord blood stem/pro-genitor cell samples, banks of frozen pools of expanded human umbilical cord blood stem/progenitor cell samples, and methods for producing such banks are also provided herein.
    Type: Application
    Filed: April 11, 2011
    Publication date: April 18, 2013
    Applicant: Fred Hutchinson Cancer Reserach Center
    Inventors: Irwin D. Bernstein, Colleen Delaney
  • Publication number: 20130081371
    Abstract: A mowing finger arrangement has a lower element and an upper element connected to each other and forms two mowing fingers. A space is formed to accommodate a cutting device between the lower element and the upper element. The two mowing fingers are connected to each other via, respectively, a connection web on the upper element and on the lower element on a rear end of the mowing finger, when viewed in working direction. At least one of the connection webs has, at least portion wise, an off-set to provide an enlarged distance between the connection webs.
    Type: Application
    Filed: September 24, 2012
    Publication date: April 4, 2013
    Applicant: Erfindergemeinschaft Gustav und Fred Schumacher GbR
    Inventor: Erfindergemeinschaft Gustav und Fred Schumach
  • Patent number: 8349554
    Abstract: A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
    Type: Grant
    Filed: August 14, 2008
    Date of Patent: January 8, 2013
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: S. Bahram Bahrami, Mandana Veiseh, James Olson
  • Patent number: 8333410
    Abstract: A multi-piece swivel coupling kit with a snap connection for ready and rapid assembly with the capability to be disassembled and reconfigured as required by the specific installation. The swivel coupling kit includes a tubular socket member having a line connecting end and multiple coupling ends and multiple tubular stem members each having a line connecting end and a coupling end connectable to one of the coupling ends of the tubular socket member. The multiple coupling ends including integral complementing annular projections and recesses which define a close fitting bearing unit creating forced engagement between the projections and recesses to establish smooth engagement and rotational support of the socket member and each of the stem members. The multiple coupling ends of the tubular socket member are configured to allow releasable configuration, reconfiguration and expansion of the multiple tubular stem members along a X axis, a Y axis and a Z axis and in a X plane, a Y plane and a Z plane.
    Type: Grant
    Filed: May 7, 2009
    Date of Patent: December 18, 2012
    Assignee: Fred Knapp Engraving Company, Inc.
    Inventor: John A. Boticki
  • Patent number: 8309315
    Abstract: In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.
    Type: Grant
    Filed: August 25, 2008
    Date of Patent: November 13, 2012
    Assignees: Van Andel Research Institute, Fred Hutchinson Cancer Research Center
    Inventors: Boliang Cao, George F. Vande Woude, Beatrice S. Knudsen, Ping Xu Zhao
  • Publication number: 20120282353
    Abstract: The present invention generally relates to the modulation of hypoxia-inducible factor (HIF) using the compounds and methods disclosed herein. These compounds and methods can be applied to the prevention, pretreatment, and/or treatment of conditions or states associated with HIF, such as hypoxia- and ischemia-related conditions and the induction of stasis.
    Type: Application
    Filed: March 26, 2012
    Publication date: November 8, 2012
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Mark B. Roth, Mark Budde
  • Publication number: 20120268278
    Abstract: A system for monitoring incontinence in one or more subjects comprises display means; input means operable by a user; one or more transmitters, each transmitter being associated with one or more subjects being monitored; the one or more transmitters being configured to transmit signals containing continence-related data for the one or more subjects, wherein the continence-related data has been obtained over time from a continence sensor associated with an absorbent article worn by each respective subject; a receiver unit configured to receive signals from the one or more transmitters; and processing means in communication with at least the receiver unit, the processing means including a display processor configured to process the received signals and communicate display information to the display means for display of a visual representation of continence-related information derived from continence sensors in the absorbent articles worn by the one or more subjects being monitored.
    Type: Application
    Filed: November 5, 2010
    Publication date: October 25, 2012
    Applicant: FRED BERGMAN HEALTHCARE PTY LTD
    Inventors: Philippa Mary Lewis, Karen Maree Carey, Alan Michael Cottenden, David Albert Barda, Peter Curran, Don Black
  • Patent number: 8285619
    Abstract: A method of using natural language processing (NLP) techniques to extract information from online news feeds and then using the information so extracted to predict changes in stock prices or volatilities. These predictions can be used to make profitable trading strategies. Company names can be recognized and simple templates describing company actions can be automatically filled using parsing or pattern matching on words in or near the sentence containing the company name. These templates can be clustered into groups which are statistically correlated with changes in the stock prices. The system is composed of two parts: message understanding component that automatically fills in simple templates and a statistical correlation component that tests the correlation of these patterns to increases or decreases in the stock price.
    Type: Grant
    Filed: January 22, 2002
    Date of Patent: October 9, 2012
    Assignee: Fred Herz Patents, LLC
    Inventors: Frederick S. M. Herz, Lyle H. Ungar, Jason M. Eisner, Walter Paul Labys
  • Publication number: 20120252839
    Abstract: Compounds are described that are useful for treating an apoptosis-associated disease, which are specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Also described is a method for treating an apoptosis-associated disease in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of an active compound that is specifically cytotoxic to tumor cells that are overexpressing Bcl-xL, and are much less cytotoxic in isogenic cells that are not overexpressing Bcl-xL. Several scaffolds of active compounds are described.
    Type: Application
    Filed: April 2, 2012
    Publication date: October 4, 2012
    Applicant: FRED HUTCHINSON CANCER RESEARCH CENTER
    Inventors: David HOCKENBERY, Julian SIMON
  • Publication number: 20120244067
    Abstract: The present invention concerns compositions and methods involving incubating biological materials under hypoxic or anoxic conditions to induce stasis or suspended animation. Methods of screening for compounds that induce stasis or compounds that increase the ability to undergo stasis are included. Such methods have ramifications for preserving biological materials as well as reducing or preventing trauma to biological materials. Also contemplated are methods for screening compounds that are active or more active under hypoxic conditions than normoxic conditions. Such methods can be used to identify antitumor compounds that would operate under hypoxic conditions in which tumor cells survive.
    Type: Application
    Filed: March 22, 2012
    Publication date: September 27, 2012
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Mark B. Roth, Pamela A. Padilla
  • Patent number: 8272908
    Abstract: A swim ring, including: at least one ring stabilizing a swim position of the swim ring; wings protruding upward from a base component or from the ring and configured with disengageable wing connectors; and suspenders configured to be attached on one side at the base component or at the ring and on the other side at the wings, wherein the ends of the suspenders are configured to be connected to the wings through disengageable suspender connectors, wherein a wing side suspender connector and a wing connector of a first wing are integrally combined to form a combined one piece wing side connector, wherein the combined one piece wing side connector, a suspender side suspender connector and a wing connector of a second wing are configured, so that establishing disengageable connections of the connectors with one another is only possible in a single connection configuration.
    Type: Grant
    Filed: September 7, 2010
    Date of Patent: September 25, 2012
    Assignee: Freds Swim Academy GmbH
    Inventor: Michaela Warmuth-Rued
  • Patent number: 8232314
    Abstract: The present invention provides methods of identifying compounds that protect against ototoxicity induced by one or more noxious stimuli, and methods of treating an individual with compounds identified using the present screening methods. Also provided are compounds demonstrated to have otoprotective effects.
    Type: Grant
    Filed: January 15, 2008
    Date of Patent: July 31, 2012
    Assignees: University of Washington, Fred Hutchinson Cancer Research Center
    Inventors: Henry C. Ou, Felipe Santos, Edwin W. Rubel, David W. Raible, Julian A. Simon
  • Publication number: 20120192314
    Abstract: The present invention provides methods for modulating the growth and/or yield of plants. In particular the methods comprises the use of agents which functionally inhibit the expression of plant D-like cyclin inhibitors including isolated polynucleotide sequences which interact with DNA or RNA encoding proteins capable of binding plant D-like cyclins. Further, the present invention provides recombinant polynucleotide sequences, vectors and host cells which encode proteins capable of binding to and inactivating the activity of plant D-like cyclin/cyclin dependent kinase complexes preventing plant cells from exiting the cell cycle. Methods for determining and agents which are inhibitors of the BRO cyclin dependent kinase inhibitor proteins which are capable of modulating plant cell cycle progression are also provided. Methods for the production of transgenic plant cells and plants with increased growth rates and yields when compared to wild-type plants are also provided.
    Type: Application
    Filed: June 8, 2007
    Publication date: July 26, 2012
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: James M. Roberts, Beth L. Kelly
  • Publication number: 20120164118
    Abstract: Provided herein are Cocal vesiculovirus envelope pseudotyped retroviral vectors that exhibit high titers, broad species and cell-type tropism, and improved serum stability. Disclosed Cocal vesiculovirus envelope pseudotyped retroviral vectors may be suitably employed for gene therapy applications and, in particular, for the ex vivo and in vivo delivery of a gene of interest to a wide variety of target cells.
    Type: Application
    Filed: May 4, 2010
    Publication date: June 28, 2012
    Applicant: Fred Hutchinson Cancer Research Center
    Inventors: Grant D. Trobridge, Hans-Peter Kiem