Patents Assigned to Fresenius Kabi Deutschland GmbH
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Patent number: 12139289Abstract: The invention relates to a system and a method for manufacturing a medical package, in particular a foil bag made of plastic. A print image with variable information is first applied by means of a thermal transfer printer which is formed as a negative print image and comprises blank spaces. The blank spaces are filled by means of a hot stamp printing process.Type: GrantFiled: May 20, 2020Date of Patent: November 12, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Thomas Brückner, Benjamin Fritz, Gerald Wegner, Stefan Faber, Alexander Stojmanovski, Marko Krenzlin
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Patent number: 12116188Abstract: A sealing cap for a container for holding a medical liquid comprises a cap body and a connection device having a sealing element arranged on the cap body. The sealing element is arranged at the opening and is retained in the cap body in a clamped manner by a, preferably annular, flanged rim. The connection device has a break-off piece, which is firmly connected to the cap body and covers an outer face of the sealing element in the outward direction. The break-off piece is integral with the cap body, is connected to the cap body by a predetermined breaking point where the break-off piece can be detached from the cap body. The sealing element outer face is substantially flat and is accessible for wiping to provide a sealing cap having a sealing element arranged that can be simply and reliably disinfected.Type: GrantFiled: June 14, 2021Date of Patent: October 15, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Torsten Brandenburger, Christian Frensch, Andreas Pfeffer, Alexander Degen
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Patent number: 12109267Abstract: The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.Type: GrantFiled: November 2, 2022Date of Patent: October 8, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Gianluca Rinaldi, Silvia Fratarcangeli, Alessandra Del Rio
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Patent number: 12102791Abstract: A drug delivery device has a housing with an adhesive pad associated with the lower surface of the housing and configured to removably attach to a human body surface. A drug reservoir is positioned within the housing and includes an outlet with a valve, with a needle fluidically connected to the reservoir and configured to define at least a portion of a fluid flow path between the reservoir and the human body surface. A controller is configured to control the components of the drug delivery device to execute a drug delivery routine. The drug delivery device also includes pressurized fluid positioned to apply a force to the reservoir. The controller moves the valve from a closed condition to an open condition during a drug delivery routine to allow the pressurized fluid to deform the reservoir or move a plunger to convey the drug out of the reservoir via the outlet.Type: GrantFiled: August 12, 2022Date of Patent: October 1, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: David R. Schiff, Sharon D. West
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Patent number: 12064396Abstract: A container for blood or a blood component is provided, the container comprising one or more container walls defining an interior chamber, the container walls comprising one or more layers, the layers comprising or consisting of a composition comprising one or more polymeric materials and at least one extractable agent selected from the group consisting of a terephthalate ester, a cyclohexane dicarboxylic acid ester, a citrate ester, and a polyol ester, wherein the container further comprises one or more additional components, wherein the container comprises less than about 3% (w/w) of di-2-ethylhexyl phthalate (DEHP), preferably wherein the container comprises less than about 3% (w/w) of phthalates. Thereby, improved blood products are provided in which the DEHP or overall phthalate content is reduced.Type: GrantFiled: October 28, 2021Date of Patent: August 20, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Karin Platenkamp, Craig L. Sandford, Koos L. Hakvoort
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Patent number: 12064916Abstract: Disclosed is a method and a system for producing an ampoule filled with a medical liquid. A preform is produced by plastic injection moulding that is then inhomogeneously heated and blown to form an ampoule body. Further disclosed is an ampoule produced by means of stretching and blowing, which comprises a connector with a break-off part in which the predetermined breaking point is aligned with the septum of the connector.Type: GrantFiled: July 2, 2020Date of Patent: August 20, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Torsten Brandenburger, Andreas Pfeffer
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Patent number: 12042619Abstract: A connector for connecting a first medical line to a second medical line is disclosed. This connector comprises an insertion shaft (12) having a flow channel that is intended to be brought into fluid communication with a lumen of a first medical line (3); a collar (10) that circumferentially extends around the insertion shaft (12), wherein the collar (10) comprises a first thread (100) on an inner side that faces the insertion shaft (12); and an elastic member (14) that is placed between the insertion shaft (12) and the collar (10), wherein the elastic member (14) comprises an abutment portion (141) abutting a surface of the insertion shaft (12) and being displaceable relative to the surface of the insertion shaft (12).Type: GrantFiled: June 5, 2019Date of Patent: July 23, 2024Assignee: Fresenius Kabi Deutschland GmbHInventor: Steffen Baumgart
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Patent number: 12005026Abstract: The invention relates to a medical package designed as an infusion bag, which medical package is made from multi-layer films that are welded to one another and is filled with a medical liquid for infusion and/or for parenteral nutrition. The invention is described by a medical package designed as an infusion bag, which is made up of a film comprising multiple layers welded to one another and has at least one weld seam, preferably longitudinal and transverse weld seams, and is filled with a medical liquid. The multi-layer film has at least one inner layer of a matrix-phase polymer system, an intermediate layer of a matrix-phase polymer system, and an outer layer of a matrix-phase polymer system.Type: GrantFiled: August 20, 2019Date of Patent: June 11, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Torsten Brandenburger, Beatrix Heuel-Hoemmen
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Patent number: 12005226Abstract: A medicament delivery device and method of use thereof. The device includes a sensor module and an injector module. The injector module is adapted to (i) be coupled to the sensor module during injection of a cannula and a needle into subcutaneous tissue and during delivery of the medicament and (ii) be removed from the sensor module after the delivery of the medicament.Type: GrantFiled: March 17, 2022Date of Patent: June 11, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Sharon D. West, Justin E. Bechstein
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Patent number: 11975102Abstract: The invention relates to lyophilized products and reconstituted emulsions for parenteral application, which comprise all the 13 essential vitamins (A, D, E, K1, C, B1, B2, B3, B5, B6, B7, B9, and B12) in a single container, as well as to methods for preparing them.Type: GrantFiled: October 22, 2018Date of Patent: May 7, 2024Assignee: FRESENIUS KABI DEUTSCHLAND GMBHInventors: Getachew Assegehegn, Edmundo Brito De La Fuente, Crispulo Gallegos-Montes, Lida A. Quinchia Bustamante
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Patent number: 11975145Abstract: An endo-tracheal catheter for use in an anesthetic procedure comprises a catheter tube to be inserted into the trachea of a patient, the catheter tube having a tubular wall defining an inner lumen for guiding a gaseous flow, and a connection piece which defines a chamber in fluid connection with the catheter tube and comprising a port for connecting a detection device to the endo-tracheal catheter for detecting at least one substance in the gaseous flow flowing through the catheter tube. An insert tube is received in the inner lumen of the catheter tube for guiding the gaseous flow through the catheter tube and/or a coating covers the tubular wall at a side facing the inner lumen for guiding the gaseous flow through the catheter tube.Type: GrantFiled: September 7, 2018Date of Patent: May 7, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Michael Becker, Dieter Pruss
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Patent number: 11964998Abstract: The present invention relates to a method for purifying anti-IL-6 receptor antibodies from a sample comprising said antibodies and impurities, through the use of a three-chromatographic columns procedure, including a chromatography on Fluorapatite-containing resin. The invention is also concerned with pharmaceutical compositions comprising the purified antibodies obtainable by the process of the invention.Type: GrantFiled: August 30, 2018Date of Patent: April 23, 2024Assignee: FRESENIUS KABI DEUTSCHLAND GMBHInventors: Harry-James Sutter, Xavier Le Saout
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Patent number: 11919924Abstract: The present invention relates to a method for purifying adalimumab or a biosimilar thereof from a sample comprising adalimumab or a biosimilar thereof and impurities, through the use of hydroxyapatite resin in a Bind/Elute (B/E) mode under conditions such that the adalimumab or a biosimilar thereof binds to the resin and at least a portion of the impurities remain unbound. The invention is also concerned with a pharmaceutical compositions=of the purified adalimumab or a biosimilar thereof, and adalimumab or a biosimilar thereof obtainable by the process of the invention.Type: GrantFiled: December 20, 2018Date of Patent: March 5, 2024Assignee: FRESENIUS KABI DEUTSCHLAND GMBHInventors: Harry-James Sutter, Matteo Costioli, Hervé Broly
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Patent number: 11911973Abstract: A control circuitry (11) comprises an adjustable capacitor (C1), and a bias source (111) configured to apply a bias voltage (V2) to said adjustable capacitor (C1) to adjust a capacitance value of the adjustable capacitor (C1). Such a control circuitry may for example be part of a sealing device (1) to seal a medical tubing (2), the sealing device (1) comprising a receptacle (100) to receive said medical tubing (2), the receptacle (100) comprising an electrode arrangement for causing a heat action on the tubing (2).Type: GrantFiled: December 1, 2021Date of Patent: February 27, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: Philipp Winter, Lars Michel, Michael Schaefer
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Patent number: 11883364Abstract: A sealing element is received between a connector and an attachment member. The sealing element includes a foot section received by a recess of the connector, a shoulder engaging an inner surface of the attachment member, and a flange engaging a support surface of the connector. The sealing element also includes a cylindrical body extending from the shoulder to the flange along an insertion direction and, where the cylindrical body deforms to create a flow path through the sealing element, and a sealing head defines an opening that transitions from a closed state to an open state when the cylindrical body deforms.Type: GrantFiled: March 8, 2019Date of Patent: January 30, 2024Assignee: Fresenius Kabi Deutschland GmbhInventor: Torsten Brandenburger
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Patent number: 11872369Abstract: Described herein are wearable devices and methods for medicament delivery. Example devices can include a housing having an underside adapted to be proximate to a skin surface, and a reservoir disposed in the housing, the reservoir configured to be filled with a medicament to be delivered to the patient. The devices can include a cannula disposed within the housing and coupled to the reservoir, in which the cannula configured to protrude from a port defined by the housing to be positioned in the skin surface. The devices can further include a capacitive sensor configured to detect whether the medicament has leaked from the delivery device, in which the capacitive sensor includes a conductor disposed in a portion of the underside of the housing.Type: GrantFiled: February 18, 2021Date of Patent: January 16, 2024Assignee: Fresenius Kabi Deutschland GmbHInventors: David R. Schiff, Vladlena Belozerova, Jason Zerweck
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Publication number: 20230414604Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.Type: ApplicationFiled: April 28, 2023Publication date: December 28, 2023Applicant: Fresenius Kabi Deutschland GmbHInventors: Alain CUINE, Didier HOARAU, Pauline ROMAIN
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Patent number: 11793723Abstract: The invention relates to an installation for producing a medical preparation, in particular for producing a preparation for parenteral nutrition. The installation comprises a pump with which liquids can be transferred from a plurality of source containers into a target container. The installation has a modular construction and comprises a weighing module and a main module with the pump. According to a further aspect of the invention, the pump is arranged at an inclination with respect to a vertical plane. According to a further aspect of the invention, the installation comprises cascaded valve nodes.Type: GrantFiled: May 10, 2021Date of Patent: October 24, 2023Assignee: Fresenius Kabi Deutschland GmbHInventors: Martin Biehl, Michael Hock, Henrik Schaake, Ulla Schöbel, Holger Lenkeit, Marcel Borgward
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Patent number: 11793722Abstract: The invention relates to a valve unit for a system for producing a parenteral nutrition, in which a three-way valve is used for respectively two connections to a source container. The valve unit is a component which is mounted on the system and can be removed again following use. The valve unit is in particular provided as a replaceable disposable component.Type: GrantFiled: August 22, 2018Date of Patent: October 24, 2023Assignee: Fresenius Kabi Deutschland GmbHInventors: Martin Biehl, Michael Hock, Lothar Tiedemann, Klaus Buettner
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Patent number: 11752209Abstract: The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.Type: GrantFiled: November 2, 2022Date of Patent: September 12, 2023Assignee: Fresenius Kabi Deutschland GmbHInventors: Gianluca Rinaldi, Silvia Fratarcangeli, Alessandra Del Rio