Abstract: A syringe packaging system that includes a tube and a cap for enclosing a pre-filled syringe is disclosed. The tube includes a tube cut flange and the cap includes a cut skirt. With a syringe barrel contained within the tube, a syringe barrel cut flange is aligned with the tube cut flange. With the pre-filled syringe enclosed within the tube and the cap, the cut skirt of the cap surrounds the syringe barrel cut flange. In one embodiment, a film is securable to a portion of the tube and a portion of the cap to connect the tube and the cap with the pre-filled syringe enclosed within the cap and the tube.

Abstract: A container for a medical liquid, comprising a connection piece via which a medical liquid can be pumped into or out of the container, an attachment part which can be attached to the connection piece and connected to a pump device to pump a medical liquid or out of the container, and a sealing element for sealing a passage between the connection piece and the attachment part. The sealing element has a slot opening which is closed against a liquid flow when the pump device is not attached to the attachment part and which is open when the pump device is attached to the attachment part such that a medical liquid can be pumped through the slot opening. The attachment part has a connection portion with an opening into which the connection piece can be inserted along an insertion direction in order to connect to the attachment part.

Abstract: The invention relates to a set of scales and to an installation for producing a medical composition using a set of scales. The set of scales comprise interchangeable securing means for a target container, the weight thereof being measured by the set of scales.

Abstract: A connector system for connecting a withdrawal device to a container for a medical fluid, in particular for a rinsing solution, comprising a first withdrawal port and a second withdrawal port which are each designed for a withdrawal of the medical fluid from the container, wherein the first withdrawal port and the second withdrawal port are designed differently and each is sealed by a resealable membrane and a break-away cap.

Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of oxygen-sensitive drugs, such systems including a primary packaging container with an oxygen permeable component, a secondary packaging with very low permeability to oxygen and an oxygen absorber.

Abstract: The invention relates to a method and a system for synthesizing a medical preparation, a peristaltic pump being used for pumping liquid from a plurality of source containers. According to the invention, the individual metering steps are verified by a weighing process, even the metering of micro-amounts being verifiable.

Abstract: The present invention relates to a novel protein formulation. In particular, the invention relates to a liquid pharmaceutical composition of an antibody directed to Interleukin-6 receptor, a method of manufacturing the composition, a kit including the composition, a package including the composition and to methods of treatment using the composition and/or package.

Abstract: The invention relates to a cannulation device (1) for providing an access to a patient through a skin of the patient, comprising a puncture needle (11) with a needle tip (113) for puncturing the skin of the patient and a cannula (12). The cannulation device (1) is characterized in that the puncture needle (11) is movably connected to the cannula (12).

Abstract: Disclosed is a container comprising an opening to bring an enteral nutrient solution into or out of the container, a base which lies opposite the opening in a direction of longitudinal extent of the container for depositing of the container upright on an underlying surface, a hanging element arranged on the base in a first position extending substantially along the base, or in a second position where it protrudes at an angle from a plane defined by the base, and a hinge device which connects the hanging element to the base at a first end of the hanging element, to transfer the hanging element from the first into the second position. A receiving region for the hanging element is formed in the base. The hanging element can be releasably fixed in the first position using a connecting device. The hanging element is fixed movably within the first position.

Abstract: The present invention relates to an assembly comprising an injection device comprising a container for a product, wherein the container includes a distal tip encompassing a channel providing a passageway for transferring the product, and an adaptor mounted onto the distal tip. The assembly further includes a heat-shrinkable film covering at least part of the container and at least part of the adaptor, wherein the heat-shrinkable film maintains the adaptor blocked in rotation and in translation relative to the container when the heat-shrinkable film is in heat-shrunk condition.

Abstract: Provided herein, generally, are pharmaceutical formulations, e.g., injectable pharmaceutical formulations with improved stability, comprising morphine sulfate or a hydrate thereof, and methods of producing and using the same. Also provided herein are kits comprising the formulations, e.g., injectable morphine formulations.

Abstract: A retention member (1) for securing a catheter (2) on a patient (P) comprises a base element (10) having a bottom side (103) and a top side (104), the bottom side being placeable on the patient (P) and the top side (104) being adapted for receiving the catheter (2). The retention member (1) furthermore comprises a ribbon (14) having a first end (140) connected to the top side (104) of the base element (10) and having a second end (141) opposite the first end (140), wherein the base element (10) comprises at least one opening (150, 151) through which the second end (141) of the ribbon (14) is insertable for fixing the catheter (2) on the retention member (1) in between the base element (10) and the ribbon (14). In this way a retention member is provided which is easy and safe to use, may suit to secure catheters of different sizes on a patient and at the same time may be manufactured in a cost-effective manner.

Abstract: A syringe packaging system that includes a tube and a cap for enclosing a pre-filled syringe, wherein the tube includes a cut flange and the cap includes a cut skirt. When the pre-filled syringe is enclosed within the tube and cap, the tube and cap are maintained together by a plurality of crush ribs on the cap or by a film secured to a portion of the tube and a portion of the cap. An injection molding gate is located on the sidewall of the tube to prevent diversion or tampering with the pre-filled syringe.

Abstract: An injection port assembly including a body having first and second mating structures configured to mate with a first connector for a first fluid pathway and a second connector on a device, respectively. A resilient barrier substantially contained within the body and compressible from a first position in which fluid flow between the first and second connectors is blocked to a more compressed second position in which fluid flow between the first and second connectors is permitted. A hollow cannula can be coupled with the first mating structure and disposed within the resilient barrier, the hollow cannula having a distal end configured to extend through the resilient barrier when the resilient barrier is in the second position, the distal end having lateral slots. The resilient barrier can have first and second annular sealing rings positioned above and below the lateral slots respectively.

Abstract: Described herein are pharmaceutical packaging systems which prevent oxidative degradation of oxygen-sensitive drugs, such systems including a primary packaging container with an oxygen permeable component, a secondary packaging with very low permeability to oxygen and an oxygen absorber.

Abstract: The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an histidine buffering agent such as histidine (or histidine buffer system such as histidine/imidiazolium-histidine), and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.

Abstract: A breaker device (1) for acting onto a closure element (40) of a medical tubing (4) comprises a drive arrangement (2) having an electric drive device (20) and a drive element (23) driven by the drive device (20), and a breaker module (3) which is arrangeable on the drive arrangement (2). The breaker module (3) comprises a housing (30), a movable part (31) movably arranged on the housing (30) and a breaking element (315) for acting onto the closure element (40) of the tubing (4), wherein the breaker module (3) in an attached state is placed on the drive arrangement (2), the drive element (23) being in operative connection with the movable part (31) in the attached state such that a movement of the drive element (23) causes the movable part (31) to move for actuating the breaking element (315). A control device (5) serves for controlling the electric drive device (20) for driving the drive element (23).

Abstract: The present invention relates to a connection system for components through which fluid flows in medicine and medical equipment, comprising a male connection cone (6, 30) and a threaded nut (7) least partially surrounding the connection cone (6) and having an internal thread (9), for captively connecting the male connection cone (6, 30) to a female receptacle of an additional component through which fluid flows. The invention is characterised in that the threaded nut (7) has radially circumferential through-holes (10) at least in some sections in the axial section of the circumferential jacket of the threaded nut and webs (11, 11?) are formed adjacent to the through-holes in the circumferential jacket, sections of the internal thread (9) being arranged on the inside of said webs in relation to the circumferential jacket. Furthermore, the invention also relates to the production of the connection system and to its use.

Abstract: The present invention relates to novel liquid pharmaceutical compositions of adalimumab, which include adalimumab or a biosimilar thereof, an acetate buffering agent/system such as sodium acetate/acetic acid, and a sugar stabiliser such as trehalose. Such a combination of components furnishes formulations having a stability (e.g. on storage and when exposed to stress) which is comparable to or an improvement upon those known in the art, and with fewer ingredients. Such advances will help adalimumab treatments to become more widely available at lower cost, and prolong the viability of pre-loaded delivery devices (e.g. pre-filled syringes) to reduce unnecessary waste of the drug.

Abstract: The invention relates to a multiple-variable dose method for treating a disorder in which TNF? activity is detrimental, comprising administering to a subject in need thereof a first induction dose of an anti-TNF? antibody which ranges from 161 to 320 mg such that a threshold level of TNF? inhibitor is achieved within an induction phase; and subsequently administering to the subject at least one treatment dose of the TNF? inhibitor within a treatment phase, such that treatment occurs.