Patents Assigned to FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG
  • Patent number: 10766030
    Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.
    Type: Grant
    Filed: November 18, 2016
    Date of Patent: September 8, 2020
    Assignees: SINAMIRA AG, FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG
    Inventors: Walter Miedl, Oliver Friedrich, Daniel Gilbert
  • Patent number: 10702498
    Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.
    Type: Grant
    Filed: June 30, 2016
    Date of Patent: July 7, 2020
    Assignees: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, FRIEDRICH-ALEXANDER-UNIVERSITAT ERLANGEN-NÜRNBERG, THE BOARD OF TRUSTEES OFTHE LELAND STANFORD JUNIOR UNIVERSITY, THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
    Inventors: Brian K. Shoichet, Henry Lin, Peter Gmeiner, Aashish Manglik, Brian Kobilka, Bryan L. Roth, Daniela Gisela Dengler
  • Publication number: 20200072841
    Abstract: The present disclosure pertains to the identification of novel biomarkers for the characterization of melanocytic lesions as can be found in skin diseases such as melanomas and psoriasis. In particular, the present invention is directed to a method for characterizing melanocytic lesions and their use in an automated or semi-automated device for the diagnosis and/or monitoring of benign, pre-malignant, and malignant melanocytic lesions, as further defined in the claims.
    Type: Application
    Filed: March 8, 2019
    Publication date: March 5, 2020
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: ANDREAS BAUR, CHRISTAN OSTALECKI, GEROLD SCHULER
  • Patent number: 10530300
    Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: January 7, 2020
    Assignees: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Hans-Martin Tröger, Norbert Franke, Albert Heuberger, Jörg Robert
  • Patent number: 10390754
    Abstract: A method and system for motion estimation modeling for cardiac and respiratory motion compensation is disclosed. Specifically, a coronary sinus catheter is tracked in a plurality of frames of a fluoroscopic image sequence; and cardiac and respiratory motion of a left atrium is estimated in each of the plurality of frames based on tracking results of the coronary sinus catheter using a trained motion estimation model.
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: August 27, 2019
    Assignees: Siemens Healthcare GmbH, FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG
    Inventors: Alexander Benjamin Brost, Sebastian Kaeppler, Martin Ostermeier, Norbert Strobel, Wen Wu, Terrence Chen
  • Patent number: 10370427
    Abstract: The present invention relates to specific T-cell receptor a-chains, T-cell receptor ?-chains and T-cell receptors comprising said T-cell receptor a-chain and/or ?-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or ?-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or ?-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 6, 2019
    Assignee: Friedrich-Alexander Universität Erlangen-Nürnberg
    Inventors: Thomas Harrer, Angela Hückelhoven
  • Patent number: 10359409
    Abstract: A method for detecting a degree of hydrogenation of a liquid comprises one or more liquid hydrogen carriers, which can be hydrogenated, comprising: detecting a material property of the liquid and determining the degree of hydrogenation of the liquid on the basis of the detected material property of the liquid.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: July 23, 2019
    Assignees: FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG, HYDROGENIOUS TECHNOLOGIES GMBH
    Inventors: Wolfgang Arlt, Katharina Stark, Peter Wasserscheid
  • Patent number: 10301184
    Abstract: The invention relates to a zeolitic material comprising zeolitic monocrystals, each of which has a pore system encompassing at least one micropore system and at least one macropore system, and to a method for producing a zeolitic material of said type. In said method, porous oxide particles are converted into the zeolitic material in the presence of an organic template and steam.
    Type: Grant
    Filed: August 21, 2015
    Date of Patent: May 28, 2019
    Assignees: Friedrich-Alexander-Universität Erlangen-Nürnberg, Technische Universität Clausthal
    Inventors: Albert Gonche Fortunatus Machoke, Alexandra Inayat, Wilhelm Schwieger, Ana Maria Beltrán Custodio, Erdmann Spiecker, Robert Güttel, Nadine Kruse
  • Publication number: 20190052227
    Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.
    Type: Application
    Filed: February 15, 2017
    Publication date: February 14, 2019
    Applicants: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Hans-Martin Tröger, Norbert Franke, Albert Heuberger, Jörg Robert
  • Publication number: 20180259566
    Abstract: A measurement method is for determining core losses, which serve to produce magnetic circuits for electrical machines. In order to allow an accurate measurement that is as quick as possible, it is proposed that a magnetic coupling is produced between a measuring coil connected in a capacitor and a core to be measured, and the measuring coil is then acted upon by an alternating frequency in order to measure the resonant frequency of the resulting resonant circuit and/or the quality of the resulting resonant circuit as a measure of the core loss.
    Type: Application
    Filed: September 9, 2016
    Publication date: September 13, 2018
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Michael SCHNEIDER, Jörg FRANKE
  • Publication number: 20180230486
    Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
    Type: Application
    Filed: December 4, 2017
    Publication date: August 16, 2018
    Applicant: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Katrin BIRKHOLZ, Jan DÖRRIE, Niels SCHAFT, Gerold SCHULER, Reinhard VOLL, Isabell PFEIFFER
  • Patent number: 9984849
    Abstract: The invention relates to an electron beam splitter (1) comprising a multi-pole electrode arrangement with a high-frequency alternating current voltage (5), which extends along a specified path (6) from an inlet side (9) to an outlet side (10), wherein the electrode arrangement (5) generates on the inlet side (9) with a first number of electrodes (7) impacted by the voltage a first oscillating electric field (61), which forms on a transversal plane a single local confinement minimum (62) in a time-averaged manner, and wherein the electrode arrangement (5) generates at least on the outlet side (10) with a second number of voltage-impacted electrodes (7) a second oscillating electric field (65), which forms at least two local confinement minimums (66, 67) in a time averaged manner.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: May 29, 2018
    Assignee: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Jakob Hammer, Peter Hommelhoff
  • Patent number: 9862968
    Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.
    Type: Grant
    Filed: October 26, 2011
    Date of Patent: January 9, 2018
    Assignee: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Katrin Birkholz, Jan Dörrie, Niels Schaft, Gerold Schuler, Reinhard Voll, Isabell Pfeiffer
  • Patent number: 9834773
    Abstract: Described are methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. Disclosed is that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms. Based on this finding, provided are multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling metabolism, a method for decreasing undesired expression and many more. Moreover, provided are means that can be used to establish said methods: for example a micro-organism in which the DasR binding site in operable linkage with a particular gene has been modified to obtain increased or decreased expression of a protein (being a desired or undesired protein) encoded by said gene.
    Type: Grant
    Filed: February 14, 2007
    Date of Patent: December 5, 2017
    Assignees: Universiteit Leiden, University of Liège, Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Sebastien Rigali, Mannfred Friedrich Bruno Titgemeyer, Gilles Philippus Van Wezel
  • Patent number: 9773295
    Abstract: In a device and a corresponding method for joining a plurality of individual digital images to form a total image, a plurality of features is determined in a first individual image by means of a selection unit using a feature-based algorithm and then tracked in a second individual image by means of a tracking unit. A transformation matrix, with which the individual images are joined in an output unit to form the total image, is calculated from the determined feature correspondences in a transformation unit. The individual images can be joined in real time and with a high degree of accuracy by means of the feature-based algorithm in combination with a robust algorithm to calculate the transformation matrix.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: September 26, 2017
    Assignees: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Christian Münzenmayer, Christian Winter, Thomas Wittenberg, Stephan Rupp, Dietrich Paulus, Tobias Bergen, Steffen Ruthotto
  • Patent number: 9502921
    Abstract: The invention relates to a circuit for a system for contactless, inductive power transmission, in particular for use in supplying power to mobile devices, and to an associated charging circuit. The circuit comprises a primary-side circuit, which is disposed on a primary side and can be connected to a primary-side supply voltage, and a secondary-side circuit, which is disposed on a secondary side and can be connected to a load to be supplied with power. Furthermore a transformer stage having galvanic isolation is provided for the contactless transfer of power from the primary side over an air gap to the secondary side, wherein at least two magnetically coupled coils are provided for inductive power transmission and can be spatially separated from one another by distancing the secondary side from the primary side. The transformer stage has a resonant converter and the secondary-side circuit further comprises a restabilization stage.
    Type: Grant
    Filed: May 27, 2011
    Date of Patent: November 22, 2016
    Assignee: FRIEDRICH-ALEXANDER-UNIVERSITÄT ERLANGEN-NÜRNBERG
    Inventors: Alexander Bucher, Thomas Durbaum
  • Patent number: 9440219
    Abstract: The invention relates to a filter material which is used, in particular in filters or as a filter for treating and/or purifying gas, in particular for clean room environments. The filter material comprises at least one activated carbon, in particular with reactive and/or catalytic finishing and the activated carbon is present in the form of discrete activated carbon particles, preferably in a spherical and/or grain form. The activated carbon comprises and/or is provided with at least one metal component which contains at least one metal-containing ionic liquid (IL), containing in particular metal ions, preferably based on a metal compound.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 13, 2016
    Assignees: Blücher GmbH, Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Bertram Böhringer, Ilsebill Eckle, Peter Wasserscheid, Daniel Roth
  • Patent number: 9269774
    Abstract: An electronic device (1) includes a semiconductor substrate (3) having a front surface (7), a first electrode (8) and a second electrode (9) disposed on the front surface (7) of the substrate (3), wherein the first electrode (8) and the second electrode (9) each have at least one epitaxial graphene monolayer (10). The at least one epitaxial graphene monolayer (10) of the first electrode (8) forms an ohmic contact with the substrate (3) and the at least one epitaxial graphene monolayer (10) of the second electrode (9) forms a Schottky barrier with the substrate (3).
    Type: Grant
    Filed: June 18, 2012
    Date of Patent: February 23, 2016
    Assignee: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Heiko B. Weber, Michael Krieger, Stefan Hertel, Florian Krach, Johannes Jobst, Daniel Waldmann
  • Patent number: 9262831
    Abstract: In a device and a corresponding method for joining a plurality of individual digital images to form a total image, a plurality of features is determined in a first individual image by means of a selection unit using a feature-based algorithm and then tracked in a second individual image by means of a tracking unit. A transformation matrix, with which the individual images are joined in an output unit to form the total image, is calculated from the determined feature correspondences in a transformation unit. The individual images can be joined in real time and with a high degree of accuracy by means of the feature-based algorithm in combination with a robust algorithm to calculate the transformation matrix.
    Type: Grant
    Filed: August 23, 2010
    Date of Patent: February 16, 2016
    Assignees: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG e.V., Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Christian Münzenmayer, Christian Winter, Thomas Wittenberg, Stephan Rupp, Dietrich Paulus, Tobias Bergen, Steffen Ruthotto
  • Patent number: 9263526
    Abstract: A semiconductor component (1, 20, 30) comprising a semiconductor substrate (3) composed of silicon carbide and comprising separate electrodes (4, 5) applied thereto, said electrodes each comprising at least one monolayer of epitaxial graphene (11) on silicon carbide, in such a way that a current channel is formed between the electrodes (4, 5) through the semiconductor substrate (3).
    Type: Grant
    Filed: March 29, 2012
    Date of Patent: February 16, 2016
    Assignee: Friedrich-Alexander-Universität Erlangen-Nürnberg
    Inventors: Heiko B. Weber, Michael Krieger, Stefan Hertel, Florian Krach, Johannes Jobst, Daniel Waldmann