Abstract: The present invention relates to fluorophenyl substituted muscarinic receptor ligands with selectivity for M3 over M2 and to the use of these compounds in the treatment of various diseases such as asthma, chronic obstructive pulmonary disease (COPD), bronchopulmonary dysplasia (BPD) and urinary incontinence.

Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.

Abstract: A topologically-protected traveling-wave amplifier includes resonators arranged in a two-dimensional array defining a periphery including a first edge. An output line is coupled to an output resonator disposed along the first edge spaced from an input resonator coupled to an output line. A synthetic gauge field generator associated with the resonators provides a topologically-protected edge state corresponding to propagation along the periphery in a propagation direction from the input resonator along the first edge to the output resonator. A parametric driving element creates pairs of photons in the edge state and amplifies a signal propagating along the first edge in the propagation direction. A signal incident from the input line propagates in the propagation direction along the first edge while being amplified and is detected at the output line as an amplified signal. A signal incident from the output line is attenuated before emerging at the input resonator.

Abstract: Described herein, inter alia, are compositions and methods for modulating mu opioid receptor activity.

Abstract: The present disclosure pertains to the identification of novel biomarkers for the characterization of melanocytic lesions as can be found in skin diseases such as melanomas and psoriasis. In particular, the present invention is directed to a method for characterizing melanocytic lesions and their use in an automated or semi-automated device for the diagnosis and/or monitoring of benign, pre-malignant, and malignant melanocytic lesions, as further defined in the claims.

Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.

Abstract: A method and system for motion estimation modeling for cardiac and respiratory motion compensation is disclosed. Specifically, a coronary sinus catheter is tracked in a plurality of frames of a fluoroscopic image sequence; and cardiac and respiratory motion of a left atrium is estimated in each of the plurality of frames based on tracking results of the coronary sinus catheter using a trained motion estimation model.

Abstract: The present invention relates to specific T-cell receptor a-chains, T-cell receptor ?-chains and T-cell receptors comprising said T-cell receptor a-chain and/or ?-chain. In particular, the invention relates to T-cell receptors and/or chains binding to the influenza matrix peptide GILGFVFTL (GL9 peptide) presented by Human Leukocyte antigen A2 (HLA-A2) molecules. The present invention further relates to soluble TCR constructs, chimeric TCRs, nucleic acids, expression constructs and cells comprising said TCR a-chain and/or ?-chain or the respective TCR. The present invention further relates to the use of the TCR a-chain and/or ?-chain or the respective TCR or the soluble TCR constructs or chimeric TCRs as a medicament, preferably in the detection, prevention and/or treatment of influenza. The present invention further relates to methods of detecting, preventing and/or treating influenza.

Abstract: A method for detecting a degree of hydrogenation of a liquid comprises one or more liquid hydrogen carriers, which can be hydrogenated, comprising: detecting a material property of the liquid and determining the degree of hydrogenation of the liquid on the basis of the detected material property of the liquid.

Abstract: The invention relates to a zeolitic material comprising zeolitic monocrystals, each of which has a pore system encompassing at least one micropore system and at least one macropore system, and to a method for producing a zeolitic material of said type. In said method, porous oxide particles are converted into the zeolitic material in the presence of an organic template and steam.

Abstract: A method of making acrylic acid in liquid phase by contacting a feed stream containing lactic acid, lactide, or mixtures thereof with a molten salt catalyst comprising a protic ionic liquid (PIL), which contains a bromide anion (Br?), is provided.

Abstract: The invention relates to a method for determining the position of a first sensor node relative to a second sensor node, wherein the first and the second sensor nodes are communicatively connected to each other and are a constituent part of a sensor network, comprising the method steps: reception of signal sections of transmitted signals from at least two transmitters by the first and the second sensor node, beginning at a time t1 for a time period tRX; determining the angle of incidence of the transmitted signals to at least one of the sensor nodes; determining the distance between the sensor nodes from the propagation time differences of the transmitted signals from the at least two transmitters received at the first and second sensor nodes; determining the position of the first sensor node relative to the second sensor node from the distance between the sensor nodes and the angle of incidence of the transmitted signals, wherein the sensor nodes determine the time t1 and the time period t1 in relation to a r

Abstract: The invention relates to a method for the frequency error correction of an oscillator of a sensor node in a sensor network, comprising the following steps: receiving a transmission signal of a transmitter, the signal being modulated by orthogonal frequency division multiplexing (OFDM); determining the frequency deviation of the oscillator using the received transmission signal; determining a correction signal for correcting the frequency deviation of the oscillator and correcting the frequency of the oscillator by means of the correction signal.

Abstract: The present invention relates to a fast, simple and very sensitive method for the detection of bacteria, comprising the steps of providing one or more suspensions each comprising at least one species of labeled test bacteriophages which specifically bind to a bacterial species to be detected; adding a sample to be tested for the presence of at least one bacterial species to be detected to the one or more suspensions; filtering the reaction mixture; detecting bacteria-bacteriophages-complexes on the surface of the filter in the retentate, provided that at least one bacterial species to be detected is present, wherein the complexes consist of bacteria of the at least one bacterial species to be detected and test bacteriophages of the at least one species of test bacteriophages bound thereto; detecting unbound test bacteriophages in the filtrate; processor-aided processing of received detection signals and output of detection results.

Abstract: A measurement method is for determining core losses, which serve to produce magnetic circuits for electrical machines. In order to allow an accurate measurement that is as quick as possible, it is proposed that a magnetic coupling is produced between a measuring coil connected in a capacitor and a core to be measured, and the measuring coil is then acted upon by an alternating frequency in order to measure the resonant frequency of the resulting resonant circuit and/or the quality of the resulting resonant circuit as a measure of the core loss.

Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.

Abstract: The invention relates to an electron beam splitter (1) comprising a multi-pole electrode arrangement with a high-frequency alternating current voltage (5), which extends along a specified path (6) from an inlet side (9) to an outlet side (10), wherein the electrode arrangement (5) generates on the inlet side (9) with a first number of electrodes (7) impacted by the voltage a first oscillating electric field (61), which forms on a transversal plane a single local confinement minimum (62) in a time-averaged manner, and wherein the electrode arrangement (5) generates at least on the outlet side (10) with a second number of voltage-impacted electrodes (7) a second oscillating electric field (65), which forms at least two local confinement minimums (66, 67) in a time averaged manner.

Abstract: The invention relates to dendritic cells, the NF?B signaling pathway of which has been manipulated by RNA transfection, to the manufacture thereof and to use thereof.

Abstract: Described are methods and means for metabolic engineering and improved product formation by a filamentous micro-organism or a low G+C gram-positive bacterium. Disclosed is that DasR and DasR binding sites play an important and universal role in the control of gene expression in micro-organisms. Based on this finding, provided are multiple useful applications, such as a method for regulating the expression of a gene of interest, a method for controlling metabolism, a method for decreasing undesired expression and many more. Moreover, provided are means that can be used to establish said methods: for example a micro-organism in which the DasR binding site in operable linkage with a particular gene has been modified to obtain increased or decreased expression of a protein (being a desired or undesired protein) encoded by said gene.

Abstract: In a device and a corresponding method for joining a plurality of individual digital images to form a total image, a plurality of features is determined in a first individual image by means of a selection unit using a feature-based algorithm and then tracked in a second individual image by means of a tracking unit. A transformation matrix, with which the individual images are joined in an output unit to form the total image, is calculated from the determined feature correspondences in a transformation unit. The individual images can be joined in real time and with a high degree of accuracy by means of the feature-based algorithm in combination with a robust algorithm to calculate the transformation matrix.