Abstract: Exemplary method, computer-accessible medium and system can be provided for determining the presence or absence of a local and/or global property of a biological tissue sample. Thus, it is possible to obtain at least one image of the sample, search the image(s) for a presence of at least one particular feature that is contained in a pre-defined set of features, and assign, to the particular feature(s). It is possible to compute, with a computer processor, at least one discriminant value that is a function of the pronunciation index that is weighted with a particular weight. The weight of each pronunciation index is a measure for a relevance of the corresponding feature with respect to the property. It is possible to determine whether the property is present in at least one part of the biological tissue sample depending on whether the discriminant value exceeds a pre-defined threshold and/or and optimized threshold.

Abstract: The invention relates to a method for machining a transparent workpiece (4) by generating non-linear absorption of laser radiation in a laser beam focus located in a volume of the workpiece (4). The object of the invention is that of providing a method of improved precision and quality, and a corresponding device, for laser machining of workpieces. In particular, it is also intended for it to be possible for workpieces made of composite materials or of other special materials, such as filter glass, to be machined at an improved level of quality. For this purpose, the method according to the invention comprises the following steps: spectroscopic measurement of the linear absorption of the laser radiation in the workpiece (4), selecting a working wavelength at which the linear absorption is low, and machining the workpiece (4) by means of application of laser radiation at the working wavelength. The invention furthermore relates to a corresponding device for machining a transparent workpiece (4).

Abstract: The invention relates to a method for stably transmitting laser radiation through an optical waveguide (3), wherein two or more modes of the laser radiation propagating in the optical waveguide (3) interfere and form a mode interference pattern in the optical waveguide, as a result of which a thermally induced refractive index grating is produced in the optical waveguide (3). It is an object of the invention to demonstrate an effective approach for stabilizing the output signal of the optical waveguide (3) in a fiber-based laser/amplifier combination at high output powers, i.e. for avoiding mode instability. The invention achieves this object by virtue of the fact that a relative spatial phase shift between the mode interference pattern and the thermally induced refractive index grating is set in the direction of propagation of the laser radiation.

Abstract: The present invention relates to compounds of formula (III) or to compounds of formula (IV) wherein R1, R2, R3 and R4 are as defined in the claims, and their use in therapeutic treatments of 5-lipoxygenase related diseases such as chronic airway inflammatory or dermatological disorders.

Abstract: An optical element including a reflective coating is disclosed. In an embodiment the reflective coating includes an adhesion-promoting layer, an at least partially reflective silver layer disposed on the adhesion-promoting layer and a protective layer system disposed on the silver layer, wherein the protective layer system includes a plurality of dielectric layers, wherein the dielectric layers include at least one first layer and at least one second layer, wherein the first layer and the second layer have a different resistance to at least two different contamination substances, wherein the dielectric layers have a thickness of not more than 30 nm, and wherein a number of the dielectric layers amounts to at least five.

Abstract: A method and a device for producing an optical component having at least three monolithically arranged optical functional surfaces and an optical component are disclosed.

Abstract: The invention relates to an optical waveguide with at least one core region (1) extending along the longitudinal extent of the optical waveguide, and with a first jacket (2) which, viewed in the cross section of the optical waveguide, surrounds the core region (1). The invention further relates to an optical arrangement with such an optical waveguide, and to a method for producing the optical waveguide. The object of the invention is to make available an optical waveguide for high-performance operation, which is improved in relation to the prior art in terms of mode instability. The invention achieves this object by virtue of the fact that the optical waveguide consists of crystalline material at least in the core region (1).

Abstract: The present invention relates to small molecule compounds and their use as HDAC inhibitors and in the treatment of various diseases, such as cancer. The present invention further relates to methods of synthesizing the compounds and methods of treatment. H-L(HA), H is a head group selected from (head group 1), (head group 2), (head group 3), (head group 4), (head group 5) and (head group 6).

Abstract: An illumination unit for lithographic exposure and a device for lithographic exposure are disclosed. In an embodiment the illumination unit includes a beam source, an electronically drivable beam deflection element for generating a temporally varying two-dimensional beam deflection, a collimation lens, a beam homogenizing element, a Fourier lens and a field lens.

Abstract: The invention relates to an optical array comprising a splitting element (1) which splits an input beam (E) into at least two partial beams (T1, T2, T3, T4), at least one optical element (V1, V2, V3, V4, MV) through which at least one of the partial beams (T1, T2, T3, T4) propagates, and at least one combining element (4) which spatially superimposes the partial beams (T1, T2, T3, T4) in one output beam (A). The object of the invention is to provide an optical array which is improved over the prior art and which permits effective and simple splitting of the input light beam, in particular a laser beam with pulsed or continuous emission. The invention achieves this object in that the splitting element (1) and/or the combining element (4) each have a partially reflective element (2, 2?) which reflects the radiation of the input beam (E) or of the output beam (A) two or more times, wherein the partially reflective element (2, 2?) has zones (a, b, c, d) of different reflectivity.

Abstract: The invention relates to an apparatus (1) for producing short synchronous radiation pulses at different wavelengths, particularly to an optically parametric oscillator, comprising at least one pump radiation source (2), preferably a pump laser, for outputting radiation at a pump wavelength, and a resonator (3) having a wavelength-dependent effective resonator length, wherein the resonator (3) has a non-linear wavelength converter (4) for producing radiation at a first and a second wavelength; a dispersive element (5) having a strong wavelength-dependent delay characteristic; and a coupling-out element (6) for at least partially coupling-out the radiation from the resonator (3). In addition, the invention relates to a method for producing short radiation pulses by means of an apparatus (1), particularly an optically parametric oscillator.

Abstract: The invention relates to a method of joining substrates. It is the object of the invention in this respect to join substrates of substrate materials together without having to exert an increased effort for a coating with additional coating processes to be carried out and to be able to achieve a good quality of the join connection in so doing. In the method in accordance with the invention a pretreatment of at least one join surface of a substrate to be joined is carried out in low pressure oxygen plasma prior to the actual joining. On the joining, a contact force acts on the substrates to be joined in the range 2 kPa to 5 MPa and in this process a heat treatment is carried out at an elevated temperature of at least 100° C. and at under pressure conditions of a maximum of 10 mbar, preferably <10?3 mbar.

Abstract: The invention relates to an optical waveguide with at least one core region (1) extending along the longitudinal extent of the optical waveguide, and with a first jacket (2) which, viewed in the cross section of the optical waveguide, surrounds the core region (1). The invention further relates to an optical arrangement with such an optical waveguide, and to a method for producing the optical waveguide. The object of the invention is to make available an optical waveguide for high-performance operation, which is improved in relation to the prior art in terms of mode instability. The invention achieves this object by virtue of the fact that the optical waveguide consists of crystalline material at least in the core region (1).

Abstract: The invention relates to an optical array comprising a splitting element (1) which splits an input beam (E) into at least two partial beams (T1, T2, T3, T4), at least one optical element (V1, V2, V3, V4, MV) through which at least one of the partial beams (T1, T2, T3, T4) propagates, and at least one combining element (4) which spatially superimposes the partial beams (T1, T2, T3, T4) in one output beam (A). The object of the invention is to provide an optical array which is improved over the prior art and which permits effective and simple splitting of the input light beam, in particular a laser beam with pulsed or continuous emission. The invention achieves this object in that the splitting element (1) and/or the combining element (4) each have a partially reflective element (2, 2?) which reflects the radiation of the input beam (E) or of the output beam (A) two or more times, wherein the partially reflective element (2, 2?) has zones (a, b, c, d) of different reflectivity.

Abstract: A method for non-invasive observations of a fundus using an ophthalmoscope is provided. The method includes illuminating a retinal region of an eye by projecting an illumination pattern of illumination light onto the retinal region, at least one of detecting a portion of fluorescent light emitted from the retinal region and detecting a portion of illumination light reflected from the retinal region, thereby capturing a series of images of the retinal region at a plurality of different relative positions of the retinal region with respect to the illumination pattern projected onto the retinal region, wherein between the capturing of at least two images of the series the relative position of the retinal region with respect to the illumination pattern projected onto the retinal region is shifted in a non-controlled manner, and processing the captured images to extract a sub-resolution image of the retinal region.

Abstract: The invention relates to an apparatus (1) for producing short synchronous radiation pulses at different wavelengths, particularly to an optically parametric oscillator, comprising at least one pump radiation source (2), preferably a pump laser, for outputting radiation at a pump wavelength, and a resonator (3) having a wavelength-dependent effective resonator length, wherein the resonator (3) has a non-linear wavelength converter (4) for producing radiation at a first and a second wavelength; a dispersive element (5) having a strong wavelength-dependent delay characteristic; and a coupling-out element (6) for at least partially coupling-out the radiation from the resonator (3). In addition, the invention relates to a method for producing short radiation pulses by means of an apparatus (1), particularly an optically parametric oscillator.

Abstract: The invention relates to a method for producing an optical assembly, comprising at least two optical functional surfaces arranged in a fixed positional relationship to one another on a common supporting structure, wherein by means of a processing machine, in various process steps, at least two optical functional surfaces and at least one reference structure having a defined and measurable relative position to the optical functional surfaces are produced. The supporting structure remains rigidly connected to the processing machine until said process steps have been completed, and wherein the optical functional surfaces are then measured relative to the at least one reference structure, and any deviation from a target shape and target position is determined, after which said process steps are repeated at least once with modified actuation of the processing machine. The invention further relates to an optical device comprising an optical assembly produced in this way and to a unit for carrying out such a method.

Abstract: The invention relates to a method and corresponding devices for reducing mode instability in an optical waveguide (1), a light signal becoming unstable in the optical waveguide (1) beyond an output power threshold and energy being transformed from a basic mode into higher order modes. The invention proposes a reduction in temperature variation (2) along the optical waveguide (1) and/or a reduction in changes in the optical waveguide (1) that are caused by spatial temperature variation as a result of mode interference.

Abstract: An assembly comprising: two ceramic bodies, which are joined by means of a joint of an active hard solder, or braze, wherein the active hard solder, or braze, has a continuous core volume, which is spaced, in each case, from the ceramic bodies by at least 1 ?m, and an average composition CK with a liquidus temperature Tl(CK), wherein the composition CK has a coefficient of thermal expansion ?(CK), wherein ?(CK)=m·?(K), wherein m?1.5, especially m?1.3 and preferably m?1.2, wherein ?(K) is the average coefficient of thermal expansion of the ceramic material of the ceramic bodies, wherein the joint has boundary layers, which border on the ceramic body, wherein at least one of the boundary layers, which lies outside of the core volume, has an average composition CB with a liquidus temperature Tl(CB), which lies not less than 50 K, preferably not less than 100 K, and especially preferably not less than 200 K, under the liquidus temperature Tl(CK) of the average composition CK of the core volume.

Abstract: The invention relates to a method and corresponding devices for reducing mode instability in an optical waveguide (1), a light signal becoming unstable in the optical waveguide (1) beyond an output power threshold and energy being transformed from a basic mode into higher order modes. The invention proposes a reduction in temperature variation (2) along the optical waveguide (1) and/or a reduction in changes in the optical waveguide (1) that are caused by spatial temperature variation as a result of mode interference.