Patents Assigned to Fukuoka University
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Patent number: 8420865Abstract: The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.Type: GrantFiled: March 10, 2009Date of Patent: April 16, 2013Assignee: Fukuoka UniversityInventors: Kosei Shioji, Hiroyuki Nakagawa, Kentaro Okuma
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Patent number: 8299277Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.Type: GrantFiled: November 14, 2007Date of Patent: October 30, 2012Assignees: National Institute of Radiological Sciences, Fukuoka UniversityInventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
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Publication number: 20120270177Abstract: A dental ultrasonic drug delivery system capable of accurately cleaning the inside of root canals and killing bacteria in dentin tubules is provided. The dental ultrasonic drug delivery system delivers a drug to a target using an ultrasonic delivery device 800. The drug is delivered in a mixed state with nanobubbles. A dental therapeutic probe for applying ultrasound is attached to the ultrasonic delivery device 800. The dental therapeutic probe is selected from: (1) a root canal insertion probe 100 which is configured to be inserted into a root canal and causes ultrasound to propagate in the root canal; (2) a dental caries therapeutic probe which causes ultrasound to propagate in a dental caries portion; (3) a periodontal disease therapeutic probe which applies ultrasound to a periodontal disease portion; and (4) a hyperesthesia therapeutic probe which applies ultrasound to hyperesthesia portion.Type: ApplicationFiled: December 16, 2010Publication date: October 25, 2012Applicants: FUKUOKA UNIVERSITY, NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGYInventors: Misako Nakashima, Katsuro Tachibana
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Patent number: 8242302Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.Type: GrantFiled: September 1, 2008Date of Patent: August 14, 2012Assignee: Fukuoka UniversityInventors: Jiro Takata, Kenichi Mishima, Manabu Nakashima, Katsunori Iwasaki, Kazuhisa Matsunaga, Yoshiharu Karube, Michihiro Fujiwara
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Patent number: 8207357Abstract: An antitumor agent which is not easily excreted from tumor cells and is suitable for a topical treatment. Specifically disclosed is a rotaxane compound with contains a compound represented by chemical formula 1 as the base structure. (In chemical formula 1, m?2, n?3, and X represents an anionic molecule or an anionic atom.Type: GrantFiled: October 21, 2009Date of Patent: June 26, 2012Assignees: Wan Station Co., Ltd., Tokyo Institute of Technology, Fukuoka University, Kinki UniversityInventors: Toshikazu Takata, Yasuhito Koyama, Kazuko Nakazono, Toshihide Hasegawa, Young-Gi Lee, Nobufumi Ono, Kazuto Nishio, Yoshihiko Fujita
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Publication number: 20110237647Abstract: The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention is a siRNA comprising a sense RNA having a base sequence of contiguous 20 to 20 bases, preferably 23 to 27 bases, of ZFAT mRNA and an anti-sense RNA having a base sequence complementary to the base sequence of the sense RNA or a shRNA comprising a double-stranded RNA (dsRNA) with the sense RNA connected to the anti-sense RNA via a loop sequence. The inhibitory RNA for inhibiting the expression of ZFAT gene according to this invention decreases a rate of cell proliferation of cancer cells, etc., induces apoptosis of cells including cancer cells, or inhibits an immunoresponse by inhibiting the expression of the ZFAT gene. Therefore, the inhibitory RNA of this invention is useful for development of molecular target agents particularly for cancer cells or immunosuppressive agents.Type: ApplicationFiled: September 8, 2008Publication date: September 29, 2011Applicant: FUKUOKA UNIVERSITYInventors: Senji Shirasawa, Takahiro Fujimoto, Toshiyuki Tsunoda, Keiko Doi, Midori Koyanagi
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Publication number: 20110237807Abstract: An antitumor agent which is not easily excreted from tumor cells and is suitable for a topical treatment. Specifically disclosed is a rotaxane compound with contains a compound represented by chemical formula 1 as the base structure.Type: ApplicationFiled: October 21, 2009Publication date: September 29, 2011Applicants: WAN STATION CO., LTD., TOKYO INSTITUTE OF TECHNOLOGY, FUKUOKA UNIVERSITY, KINKI UNIVERSITYInventors: Toshikazu Takata, Yasuhito Koyama, Kazuko Nakazono, Toshihide Hasegawa, Young-Gi Lee, Nobufumi Ono, Kazuto Nishio, Yoshihiko Fujita
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Publication number: 20110059024Abstract: To provide a liposome composition, which contains at least one liposome, gas entrapped in the liposome, and at least one fullerene encapsulated in or adsorbed on the liposome.Type: ApplicationFiled: September 8, 2010Publication date: March 10, 2011Applicants: FUJIFILM CORPORATION, FUKUOKA UNIVERSITYInventors: Hiroyuki HIRAI, Katsuro TACHIBANA
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Publication number: 20110059020Abstract: To provide a liposome composition, which contains at least one liposome; gas entrapped in the liposome, and at least one metal oxide particle encapsulated in or adsorbed on the liposome, wherein the liposome composition satisfies a ratio B/A of 0.01 to 5, where A is a volume of the gas contained in the liposome on the basis of micro liter, and B is a mass of the at least one metal oxide particle contained in the liposome on the basis of milligram.Type: ApplicationFiled: September 7, 2010Publication date: March 10, 2011Applicants: FUJIFILM Corporation, FUKUOKA UNIVERSITYInventors: Hiroyuki HIRAI, Katsuro Tachibana
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Publication number: 20110015440Abstract: The invention provides a novel peroxide scavenger comprising a phosphine compound represented by general formula [I]: wherein Z1 and Z2 each represents a cyclic group; Ar represents an arylene group; R represents an aliphatic hydrocarbon group; Y represents phosphorus (P), nitrogen (N), or bismuth (Bi); and R1, R2, and R3 each represents a cyclic group, particularly a peroxide scavenger that can scavenge peroxides such as reactive oxygen species which are generated in mitochondria upon exposure to oxidative stress and localized in mitochondria. The phosphine compound of the invention is oxidized by the peroxides localized in mitochondria to increase the fluorescence intensity, whereby the peroxides can be scavenged.Type: ApplicationFiled: March 10, 2009Publication date: January 20, 2011Applicant: Fukuoka UniversityInventors: Kosei Shioji, Hiroyuki Nakagawa, Kentaro Okuma
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Publication number: 20100217006Abstract: It is intended to provide a drug which is efficacious in treating and preventing diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof. Because of containing as the active ingredient a substance selected from among farnesol, a farnesol derivative, a tocopherol derivative, a tocotrienol derivative, pharmacologically acceptable salts thereof and solvates thereof, the above-described inhibitor of ischemic disorders can exert therapeutic and preventive effects on diseases wherein ischemia or an inflammatory substance associated with ischemia participates in the onset or worsening thereof (for example, brain infarction, brain edema, cardiac infarction, etc.) not only by the administration in the acute ischemic stage but also by the therapeutic administration in subacute and/or chronic stages after ischemia-reperfusion. It is also intended to provide a farnesol carboxylic acid ester derivative and a method of producing the same.Type: ApplicationFiled: September 1, 2008Publication date: August 26, 2010Applicant: FUKUOKA UNIVERSITYInventors: Jiro Takata, Kenichi Mishima, Manabu Nakashima, Katsunori Iwasaki, Kazuhisa Matsunaga, Yoshiharu Karube, Michihiro Fujiwara
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Publication number: 20100173277Abstract: An objective of the present invention is to provide effective methods for suppressing rejection in organ transplantation, in particular, pancreatic islet transplantation which is useful in treating diabetes. The present invention demonstrated that antibodies against HMGB-1 suppressed the rejection in pancreatic islet transplantation and promoted the survival of grafted pancreatic islets. Thus, the present invention provides agents that comprise an anti-HMGB-1 antibody for suppressing rejection in organ transplantation.Type: ApplicationFiled: February 15, 2008Publication date: July 8, 2010Applicants: Fukuoka University, Kagoshima University, Shino-Test CorporationInventors: Yohichi Yasunami, Ikuro Maruyama, Shingo Yamada
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Publication number: 20100048512Abstract: Administration of either a tocopherol represented by the general formula (1) or a tocotrienol compound ester derivative before or after exposure to radiation is effective in preventing or treating health disorders caused by the radiation exposure.Type: ApplicationFiled: November 14, 2007Publication date: February 25, 2010Applicants: National Institute of Radiological Sciences, Fukuoka UniversityInventors: Kazunori Anzai, Megumi Ueno, Haruko Yakumaru, Junichi Ueda, Makoto Akashi, Shizuko Kobayashi, Jiro Takata, Nobuo Ikota
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Publication number: 20100004275Abstract: A medicament for suppressing development of tolerance to analgesic effect induced by administration of a narcotic analgesic such as morphine, which comprises an antagonist of the vasopressin receptor 1b as an active ingredient.Type: ApplicationFiled: June 8, 2009Publication date: January 7, 2010Applicants: KYOTO UNIVERSITY, FUKUOKA UNIVERSITY, JAPAN HEALTH SCIENCES FOUNDATIONInventors: Gozoh Tsujimoto, Yukio Takano, Kenji Honda, Akito Tanoue
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Publication number: 20090220499Abstract: The present inventors investigated anti-IL-6 receptor antibodies for their effect in suppressing damage to transplanted islets after islet transplantation. As a result, they found that anti-IL-6 receptor antibodies reduced damage to transplanted islets, improved islet survival, and corrected hyperglycemia in recipients. Further, they revealed that administration of the anti-IL-6 receptor antibodies of the present invention suppressed the production of inflammatory cytokines by infiltrating cells after transplantation. Specifically, the present inventors discovered for the first time that damage to transplanted islets after islet transplantation can be suppressed by using anti-IL-6 receptor antibodies according to the present invention.Type: ApplicationFiled: October 13, 2006Publication date: September 3, 2009Applicant: FUKUOKA UNIVERSITYInventor: Yohichi Yasunami
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Publication number: 20080227802Abstract: A medicament for suppressing development of tolerance to analgesic effect induced by administration of a narcotic analgesic such as morphine, which comprises an antagonist of the vasopressin receptor 1b as an active ingredient.Type: ApplicationFiled: December 26, 2005Publication date: September 18, 2008Applicants: KYOTO UNIVERSITY, FUKUOKA UNIVERSITY, JAPAN HEALTH SCIENCES FOUNDATIONInventors: Gozoh Tsujimoto, Yukio Takano, Kenji Honda, Akito Tanoue
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Publication number: 20080194458Abstract: The artificial pulmonary surfactant composition according to the present invention comprises a lipid mixture system containing no protein or peptide or a protein/peptide-lipid mixture prepared by adding a protein or a peptide to the above lipid mixture system. The artificial pulmonary surfactant composition of this invention is useful for RDS and ARDS as well as for the mitigation or prevention of respiratory insufficiencies caused by pneumonia, respiratory difficulties caused by asthma, etc. and it can be prepared at lower costs.Type: ApplicationFiled: April 28, 2005Publication date: August 14, 2008Applicant: FUKUOKA UNIVERSITYInventors: Sannamu Lee, Ko Yukikate, Yoshihiro Nakamura